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DE69112914D1 - Herstellungsverfahren von Mikrokugeln. - Google Patents

Herstellungsverfahren von Mikrokugeln.

Info

Publication number
DE69112914D1
DE69112914D1 DE69112914T DE69112914T DE69112914D1 DE 69112914 D1 DE69112914 D1 DE 69112914D1 DE 69112914 T DE69112914 T DE 69112914T DE 69112914 T DE69112914 T DE 69112914T DE 69112914 D1 DE69112914 D1 DE 69112914D1
Authority
DE
Germany
Prior art keywords
fatty acid
solvent
acid ester
mixed solvent
microspheres
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69112914T
Other languages
English (en)
Other versions
DE69112914T2 (de
Inventor
Ichiro Yamakawa
Ryoichi Machida
Sumio Watanabe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP15284990A external-priority patent/JPH0446115A/ja
Priority claimed from JP15285090A external-priority patent/JPH0446116A/ja
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of DE69112914D1 publication Critical patent/DE69112914D1/de
Application granted granted Critical
Publication of DE69112914T2 publication Critical patent/DE69112914T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69112914T 1990-06-13 1991-06-12 Herstellungsverfahren von Mikrokugeln. Expired - Fee Related DE69112914T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP15284990A JPH0446115A (ja) 1990-06-13 1990-06-13 マイクロスフィアの製造法
JP15285090A JPH0446116A (ja) 1990-06-13 1990-06-13 マイクロスフィアの製造方法
JP4857991 1991-02-22

Publications (2)

Publication Number Publication Date
DE69112914D1 true DE69112914D1 (de) 1995-10-19
DE69112914T2 DE69112914T2 (de) 1996-04-04

Family

ID=27293336

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69112914T Expired - Fee Related DE69112914T2 (de) 1990-06-13 1991-06-12 Herstellungsverfahren von Mikrokugeln.

Country Status (9)

Country Link
US (1) US5980947A (de)
EP (1) EP0461630B1 (de)
JP (1) JP3116311B2 (de)
AT (1) ATE127686T1 (de)
CA (1) CA2044353A1 (de)
DE (1) DE69112914T2 (de)
DK (1) DK0461630T3 (de)
ES (1) ES2076412T3 (de)
GR (1) GR3017411T3 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2651320B2 (ja) * 1992-07-16 1997-09-10 田辺製薬株式会社 徐放性マイクロスフェア製剤の製造方法
DK0582459T3 (da) * 1992-08-07 1998-04-27 Takeda Chemical Industries Ltd Fremstilling af mikrokapsler af vandopløselige lægemidler
TW333456B (en) * 1992-12-07 1998-06-11 Takeda Pharm Ind Co Ltd A pharmaceutical composition of sustained-release preparation the invention relates to a pharmaceutical composition of sustained-release preparation which comprises a physiologically active peptide.
GB9310030D0 (en) * 1993-05-15 1993-06-30 Scras Dry processed particles and process for the preparation of the same
NZ260909A (en) * 1993-07-05 1995-04-27 Takeda Chemical Industries Ltd Production of sustained release preparation by allowing a water-soluble polypeptide to permeate into a biodegradable matrix in an aqueous solution
WO1997001331A2 (en) 1995-06-27 1997-01-16 Takeda Chemical Industries, Ltd. Method of producing sustained-release preparation
DE19545257A1 (de) 1995-11-24 1997-06-19 Schering Ag Verfahren zur Herstellung von morphologisch einheitlichen Mikrokapseln sowie nach diesem Verfahren hergestellte Mikrokapseln
AU2043297A (en) 1996-03-28 1997-10-17 Takeda Chemical Industries Ltd. Sustained-release preparation and its production
KR19990065921A (ko) * 1998-01-19 1999-08-16 김충섭 항생제의서방성제제
AU2001248825A1 (en) * 2000-04-24 2001-11-07 Tanabe Seiyaku Co., Ltd. Process for producing microsphere
JP2002129057A (ja) * 2000-10-27 2002-05-09 Riken Vitamin Co Ltd 多芯型カロテノイドビーズ
US20040115277A1 (en) * 2000-12-13 2004-06-17 Thomas Kissel Microparticles with an improved release profile and method for the production thereof
ES2292634T3 (es) 2000-12-21 2008-03-16 Alrise Biosystems Gmbh Procedimiento de transicion de fase inducida para la produccion de microparticulas que contienen agentes hidrofilos activos.
US20040121008A1 (en) * 2001-03-16 2004-06-24 Keiko Shiraishi Process for producing sustained release preparation
US20040131681A1 (en) * 2002-09-05 2004-07-08 Ambrose Catherine G. Antibiotic microspheres for treatment of infections and osteomyelitis
US8986737B2 (en) * 2002-09-05 2015-03-24 Wm. Marsh Rice University Antibiotic microspheres for treatment and prevention of osteomyelitis and enhancement of bone regrowth
CN1688275B (zh) * 2002-09-11 2012-05-30 田边三菱制药株式会社 微球的制备方法
EP1629833A4 (de) * 2003-06-03 2010-04-21 Santen Pharmaceutical Co Ltd Verfahren zur herstellung eines mikroteilchens
EP1909771A1 (de) * 2005-08-02 2008-04-16 Miv Therapeutics Inc. Mikrovorrichtungen mit nanokapseln für die kontrollierte abgabe von arzneimitteln und herstellungsverfahren dafür
JP2007222807A (ja) * 2006-02-24 2007-09-06 Nisso Engineering Co Ltd 修復型マイクロカプセルの製造方法
JP4564098B2 (ja) * 2006-12-18 2010-10-20 武田薬品工業株式会社 徐放性組成物およびその製造法
KR101105292B1 (ko) * 2009-06-05 2012-01-17 주식회사 리젠 바이오텍 생분해성 고분자 미세입자와 그의 제조방법
US10232047B2 (en) 2011-12-20 2019-03-19 Vyome Biosciences Private Limited Topical oil composition for the treatment of fungal infections
JP2014028764A (ja) * 2012-07-31 2014-02-13 Pure Green Kk 水溶性生理活生物質のマイクロスフィアを含有する油脂及びその製造方法
WO2014195872A1 (en) * 2013-06-04 2014-12-11 Vyome Biosciences Pvt. Ltd. Coated particles and compositions comprising same
JP6944033B1 (ja) * 2020-10-05 2021-10-06 ミヨシ油脂株式会社 生分解性樹脂水系分散体とその製造方法、および生分解性樹脂水系分散体を用いた食品包装用紙
CN114656677B (zh) * 2022-02-11 2022-12-16 华南理工大学 一种基于w/o/w型复乳溶剂挥发的木质素多孔微球及其制备方法与应用
CN119192657A (zh) * 2024-08-22 2024-12-27 清泽医疗科技(广东)有限公司 聚羟基脂肪酸酯微球及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4933105A (en) * 1980-06-13 1990-06-12 Sandoz Pharm. Corp. Process for preparation of microspheres
US4542025A (en) * 1982-07-29 1985-09-17 The Stolle Research And Development Corporation Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
US4671954A (en) * 1983-12-13 1987-06-09 University Of Florida Microspheres for incorporation of therapeutic substances and methods of preparation thereof
ATE61935T1 (de) * 1985-02-07 1991-04-15 Takeda Chemical Industries Ltd Verfahren zur herstellung von mikrokapseln.
JPS6341416A (ja) * 1986-08-08 1988-02-22 Takeda Chem Ind Ltd 鎮痛性ペプチド含有マイクロカプセルの製造法
JPS63122620A (ja) * 1986-11-12 1988-05-26 Sanraku Inc ポリ乳酸マイクロスフエア及びその製造方法
US4954338A (en) * 1987-08-05 1990-09-04 Rohm And Haas Company Microbicidal microemulsion

Also Published As

Publication number Publication date
CA2044353A1 (en) 1991-12-14
ATE127686T1 (de) 1995-09-15
EP0461630A2 (de) 1991-12-18
GR3017411T3 (en) 1995-12-31
DE69112914T2 (de) 1996-04-04
DK0461630T3 (da) 1995-11-13
JPH0665063A (ja) 1994-03-08
ES2076412T3 (es) 1995-11-01
JP3116311B2 (ja) 2000-12-11
EP0461630A3 (en) 1992-04-01
EP0461630B1 (de) 1995-09-13
US5980947A (en) 1999-11-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee