DE60317690D1 - Verfahren zur herstellung von valsartan - Google Patents

Verfahren zur herstellung von valsartan

Info

Publication number: DE60317690D1
Authority: DE; Germany
Prior art keywords: preparing valsartan; valsartan; preparing
Prior art date: 2002-09-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60317690T

Other languages

English (en)

Other versions

DE60317690T2 (de

Inventor

Donatienne Denni-Dischert

Hans Hirt

Dan Neville

Gottfried Sedelmeier

Anita Schnyder

Nadine Derrien

Daniel Kaufmann

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novartis AG

Original Assignee

Novartis AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-23

Filing date

2003-09-22

Publication date

2008-01-03

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9944606&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60317690(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-09-22 Application filed by Novartis AG filed Critical Novartis AG

2008-01-03 Publication of DE60317690D1 publication Critical patent/DE60317690D1/de

2008-10-30 Application granted granted Critical

2008-10-30 Publication of DE60317690T2 publication Critical patent/DE60317690T2/de

2023-09-23 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DE60317690T 2002-09-23 2003-09-22 Verfahren zur herstellung von valsartan Expired - Lifetime DE60317690T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB0222056.4A GB0222056D0 (en)	2002-09-23	2002-09-23	Process for the manufacture of organic compounds
GB0222056		2002-09-23
PCT/EP2003/010543 WO2004026847A1 (en)	2002-09-23	2003-09-22	Process for the manufacture of valsartan

Publications (2)

Publication Number	Publication Date
DE60317690D1 true DE60317690D1 (de)	2008-01-03
DE60317690T2 DE60317690T2 (de)	2008-10-30

Family

ID=9944606

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60317690T Expired - Lifetime DE60317690T2 (de)	2002-09-23	2003-09-22	Verfahren zur herstellung von valsartan

Country Status (30)

Country	Link
US (3)	US20060069268A1 (de)
EP (2)	EP1878729A1 (de)
JP (2)	JP4787498B2 (de)
KR (2)	KR20110015703A (de)
CN (2)	CN100357279C (de)
AR (1)	AR041360A1 (de)
AU (1)	AU2003270241B2 (de)
BR (1)	BR0314132A (de)
CA (1)	CA2502629A1 (de)
CY (1)	CY1107878T1 (de)
DE (1)	DE60317690T2 (de)
DK (1)	DK1546122T3 (de)
EC (2)	ECSP055695A (de)
ES (1)	ES2295623T3 (de)
GB (1)	GB0222056D0 (de)
HK (1)	HK1079771A1 (de)
IL (1)	IL167426A (de)
MX (1)	MXPA05003140A (de)
MY (1)	MY138618A (de)
NO (2)	NO20051970L (de)
NZ (2)	NZ538927A (de)
PE (2)	PE20050088A1 (de)
PL (1)	PL374862A1 (de)
PT (1)	PT1546122E (de)
RU (2)	RU2348619C2 (de)
SG (1)	SG155049A1 (de)
SI (1)	SI1546122T1 (de)
TW (2)	TWI338003B (de)
WO (1)	WO2004026847A1 (de)
ZA (1)	ZA200502159B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7199144B2 (en)	2003-04-21	2007-04-03	Teva Pharmaceuticals Industries, Ltd.	Process for the preparation of valsartan and intermediates thereof
EP1511739B1 (de) *	2003-03-17	2008-04-30	Teva Pharmaceutical Industries Ltd.	Polymorphe formen von valsartan
US7378531B2 (en)	2003-04-21	2008-05-27	Teva Pharmaceutical Industries Ltd	Process for the preparation of valsartan
EP1556363A2 (de) *	2003-04-21	2005-07-27	Teva Pharmaceutical Industries Limited	Verfahren zur herstellung von valsartan und zwischenprodukte davon
GB0316546D0 (en)	2003-07-15	2003-08-20	Novartis Ag	Process for the manufacture of organic compounds
GB0402262D0 (en) *	2004-02-02	2004-03-10	Novartis Ag	Process for the manufacture of organic compounds
EP1661891A1 (de) *	2004-11-30	2006-05-31	KRKA, D.D., Novo Mesto	Verfahren zur Herstellung von Valsartan
GB0514206D0 (en)	2005-07-11	2005-08-17	Novartis Ag	Organic compounds
ES2288376B1 (es) *	2005-10-20	2008-11-01	Inke, S.A.	Procedimiento para la obtencion de intermedios utiles en la obtencion de un compuesto farmaceuticamente activo.
WO2007057919A2 (en) *	2005-10-25	2007-05-24	Alembic Limited	An improved process for preparation of (s)-n-(1-carboxy-2-methyl-prop-1-yl)-n-pentanoyl-n-[2'-(1h-tetrazol-5-yl)biphenyl-4-ylmethyl]-amine
EP2057132A2 (de) *	2006-07-03	2009-05-13	Aurobindo Pharma Limited	Verfahren zur herstellung des angiotensin-ii-antagonisten valsartan
ES2315141B1 (es) *	2006-11-23	2009-12-22	Quimica Sintetica, S.A	Procedimiento para la preparacion de cardesartan cilexetilo en forma cristalina.
CN101200455B (zh) *	2007-09-29	2010-08-18	泰兴市江神化工有限公司	沙坦类治疗高血压药物主环5-(4'-甲酰基联苯-2-基)-1h-四氮唑的制备方法
US7943794B2 (en) *	2008-02-13	2011-05-17	Ranbaxy Laboratories Limited	Processes for the preparation of intermediates of valsartan
KR101012135B1 (ko) *	2008-12-18	2011-02-07	주식회사 대희화학	발사르탄 메틸 에스테르의 제조방법
EP2316821A1 (de)	2009-10-27	2011-05-04	Novartis AG	Verfahren zur Herstellung organischer Verbindungen
SG187007A1 (en) *	2010-08-03	2013-02-28	Novartis Ag	Highly crystalline valsartan
CN102351804B (zh) *	2011-09-30	2013-07-31	浙江新赛科药业有限公司	一种缬沙坦消旋体的回收方法
CN103554047A (zh) *	2013-10-11	2014-02-05	镇江市高等专科学校	制备缬沙坦的方法
CN103923028B (zh) *	2014-05-04	2017-05-24	青岛雪洁助剂有限公司	一种缬沙坦甲酯的制备方法
CN104072433A (zh) *	2014-07-16	2014-10-01	南京正大天晴制药有限公司	一种缬沙坦的水解杂质化合物及其制备方法、检测方法和用途
CN104151199A (zh) *	2014-08-13	2014-11-19	苏州卫生职业技术学院	一种缬沙坦的合成方法
CN104844476B (zh) *	2015-04-03	2016-08-24	李凌	一种医药中间体联苯类化合物的合成方法
CN112014479A (zh) *	2019-05-28	2020-12-01	珠海润都制药股份有限公司	一种缬沙坦中正戊酰氯的检测方法
CN116655498B (zh) *	2023-05-24	2025-01-28	江苏阿尔法集团福瑞药业(宿迁)有限公司	一种沙库巴曲中间体的制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2084801T3 (es) *	1990-02-19	1996-05-16	Ciba Geigy Ag	Acil compuestos.
US5260325A (en) *	1991-08-19	1993-11-09	E. I. Du Pont De Nemours And Company	Angiotensin II receptor blocking tertiary amides
FR2688503B1 (fr) *	1992-03-16	1994-05-06	Synthelabo	Procede de preparation de derives de 2-(tetrazol-5-yl)-[1,1'-biphenyle].
EP0550313A1 (de) *	1991-12-30	1993-07-07	Synthelabo	2-(Tetranol-5-yl)-(1,1'-Biphenyl)derivate, ihre Herstellung und Anwendung als Zwischenverbindungen
US5284957A (en) *	1992-09-03	1994-02-08	Eli Lilly And Company	Excitatory amino acid receptor antagonists
JPH08165292A (ja) *	1993-10-07	1996-06-25	Techno Res Kk	アデニン誘導体、その製造法及び用途
US5412102A (en) *	1994-05-27	1995-05-02	Syntex (U.S.A.) Inc.	Processes for preparing 1-butyl-2-[2'-(2H-tetrazol-5-yl) biphenyl-4-ylmethyl]-1H-indole-3-carboxylic acid
US5468867A (en) *	1994-05-27	1995-11-21	Syntex (U.S.A.) Inc.	Process for preparing1-butyl-2-[2'-(2H-tetrazol-5-yl)biphenyl-4-ylmethyl1-1H-indole-3-carboxylic acid
WO1996009301A1 (fr) *	1994-09-20	1996-03-28	Wakunaga Seiyaku Kabushiki Kaisha	Procede de production d'un derive de n-biphenylmethylthiadiazoline ou un sel de celui-ci et son intermediaire de production
HUP9900871A3 (en) *	1995-06-07	2000-07-28	Wyeth Corp	Process for preparation of biphenyl derivatives
CN1137887C (zh) *	2000-04-07	2004-02-11	常州四药制药有限公司	一种合成缬沙坦的改进方法
ES2309090T3 (es) *	2000-07-19	2008-12-16	Novartis Ag	Sales de valsartan.
GB0402262D0 (en) *	2004-02-02	2004-03-10	Novartis Ag	Process for the manufacture of organic compounds

2002
- 2002-09-23 GB GBGB0222056.4A patent/GB0222056D0/en not_active Ceased
2003
- 2003-09-22 MX MXPA05003140A patent/MXPA05003140A/es active IP Right Grant
- 2003-09-22 RU RU2005112444/04A patent/RU2348619C2/ru not_active IP Right Cessation
- 2003-09-22 SG SG200702272-6A patent/SG155049A1/en unknown
- 2003-09-22 CA CA002502629A patent/CA2502629A1/en not_active Abandoned
- 2003-09-22 PT PT03750599T patent/PT1546122E/pt unknown
- 2003-09-22 TW TW098146486A patent/TWI338003B/zh not_active IP Right Cessation
- 2003-09-22 US US10/528,323 patent/US20060069268A1/en not_active Abandoned
- 2003-09-22 KR KR1020117002725A patent/KR20110015703A/ko not_active Ceased
- 2003-09-22 SI SI200331125T patent/SI1546122T1/sl unknown
- 2003-09-22 AU AU2003270241A patent/AU2003270241B2/en not_active Ceased
- 2003-09-22 TW TW092126088A patent/TWI329106B/zh not_active IP Right Cessation
- 2003-09-22 CN CNB038245140A patent/CN100357279C/zh not_active Expired - Fee Related
- 2003-09-22 NZ NZ538927A patent/NZ538927A/en not_active IP Right Cessation
- 2003-09-22 ES ES03750599T patent/ES2295623T3/es not_active Expired - Lifetime
- 2003-09-22 RU RU2008133680/04A patent/RU2412173C2/ru not_active IP Right Cessation
- 2003-09-22 BR BR0314132-2A patent/BR0314132A/pt not_active IP Right Cessation
- 2003-09-22 PL PL03374862A patent/PL374862A1/xx not_active Application Discontinuation
- 2003-09-22 NZ NZ566863A patent/NZ566863A/en not_active IP Right Cessation
- 2003-09-22 DK DK03750599T patent/DK1546122T3/da active
- 2003-09-22 EP EP07113176A patent/EP1878729A1/de not_active Withdrawn
- 2003-09-22 EP EP03750599A patent/EP1546122B8/de not_active Revoked
- 2003-09-22 WO PCT/EP2003/010543 patent/WO2004026847A1/en active Application Filing
- 2003-09-22 JP JP2004537146A patent/JP4787498B2/ja not_active Expired - Fee Related
- 2003-09-22 KR KR1020057004873A patent/KR20050057529A/ko not_active Ceased
- 2003-09-22 DE DE60317690T patent/DE60317690T2/de not_active Expired - Lifetime
- 2003-09-22 CN CN2007101692527A patent/CN101153027B/zh not_active Expired - Fee Related
- 2003-09-22 MY MYPI20033603A patent/MY138618A/en unknown
- 2003-09-23 PE PE2003000976A patent/PE20050088A1/es not_active Application Discontinuation
- 2003-09-23 PE PE2008001800A patent/PE20091387A1/es not_active Application Discontinuation
- 2003-09-23 AR ARP030103458A patent/AR041360A1/es unknown
2005
- 2005-03-14 IL IL167426A patent/IL167426A/en not_active IP Right Cessation
- 2005-03-15 ZA ZA200502159A patent/ZA200502159B/en unknown
- 2005-03-21 EC EC2005005695A patent/ECSP055695A/es unknown
- 2005-04-22 NO NO20051970A patent/NO20051970L/no not_active Application Discontinuation
- 2005-12-20 HK HK05111768A patent/HK1079771A1/xx not_active IP Right Cessation
2008
- 2008-02-04 CY CY20081100145T patent/CY1107878T1/el unknown
- 2008-12-23 US US12/317,426 patent/US20090111995A1/en not_active Abandoned
2010
- 2010-02-11 EC EC2010005695A patent/ECSP105695A/es unknown
- 2010-06-15 US US12/815,704 patent/US20100249429A1/en not_active Abandoned
- 2010-08-02 JP JP2010173583A patent/JP2010254709A/ja active Pending
2011
- 2011-06-15 NO NO20110856A patent/NO20110856L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
CA2502629A1 (en)	2004-04-01
MY138618A (en)	2009-07-31
RU2008133680A (ru)	2010-02-27
US20090111995A1 (en)	2009-04-30
TWI329106B (en)	2010-08-21
TW201016673A (en)	2010-05-01
NO20110856L (no)	2005-06-16
AU2003270241B2 (en)	2007-08-23
BR0314132A (pt)	2005-06-28
SG155049A1 (en)	2009-09-30
JP2006502178A (ja)	2006-01-19
TWI338003B (en)	2011-03-01
PE20050088A1 (es)	2005-02-21
CN1688556A (zh)	2005-10-26
CY1107878T1 (el)	2013-06-19
IL167426A (en)	2010-11-30
US20060069268A1 (en)	2006-03-30
ES2295623T3 (es)	2008-04-16
EP1546122A1 (de)	2005-06-29
ECSP105695A (es)	2010-03-31
DK1546122T3 (da)	2008-03-03
PE20091387A1 (es)	2009-10-13
KR20050057529A (ko)	2005-06-16
AR041360A1 (es)	2005-05-11
CN100357279C (zh)	2007-12-26
TW200413337A (en)	2004-08-01
US20100249429A1 (en)	2010-09-30
AU2003270241A1 (en)	2004-04-08
DE60317690T2 (de)	2008-10-30
JP2010254709A (ja)	2010-11-11
CN101153027B (zh)	2010-08-18
NO20051970L (no)	2005-06-16
KR20110015703A (ko)	2011-02-16
NZ566863A (en)	2009-08-28
PL374862A1 (en)	2005-11-14
RU2005112444A (ru)	2006-01-20
WO2004026847A1 (en)	2004-04-01
EP1546122B1 (de)	2007-11-21
EP1546122B8 (de)	2008-05-28
ZA200502159B (en)	2005-09-21
PT1546122E (pt)	2008-02-14
NZ538927A (en)	2008-05-30
SI1546122T1 (sl)	2008-04-30
MXPA05003140A (es)	2005-06-22
ECSP055695A (es)	2005-05-30
CN101153027A (zh)	2008-04-02
GB0222056D0 (en)	2002-10-30
RU2348619C2 (ru)	2009-03-10
RU2412173C2 (ru)	2011-02-20
JP4787498B2 (ja)	2011-10-05
HK1079771A1 (en)	2006-04-13
EP1878729A1 (de)	2008-01-16

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DE60317690D1 (de)	2008-01-03	Verfahren zur herstellung von valsartan
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DE60330749D1 (de)	2010-02-11	Verfahren zur herstellung von 7-alpha-methylsteroide

Legal Events

Date	Code	Title	Description
2008-12-04	8363	Opposition against the patent
2010-05-20	8328	Change in the person/name/address of the agent	Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336
2011-06-16	8328	Change in the person/name/address of the agent	Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN