[go: up one dir, main page]

DE69231486D1 - Zusammensetzung enthaltend pdgf und dexamethason zur förderung von gewebsreparatur und -regenerierung - Google Patents

Zusammensetzung enthaltend pdgf und dexamethason zur förderung von gewebsreparatur und -regenerierung

Info

Publication number
DE69231486D1
DE69231486D1 DE69231486T DE69231486T DE69231486D1 DE 69231486 D1 DE69231486 D1 DE 69231486D1 DE 69231486 T DE69231486 T DE 69231486T DE 69231486 T DE69231486 T DE 69231486T DE 69231486 D1 DE69231486 D1 DE 69231486D1
Authority
DE
Germany
Prior art keywords
regeneration
dexamethasone
composition containing
tissue repair
pdgf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69231486T
Other languages
English (en)
Other versions
DE69231486T2 (de
Inventor
Robert Bruce Rutherford
Marc F Charette
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Connecticut
Creative Biomolecules Inc
Original Assignee
University of Connecticut
Creative Biomolecules Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Connecticut, Creative Biomolecules Inc filed Critical University of Connecticut
Publication of DE69231486D1 publication Critical patent/DE69231486D1/de
Application granted granted Critical
Publication of DE69231486T2 publication Critical patent/DE69231486T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69231486T 1991-03-12 1992-03-12 Zusammensetzung enthaltend pdgf und dexamethason zur förderung von gewebsreparatur und -regenerierung Expired - Fee Related DE69231486T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/669,070 US5149691A (en) 1991-03-12 1991-03-12 Issue repair and regeneration through the use of platelet derived growth factor (pdgf) in combination with dexamethasone
PCT/US1992/002043 WO1992016181A2 (en) 1991-03-12 1992-03-12 Composition for promoting tissue repair and regeneration

Publications (2)

Publication Number Publication Date
DE69231486D1 true DE69231486D1 (de) 2000-11-02
DE69231486T2 DE69231486T2 (de) 2001-04-26

Family

ID=24684879

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69231486T Expired - Fee Related DE69231486T2 (de) 1991-03-12 1992-03-12 Zusammensetzung enthaltend pdgf und dexamethason zur förderung von gewebsreparatur und -regenerierung

Country Status (8)

Country Link
US (2) US5149691A (de)
EP (1) EP0575484B1 (de)
JP (1) JPH07505858A (de)
AT (1) ATE196604T1 (de)
AU (1) AU656372B2 (de)
CA (1) CA2106073C (de)
DE (1) DE69231486T2 (de)
WO (1) WO1992016181A2 (de)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5149691A (en) * 1991-03-12 1992-09-22 Creative Biomolecules, Inc. Issue repair and regeneration through the use of platelet derived growth factor (pdgf) in combination with dexamethasone
US7384634B2 (en) * 1991-08-30 2008-06-10 University Of South Florida Connective tissue growth factor
US5408040A (en) * 1991-08-30 1995-04-18 University Of South Florida Connective tissue growth factor(CTGF)
US5837258A (en) 1991-08-30 1998-11-17 University Of South Florida Induction of tissue, bone or cartilage formation using connective tissue growth factor
US5770209A (en) * 1991-08-30 1998-06-23 University Of South Florida Acceleration of wound healing using connective tissue growth factor
US5326695A (en) * 1992-05-15 1994-07-05 Ludwig Institute For Cancer Research Platelet derived growth factor agonists
US5444151A (en) * 1992-05-15 1995-08-22 Ludwig Institute For Cancer Research Platelet derived growth factor antagonists
DE4228457A1 (de) * 1992-08-27 1994-04-28 Beiersdorf Ag Herstellung von heterodimerem PDGF-AB mit Hilfe eines bicistronischen Vektorsystems in Säugerzellen
US5455041A (en) * 1993-09-13 1995-10-03 Research Foundation Of State University Of New York At Buffalo Method for inducing periodontal tissue regeneration
US5942496A (en) * 1994-02-18 1999-08-24 The Regent Of The University Of Michigan Methods and compositions for multiple gene transfer into bone cells
US6551618B2 (en) 1994-03-15 2003-04-22 University Of Birmingham Compositions and methods for delivery of agents for neuronal regeneration and survival
EP0743066A3 (de) * 1995-05-16 1998-09-30 Mitsui Pharmaceuticals, Inc. Wundheilmittel
US5776193A (en) * 1995-10-16 1998-07-07 Orquest, Inc. Bone grafting matrix
US6902584B2 (en) 1995-10-16 2005-06-07 Depuy Spine, Inc. Bone grafting matrix
US5885829A (en) * 1996-05-28 1999-03-23 The Regents Of The University Of Michigan Engineering oral tissues
DE19754140A1 (de) * 1997-12-05 1999-06-24 Era Beschichtung Gmbh & Co Kg Innenraummaterial auf der Basis von Kunststoff, Verfahren zu dessen Herstellung und Verwendung desselben
WO1999066797A1 (en) 1998-06-22 1999-12-29 Worden Charles E Enriched platelet wound healant
AU1430601A (en) * 1999-11-02 2001-05-14 Eli Lilly And Company Methods of using lp8, a pdgf-related protein, to treat musculoskeletal disorders
DE60233871D1 (de) 2001-03-05 2009-11-12 Siemens Healthcare Diagnostics Verfahren und primer zur analyse von hiv-1-mutationen
CN1627951A (zh) * 2001-06-07 2005-06-15 美商·邱氏顾问股份有限公司 用以预防及治疗口疮溃疡与单纯疱疹性损害的组成物及方法
US7819888B2 (en) * 2001-10-23 2010-10-26 Innovasive Devices, Inc. Method and apparatus for harvesting and implanting bone plugs
DE10152956A1 (de) * 2001-10-26 2003-05-15 Fresenius Kabi De Gmbh Pharmazeutische Zusammensetzung, einen Wachstumsfaktor und/oder ein Zytokin und ein antiseptisches Biguanid umfassend
US20050142208A1 (en) * 2002-05-09 2005-06-30 Won Min Yoo Pharmceutical composition for treatment of wounds conntaining blood plasma or serum
US6616923B1 (en) * 2002-07-26 2003-09-09 Chiou Consulting, Inc. Aqueous compositions for facial cosmetics
US20040018220A1 (en) * 2002-07-26 2004-01-29 Chiou Consulting, Inc. Aqueous compositions for facial cosmetics
JP4489761B2 (ja) 2003-03-14 2010-06-23 ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク マイクロ流体無膜交換装置を有する血液ベースの治療のためのシステム及び方法
US20060076295A1 (en) 2004-03-15 2006-04-13 The Trustees Of Columbia University In The City Of New York Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
US7309232B2 (en) * 2003-10-10 2007-12-18 Dentigenix Inc. Methods for treating dental conditions using tissue scaffolds
US7258875B2 (en) * 2003-12-04 2007-08-21 Chiou Consulting, Inc. Compositions and methods for topical treatment of skin infection
US8293890B2 (en) 2004-04-30 2012-10-23 Advanced Cardiovascular Systems, Inc. Hyaluronic acid based copolymers
GB0414803D0 (en) * 2004-07-01 2004-08-04 Glaxo Group Ltd Composition
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
US20060115266A1 (en) * 2004-12-01 2006-06-01 Gil Levi All-optical protection signaling systems and methods in optical communication networks
CA2617578C (en) 2005-08-01 2013-12-17 Genera Doo Methods and compositions for regenerating articular cartilage
EP1951327A2 (de) 2005-11-17 2008-08-06 Biomimetic Therapeutics, Inc. Kiefer- und gesichtsknochenerweiterung mithilfe von rhpdgf-bb und einer biokompatiblen matrix
MX2008009493A (es) 2006-01-23 2008-10-03 Imagene Co Ltd Peptido novedoso y uso del mismo.
AU2007212273B2 (en) * 2006-02-09 2013-10-10 Biomimetic Therapeutics, Llc Compositions and methods for treating bone
EP2019658B1 (de) 2006-05-22 2012-01-25 The Trustees of Columbia University in the City of New York Verfahren für membranlosen mikrofluidaustausch in einem h-filter und filterung der extraktionsflüssigkeitsausgangsströme
EP2049145B1 (de) 2006-06-30 2018-03-14 BioMimetic Therapeutics, LLC Pdgf-biomatrix-zusammensetzungen und methode für die behandlung von rotationsmanschettenverletzungen
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
AU2013203287B2 (en) * 2006-11-03 2015-12-17 Biomimetic Therapeutics, Llc. Compositions and methods for arthrodetic procedures
EP2462895B1 (de) * 2006-11-03 2016-11-02 BioMimetic Therapeutics, LLC Zusammensetzungen und Verfahren für Behandlungen von Arthodese
US9511076B2 (en) * 2008-05-30 2016-12-06 Clarion Research Group Formulations and methods for recovery from dental surgery
US8282963B2 (en) * 2007-10-15 2012-10-09 The Regents Of The University Of Colorado, A Body Corporate Methods for extracting platelets and compositions obtained therefrom
WO2009087117A1 (en) 2008-01-07 2009-07-16 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg Use of peptides for promoting wound healing
CN102065926A (zh) 2008-02-04 2011-05-18 纽约市哥伦比亚大学理事会 流体分离装置、系统和方法
ES2422259T3 (es) 2008-02-07 2013-09-10 Biomimetic Therapeutics Inc Composiciones para la osteogénesis por distracción
KR20110067035A (ko) 2008-09-09 2011-06-20 바이오미메틱 세라퓨틱스, 인크. 건 및 인대 손상의 치료를 위한 혈소판-유래 성장 인자 조성물 및 방법
JP5839467B2 (ja) * 2009-03-06 2016-01-06 ユニベルシテ パリ デカルト 癌を治療するための方法
BR112012020566B1 (pt) 2010-02-22 2021-09-21 Biomimetic Therapeutics, Llc Composição de fator de crescimento derivado de plaqueta
US8288334B2 (en) 2010-06-14 2012-10-16 Gene Signal International Sa Peptides for wound healing
ES2410804T3 (es) 2010-06-14 2013-07-03 Gene Signal International Sa Péptidos para la curación de heridas
WO2011157716A1 (en) 2010-06-14 2011-12-22 Gene Signal International Sa Novel peptides for wound healing
JP6177129B2 (ja) 2010-07-12 2017-08-09 エータイアー ファーマ， インコーポレイテッド ヒスチジルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
WO2013062995A1 (en) * 2011-10-25 2013-05-02 Biomimetic Therapeutics, Inc. Compositions and methods for treating deep partial and full thickness wounds and injuries
JP6170077B2 (ja) 2012-02-16 2017-07-26 エータイアー ファーマ， インコーポレイテッド 自己免疫および炎症疾患を処置するためのヒスチジルｔＲＮＡ合成酵素
CN114717206A (zh) 2013-03-15 2022-07-08 Atyr 医药公司 组氨酰-trna合成酶-fc缀合物
WO2016061219A1 (en) 2014-10-14 2016-04-21 Samuel Lynch Compositions for treating wounds
EP3612215B1 (de) 2017-04-20 2024-08-28 aTyr Pharma, Inc. Zusammensetzungen zur behandlung von lungenentzündungen
KR102668789B1 (ko) 2018-11-23 2024-05-24 (주)메디코스바이오텍 창상치료용 약학조성물
CZ308845B6 (cs) 2019-01-21 2021-07-07 Globetech Innovation S.R.O Farmaceutická směs topicky hojivých peptidových složek pro použití k topické léčbě kožních defektů a/nebo k topickému hojení ran
PL245202B1 (pl) 2020-03-06 2024-06-03 Gdanski Univ Medyczny Lipopeptydowe koniugaty i ich sole, sposób wytwarzania lipopeptydowych koniugatów i ich soli, kompozycja farmaceutyczna zawierająca lipopeptydowy koniugat i jego sole do leczenia ran przewlekłych

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6028999A (ja) * 1983-06-30 1985-02-14 Maruho Kk 細胞増殖促進作用を有するたんぱく質、その組成物と製造方法
US4957742A (en) * 1984-11-29 1990-09-18 Regents Of The University Of Minnesota Method for promoting hair growth
US5124316A (en) * 1986-11-14 1992-06-23 President And Fellows Of Harvard College Method for periodontal regeneration
US4861757A (en) * 1986-11-14 1989-08-29 Institute Of Molecular Biology Wound healing and bone regeneration using PDGF and IGF-I
DE3781682T2 (de) * 1986-12-11 1993-01-21 British Tech Group Verbesserungen im gebrauch oder in bezug auf den gebrauch von egf.
US4808402A (en) * 1987-05-29 1989-02-28 Northwestern University Method and compositions for modulating neovascularization
US4874746A (en) * 1987-12-22 1989-10-17 Institute Of Molecular Biology, Inc. Wound headling composition of TGF-alpha and PDGF
AU657472B2 (en) * 1990-03-06 1995-03-16 Claude Paul Genero Towel or blanket support device
US5149691A (en) * 1991-03-12 1992-09-22 Creative Biomolecules, Inc. Issue repair and regeneration through the use of platelet derived growth factor (pdgf) in combination with dexamethasone
ES2123004T3 (es) * 1991-04-12 1999-01-01 Creative Biomolecules Inc Uso de factor de crecimiento derivado de plaquetas en la preparacion de un medicamento para el tratamiento de ulceras gastrointestinales.

Also Published As

Publication number Publication date
WO1992016181A3 (en) 1992-11-12
ATE196604T1 (de) 2000-10-15
US5149691A (en) 1992-09-22
WO1992016181A2 (en) 1992-10-01
AU656372B2 (en) 1995-02-02
CA2106073A1 (en) 1993-09-13
AU1559192A (en) 1992-10-21
CA2106073C (en) 2003-09-30
JPH07505858A (ja) 1995-06-29
US5376636A (en) 1994-12-27
EP0575484B1 (de) 2000-09-27
EP0575484A1 (de) 1993-12-29
DE69231486T2 (de) 2001-04-26

Similar Documents

Publication Publication Date Title
DE69231486D1 (de) Zusammensetzung enthaltend pdgf und dexamethason zur förderung von gewebsreparatur und -regenerierung
DE69230344D1 (de) Zusammensetzungen und methoden zur wundbehandlung
ATE88899T1 (de) Wundheilung und knochenregeneration.
ATE237303T1 (de) Verwendung von zusammensetzungen mit benzoylperoxyd, glycolsäure und zink zur behandlung von dermatologischen krankheiten
ATE214933T1 (de) Dermatologische zusammensetzungen, welche benzylneroxid und ein mittel zur verminderung von hautreizungen enthalten
NO862964D0 (no) Saarhelingsmidler.
DE3588023D1 (de) Mittel zur Behandlung von Herzerkrankungen.
ATE435030T1 (de) Heilung von wunden oder fibrotischen krankheiten unter verwendung von wenigstens einem agens gegen einen wachstumsfaktor
DE69902234D1 (de) Matrixprotein enthaltende zusammensetzungen zur wundheilung
ATE71294T1 (de) Mittel zur behandlung von akne vulgaris und deren herstellung.
ATE55695T1 (de) Verwendung von defibrotid zur herstellung pharmazeutischer zusammensetzungen zur behandlung peripherer arteriopathien.
DE69535081D1 (de) Verwendung von Prostaglandin A oder dessen Derivaten zur Behandlung von Psoriasis
DE68905342D1 (de) Verwendung von minoxidil zur wundheilung.
DE3879949D1 (de) Stimulierung von makrophagen durch homologe oder analoge von quadrol.
ES540447A0 (es) Un metodo de preparar un vendaje
NO933742L (no) Humant, benavledet, insulinlignende vekstfaktorbindingsprotein
ATE159171T1 (de) Arzneimittelzusammensetzung enthaltend tcf-ii
DE69831336D1 (de) Tazaroten und uvb-phototherapie zur behandlung von psoriasis
JPS63215631A (ja) 創傷治療剤
DE69732851D1 (de) Verwendung von dextrinsulfat zur behandlung von sehr vasculären tumoren
ATE253945T1 (de) Verwendung von wundverbänden zur behandlung von akuten wunden
RU97104977A (ru) Способ лечения трофических язв и длительно незаживающих ран
RU95119300A (ru) Средство для лечения длительно незаживающих ран

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee