DE60213541D1 - Discodermolid-Analoga und ihre pharmazeutische Verwendung - Google Patents
Discodermolid-Analoga und ihre pharmazeutische VerwendungInfo
- Publication number
- DE60213541D1 DE60213541D1 DE60213541T DE60213541T DE60213541D1 DE 60213541 D1 DE60213541 D1 DE 60213541D1 DE 60213541 T DE60213541 T DE 60213541T DE 60213541 T DE60213541 T DE 60213541T DE 60213541 D1 DE60213541 D1 DE 60213541D1
- Authority
- DE
- Germany
- Prior art keywords
- pharmaceutical use
- discodermolide analogs
- discodermolide
- compounds
- analogs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- AADVCYNFEREWOS-OBRABYBLSA-N Discodermolide Chemical class C=C\C=C/[C@H](C)[C@H](OC(N)=O)[C@@H](C)[C@H](O)[C@@H](C)C\C(C)=C/[C@H](C)[C@@H](O)[C@@H](C)\C=C/[C@@H](O)C[C@@H]1OC(=O)[C@H](C)[C@@H](O)[C@H]1C AADVCYNFEREWOS-OBRABYBLSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33239901P | 2001-11-16 | 2001-11-16 | |
| US332399P | 2001-11-16 | ||
| US34339401P | 2001-12-21 | 2001-12-21 | |
| US343394P | 2001-12-21 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60213541D1 true DE60213541D1 (de) | 2006-09-14 |
| DE60213541T2 DE60213541T2 (de) | 2007-10-04 |
Family
ID=26988201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60213541T Expired - Lifetime DE60213541T2 (de) | 2001-11-16 | 2002-11-15 | Discodermolid-Analoga und ihre pharmazeutische Verwendung |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6833367B2 (de) |
| EP (1) | EP1312608B1 (de) |
| JP (1) | JP4410986B2 (de) |
| AT (1) | ATE334977T1 (de) |
| CY (1) | CY1106201T1 (de) |
| DE (1) | DE60213541T2 (de) |
| DK (1) | DK1312608T3 (de) |
| ES (1) | ES2267928T3 (de) |
| PT (1) | PT1312608E (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005084349A2 (en) * | 2004-03-02 | 2005-09-15 | Kosan Biosciences, Inc. | Compounds useful for the synthesis of (+)-discodermolide and methods therefor |
| US7214708B2 (en) * | 2004-11-18 | 2007-05-08 | Kosan Biosciences Incorporated | Synthetic discodermolide analogs |
| FR2951720B1 (fr) * | 2009-10-28 | 2011-12-16 | Pf Medicament | Molecules polyketides comme agents anticancereux |
| JP5822169B2 (ja) * | 2010-07-01 | 2015-11-24 | ユーハン・コーポレイションＹＵＨＡＮ Ｃｏｒｐｏｒａｔｉｏｎ | ＨＭＧ−ＣｏＡ還元酵素阻害剤及びその中間体の製造方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5010099A (en) * | 1989-08-11 | 1991-04-23 | Harbor Branch Oceanographic Institution, Inc. | Discodermolide compounds, compositions containing same and method of preparation and use |
| US5681847A (en) * | 1995-12-05 | 1997-10-28 | Harbor Branch Oceanographic Institution, Inc. | Methods of using discodermolide compounds |
| US6096904A (en) | 1996-12-03 | 2000-08-01 | The Trustees Of The University Of Pennsylvania | Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives |
| US6242616B1 (en) * | 1996-12-03 | 2001-06-05 | The Trustees Of The University Of Pennsylvania | Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives |
| US6870058B2 (en) | 1996-12-03 | 2005-03-22 | The Trustees Of The University Of Pennsylvania | Compounds which mimic the chemical and biological properties of discodermolide |
| US5789605A (en) | 1996-12-03 | 1998-08-04 | Trustees Of The University Of Pennsylvania | Synthetic techniques and intermediates for polyhydroxy, dienyl lactones and mimics thereof |
| US6127406A (en) | 1998-10-09 | 2000-10-03 | Harbor Branch Oceanographic Institution, Inc. | Discodermolide compounds and methods of use |
| ES2236208T3 (es) * | 2000-03-01 | 2005-07-16 | Harbor Branch Oceanographic Institution, Inc. | Analogos biologicamente activos de discodermolida. |
-
2002
- 2002-11-12 US US10/292,134 patent/US6833367B2/en not_active Expired - Fee Related
- 2002-11-15 AT AT02025728T patent/ATE334977T1/de not_active IP Right Cessation
- 2002-11-15 PT PT02025728T patent/PT1312608E/pt unknown
- 2002-11-15 DE DE60213541T patent/DE60213541T2/de not_active Expired - Lifetime
- 2002-11-15 ES ES02025728T patent/ES2267928T3/es not_active Expired - Lifetime
- 2002-11-15 DK DK02025728T patent/DK1312608T3/da active
- 2002-11-15 JP JP2002332243A patent/JP4410986B2/ja not_active Expired - Fee Related
- 2002-11-15 EP EP02025728A patent/EP1312608B1/de not_active Expired - Lifetime
-
2004
- 2004-09-29 US US10/952,950 patent/US7148218B2/en not_active Expired - Fee Related
-
2006
- 2006-10-16 CY CY20061101483T patent/CY1106201T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE60213541T2 (de) | 2007-10-04 |
| EP1312608A2 (de) | 2003-05-21 |
| EP1312608A3 (de) | 2003-06-18 |
| PT1312608E (pt) | 2006-12-29 |
| EP1312608B1 (de) | 2006-08-02 |
| US7148218B2 (en) | 2006-12-12 |
| US6833367B2 (en) | 2004-12-21 |
| US20030153601A1 (en) | 2003-08-14 |
| JP4410986B2 (ja) | 2010-02-10 |
| US20050080080A1 (en) | 2005-04-14 |
| CY1106201T1 (el) | 2011-06-08 |
| ATE334977T1 (de) | 2006-08-15 |
| ES2267928T3 (es) | 2007-03-16 |
| DK1312608T3 (da) | 2006-11-27 |
| JP2003160575A (ja) | 2003-06-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336 |
|
| 8328 | Change in the person/name/address of the agent |
Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN |