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DE69431833D1 - Antitumorverbindungen, pharmazeutische zusammensetzungen, verfahren zu ihrer herstellung und behandlungsmethoden - Google Patents

Antitumorverbindungen, pharmazeutische zusammensetzungen, verfahren zu ihrer herstellung und behandlungsmethoden

Info

Publication number
DE69431833D1
DE69431833D1 DE69431833T DE69431833T DE69431833D1 DE 69431833 D1 DE69431833 D1 DE 69431833D1 DE 69431833 T DE69431833 T DE 69431833T DE 69431833 T DE69431833 T DE 69431833T DE 69431833 D1 DE69431833 D1 DE 69431833D1
Authority
DE
Germany
Prior art keywords
pharmaceutical compositions
production
treatment methods
antitumor compounds
novel taxanes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69431833T
Other languages
English (en)
Other versions
DE69431833T2 (de
Inventor
Iwao Ojima
Ezio Bombardelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Indena SpA
Research Foundation of the State University of New York
Original Assignee
Indena SpA
Research Foundation of the State University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena SpA, Research Foundation of the State University of New York filed Critical Indena SpA
Publication of DE69431833D1 publication Critical patent/DE69431833D1/de
Application granted granted Critical
Publication of DE69431833T2 publication Critical patent/DE69431833T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE69431833T 1993-03-26 1994-03-24 Antitumorverbindungen, pharmazeutische zusammensetzungen, verfahren zu ihrer herstellung und behandlungsmethoden Expired - Lifetime DE69431833T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/040,189 US5475011A (en) 1993-03-26 1993-03-26 Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
PCT/US1994/003215 WO1994022856A1 (en) 1993-03-26 1994-03-24 Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment

Publications (2)

Publication Number Publication Date
DE69431833D1 true DE69431833D1 (de) 2003-01-16
DE69431833T2 DE69431833T2 (de) 2003-11-06

Family

ID=21909617

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69431833T Expired - Lifetime DE69431833T2 (de) 1993-03-26 1994-03-24 Antitumorverbindungen, pharmazeutische zusammensetzungen, verfahren zu ihrer herstellung und behandlungsmethoden

Country Status (19)

Country Link
US (3) US5475011A (de)
EP (1) EP0690856B1 (de)
JP (2) JP3157165B2 (de)
KR (1) KR100223720B1 (de)
CN (1) CN1067682C (de)
AT (1) ATE229018T1 (de)
AU (1) AU676041B2 (de)
CA (1) CA2158147C (de)
CZ (1) CZ288924B6 (de)
DE (1) DE69431833T2 (de)
DK (1) DK0690856T3 (de)
ES (1) ES2190440T3 (de)
HU (1) HUT73848A (de)
NO (1) NO311722B1 (de)
PL (2) PL179587B1 (de)
PT (1) PT690856E (de)
RU (1) RU2137764C1 (de)
SK (1) SK282317B6 (de)
WO (1) WO1994022856A1 (de)

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US6177456B1 (en) 1995-10-02 2001-01-23 Xechem International, Inc. Monohalocephalomannines having anticancer and antileukemic activity and method of preparation therefor
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DE69812395T2 (de) 1997-08-21 2004-02-05 Florida State University, Tallahassee Verfahren zur synthese von taxanen
US6235776B1 (en) 1998-11-12 2001-05-22 Cell Pathways, Inc. Method for treating a patient with neoplasia by treatment with a paclitaxel derivative
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ITMI991483A1 (it) 1999-07-06 2001-01-06 Indena Spa Derivati tassanici e procedimenti per la loro preparazione
EP1229934B1 (de) 1999-10-01 2014-03-05 Immunogen, Inc. Zusammensetzungen und verfahren zur behandlung von krebs mittels immunkonjugaten und chemotherapeutischen agenzien
DE60032633T2 (de) * 1999-11-24 2007-10-04 Immunogen Inc., Cambridge Zytotoxische mittel, die taxane enthalten und ihre therapeutische anwendung
HUP0200756A3 (en) * 2000-02-02 2005-02-28 Univ Florida State Res Found C7 carbonate substituted taxanes as antitumor agents and pharmaceutical compositions containing them
JP2003522171A (ja) 2000-02-02 2003-07-22 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド 抗腫瘍剤としてのｃ１０カーボネート置換タキサン
US6649632B2 (en) * 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
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US7615653B2 (en) * 2006-03-15 2009-11-10 The Research Foundation Of State University Of New York Anti-tuberculosis taxane compounds
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KR101764081B1 (ko) 2008-04-30 2017-08-01 이뮤노젠 아이엔씨 가교제 및 그 용도
KR20190049930A (ko) 2008-05-23 2019-05-09 더 유니버시티 오브 브리티쉬 콜롬비아 리포좀 나노입자에 사용하기 위한 변형된 약물
CN101838281B (zh) * 2010-05-20 2015-02-18 上海博速医药科技有限公司 一种多西他赛手性侧链中间体的制备方法
CN103732229A (zh) 2011-08-02 2014-04-16 安斯泰来制药株式会社 基于药剂的联用的癌症治疗方法
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CN104650109B (zh) * 2013-11-22 2019-01-01 江苏天士力帝益药业有限公司 紫杉烷类化合物
CN114262344A (zh) 2014-02-28 2022-04-01 杭州多禧生物科技有限公司 带电荷链接体及其在共轭反应上的应用
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US5475011A (en) * 1993-03-26 1995-12-12 The Research Foundation Of State University Of New York Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment

Also Published As

Publication number Publication date
EP0690856A1 (de) 1996-01-10
CN1123547A (zh) 1996-05-29
JPH11322737A (ja) 1999-11-24
EP0690856B1 (de) 2002-12-04
HUT73848A (en) 1996-09-30
JP3145993B2 (ja) 2001-03-12
EP0690856A4 (de) 1996-02-07
RU2137764C1 (ru) 1999-09-20
DK0690856T3 (da) 2003-03-31
PT690856E (pt) 2003-04-30
NO311722B1 (no) 2002-01-14
PL180708B1 (pl) 2001-03-30
NO953796D0 (no) 1995-09-25
JP3157165B2 (ja) 2001-04-16
KR100223720B1 (ko) 1999-10-15
US5599820A (en) 1997-02-04
CA2158147A1 (en) 1994-10-13
CZ248095A3 (en) 1996-03-13
ES2190440T3 (es) 2003-08-01
ATE229018T1 (de) 2002-12-15
US5475011A (en) 1995-12-12
AU6491694A (en) 1994-10-24
HU9502642D0 (en) 1995-11-28
JPH08508497A (ja) 1996-09-10
WO1994022856A1 (en) 1994-10-13
SK282317B6 (sk) 2002-01-07
AU676041B2 (en) 1997-02-27
CA2158147C (en) 1999-10-05
NO953796L (no) 1995-11-15
US5705508A (en) 1998-01-06
DE69431833T2 (de) 2003-11-06
CN1067682C (zh) 2001-06-27
SK118395A3 (en) 1996-06-05
CZ288924B6 (cs) 2001-09-12
PL310827A1 (en) 1996-01-08
PL179587B1 (pl) 2000-09-29
KR960701045A (ko) 1996-02-24

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