DE60204611D1 - Sulfonyl-pyridazinon-derivate zur verwendung als aldose-reduktase-inhibitoren - Google Patents
Sulfonyl-pyridazinon-derivate zur verwendung als aldose-reduktase-inhibitorenInfo
- Publication number
- DE60204611D1 DE60204611D1 DE60204611T DE60204611T DE60204611D1 DE 60204611 D1 DE60204611 D1 DE 60204611D1 DE 60204611 T DE60204611 T DE 60204611T DE 60204611 T DE60204611 T DE 60204611T DE 60204611 D1 DE60204611 D1 DE 60204611D1
- Authority
- DE
- Germany
- Prior art keywords
- reductase inhibitors
- aldose reductase
- sulfonyl
- pyridazinone derivatives
- prodrug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003288 aldose reductase inhibitor Substances 0.000 title abstract 2
- 229940090865 aldose reductase inhibitors used in diabetes Drugs 0.000 title abstract 2
- UUAVJCDYOHIIQW-UHFFFAOYSA-N 4-sulfonylpyridazin-3-one Chemical class O=C1N=NC=CC1=S(=O)=O UUAVJCDYOHIIQW-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 2
- 239000000651 prodrug Substances 0.000 abstract 2
- 208000002249 Diabetes Complications Diseases 0.000 abstract 1
- 206010012655 Diabetic complications Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/18—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27225401P | 2001-02-28 | 2001-02-28 | |
| US272254P | 2001-02-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60204611D1 true DE60204611D1 (de) | 2005-07-21 |
| DE60204611T2 DE60204611T2 (de) | 2006-05-11 |
Family
ID=23039045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60204611T Expired - Fee Related DE60204611T2 (de) | 2001-02-28 | 2002-02-20 | Sulfonyl-pyridazinon-derivate zur Verwendung als Aldose-reduktase-inhibitoren |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6730674B2 (de) |
| EP (1) | EP1236720B1 (de) |
| JP (1) | JP2003128657A (de) |
| AT (1) | ATE297902T1 (de) |
| BR (1) | BR0200536A (de) |
| CA (1) | CA2373395C (de) |
| DE (1) | DE60204611T2 (de) |
| ES (1) | ES2240657T3 (de) |
| MX (1) | MXPA02002252A (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2200184T7 (es) | 1996-07-24 | 2015-02-10 | Warner-Lambert Company Llc | Isobutilgaba y sus derivados para el tratamiento del dolor |
| NZ528150A (en) * | 2001-04-30 | 2005-03-24 | Pfizer Prod Inc | Combinations of aldose reductase inhibitors and cyclooxygenase-2 inhibitors |
| AU761191B2 (en) * | 2001-05-24 | 2003-05-29 | Pfizer Products Inc. | Therapies for tissue damage resulting from ischemia |
| KR20030061051A (ko) * | 2002-01-07 | 2003-07-18 | 대한민국 (경상대학교 총장) | 신규한 아렌(혹은 알케인)술폰일피리다진온 유도체, 이의제조방법 및 유기반응에서의 용도 |
| ATE493973T1 (de) | 2004-06-04 | 2011-01-15 | Teva Pharma | Irbesartan enthaltende pharmazeutische zusammensetzung |
| AU2006271721C1 (en) * | 2005-07-21 | 2013-09-19 | F. Hoffmann-La Roche Ag | Pyridazinone derivatives as thyroid hormone receptor agonists |
| JP2010043063A (ja) | 2008-05-09 | 2010-02-25 | Agency For Science Technology & Research | 川崎病の診断及び治療 |
| GB0907601D0 (en) * | 2009-05-01 | 2009-06-10 | Equateq Ltd | Novel methods |
| WO2017168174A1 (en) | 2016-04-02 | 2017-10-05 | N4 Pharma Uk Limited | New pharmaceutical forms of sildenafil |
| WO2018002673A1 (en) | 2016-07-01 | 2018-01-04 | N4 Pharma Uk Limited | Novel formulations of angiotensin ii receptor antagonists |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE574204A (fr) * | 1958-12-24 | 1959-06-24 | Henri Morren | Dérives de sulfonyl-pyridazine |
| IE47592B1 (en) | 1977-12-29 | 1984-05-02 | Ici Ltd | Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof,and process for their manufacture |
| US4939140A (en) | 1985-11-07 | 1990-07-03 | Pfizer Inc. | Heterocyclic oxophthalazinyl acetic acids |
| US4996204A (en) | 1989-05-11 | 1991-02-26 | Pfizer Inc. | Pyrido[2,3-d]pyridazinones as aldose reductase inhibitors |
| FR2647676A1 (fr) | 1989-06-05 | 1990-12-07 | Union Pharma Scient Appl | Nouveaux derives de pyridazinone, leurs procedes de preparation, medicaments les contenant, utiles notamment comme inhibiteurs de l'aldose reductase |
| JPH06500793A (ja) * | 1991-03-28 | 1994-01-27 | フアイザー・インコーポレイテツド | ピリダジノン酢酸 |
| TWI238064B (en) | 1995-06-20 | 2005-08-21 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
| EP1491540B1 (de) * | 2001-03-30 | 2006-12-13 | Pfizer Products Inc. | Zwischenprodukten für die Herstellung von Pyridazinon Aldose Reductase Inhibitoren. |
| AU761191B2 (en) * | 2001-05-24 | 2003-05-29 | Pfizer Products Inc. | Therapies for tissue damage resulting from ischemia |
-
2002
- 2002-02-20 AT AT02251173T patent/ATE297902T1/de not_active IP Right Cessation
- 2002-02-20 ES ES02251173T patent/ES2240657T3/es not_active Expired - Lifetime
- 2002-02-20 EP EP02251173A patent/EP1236720B1/de not_active Expired - Lifetime
- 2002-02-20 DE DE60204611T patent/DE60204611T2/de not_active Expired - Fee Related
- 2002-02-26 CA CA002373395A patent/CA2373395C/en not_active Expired - Fee Related
- 2002-02-26 US US10/085,609 patent/US6730674B2/en not_active Expired - Fee Related
- 2002-02-27 BR BR0200536-0A patent/BR0200536A/pt not_active IP Right Cessation
- 2002-02-27 MX MXPA02002252A patent/MXPA02002252A/es unknown
- 2002-02-27 JP JP2002050684A patent/JP2003128657A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CA2373395A1 (en) | 2002-08-28 |
| MXPA02002252A (es) | 2002-09-30 |
| US20030004139A1 (en) | 2003-01-02 |
| ATE297902T1 (de) | 2005-07-15 |
| EP1236720A1 (de) | 2002-09-04 |
| BR0200536A (pt) | 2003-04-29 |
| DE60204611T2 (de) | 2006-05-11 |
| ES2240657T3 (es) | 2005-10-16 |
| EP1236720B1 (de) | 2005-06-15 |
| JP2003128657A (ja) | 2003-05-08 |
| CA2373395C (en) | 2006-01-10 |
| US6730674B2 (en) | 2004-05-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |