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DE60230860D1 - Von tryptophanyl-trna-synthetase stammende polypeptide zur regulierung der angiogenese - Google Patents

Von tryptophanyl-trna-synthetase stammende polypeptide zur regulierung der angiogenese

Info

Publication number
DE60230860D1
DE60230860D1 DE60230860T DE60230860T DE60230860D1 DE 60230860 D1 DE60230860 D1 DE 60230860D1 DE 60230860 T DE60230860 T DE 60230860T DE 60230860 T DE60230860 T DE 60230860T DE 60230860 D1 DE60230860 D1 DE 60230860D1
Authority
DE
Germany
Prior art keywords
polypeptide
sequence
angiogenesis
tryptophanyl
trna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60230860T
Other languages
English (en)
Inventor
Paul Schimmel
Keisuke Wakasugi
Martin Friedlander
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Application granted granted Critical
Publication of DE60230860D1 publication Critical patent/DE60230860D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y601/00—Ligases forming carbon-oxygen bonds (6.1)
    • C12Y601/01—Ligases forming aminoacyl-tRNA and related compounds (6.1.1)
    • C12Y601/01002—Tryptophan-tRNA ligase (6.1.1.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
DE60230860T 2001-02-23 2002-02-22 Von tryptophanyl-trna-synthetase stammende polypeptide zur regulierung der angiogenese Expired - Lifetime DE60230860D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27095101P 2001-02-23 2001-02-23
PCT/US2002/005185 WO2002067970A1 (en) 2001-02-23 2002-02-22 TRYPTOPHANYL-tRNA SYNTHETASE DERIVED POLYPEPTIDES USEFUL FOR THE REGULATION OF ANGIOGENESIS

Publications (1)

Publication Number Publication Date
DE60230860D1 true DE60230860D1 (de) 2009-03-05

Family

ID=23033541

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60230860T Expired - Lifetime DE60230860D1 (de) 2001-02-23 2002-02-22 Von tryptophanyl-trna-synthetase stammende polypeptide zur regulierung der angiogenese

Country Status (19)

Country Link
US (1) US20030017564A1 (de)
EP (2) EP1377305B1 (de)
JP (2) JP4361734B2 (de)
KR (1) KR100869914B1 (de)
CN (1) CN100486992C (de)
AT (1) ATE420653T1 (de)
AU (2) AU2002306558B2 (de)
BR (1) BR0207449A (de)
CA (1) CA2438273C (de)
DE (1) DE60230860D1 (de)
ES (1) ES2318063T3 (de)
HK (1) HK1069322A1 (de)
IL (3) IL157558A0 (de)
MX (1) MXPA03007586A (de)
NZ (1) NZ528193A (de)
PL (1) PL208008B1 (de)
RU (1) RU2297425C2 (de)
WO (1) WO2002067970A1 (de)
ZA (1) ZA200307383B (de)

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US20060104963A1 (en) * 2002-07-25 2006-05-18 The Scripps Research Institute Treatment of cone cell degeneration with transfected lineage negative hematopoietic stem cells
US20060104962A1 (en) * 2002-07-25 2006-05-18 The Scripps Research Institute Transfected hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith
MXPA05000972A (es) * 2002-07-25 2005-09-12 Scripps Research Inst Celulas madres hematopoyeticas y metodo de tratamiento de enfermedades oculares neovasculares con las mismas.
US7838290B2 (en) * 2002-07-25 2010-11-23 The Scripps Research Institute Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith
AU2005249586B2 (en) * 2004-06-04 2010-12-23 The Scripps Research Institute Compositions and methods for treatment of neovascular diseases
US20060078556A1 (en) * 2004-10-07 2006-04-13 Paul Glidden Antibodies and epitopes specific to tRNA synthetase fragments
US20060079441A1 (en) * 2004-10-07 2006-04-13 Paul Glidden Methods of modulating angiogenesis
US20060079472A1 (en) * 2004-10-07 2006-04-13 Paul Glidden Methods for treating angiogenesis
US20060079672A1 (en) * 2004-10-07 2006-04-13 Paul Glidden Kits for modulating angiogenesis
US20060078886A1 (en) * 2004-10-07 2006-04-13 Paul Glidden Business methods for modulating angiogenesis
US8282921B2 (en) 2004-08-02 2012-10-09 Paul Glidden tRNA synthetase fragments
US20060079474A1 (en) * 2004-10-07 2006-04-13 Paul Glidden Analogs of tRNA synthetase fragments and uses thereof
US20060079673A1 (en) * 2004-08-02 2006-04-13 Paul Glidden Polynucleotides encoding tRNA synthetase fragments and uses thereof
US20060078553A1 (en) * 2004-10-07 2006-04-13 Paul Glidden Diverse multi-unit complexes including a tRNA synthetase fragment
US20060024286A1 (en) * 2004-08-02 2006-02-02 Paul Glidden Variants of tRNA synthetase fragments and uses thereof
US20060024288A1 (en) * 2004-08-02 2006-02-02 Pfizer Inc. tRNA synthetase fragments
US20060079473A1 (en) * 2004-10-07 2006-04-13 Paul Glidden Multi-unit complexes and uses thereof
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CN103108655B (zh) 2010-05-03 2017-04-05 Atyr 医药公司 与丝氨酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现
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AU2011248227B2 (en) 2010-05-03 2016-12-01 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases
AU2011248355B2 (en) 2010-05-03 2017-01-19 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Arginyl-tRNA synthetases
CA2798139C (en) 2010-05-04 2019-09-24 Atyr Pharma, Inc. Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of p38 multi-trna synthetase complex
JP6008843B2 (ja) 2010-05-04 2016-10-19 エータイアー ファーマ， インコーポレイテッド グルタミル−プロリルｔＲＮＡ合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見
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Also Published As

Publication number Publication date
MXPA03007586A (es) 2003-12-11
ATE420653T1 (de) 2009-01-15
ZA200307383B (en) 2005-03-30
CN1527719A (zh) 2004-09-08
WO2002067970A1 (en) 2002-09-06
US20030017564A1 (en) 2003-01-23
HK1069322A1 (en) 2005-05-20
EP1377305A1 (de) 2004-01-07
JP2009261409A (ja) 2009-11-12
AU2007219318A1 (en) 2007-10-18
CA2438273A1 (en) 2002-09-06
PL208008B1 (pl) 2011-03-31
RU2003128420A (ru) 2005-02-20
RU2297425C2 (ru) 2007-04-20
CN100486992C (zh) 2009-05-13
PL364596A1 (en) 2004-12-13
AU2007219318B2 (en) 2009-12-17
AU2002306558B2 (en) 2007-06-28
EP1377305B1 (de) 2009-01-14
BR0207449A (pt) 2004-04-06
EP1377305A4 (de) 2005-02-09
CA2438273C (en) 2013-06-18
ES2318063T3 (es) 2009-05-01
JP2004532010A (ja) 2004-10-21
IL201755A (en) 2015-01-29
KR100869914B1 (ko) 2008-11-21
JP4448925B2 (ja) 2010-04-14
IL157558A (en) 2010-06-16
EP2080520A1 (de) 2009-07-22
JP4361734B2 (ja) 2009-11-11
NZ528193A (en) 2006-02-24
IL157558A0 (en) 2004-03-28
KR20030078935A (ko) 2003-10-08

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