[go: up one dir, main page]

DE69836630D1 - Menschliche toll-ähnliche rezeptorproteine, zugehörige reagenzien und verfahren - Google Patents

Menschliche toll-ähnliche rezeptorproteine, zugehörige reagenzien und verfahren

Info

Publication number
DE69836630D1
DE69836630D1 DE69836630T DE69836630T DE69836630D1 DE 69836630 D1 DE69836630 D1 DE 69836630D1 DE 69836630 T DE69836630 T DE 69836630T DE 69836630 T DE69836630 T DE 69836630T DE 69836630 D1 DE69836630 D1 DE 69836630D1
Authority
DE
Germany
Prior art keywords
methods
proteins
highly similar
related reagents
receptors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
DE69836630T
Other languages
English (en)
Other versions
DE69836630T2 (de
Inventor
T Hardiman
L Rock
Fernando Bazan
A Kastelein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27366459&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69836630(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of DE69836630D1 publication Critical patent/DE69836630D1/de
Application granted granted Critical
Publication of DE69836630T2 publication Critical patent/DE69836630T2/de
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69836630T 1997-05-07 1998-05-07 Menschliche toll-ähnliche rezeptorproteine, zugehörige reagenzien und verfahren Revoked DE69836630T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US4429397P 1997-05-07 1997-05-07
US44293P 1997-05-07
US7221298P 1998-01-22 1998-01-22
US72212P 1998-01-22
US7694798P 1998-03-05 1998-03-05
US76947P 1998-03-05
PCT/US1998/008979 WO1998050547A2 (en) 1997-05-07 1998-05-07 Human toll-like receptor proteins, related reagents and methods

Publications (2)

Publication Number Publication Date
DE69836630D1 true DE69836630D1 (de) 2007-01-25
DE69836630T2 DE69836630T2 (de) 2007-10-11

Family

ID=27366459

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69841170T Expired - Lifetime DE69841170D1 (de) 1997-05-07 1998-05-07 Menschliche Toll-ähliche Rezeptorproteine, zugehörige Reagenzien und Verfahren
DE69836630T Revoked DE69836630T2 (de) 1997-05-07 1998-05-07 Menschliche toll-ähnliche rezeptorproteine, zugehörige reagenzien und verfahren
DE69841514T Expired - Lifetime DE69841514D1 (de) 1997-05-07 1998-05-07 Menschliche Toll-Like-Rezeptorproteine, zugehörige Reagenzien und Verfahren

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69841170T Expired - Lifetime DE69841170D1 (de) 1997-05-07 1998-05-07 Menschliche Toll-ähliche Rezeptorproteine, zugehörige Reagenzien und Verfahren

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69841514T Expired - Lifetime DE69841514D1 (de) 1997-05-07 1998-05-07 Menschliche Toll-Like-Rezeptorproteine, zugehörige Reagenzien und Verfahren

Country Status (20)

Country Link
EP (4) EP1988166A1 (de)
JP (4) JP2002514083A (de)
KR (1) KR100388860B1 (de)
CN (4) CN101486759A (de)
AT (3) ATE443139T1 (de)
AU (1) AU740333B2 (de)
CA (1) CA2289912C (de)
CY (1) CY1109645T1 (de)
DE (3) DE69841170D1 (de)
DK (2) DK1798288T3 (de)
ES (3) ES2279572T3 (de)
HK (3) HK1022175A1 (de)
ID (1) ID28299A (de)
IL (1) IL132614A0 (de)
NO (1) NO995458L (de)
NZ (1) NZ338073A (de)
PL (1) PL336635A1 (de)
PT (1) PT1798288E (de)
SK (1) SK146599A3 (de)
WO (1) WO1998050547A2 (de)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6812327B1 (en) 1996-10-25 2004-11-02 Human Genome Sciences, Inc. Neutrokine-alpha polypeptides
US8212004B2 (en) 1999-03-02 2012-07-03 Human Genome Sciences, Inc. Neutrokine-alpha fusion proteins
US7696327B1 (en) 1997-10-17 2010-04-13 Genentech, Inc. Antibodies to human Toll homologues
US20030032090A1 (en) 1997-05-07 2003-02-13 Schering Corporation, A New Jersey Corporation Human receptor proteins; related reagents and methods
WO2001090151A2 (en) * 2000-05-25 2001-11-29 Schering Corporation Human receptor proteins; related reagents and methods
EP1025227B1 (de) * 1997-10-17 2005-12-28 Genentech, Inc. Menschliche toll homologen
AU2003203679B2 (en) * 1997-10-17 2007-04-05 Genentech, Inc. Human toll homologues
JP2000128900A (ja) * 1998-10-26 2000-05-09 Japan Science & Technology Corp 新規トル様（Ｔｏｌｌ−ｌｉｋｅ）レセプター及びその遺伝子
US6303321B1 (en) 1999-02-11 2001-10-16 North Shore-Long Island Jewish Research Institute Methods for diagnosing sepsis
US6740487B1 (en) * 1999-06-10 2004-05-25 University Of Iowa Research Foundation Variant TLR4 nucleic acid and uses thereof
CA2389765A1 (en) * 1999-11-02 2001-05-10 Chiron Corporation Cpg receptor (cpg-r) and methods relating thereto
GB9927332D0 (en) * 1999-11-18 2000-01-12 Leiv Eiriksson Nyfotek As Novel antibody and uses thereof
GB0001704D0 (en) * 2000-01-25 2000-03-15 Glaxo Group Ltd Protein
US20030083244A1 (en) * 2000-04-26 2003-05-01 Vernet Corine A.M. Novel proteins and nucleic acids encoding same
US7879328B2 (en) 2000-06-16 2011-02-01 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to B lymphocyte stimulator
WO2002002641A1 (en) 2000-06-16 2002-01-10 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to blys
JP2002034565A (ja) * 2000-07-19 2002-02-05 Japan Science & Technology Corp 細菌ｄｎａを特異的に認識する受容体タンパク質
JP2004532604A (ja) * 2000-08-18 2004-10-28 ダイアックス コーポレーション Ｂリンパ球刺激因子タンパク質（ＢＬｙＳ）のための結合性ポリペプチド
AU2001288301A1 (en) * 2000-08-18 2002-03-04 Human Genome Sciences, Inc. Binding polypeptides and methods based thereon
CA2419894A1 (en) 2000-09-15 2002-03-21 Coley Pharmaceutical Gmbh Process for high throughput screening of cpg-based immuno-agonist/antagonist
US7304034B2 (en) 2001-05-15 2007-12-04 The Feinstein Institute For Medical Research Use of HMGB fragments as anti-inflammatory agents
US7220723B2 (en) 2001-05-15 2007-05-22 The Feinstein Institute For Medical Research Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents
EP1451581A4 (de) * 2001-10-05 2006-01-11 Coley Pharm Gmbh Agonisten und antagonisten der signalisierung des toll-ähnlichen rezeptors 3
AU2002343728A1 (en) * 2001-11-16 2003-06-10 3M Innovative Properties Company Methods and compositions related to irm compounds and toll-like receptor pathways
GB0127618D0 (en) * 2001-11-17 2002-01-09 Univ Nottingham "Composition and method for treatment of wounds"
JP2004016021A (ja) 2002-06-12 2004-01-22 Japan Science & Technology Corp 抗体および阻害剤並びにそれを用いた形質転換方法および形質転換キット
WO2004053452A2 (en) * 2002-12-11 2004-06-24 3M Innovative Properties Company Assays relating to toll-like receptor activity
WO2004094671A2 (en) * 2003-04-22 2004-11-04 Coley Pharmaceutical Gmbh Methods and products for identification and assessment of tlr ligands
US7696169B2 (en) 2003-06-06 2010-04-13 The Feinstein Institute For Medical Research Inhibitors of the interaction between HMGB polypeptides and toll-like receptor 2 as anti-inflammatory agents
EP1668035A2 (de) 2003-09-11 2006-06-14 Critical Therapeutics, Inc. Monoklonale antikörper gegen hmgb1
BRPI0414856A (pt) 2003-10-03 2006-11-21 3M Innovative Properties Co imidazoquinolinas alcóxi-substituìdas
TW200516153A (en) * 2003-10-03 2005-05-16 Hitachi Chemical Co Ltd Human toll-like receptor 3 gene polymorphism as marker for inherited factor of allergic disease and utilization of the same
TW200514850A (en) * 2003-10-03 2005-05-01 Hitachi Chemical Co Ltd Method of evaluating risk for viral infection
EP1697389A4 (de) 2003-10-24 2008-12-24 Eisai R&D Man Co Ltd Verbindungen und verfahren zur behandlung von mit dem toll-like receptor 2 in zusammenhang stehenden krankheiten und leiden
EP1687307B1 (de) 2003-11-25 2016-01-06 3M Innovative Properties Company Substituierte imidazoringsysteme und verfahren
JP2008022701A (ja) * 2004-09-24 2008-02-07 Japan Science & Technology Agency 可溶型Ｔｏｌｌ様受容体４タンパク質
CA2587676A1 (en) 2004-11-19 2006-05-26 Institut Gustave Roussy Improved treatment of cancer by double-stranded rna
TWI487535B (zh) 2004-11-30 2015-06-11 Centocor Inc 類鐸受體３（ｔｏｌｌ ｌｉｋｅ ｒｅｃｅｐｔｏｒ３）拮抗劑，方法及用途
US9248127B2 (en) 2005-02-04 2016-02-02 3M Innovative Properties Company Aqueous gel formulations containing immune response modifiers
US7700728B2 (en) 2005-03-24 2010-04-20 Schering Corporation Use of chimeric receptors in a screening assay for identifying agonists and antagonists of cell receptors
US7498409B2 (en) 2005-03-24 2009-03-03 Schering Corporation Screening assay for TLR7, TLR8 and TLR9 agonists and antagonists
US9168286B2 (en) 2005-10-13 2015-10-27 Human Genome Sciences, Inc. Methods and compositions for use in treatment of patients with autoantibody positive disease
JP5199878B2 (ja) 2005-10-27 2013-05-15 セントカー・インコーポレーテツド Ｔｏｌｌ様受容体３モジュレーター、方法および用途
CN106237316A (zh) 2006-03-07 2016-12-21 法克斯因内特公司 包含血细胞凝集素的组合物、制造其的方法与使用其的方法
US8211649B2 (en) 2006-03-31 2012-07-03 Human Genome Sciences, Inc. Methods of diagnosing and prognosing hodgkin's lymphoma
CN101134046B (zh) * 2006-09-01 2011-10-05 中国医学科学院药物研究所 Tlr4和tlr9激动剂复方在抑制肿瘤转移中的应用
US20080299138A1 (en) * 2007-05-25 2008-12-04 Duffy Karen E Toll-Like Receptor 3 Modulators and Uses Thereof
US20110076296A1 (en) 2008-04-25 2011-03-31 Innate Pharma S.A. TLR3 Agonist Compositions
EP2116602A1 (de) 2008-05-07 2009-11-11 Institut Gustave Roussy Kombinationsprodukte zur Behandlung von Krebs
WO2010031749A1 (en) 2008-09-17 2010-03-25 Innate Pharma Compositions and methods for detecting tlr3
WO2010033294A1 (en) 2008-09-22 2010-03-25 Cedars-Sinai Medical Center Short-form human md-2 as a negative regulator of toll-like receptor 4 signaling
US9512196B2 (en) 2008-09-22 2016-12-06 Cedars-Sinai Medical Center Short-form human MD-2 as a negative regulator of toll-like receptor 4 signaling
ES2543095T3 (es) 2009-07-10 2015-08-14 Innate Pharma Agentes de unión a TLR3
JP5830744B2 (ja) * 2009-08-19 2015-12-09 国立大学法人東京工業大学 乳酸菌の付着性を誘導するペプチド及びその用途
JP2013538558A (ja) 2010-07-19 2013-10-17 イエダ リサーチ アンド ディベロップメント カンパニー リミテッド Ｔｌｒ媒介疾患を治療するためのｔｏｌｌ様受容体（ｔｌｒ）の膜貫通型ドメインに基づくペプチド
US9814740B2 (en) 2010-12-21 2017-11-14 Duke University Methods and compositions combining immunotherapy with monocyte activation
EP2663329A2 (de) 2011-01-12 2013-11-20 Innate Pharma Tlr3-binder
AU2012262021B2 (en) 2011-06-01 2016-07-28 Janus Biotherapeutics, Inc. Novel immune system modulators
CN103717070A (zh) 2011-06-01 2014-04-09 贾纳斯生物治疗有限公司 新型免疫系统调节剂
JP2014528449A (ja) 2011-10-04 2014-10-27 ジャナス バイオセラピューティクス，インク． 新規なイミダゾールキノリン系免疫系調節剤
EP2766384B1 (de) * 2011-10-10 2016-11-23 Yeda Research and Development Co. Ltd. Agonistenpeptide aus dem rezeptor des typs toll-4 (tlr-4) zur modulierung der immunreaktions vom tlr-4 verursacht
WO2013178736A1 (en) 2012-05-31 2013-12-05 Innate Pharma Tlr3 binding agents
US10017739B2 (en) 2012-09-06 2018-07-10 Duke University Methods of expanding and assessing B cells and using expanded B cells to treat disease
CN113502299B (zh) * 2021-07-20 2023-03-14 中国农业大学 一种抗金黄色葡萄球菌遗传修饰山羊生产方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2046920B1 (de) 1969-06-19 1974-05-03 Citizen Watch Co Ltd
US3940475A (en) 1970-06-11 1976-02-24 Biological Developments, Inc. Radioimmune method of assaying quantitatively for a hapten
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3939350A (en) 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4277437A (en) 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4659678A (en) 1982-09-29 1987-04-21 Serono Diagnostics Limited Immunoassay of antigens
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4859609A (en) 1986-04-30 1989-08-22 Genentech, Inc. Novel receptors for efficient determination of ligands and their antagonists or agonists
US5789192A (en) 1992-12-10 1998-08-04 Schering Corporation Mammalian receptors for interleukin-10 (IL-10)
WO1998002557A2 (en) * 1996-07-12 1998-01-22 Schering Corporation MAMMALIAN TNF-α CONVERTASES
DE69835751T2 (de) * 1997-08-01 2007-10-04 Serono Genetics Institute S.A. 5' ests für proteine, die nicht gewebespezifisch sind
EP1025227B1 (de) * 1997-10-17 2005-12-28 Genentech, Inc. Menschliche toll homologen

Also Published As

Publication number Publication date
EP0980429B1 (de) 2006-12-13
ES2340210T3 (es) 2010-05-31
DK1798288T3 (da) 2010-01-04
NZ338073A (en) 2001-09-28
ATE348157T1 (de) 2007-01-15
NO995458D0 (no) 1999-11-08
CY1109645T1 (el) 2012-05-23
ES2279572T3 (es) 2007-08-16
KR100388860B1 (ko) 2003-06-25
HK1022175A1 (en) 2000-07-28
JP2005120106A (ja) 2005-05-12
EP0980429A2 (de) 2000-02-23
IL132614A0 (en) 2001-03-19
ATE443139T1 (de) 2009-10-15
EP1798288A2 (de) 2007-06-20
CN1225555C (zh) 2005-11-02
CN1800214A (zh) 2006-07-12
DE69841170D1 (de) 2009-10-29
ES2331622T3 (es) 2010-01-11
CN101486759A (zh) 2009-07-22
KR20010012323A (ko) 2001-02-15
AU740333B2 (en) 2001-11-01
CA2289912A1 (en) 1998-11-12
JP2006052232A (ja) 2006-02-23
HK1102720A1 (en) 2007-12-07
DK0980429T3 (da) 2007-04-10
CA2289912C (en) 2011-07-26
CN1935840A (zh) 2007-03-28
WO1998050547A3 (en) 1999-03-11
DE69836630T2 (de) 2007-10-11
PL336635A1 (en) 2000-07-03
HK1112018A1 (en) 2008-08-22
ID28299A (id) 2001-05-10
CN1263555A (zh) 2000-08-16
EP1988166A1 (de) 2008-11-05
EP1798288B1 (de) 2009-09-16
DE69841514D1 (de) 2010-04-01
WO1998050547A2 (en) 1998-11-12
EP1798288A3 (de) 2007-09-12
AU7175498A (en) 1998-11-27
JP2002514083A (ja) 2002-05-14
PT1798288E (pt) 2009-12-23
JP2009089713A (ja) 2009-04-30
EP1925666A1 (de) 2008-05-28
NO995458L (no) 1999-11-08
ATE458053T1 (de) 2010-03-15
EP1925666B1 (de) 2010-02-17
SK146599A3 (en) 2000-07-11

Similar Documents

Publication Publication Date Title
DE69836630D1 (de) Menschliche toll-ähnliche rezeptorproteine, zugehörige reagenzien und verfahren
ATE396264T1 (de) Zytokinrezeptoruntereinheit-proteine aus säugetieren, damit zusammenhängende reagenzien und methoden
AU2001294541A1 (en) Mammalian genes; related reagents and methods
ZA200604026B (en) IL-23 and its receptor ; related reagents and methods
FI963101L (fi) Anti-TNF-vasta-aineiden käyttö lääkkeenä sellaisten sairauksien hoitoon, joissa seerumin interleukiini-6-taso on kohonnut
CY1109093T1 (el) Πρωτεϊνες των υποδοχεων θηλαστικων, σχετικα αντιδραστηρια και σχετικες μεθοδοι
EP1908837A3 (de) Menschliche Rezeptorproteine, zugehörige Reagenzien und Verfahren
WO1999046379A3 (en) Human receptor proteins; related reagents and methods
ATE265533T1 (de) Saeugetierchemokine
WO2001057219A3 (en) Mammalian interleukin-1-delta and -epsilon. their use in therapeutic and diagnostic methods
WO1999019480A3 (en) Human receptor proteins; related reagents and methods
BR9808747A (pt) Proteìnas receptoras humanas; reagentes relacionados e métodos

Legal Events

Date Code Title Description
8381 Inventor (new situation)

Inventor name: HARDIMAN, GERARD, T., WATERTOWN, MA 02172, US

Inventor name: ROCK, FERNANDO, L., FOSTER CITY, CA 94404, US

Inventor name: BAZAN, FERNANDO, J., MENLO PARK, CA 94025, US

Inventor name: KASTELEIN, ROBERT, A., REDWOOD CITY, CA 94062, US

8363 Opposition against the patent
8331 Complete revocation