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DE69518237D1 - Feste pharmazeutische zubereitung mit (s)-2-(4-isobutylphenyl)propionsäure als wirkstoff und mikrokristalliner cellulose und kolloidalem silica als hilfstoff - Google Patents

Feste pharmazeutische zubereitung mit (s)-2-(4-isobutylphenyl)propionsäure als wirkstoff und mikrokristalliner cellulose und kolloidalem silica als hilfstoff

Info

Publication number
DE69518237D1
DE69518237D1 DE69518237T DE69518237T DE69518237D1 DE 69518237 D1 DE69518237 D1 DE 69518237D1 DE 69518237 T DE69518237 T DE 69518237T DE 69518237 T DE69518237 T DE 69518237T DE 69518237 D1 DE69518237 D1 DE 69518237D1
Authority
DE
Germany
Prior art keywords
isobutylphenyl
propionic acid
solid pharmaceutical
pct
colloidal silica
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69518237T
Other languages
English (en)
Other versions
DE69518237T2 (de
Inventor
Federico Stroppolo
Daniele Bonadeo
Alberto Pagano
Annibale Gazzaniga
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zambon SpA
Original Assignee
Zambon SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon SpA filed Critical Zambon SpA
Publication of DE69518237D1 publication Critical patent/DE69518237D1/de
Application granted granted Critical
Publication of DE69518237T2 publication Critical patent/DE69518237T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69518237T 1994-06-17 1995-05-26 Feste pharmazeutische zubereitung mit (s)-2-(4-isobutylphenyl)propionsäure als wirkstoff und mikrokristalliner cellulose und kolloidalem silica als hilfstoff Expired - Lifetime DE69518237T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI941262A IT1270239B (it) 1994-06-17 1994-06-17 Composizione farmaceutica solida contenente acido (s)-2-(4- isobutilfenil) propionico come principio attivo
PCT/EP1995/002010 WO1995035104A1 (en) 1994-06-17 1995-05-26 Solid pharmaceutical compositions containing (s)-2-(4-isobutylphenyl)propionic acid active ingredient and microcrystalline cellulose and colloidal silica as excipients

Publications (2)

Publication Number Publication Date
DE69518237D1 true DE69518237D1 (de) 2000-09-07
DE69518237T2 DE69518237T2 (de) 2001-02-22

Family

ID=11369126

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69518237T Expired - Lifetime DE69518237T2 (de) 1994-06-17 1995-05-26 Feste pharmazeutische zubereitung mit (s)-2-(4-isobutylphenyl)propionsäure als wirkstoff und mikrokristalliner cellulose und kolloidalem silica als hilfstoff

Country Status (16)

Country Link
US (1) US5869102A (de)
EP (1) EP0758889B1 (de)
JP (1) JP3836507B2 (de)
AT (1) ATE195073T1 (de)
AU (1) AU696778B2 (de)
CZ (1) CZ285199B6 (de)
DE (1) DE69518237T2 (de)
DK (1) DK0758889T3 (de)
ES (1) ES2149990T3 (de)
GR (1) GR3034655T3 (de)
HU (1) HU219246B (de)
IT (1) IT1270239B (de)
NZ (1) NZ287445A (de)
PT (1) PT758889E (de)
RU (1) RU2168980C2 (de)
WO (1) WO1995035104A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585115A (en) 1995-01-09 1996-12-17 Edward H. Mendell Co., Inc. Pharmaceutical excipient having improved compressability
US6471994B1 (en) 1995-01-09 2002-10-29 Edward Mendell Co., Inc. Pharmaceutical excipient having improved compressibility
US5948438A (en) * 1995-01-09 1999-09-07 Edward Mendell Co., Inc. Pharmaceutical formulations having improved disintegration and/or absorptivity
US6395303B1 (en) 1996-06-10 2002-05-28 Edward Mendell Co., Inc. Process for preparing a directly compressible solid dosage form containing microcrystalline cellulose
US6936277B2 (en) 1995-01-09 2005-08-30 J. Rettenmaier & Soehne Gmbh & Co. Kg Pharmaceutical excipient having improved compressibility
US6852336B2 (en) 1995-11-15 2005-02-08 J. Rettenmaier & Soehne Gmbh + Co. Kg Directly compressible high load acetaminophen formulations
US5733578A (en) 1995-11-15 1998-03-31 Edward Mendell Co., Inc. Directly compressible high load acetaminophen formulations
US6391337B2 (en) 1995-11-15 2002-05-21 Edward Mendell Co., Inc. Directly compressible high load acetaminophen formulations
US6348216B1 (en) * 1996-06-10 2002-02-19 Knoll Pharmaceutical Company Ibuprofen and narcotic analgesic compositions
US6361794B1 (en) 1996-06-12 2002-03-26 Basf Corporation Method of making ibuprofen and narcotic analgesic composition
US5990176A (en) * 1997-01-27 1999-11-23 Abbott Laboratories Fluoroether compositions and methods for inhibiting their degradation in the presence of a Lewis acid
DE10003757A1 (de) * 2000-01-28 2001-08-02 Knoll Ag Ibuprofen-Wirkstoffzubereitung
KR100700721B1 (ko) * 2000-09-08 2007-03-27 지상철 안정성 및 용출율이 향상된 ｓ(+)-이부프로펜의 정제
US6926938B2 (en) * 2001-01-10 2005-08-09 Suheung Capsule Co., Ltd. Hardshell gelatin capsule reducing the static electricity and enhancing the lubrication of film
US20030008003A1 (en) * 2001-04-10 2003-01-09 Fahkreddin Jamali Compositions for enhanced absorption of NSAIDs
US6551615B1 (en) 2001-10-18 2003-04-22 M/S. Strides Arcolab Limited Dexibuprofen-containing soft gelatin capsules and process for preparing the same
US20040109889A1 (en) * 2002-12-04 2004-06-10 Bunick Frank J. Surface treatment composition for soft substrates
EP1902708A1 (de) 2006-09-25 2008-03-26 Losan Pharma GmbH Wirkstoff enthaltende stabilisierte feste Arzneimittelformen und Verfahren zu ihrer Herstellung
WO2013154512A1 (en) * 2012-04-13 2013-10-17 Mahmut Bilgic Pharmaceutical formulations comprising dexibuprofen
WO2014078435A1 (en) 2012-11-14 2014-05-22 W. R. Grace & Co.-Conn. Compositions containing a biologically active material and a non-ordered inorganic oxide

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4681897A (en) * 1984-01-16 1987-07-21 The Procter & Gamble Company Pharmaceutical products providing enhanced analgesia
DK62184D0 (da) * 1984-02-10 1984-02-10 Benzon As Alfred Diffusionsovertrukket polydepotpraeparat
GB8521350D0 (en) * 1985-08-28 1985-10-02 Euro Celtique Sa Analgesic composition
GB8623557D0 (en) * 1986-10-01 1986-11-05 Boots Co Plc Therapeutic agents
EP0267321B1 (de) * 1986-11-14 1990-02-28 MEDICEChem.-Pharm. Fabrik Pütter GmbH & Co. KG Ibuprofen enthaltendes Arzneimittel
GB8629567D0 (en) * 1986-12-10 1987-01-21 Boots Co Plc Therapeutic agents
GB8905815D0 (en) * 1989-03-14 1989-04-26 Beecham Group Plc Medicament
US5164398A (en) * 1991-04-01 1992-11-17 Merck & Co., Inc. Ibuprofen-antitussive combinations
HU219242B (en) * 1991-05-13 2001-03-28 Boots Co Plc S(+)-ibuprofen sodium salt dihydrate, pharmaceutical composition comprising this compound and process for production of them
DK138592D0 (da) * 1992-11-17 1992-11-17 Nycomed Dak As Tabletter

Also Published As

Publication number Publication date
DK0758889T3 (da) 2000-11-27
US5869102A (en) 1999-02-09
CZ285199B6 (cs) 1999-06-16
ATE195073T1 (de) 2000-08-15
HUT76325A (en) 1997-08-28
PT758889E (pt) 2000-12-29
NZ287445A (en) 1998-05-27
IT1270239B (it) 1997-04-29
ES2149990T3 (es) 2000-11-16
AU2616795A (en) 1996-01-15
ITMI941262A0 (it) 1994-06-17
RU2168980C2 (ru) 2001-06-20
HU9603463D0 (en) 1997-02-28
JP3836507B2 (ja) 2006-10-25
CZ366296A3 (en) 1997-11-12
GR3034655T3 (en) 2001-01-31
WO1995035104A1 (en) 1995-12-28
HU219246B (en) 2001-03-28
EP0758889B1 (de) 2000-08-02
EP0758889A1 (de) 1997-02-26
JPH10501537A (ja) 1998-02-10
DE69518237T2 (de) 2001-02-22
AU696778B2 (en) 1998-09-17
ITMI941262A1 (it) 1995-12-17

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ZAMBON S.P.A., BRESSO, IT