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DE69233672D1 - Beta-Lactame verwendbar zur Herstellung von substituierten Isoserinestern mit Metallalkoxiden - Google Patents

Beta-Lactame verwendbar zur Herstellung von substituierten Isoserinestern mit Metallalkoxiden

Info

Publication number
DE69233672D1
DE69233672D1 DE69233672T DE69233672T DE69233672D1 DE 69233672 D1 DE69233672 D1 DE 69233672D1 DE 69233672 T DE69233672 T DE 69233672T DE 69233672 T DE69233672 T DE 69233672T DE 69233672 D1 DE69233672 D1 DE 69233672D1
Authority
DE
Germany
Prior art keywords
beta
preparation
deriv
taxane
metal alkoxides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69233672T
Other languages
English (en)
Other versions
DE69233672T2 (de
Inventor
Robert A Holton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Florida State University
Original Assignee
Florida State University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Florida State University filed Critical Florida State University
Application granted granted Critical
Publication of DE69233672D1 publication Critical patent/DE69233672D1/de
Publication of DE69233672T2 publication Critical patent/DE69233672T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D205/00Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/22Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00Preparation of carboxylic acid amides
    • C07C231/12Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/64Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/81Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/82Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/87Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D305/00Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/003Compounds containing elements of Groups 4 or 14 of the Periodic Table without C-Metal linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/56Ring systems containing bridged rings
    • C07C2603/58Ring systems containing bridged rings containing three rings
    • C07C2603/60Ring systems containing bridged rings containing three rings containing at least one ring with less than six members
    • C07C2603/62Ring systems containing bridged rings containing three rings containing at least one ring with less than six members containing three- or four-membered rings
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Cephalosporin Compounds (AREA)
  • Glass Compositions (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cosmetics (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
DE69233672T 1991-09-23 1992-09-22 Beta-Lactame verwendbar zur Herstellung von substituierten Isoserinestern mit Metallalkoxiden Expired - Lifetime DE69233672T2 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US76380591A 1991-09-23 1991-09-23
US763805 1991-09-23
US86295592A 1992-04-03 1992-04-03
US862955 1992-04-03
US86384992A 1992-04-06 1992-04-06
US863849 1997-05-27

Publications (2)

Publication Number Publication Date
DE69233672D1 true DE69233672D1 (de) 2007-02-08
DE69233672T2 DE69233672T2 (de) 2007-10-18

Family

ID=29716161

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69228756T Expired - Lifetime DE69228756T2 (de) 1991-09-23 1992-09-22 Darstellung von substituierten isoserinestern unter verwendung von metallalkoxiden und beta-lactams
DE69233672T Expired - Lifetime DE69233672T2 (de) 1991-09-23 1992-09-22 Beta-Lactame verwendbar zur Herstellung von substituierten Isoserinestern mit Metallalkoxiden
DE69233292T Expired - Lifetime DE69233292T2 (de) 1991-09-23 1992-09-22 Metallalkoxide

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69228756T Expired - Lifetime DE69228756T2 (de) 1991-09-23 1992-09-22 Darstellung von substituierten isoserinestern unter verwendung von metallalkoxiden und beta-lactams

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69233292T Expired - Lifetime DE69233292T2 (de) 1991-09-23 1992-09-22 Metallalkoxide

Country Status (16)

Country Link
EP (3) EP0884314B1 (de)
JP (2) JP3469237B2 (de)
KR (1) KR100252493B1 (de)
AT (3) ATE258171T1 (de)
CA (3) CA2098478C (de)
CZ (2) CZ287417B6 (de)
DE (3) DE69228756T2 (de)
DK (3) DK0884314T3 (de)
ES (3) ES2214665T3 (de)
FI (1) FI113046B (de)
GR (1) GR3030329T3 (de)
HU (1) HU226369B1 (de)
NO (1) NO306209B1 (de)
RU (1) RU2128654C1 (de)
SG (2) SG52496A1 (de)
WO (1) WO1993006079A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6521660B2 (en) 1991-09-23 2003-02-18 Florida State University 3′-alkyl substituted taxanes and pharmaceutical compositions containing them
US5284865A (en) 1991-09-23 1994-02-08 Holton Robert A Cyclohexyl substituted taxanes and pharmaceutical compositions containing them
US5710287A (en) 1991-09-23 1998-01-20 Florida State University Taxanes having an amino substituted side-chain and pharmaceutical compositions containing them
US6005138A (en) 1991-09-23 1999-12-21 Florida State University Tricyclic taxanes having a butenyl substituted side-chain and pharmaceutical compositions containing them
US5430160A (en) 1991-09-23 1995-07-04 Florida State University Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides
US7074945B2 (en) 1991-09-23 2006-07-11 Florida State University Metal alkoxide taxane derivatives
US5294637A (en) * 1992-07-01 1994-03-15 Bristol-Myers Squibb Company Fluoro taxols
US5380751A (en) * 1992-12-04 1995-01-10 Bristol-Myers Squibb Company 6,7-modified paclitaxels
AU679206B2 (en) * 1992-12-23 1997-06-26 Bristol-Myers Squibb Company Novel sidechain-bearing taxanes and intermediates thereof
US5646176A (en) * 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives
ZA94128B (en) * 1993-02-01 1994-08-19 Univ New York State Res Found Process for the preparation of taxane derivatives and betalactam intermediates therefor
TW467896B (en) * 1993-03-19 2001-12-11 Bristol Myers Squibb Co Novel β-lactams, methods for the preparation of taxanes and sidechain-bearing taxanes
ATE295164T1 (de) * 1993-03-22 2005-05-15 Univ Florida State Taxane mit furyl oder thienyl enthaltender substituierter seitenkette
US5677470A (en) * 1994-06-28 1997-10-14 Tanabe Seiyaku Co., Ltd. Baccatin derivatives and processes for preparing the same
US6201140B1 (en) 1994-07-28 2001-03-13 Bristol-Myers Squibb Company 7-0-ethers of taxane derivatives
CA2162759A1 (en) * 1994-11-17 1996-05-18 Kenji Tsujihara Baccatin derivatives and processes for preparing the same
DE19509697A1 (de) * 1995-03-08 1996-09-12 Schering Ag Neue Borneole, Verfahren zu ihrer Herstellung und ihre pharmazeutische Verwendung
US6051600A (en) * 1995-09-12 2000-04-18 Mayhew; Eric Liposomal hydrolysis-promoting hydrophobic taxane derivatives
US6107332A (en) 1995-09-12 2000-08-22 The Liposome Company, Inc. Hydrolysis-promoting hydrophobic taxane derivatives
HUP9903318A3 (en) 1996-05-08 2000-12-28 Upjohn Co Intermediates for prepare taxol
KR100603877B1 (ko) 1999-05-28 2006-07-25 브리스톨-마이어즈 스퀴브 컴페니 디알킬디클로로실란을 사용한 파클리탁셀의 반합성
US6649632B2 (en) 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
ATE394402T1 (de) 2000-12-01 2008-05-15 Biogen Idec Inc Kondensierte purinderivate als a1- adenosinrezeptorantagonisten
HUP0600533A2 (en) 2001-11-30 2006-11-28 Bristol Myers Squibb Co Paclitaxel solvates
PL194032B1 (pl) * 2002-12-19 2007-04-30 Agropharm Sa Sposób wytwarzania półproduktów użytecznych w syntezie paklitakselu
US6956123B2 (en) * 2003-03-17 2005-10-18 Natural Pharmaccuticals, Inc. Purification of taxanes and taxane mixtures using polyethyleneimine-bonded resins
US8703982B2 (en) 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
SV2006002010A (es) 2004-02-13 2006-08-23 Univ Florida State Res Found Taxanos sustituidos con esteres de ciclopentilo en c10
WO2006116532A2 (en) 2005-04-28 2006-11-02 University Of Massachusetts Lowell Synthesis of oligo/poly(catechins) and methods of use
WO2009145981A1 (en) 2008-03-31 2009-12-03 Florida State University Research Foundation, Inc. C(10) ethyl ester and c(10) cyclopropyl ester substituted taxanes
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
CA2944401A1 (en) 2014-04-03 2015-10-08 Invictus Oncology Pvt. Ltd. Supramolecular combinatorial therapeutics

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5136060A (en) * 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene

Also Published As

Publication number Publication date
FI113046B (fi) 2004-02-27
DE69233292T2 (de) 2004-06-09
EP0605637A4 (en) 1994-08-24
NO941022L (no) 1994-05-20
NO941022D0 (no) 1994-03-22
CZ66094A3 (en) 1994-12-15
EP0884314B1 (de) 2004-01-21
SG97130A1 (en) 2003-07-18
EP1193252A2 (de) 2002-04-03
ES2132129T3 (es) 1999-08-16
CA2254273C (en) 2003-03-25
DE69228756D1 (de) 1999-04-29
AU647971B2 (en) 1994-03-31
EP1193252A3 (de) 2003-11-05
CA2098478A1 (en) 1993-03-24
CZ290590B6 (en) 2002-08-14
HU226369B1 (en) 2008-09-29
JP2004043439A (ja) 2004-02-12
SG52496A1 (en) 1998-09-28
HU9400830D0 (en) 1994-06-28
EP1193252B1 (de) 2006-12-27
AU2689092A (en) 1993-04-27
RU2128654C1 (ru) 1999-04-10
GR3030329T3 (en) 1999-09-30
CA2254273A1 (en) 1993-03-24
DE69233672T2 (de) 2007-10-18
DK1193252T3 (da) 2007-04-30
FI941325A0 (fi) 1994-03-22
ES2277964T3 (es) 2007-08-01
DE69228756T2 (de) 1999-10-07
ES2214665T3 (es) 2004-09-16
EP0605637A1 (de) 1994-07-13
DK0605637T3 (da) 1999-10-11
DE69233292D1 (de) 2004-02-26
WO1993006079A1 (en) 1993-04-01
CA2418125A1 (en) 1993-03-24
ATE349424T1 (de) 2007-01-15
HUT71795A (en) 1996-02-28
FI941325L (fi) 1994-05-04
EP0884314A2 (de) 1998-12-16
NO306209B1 (no) 1999-10-04
ATE178060T1 (de) 1999-04-15
JP3469237B2 (ja) 2003-11-25
ATE258171T1 (de) 2004-02-15
CA2098478C (en) 1999-09-14
CZ287417B6 (cs) 2000-11-15
EP0884314A3 (de) 2002-05-02
CA2418125C (en) 2007-12-04
DK0884314T3 (da) 2004-05-24
EP0605637B1 (de) 1999-03-24
KR100252493B1 (ko) 2000-05-01
JPH07502983A (ja) 1995-03-30

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