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DE69119853D1 - Einschlusskomplexe des n-ethoxycarbonyl-3-morpholino-sydnonimins oder seine mit cyclodextrin-derivaten gebildeten salze, herstellung dieser komplexe und pharmazeutische zusammensetzungen, die diese komplexe enthalten - Google Patents

Einschlusskomplexe des n-ethoxycarbonyl-3-morpholino-sydnonimins oder seine mit cyclodextrin-derivaten gebildeten salze, herstellung dieser komplexe und pharmazeutische zusammensetzungen, die diese komplexe enthalten

Info

Publication number
DE69119853D1
DE69119853D1 DE69119853T DE69119853T DE69119853D1 DE 69119853 D1 DE69119853 D1 DE 69119853D1 DE 69119853 T DE69119853 T DE 69119853T DE 69119853 T DE69119853 T DE 69119853T DE 69119853 D1 DE69119853 D1 DE 69119853D1
Authority
DE
Germany
Prior art keywords
complexes
cyclodextrin
sydnonimine
ethoxycarbonyl
morpholino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69119853T
Other languages
English (en)
Other versions
DE69119853T2 (de
Inventor
Maria Vikmon
Jozsef Szejtli
Jozsef Gaal
Istvan Hermecz
Agnes Hovarth
Katalin Marmarosi
Gabor Hovarth
Iren Munkacsi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Therabel Industries SA
Original Assignee
Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer es Vegyeszeti Termekek Gyara Zrt
Application granted granted Critical
Publication of DE69119853D1 publication Critical patent/DE69119853D1/de
Publication of DE69119853T2 publication Critical patent/DE69119853T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/04—1,2,3-Oxadiazoles; Hydrogenated 1,2,3-oxadiazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials Engineering (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69119853T 1990-03-28 1991-03-28 Einschlusskomplexe des n-ethoxycarbonyl-3-morpholino-sydnonimins oder seine mit cyclodextrin-derivaten gebildeten salze, herstellung dieser komplexe und pharmazeutische zusammensetzungen, die diese komplexe enthalten Expired - Lifetime DE69119853T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU901868A HU210921B (en) 1990-03-28 1990-03-28 Process for preparing inclusion complexes of n-ethoxycarbonyl-3-morpholino-sydnonimine formed with cyclodextrines and pharmaceutical compositions containing them
PCT/HU1991/000012 WO1991014680A1 (en) 1990-03-28 1991-03-28 Inclusion complexes of n-ethoxycarbonyl-3-morpholino-sydnonimine or salts formed with cyclodextrin derivatives, preparation thereof and pharmaceutical compositions containing the same

Publications (2)

Publication Number Publication Date
DE69119853D1 true DE69119853D1 (de) 1996-07-04
DE69119853T2 DE69119853T2 (de) 1996-10-10

Family

ID=10956592

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69119853T Expired - Lifetime DE69119853T2 (de) 1990-03-28 1991-03-28 Einschlusskomplexe des n-ethoxycarbonyl-3-morpholino-sydnonimins oder seine mit cyclodextrin-derivaten gebildeten salze, herstellung dieser komplexe und pharmazeutische zusammensetzungen, die diese komplexe enthalten

Country Status (34)

Country Link
US (1) US5403840A (de)
EP (1) EP0477315B1 (de)
JP (1) JP2582497B2 (de)
KR (1) KR950004705B1 (de)
CN (1) CN1051080C (de)
AT (1) ATE138656T1 (de)
AU (1) AU638824B2 (de)
BG (1) BG61689B1 (de)
BR (1) BR9105136A (de)
CA (1) CA2054188C (de)
CZ (1) CZ287353B6 (de)
DE (1) DE69119853T2 (de)
DK (1) DK0477315T3 (de)
ES (1) ES2090320T3 (de)
FI (1) FI102460B1 (de)
GE (1) GEP19991832B (de)
GR (1) GR3020684T3 (de)
HR (1) HRP920561B1 (de)
HU (1) HU210921B (de)
IL (1) IL97714A (de)
LT (1) LT3394B (de)
LV (1) LV10245B (de)
MC (1) MC2185A1 (de)
MD (1) MD679G2 (de)
NO (1) NO179611C (de)
OA (1) OA10029A (de)
PL (1) PL165868B1 (de)
RO (1) RO109649B1 (de)
RU (1) RU2111216C1 (de)
SI (1) SI9110908A (de)
SK (1) SK279891B6 (de)
TJ (1) TJ231R3 (de)
UA (1) UA27226C2 (de)
WO (1) WO1991014680A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA949182B (en) * 1993-12-02 1995-07-26 South African Druggists Ltd Pharmaceutical composition
GB2290964A (en) * 1994-07-08 1996-01-17 Arto Olavi Urtti Transdermal drug delivery system
GB9915231D0 (en) 1999-06-29 1999-09-01 Pfizer Ltd Pharmaceutical complex
FR2805462B1 (fr) * 2000-02-24 2003-08-15 Therabel Res Nouvelle forme galenique orale a liberation prolongee de la molsidomine
ITTO20120056A1 (it) * 2012-01-24 2013-07-25 Borla Ind Connettore per linee medicali di infusione, trasfusione e simili
ITTO20130433A1 (it) * 2013-05-29 2014-11-30 Borla Ind Connettore per linee medicali
BE1028879B1 (fr) 2020-12-11 2022-07-12 Europharmaceuticals Comprimé à libération prolongée de la molsidomine

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1695897C3 (de) * 1966-07-04 1979-02-15 Takeda Chemical Industries Ltd N-Acyl-sydnonimine, deren Salze, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE3221425A1 (de) * 1982-06-07 1983-12-08 Boehringer Ingelheim KG, 6507 Ingelheim Hydrolyseempfindlichen wirkstoff enthaltende, lagerstabile tablette
DK243084A (da) 1983-05-26 1984-11-27 Takeda Chemical Industries Ltd Perkutane farmaceutiske praeparater til udvortes brug
GB8506792D0 (en) * 1985-03-15 1985-04-17 Janssen Pharmaceutica Nv Derivatives of y-cyclodextrin
DE3522191A1 (de) * 1985-06-21 1987-01-15 Cassella Ag Photostabilisierung von sydnoniminen
GB8613688D0 (en) * 1986-06-05 1986-07-09 Euro Celtique Sa Pharmaceutical composition
JPH0819004B2 (ja) * 1986-12-26 1996-02-28 日清製粉株式会社 徐放性医薬製剤
IT1204725B (it) * 1987-06-17 1989-03-10 Edmond Pharma Srl Complessi di inclusione del dipiridamolo con ciclodestrine
DE68901043D1 (de) * 1988-01-14 1992-04-30 Akzo Nv Waessriges pharmazeutisches praeparat.
US5120732A (en) * 1988-06-14 1992-06-09 Cassella Aktiengesellschaft Substituted 3-aminosyndone imines, a process for their preparation and their use
IT1227626B (it) * 1988-11-28 1991-04-23 Vectorpharma Int Farmaci supportati aventi velocita' di dissoluzione aumentata e procedimento per la loro preparazione
SE8904296D0 (sv) * 1989-12-21 1989-12-21 Pharmacia Ab Transdermal system
HU212730B (en) * 1990-03-28 1996-10-28 Chinoin Gyogyszer Es Vegyeszet Process for producing inclusion complexes of cyclodextrine or its derivative and 3-morpholino-sydnonimine or its salt or its tautomer and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
FI102460B (fi) 1998-12-15
EP0477315B1 (de) 1996-05-29
CA2054188C (en) 1996-07-23
RU2111216C1 (ru) 1998-05-20
LV10245B (en) 1995-08-20
AU7574591A (en) 1991-10-21
IL97714A (en) 1995-03-30
GR3020684T3 (en) 1996-10-31
NO179611C (no) 1996-11-13
ES2090320T3 (es) 1996-10-16
EP0477315A1 (de) 1992-04-01
ATE138656T1 (de) 1996-06-15
MD679G2 (ro) 1997-11-30
NO914649L (no) 1991-11-27
DE69119853T2 (de) 1996-10-10
BR9105136A (pt) 1992-08-04
TJ231R3 (en) 1999-11-24
HU901868D0 (en) 1990-08-28
MC2185A1 (fr) 1992-09-16
WO1991014680A1 (en) 1991-10-03
NO914649D0 (no) 1991-11-27
KR950004705B1 (ko) 1995-05-04
KR920701182A (ko) 1992-08-11
LV10245A (lv) 1994-10-20
CS85191A3 (en) 1991-11-12
LTIP386A (en) 1994-12-27
UA27226C2 (uk) 2000-08-15
SK279891B6 (sk) 1999-05-07
RO109649B1 (ro) 1995-04-28
HRP920561A2 (hr) 1994-04-30
CN1056688A (zh) 1991-12-04
FI102460B1 (fi) 1998-12-15
OA10029A (en) 1996-10-14
PL165868B1 (pl) 1995-02-28
FI915569A0 (fi) 1991-11-26
PL293022A1 (en) 1992-12-28
JPH04506362A (ja) 1992-11-05
BG95531A (bg) 1993-12-24
AU638824B2 (en) 1993-07-08
NO179611B (no) 1996-08-05
CZ287353B6 (cs) 2000-11-15
HU210921B (en) 1995-09-28
CN1051080C (zh) 2000-04-05
IL97714A0 (en) 1992-06-21
US5403840A (en) 1995-04-04
HUT58109A (en) 1992-01-28
GEP19991832B (en) 1999-11-05
JP2582497B2 (ja) 1997-02-19
BG61689B1 (bg) 1998-03-31
HRP920561B1 (en) 1999-12-31
LT3394B (en) 1995-09-25
SI9110908A (sl) 1998-06-30
MD679F1 (en) 1997-02-28
DK0477315T3 (da) 1996-09-30
CA2054188A1 (en) 1991-09-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: THERABEL INDUSTRIES S.A., LA SEYNE-SUR-MER, FR