DE69434801D1 - Verfahren zur herstellung von taxanderivaten und beta-lactam zwischenprodukte - Google Patents

Verfahren zur herstellung von taxanderivaten und beta-lactam zwischenprodukte

Info

Publication number: DE69434801D1
Authority: DE; Germany
Prior art keywords: taxol; taxotere; beta; analogues; side chain
Prior art date: 1993-02-01
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69434801T

Other languages

English (en)

Other versions

DE69434801T2 (de

Inventor

Iwao Ojima

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Research Foundation of the State University of New York

Original Assignee

Research Foundation of the State University of New York

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-02-01

Filing date

1994-01-28

Publication date

2006-09-07

1994-01-28 Application filed by Research Foundation of the State University of New York filed Critical Research Foundation of the State University of New York

2006-09-07 Publication of DE69434801D1 publication Critical patent/DE69434801D1/de

2007-08-09 Application granted granted Critical

2007-08-09 Publication of DE69434801T2 publication Critical patent/DE69434801T2/de

2014-01-29 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

150000003952 β-lactams Chemical class 0.000 title abstract 2
239000013067 intermediate product Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
229930012538 Paclitaxel Natural products 0.000 abstract 5
229960001592 paclitaxel Drugs 0.000 abstract 5
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 5
ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 abstract 4
OVMSOCFBDVBLFW-VHLOTGQHSA-N 5beta,20-epoxy-1,7beta,13alpha-trihydroxy-9-oxotax-11-ene-2alpha,4alpha,10beta-triyl 4,10-diacetate 2-benzoate Chemical compound O([C@@H]1[C@@]2(C[C@H](O)C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)O)C(=O)C1=CC=CC=C1 OVMSOCFBDVBLFW-VHLOTGQHSA-N 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 2
230000000259 anti-tumor effect Effects 0.000 abstract 2
229940063683 taxotere Drugs 0.000 abstract 2
239000002246 antineoplastic agent Substances 0.000 abstract 1
229940041181 antineoplastic drug Drugs 0.000 abstract 1
239000012736 aqueous medium Substances 0.000 abstract 1
229930014667 baccatin III Natural products 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
238000002512 chemotherapy Methods 0.000 abstract 1
230000008878 coupling Effects 0.000 abstract 1
238000010168 coupling process Methods 0.000 abstract 1
238000005859 coupling reaction Methods 0.000 abstract 1
230000003013 cytotoxicity Effects 0.000 abstract 1
231100000135 cytotoxicity Toxicity 0.000 abstract 1
229930004069 diterpene Natural products 0.000 abstract 1
150000004141 diterpene derivatives Chemical class 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
230000004048 modification Effects 0.000 abstract 1
238000012986 modification Methods 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
125000002456 taxol group Chemical group 0.000 abstract 1
230000001988 toxicity Effects 0.000 abstract 1
231100000419 toxicity Toxicity 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)

DE69434801T 1993-02-01 1994-01-28 Verfahren zur herstellung von taxanderivaten und beta-lactam zwischenprodukte Expired - Lifetime DE69434801T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US1192293A	1993-02-01	1993-02-01
US11922		1993-02-01
PCT/US1994/000669 WO1994018164A1 (en)	1993-02-01	1994-01-28	PROCESS FOR PREPARATION OF TAXANE DERIVATIVES AND β-LACTAM INTERMEDIATES THEREFOR

Publications (2)

Publication Number	Publication Date
DE69434801D1 true DE69434801D1 (de)	2006-09-07
DE69434801T2 DE69434801T2 (de)	2007-08-09

Family

ID=21752542

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69434801T Expired - Lifetime DE69434801T2 (de)	1993-02-01	1994-01-28	Verfahren zur herstellung von taxanderivaten und beta-lactam zwischenprodukte

Country Status (17)

Country	Link
EP (1)	EP0681568B1 (de)
JP (1)	JP3492367B2 (de)
KR (1)	KR960700226A (de)
AT (1)	ATE334115T1 (de)
AU (1)	AU687782B2 (de)
CA (1)	CA2154071C (de)
CZ (1)	CZ192195A3 (de)
DE (1)	DE69434801T2 (de)
FI (1)	FI953645L (de)
MX (1)	MX9400806A (de)
NO (1)	NO953011L (de)
NZ (1)	NZ261529A (de)
PL (1)	PL310075A1 (de)
RU (1)	RU95116366A (de)
SK (1)	SK90295A3 (de)
WO (1)	WO1994018164A1 (de)
ZA (1)	ZA94128B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5710287A (en)	1991-09-23	1998-01-20	Florida State University	Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
FR2698871B1 (fr)	1992-12-09	1995-02-24	Rhone Poulenc Rorer Sa	Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
US6593482B2 (en)	1993-02-01	2003-07-15	Aventis Pharma S.A.	Methods for preparing new taxoids and pharmaceutical compositions containing them
FR2732340B1 (fr) *	1995-03-27	1997-04-30	Rhone Poulenc Rorer Sa	Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
US6040466A (en) *	1996-03-25	2000-03-21	Rhone Poulenc Rorer Sa	Taxoids, their preparation and pharmaceutical compositions containing them
US6232477B1 (en)	1996-03-25	2001-05-15	Aventis Pharma S.A.	Methods of preparing new taxoids and pharmaceutical compositions containing them
CA2120221A1 (en) *	1993-04-23	1994-10-24	Allan W. Rey	N-substituted 2-azetidinones
US5677470A (en) *	1994-06-28	1997-10-14	Tanabe Seiyaku Co., Ltd.	Baccatin derivatives and processes for preparing the same
CA2162759A1 (en) *	1994-11-17	1996-05-18	Kenji Tsujihara	Baccatin derivatives and processes for preparing the same
MA23823A1 (fr) *	1995-03-27	1996-10-01	Aventis Pharma Sa	Nouveaux taxoides, leur preparation et les compositions qui les contiennent
US6372780B2 (en)	1995-03-27	2002-04-16	Aventis Pharma S.A.	Methods of treating cell lines expressing multidrug resistance P-glycoprotein
US5847170A (en) *	1995-03-27	1998-12-08	Rhone-Poulenc Rorer, S.A.	Taxoids, their preparation and pharmaceutical compositions containing them
KR20000069431A (ko) *	1996-12-13	2000-11-25	피터 지. 스트링거	Ｐｓａ의 효소 활성 억제제
US5811452A (en) *	1997-01-08	1998-09-22	The Research Foundation Of State University Of New York	Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
US6156789A (en) *	1998-03-17	2000-12-05	Rhone-Poulenc Rorer S.A.	Method for treating abnormal cell proliferation in the brain
US6916942B2 (en)	2000-02-03	2005-07-12	Bristol-Myers Squibb Company	Process for the preparation of C-4 carbonate taxanes
AU2006258065A1 (en)	2005-06-10	2006-12-21	Florida State University Research Foundation, Inc.	Processes for the production of polycyclic fused ring compounds
US7550608B2 (en)	2005-06-10	2009-06-23	Florida State University Research Foundation, Inc.	Processes for the preparation of docetaxel
PT2493466T (pt)	2009-10-29	2021-03-29	Sanofi Mature Ip	Nova utilização antifúngica do cabazitaxel
CA2845388A1 (en)	2011-09-21	2013-03-28	Irun R. Cohen	Beta-lactam compounds for enhancing t cell-mediated immune responses
EP2758054B1 (de)	2011-09-21	2017-04-12	Stem Cell Medicine Ltd.	Beta-lactam-verbindungen zur behandlung von diabetes
CN102408356A (zh) *	2011-09-28	2012-04-11	北京东方协和医药生物技术有限公司	一种多西他赛手性侧链中间体的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5175315A (en) *	1989-05-31	1992-12-29	Florida State University	Method for preparation of taxol using β-lactam
CA2071160A1 (en) *	1991-07-31	1993-02-01	Vittorio Farina	Asymmetric synthesis of taxol side chain
JP3304088B2 (ja) *	1991-09-23	2002-07-22	フロリダ・ステイト・ユニバーシティ	１０−デスアセトキシタキソール誘導体
US5229526A (en) *	1991-09-23	1993-07-20	Florida State University	Metal alkoxides
EP1193252B1 (de) *	1991-09-23	2006-12-27	Florida State University	Beta-Lactame verwendbar zur Herstellung von substituierten Isoserinestern mit Metallalkoxiden

1994
- 1994-01-10 ZA ZA94128A patent/ZA94128B/xx unknown
- 1994-01-28 CA CA002154071A patent/CA2154071C/en not_active Expired - Lifetime
- 1994-01-28 PL PL94310075A patent/PL310075A1/xx unknown
- 1994-01-28 JP JP51806494A patent/JP3492367B2/ja not_active Expired - Lifetime
- 1994-01-28 KR KR1019950703149A patent/KR960700226A/ko not_active Withdrawn
- 1994-01-28 AU AU60313/94A patent/AU687782B2/en not_active Expired - Fee Related
- 1994-01-28 NZ NZ261529A patent/NZ261529A/en not_active IP Right Cessation
- 1994-01-28 DE DE69434801T patent/DE69434801T2/de not_active Expired - Lifetime
- 1994-01-28 RU RU95116366/04A patent/RU95116366A/ru unknown
- 1994-01-28 EP EP94906685A patent/EP0681568B1/de not_active Expired - Lifetime
- 1994-01-28 WO PCT/US1994/000669 patent/WO1994018164A1/en active IP Right Grant
- 1994-01-28 AT AT94906685T patent/ATE334115T1/de not_active IP Right Cessation
- 1994-01-28 SK SK902-95A patent/SK90295A3/sk unknown
- 1994-01-28 CZ CZ951921A patent/CZ192195A3/cs unknown
- 1994-01-31 MX MX9400806A patent/MX9400806A/es unknown
1995
- 1995-07-31 FI FI953645A patent/FI953645L/fi unknown
- 1995-07-31 NO NO953011A patent/NO953011L/no unknown

Also Published As

Publication number	Publication date
ZA94128B (en)	1994-08-19
NZ261529A (en)	1997-05-26
JP3492367B2 (ja)	2004-02-03
WO1994018164A1 (en)	1994-08-18
AU6031394A (en)	1994-08-29
CZ192195A3 (en)	1995-12-13
SK90295A3 (en)	1996-05-08
DE69434801T2 (de)	2007-08-09
NO953011D0 (no)	1995-07-31
KR960700226A (ko)	1996-01-19
EP0681568A1 (de)	1995-11-15
PL310075A1 (en)	1995-11-27
RU95116366A (ru)	1997-06-10
FI953645A0 (fi)	1995-07-31
MX9400806A (es)	1994-08-31
CA2154071A1 (en)	1994-08-18
ATE334115T1 (de)	2006-08-15
EP0681568B1 (de)	2006-07-26
JPH08506339A (ja)	1996-07-09
CA2154071C (en)	2005-06-28
NO953011L (no)	1995-09-21
FI953645L (fi)	1995-09-27
AU687782B2 (en)	1998-03-05

Publication	Publication Date	Title
DE69434801D1 (de)	2006-09-07	Verfahren zur herstellung von taxanderivaten und beta-lactam zwischenprodukte
DK0773938T3 (da)	1999-09-20	Semi-syntetiske taxaner med anti-tumoraktivitet
RU95114377A (ru)	1997-06-10	7-гало- и 7бета, 8бета -метано-таксолы, фармацевтическая композиция, промежуточные соединения, способы получения промежуточных соединений
DK0690856T3 (da)	2003-03-31	Antitumorforbindelser, farmaceutiske præparater, fremgangsmåder til fremstilling deraf og til behandling
FI951596A0 (fi)	1995-04-04	Menetelmä 10-desasetyylibakkatiini-III:n saamiseksi
EA200000282A1 (ru)	2000-10-30	Способ введения таксана пациенту, нуждающемуся в лечении таксаном, способ лечения человека таксаном (варианты)
MX9305766A (es)	1995-01-31	Procedimiento para la preparacion de derivados de taxano y productosobtenidos por medio del mismo.
IT1276041B1 (it)	1997-10-24	Uso del taxol per la produzione di un medicamento per il trattamento delle forme cancerose
MX9306924A (es)	1994-05-31	Composiciones antitumorales que contienen derivados de taxano.
EE9800149A (et)	1998-12-15	Meetod taksaanide külgahela prekursorite valmistamiseks, sellel meetodil saadud ühendid, ning taksaanide valmistamismeetod ja nende derivaadid
HUT68589A (en)	1995-06-28	The cyclodextrin cluster complexes of taxol, taxotere, or taxus, process for their production, and use of them
ES2166448T3 (es)	2002-04-16	(2r,3s)-3-fenilisoserina con el hidroxilo en c-2' protegido con un grupo bencilo y el n protegido con un grupo carbamato, y procedimiento de produccion para la misma.
RU93058546A (ru)	1996-12-27	Способ получения производных эрголина, фармацевтическая композиция
ATE241376T1 (de)	2003-06-15	Zusammensetzungen, die dolastatin-15-analoge in kombination mit taxane und dessen derivaten enthalten
KR950700684A (ko)	1995-02-20	시클릭 항-종양 촉진제 화합물, 그의 조성물, 제조 방법 및 용도(Cyclic Anti-Tumor Promoter Compounds, Compositions and Methods for Production and Use)
IT1274356B (it)	1997-07-17	Tassani semisintetici odtati di attivita' antitumorale
IT1278108B1 (it)	1997-11-17	Secotassani dotati di attivita' antitumorale.

Legal Events

Date	Code	Title	Description
2007-09-13	8364	No opposition during term of opposition