DE69232944D1 - Veränderte Immunglobuline für spezifische FC-Epsilon Rezeptoren - Google Patents
Veränderte Immunglobuline für spezifische FC-Epsilon RezeptorenInfo
- Publication number
- DE69232944D1 DE69232944D1 DE69232944T DE69232944T DE69232944D1 DE 69232944 D1 DE69232944 D1 DE 69232944D1 DE 69232944 T DE69232944 T DE 69232944T DE 69232944 T DE69232944 T DE 69232944T DE 69232944 D1 DE69232944 D1 DE 69232944D1
- Authority
- DE
- Germany
- Prior art keywords
- ige
- receptor
- specific
- binding
- useful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000009438 IgE Receptors Human genes 0.000 title abstract 4
- 108010073816 IgE Receptors Proteins 0.000 title abstract 4
- 108060003951 Immunoglobulin Proteins 0.000 title 1
- 102000018358 immunoglobulin Human genes 0.000 title 1
- 229940072221 immunoglobulins Drugs 0.000 title 1
- 102000005962 receptors Human genes 0.000 abstract 3
- 108020003175 receptors Proteins 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- 210000003719 b-lymphocyte Anatomy 0.000 abstract 1
- 210000003651 basophil Anatomy 0.000 abstract 1
- 210000001772 blood platelet Anatomy 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 210000003979 eosinophil Anatomy 0.000 abstract 1
- 210000003630 histaminocyte Anatomy 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 210000001616 monocyte Anatomy 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
- C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE122006000006C DE122006000006I2 (de) | 1991-08-14 | 1992-08-14 | Veränderte Immunglobuline für spezifische FC-Epsilon Rezeptoren |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74476891A | 1991-08-14 | 1991-08-14 | |
US87949592A | 1992-05-07 | 1992-05-07 | |
PCT/US1992/006860 WO1993004173A1 (en) | 1991-08-14 | 1992-08-14 | Immunoglobulin variants for specific fc epsilon receptors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69232944D1 true DE69232944D1 (de) | 2003-04-10 |
DE69232944T2 DE69232944T2 (de) | 2003-12-24 |
Family
ID=27114350
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69232944T Expired - Lifetime DE69232944T2 (de) | 1991-08-14 | 1992-08-14 | Veränderte Immunglobuline für spezifische FC-Epsilon Rezeptoren |
DE69233716T Expired - Lifetime DE69233716T2 (de) | 1991-08-14 | 1992-08-14 | Immunglobulinvarianten für spezifische Fc-epsilon Rezeptoren |
DE122006000006C Active DE122006000006I2 (de) | 1991-08-14 | 1992-08-14 | Veränderte Immunglobuline für spezifische FC-Epsilon Rezeptoren |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69233716T Expired - Lifetime DE69233716T2 (de) | 1991-08-14 | 1992-08-14 | Immunglobulinvarianten für spezifische Fc-epsilon Rezeptoren |
DE122006000006C Active DE122006000006I2 (de) | 1991-08-14 | 1992-08-14 | Veränderte Immunglobuline für spezifische FC-Epsilon Rezeptoren |
Country Status (11)
Country | Link |
---|---|
EP (2) | EP1260521B1 (de) |
JP (1) | JP3457962B2 (de) |
AT (1) | ATE233813T1 (de) |
AU (2) | AU2498192A (de) |
CA (1) | CA2113813C (de) |
DE (3) | DE69232944T2 (de) |
DK (2) | DK0602126T3 (de) |
ES (2) | ES2193136T3 (de) |
LU (1) | LU91219I2 (de) |
NL (1) | NL300220I2 (de) |
WO (1) | WO1993004173A1 (de) |
Families Citing this family (96)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5770396A (en) * | 1992-04-16 | 1998-06-23 | The United States Of America As Represented By The Department Of Health And Human Services | Isolation characterization, and use of the human beta subunit of the high affinity receptor for immunoglobulin E |
EP0589840B1 (de) * | 1992-09-24 | 2004-04-14 | Novartis AG | Umgestaltete monoklonale Antikörper gegen ein Immunglobulinisotyp |
US6066718A (en) * | 1992-09-25 | 2000-05-23 | Novartis Corporation | Reshaped monoclonal antibodies against an immunoglobulin isotype |
US5958708A (en) * | 1992-09-25 | 1999-09-28 | Novartis Corporation | Reshaped monoclonal antibodies against an immunoglobulin isotype |
US5914110A (en) * | 1993-09-07 | 1999-06-22 | Smithkline Beecham Corporation | Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders |
US5928904A (en) * | 1993-09-07 | 1999-07-27 | Smithkline Beecham Corporation | DNA encoding recombinant IL4 antibodies useful in treatment of IL4 mediated disorders |
US20020193575A1 (en) | 1993-09-07 | 2002-12-19 | Smithkline Beecham P.L.C. | Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders |
GB9324013D0 (en) * | 1993-11-22 | 1994-01-12 | 3I Res Expl Ltd | Polypeptides |
EP0739214B1 (de) * | 1994-01-18 | 1998-03-18 | Genentech, Inc. | Verfahren zur behandlung von parasitären infektionen unter verwendung von ige-antagonisten |
US20040197326A1 (en) * | 1995-07-27 | 2004-10-07 | Genentech, Inc. | Method for treatment of allergic asthma |
US6685940B2 (en) | 1995-07-27 | 2004-02-03 | Genentech, Inc. | Protein formulation |
US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
KR100584051B1 (ko) * | 1996-03-01 | 2006-05-30 | 노파르티스 아게 | 알레르기에 대한 백신 접종 및 치료를 위한 펩티드임뮤노겐 |
US5958880A (en) * | 1996-12-19 | 1999-09-28 | Heska Corporation | Feline Fc epsilon receptor alpha chain proteins and therapeutic uses thereof |
US7122636B1 (en) | 1997-02-21 | 2006-10-17 | Genentech, Inc. | Antibody fragment-polymer conjugates and uses of same |
US6172213B1 (en) | 1997-07-02 | 2001-01-09 | Genentech, Inc. | Anti-IgE antibodies and method of improving polypeptides |
US5994511A (en) * | 1997-07-02 | 1999-11-30 | Genentech, Inc. | Anti-IgE antibodies and methods of improving polypeptides |
US6057127A (en) * | 1998-01-29 | 2000-05-02 | Heska Corporation | Equine Fc epsilon receptor alpha chain nucleic acid molecules and uses thereof |
US7393529B2 (en) * | 1998-04-09 | 2008-07-01 | Idexx Laboratories, Inc. | Methods and compositions for inhibiting binding of IgE to a high affinity receptor |
US6504013B1 (en) * | 2000-02-01 | 2003-01-07 | Idexx Laboratories, Inc. | Canine allergy therapeutic recombinant chimeric anti-IgE monoclonal antibody |
GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
US6299875B1 (en) | 1998-06-04 | 2001-10-09 | Panacea Pharmaceuticals, Llc | Methods to block IGE binding to cell surface receptors of mast cells |
TWI227241B (en) | 1998-06-20 | 2005-02-01 | United Biomedical Inc | IgE-CH3 domain antigen peptide, peptide conjugate containing the same, and pharmaceutical composition for treating allergies containing the peptide conjugate |
JP2002537403A (ja) * | 1999-02-25 | 2002-11-05 | スミスクライン ビーチャム バイオロジカルズ ソシエテ アノニム | IgEのC−イプシロン−3またはC−イプシロン−4ドメイン由来のエピトープまたはミモトープ、その拮抗薬、及びそれらの治療的使用 |
US6889145B1 (en) | 2000-03-15 | 2005-05-03 | Northwestern University | Three-dimensional model of a Fc region of an IgE antibody and uses thereof |
US8703126B2 (en) | 2000-10-12 | 2014-04-22 | Genentech, Inc. | Reduced-viscosity concentrated protein formulations |
JP4340062B2 (ja) | 2000-10-12 | 2009-10-07 | ジェネンテック・インコーポレーテッド | 粘度の減少した濃縮タンパク質製剤 |
ATE417858T1 (de) | 2002-02-05 | 2009-01-15 | Genentech Inc | Proteinaufreinigung |
PT1501369E (pt) | 2002-04-26 | 2015-09-21 | Genentech Inc | Purificação de proteínas com base na não afinidade |
US7361740B2 (en) | 2002-10-15 | 2008-04-22 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
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US9320792B2 (en) | 2002-11-08 | 2016-04-26 | Ablynx N.V. | Pulmonary administration of immunoglobulin single variable domains and constructs thereof |
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US20060034845A1 (en) | 2002-11-08 | 2006-02-16 | Karen Silence | Single domain antibodies directed against tumor necrosis factor alpha and uses therefor |
JP4869064B2 (ja) | 2003-04-04 | 2012-02-01 | ジェネンテック, インコーポレイテッド | 高濃度抗体及びタンパク質製剤 |
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US20230357815A1 (en) | 2020-09-22 | 2023-11-09 | Bristol-Myers Squibb Company | Methods for increasing productivity of therapeutic proteins |
US20250115666A1 (en) | 2021-08-05 | 2025-04-10 | Bristol-Myers Squibb Company | Cell culture methods for producing therapeutic proteins |
US20240390869A1 (en) | 2021-09-21 | 2024-11-28 | Bristol-Myers Squibb Company | Methods of controlling the level of dissolved oxygen (do) in a solution comprising a recombinant protein in a storage container |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4954617A (en) * | 1986-07-07 | 1990-09-04 | Trustees Of Dartmouth College | Monoclonal antibodies to FC receptors for immunoglobulin G on human mononuclear phagocytes |
JPS63225397A (ja) * | 1986-10-03 | 1988-09-20 | Dainippon Pharmaceut Co Ltd | 抗アレルギー作用を有する新規ペプチド |
US4940782A (en) * | 1987-06-08 | 1990-07-10 | G. D. Searle & Co. | Monoclonal antibodies against IgE-associated determinants, hybrid cell lines producing these antibodies, and use therefore |
GB8727045D0 (en) * | 1987-11-19 | 1987-12-23 | Research Corp Ltd | Immunoglobulin e competitor |
EP0407392B2 (de) * | 1987-12-31 | 1998-10-28 | Tanox Biosystems, Inc. | Antigene epitope, die sich ausschliesslich auf ige-tragenden b-lymphocyten befinden |
-
1992
- 1992-08-14 ES ES92918713T patent/ES2193136T3/es not_active Expired - Lifetime
- 1992-08-14 JP JP50447593A patent/JP3457962B2/ja not_active Expired - Lifetime
- 1992-08-14 DE DE69232944T patent/DE69232944T2/de not_active Expired - Lifetime
- 1992-08-14 WO PCT/US1992/006860 patent/WO1993004173A1/en active IP Right Grant
- 1992-08-14 AT AT92918713T patent/ATE233813T1/de active
- 1992-08-14 DE DE69233716T patent/DE69233716T2/de not_active Expired - Lifetime
- 1992-08-14 EP EP02009009A patent/EP1260521B1/de not_active Expired - Lifetime
- 1992-08-14 AU AU24981/92A patent/AU2498192A/en not_active Abandoned
- 1992-08-14 DK DK92918713T patent/DK0602126T3/da active
- 1992-08-14 ES ES02009009T patent/ES2296839T3/es not_active Expired - Lifetime
- 1992-08-14 CA CA002113813A patent/CA2113813C/en not_active Expired - Lifetime
- 1992-08-14 EP EP92918713A patent/EP0602126B1/de not_active Expired - Lifetime
- 1992-08-14 DK DK02009009T patent/DK1260521T3/da active
- 1992-08-14 DE DE122006000006C patent/DE122006000006I2/de active Active
-
1996
- 1996-10-24 AU AU70380/96A patent/AU706584C/en not_active Expired
-
2006
- 2006-02-02 NL NL300220C patent/NL300220I2/nl unknown
- 2006-02-02 LU LU91219C patent/LU91219I2/fr unknown
Also Published As
Publication number | Publication date |
---|---|
CA2113813A1 (en) | 1993-03-04 |
DE122006000006I2 (de) | 2011-06-16 |
EP1260521A3 (de) | 2004-01-02 |
HK1014542A1 (en) | 1999-09-30 |
AU2498192A (en) | 1993-03-16 |
AU706584C (en) | 2003-07-10 |
EP1260521B1 (de) | 2007-11-21 |
EP0602126A1 (de) | 1994-06-22 |
ATE233813T1 (de) | 2003-03-15 |
DK0602126T3 (da) | 2003-06-16 |
DE69233716T2 (de) | 2008-10-30 |
LU91219I2 (fr) | 2006-04-03 |
CA2113813C (en) | 2005-04-12 |
JPH06509944A (ja) | 1994-11-10 |
NL300220I2 (nl) | 2006-08-01 |
DE69232944T2 (de) | 2003-12-24 |
DK1260521T3 (da) | 2008-03-25 |
HK1050696A1 (en) | 2003-07-04 |
NL300220I1 (nl) | 2006-04-03 |
ES2193136T3 (es) | 2003-11-01 |
DE69233716D1 (de) | 2008-01-03 |
EP0602126B1 (de) | 2003-03-05 |
AU7038096A (en) | 1997-01-16 |
ES2296839T3 (es) | 2008-05-01 |
AU706584B2 (en) | 1999-06-17 |
WO1993004173A1 (en) | 1993-03-04 |
EP1260521A2 (de) | 2002-11-27 |
JP3457962B2 (ja) | 2003-10-20 |
DE122006000006I1 (de) | 2006-04-27 |
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