DE602005018965D1 - Herstellung von pregabalin und verwandten verbindungen - Google Patents

Herstellung von pregabalin und verwandten verbindungen

Info

Publication number: DE602005018965D1
Authority: DE; Germany
Prior art keywords: pregabalin; preparation; related compounds; compounds
Prior art date: 2004-06-21
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE602005018965T

Other languages

English (en)

Inventor

Shanghui Hu

Carlos A Martinez

Junhua Tao

William E Tully

Patrick G T Kelleher

Yves R Dumond

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Warner Lambert Co LLC

Original Assignee

Warner Lambert Co LLC

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-06-21

Filing date

2005-06-09

Publication date

2010-03-04

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35295367&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE602005018965(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2005-06-09 Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC

2010-03-04 Publication of DE602005018965D1 publication Critical patent/DE602005018965D1/de

2025-06-10 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/12—Formation of amino and carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
- C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
- C07C227/20—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/001—Amines; Imines
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/002—Nitriles (-CN)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Zoology (AREA)
Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Neurosurgery (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biomedical Technology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DE602005018965T 2004-06-21 2005-06-09 Herstellung von pregabalin und verwandten verbindungen Expired - Lifetime DE602005018965D1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US58167104P	2004-06-21	2004-06-21
US62903404P	2004-11-18	2004-11-18
PCT/IB2005/001924 WO2006000904A2 (en)	2004-06-21	2005-06-09	Preparation of pregabalin and related compounds

Publications (1)

Publication Number	Publication Date
DE602005018965D1 true DE602005018965D1 (de)	2010-03-04

Family

ID=35295367

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE602005018965T Expired - Lifetime DE602005018965D1 (de)	2004-06-21	2005-06-09	Herstellung von pregabalin und verwandten verbindungen

Country Status (32)

Country	Link
US (4)	US20050283023A1 (de)
EP (1)	EP1831154B1 (de)
JP (5)	JP4174551B2 (de)
KR (3)	KR100847929B1 (de)
CN (2)	CN1972904B (de)
AP (1)	AP2466A (de)
AR (1)	AR049446A1 (de)
AT (1)	ATE455093T1 (de)
AU (1)	AU2005256945B2 (de)
BR (1)	BRPI0512347B8 (de)
CA (1)	CA2571040C (de)
CR (2)	CR8765A (de)
CY (1)	CY1110337T1 (de)
DE (1)	DE602005018965D1 (de)
DK (1)	DK1831154T3 (de)
EA (3)	EA011765B1 (de)
ES (1)	ES2336014T3 (de)
GE (1)	GEP20104895B (de)
HR (1)	HRP20100054T1 (de)
IL (1)	IL179614A0 (de)
MA (1)	MA28674B1 (de)
ME (1)	ME01067B (de)
MX (1)	MXPA06014228A (de)
NO (1)	NO338097B1 (de)
NZ (1)	NZ552220A (de)
PL (1)	PL1831154T3 (de)
PT (1)	PT1831154E (de)
RS (1)	RS51210B (de)
SI (1)	SI1831154T1 (de)
TW (6)	TWI402248B (de)
UA (1)	UA83575C2 (de)
WO (1)	WO2006000904A2 (de)

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ATE486841T1 (de)	2005-05-10	2010-11-15	Teva Pharma	Verfahren zur herstellung von pregabalin und salzen daraus
CZ297970B6 (cs) *	2005-08-10	2007-05-09	Zentiva, A. S	Zpusob výroby (S)-3-(aminomethyl)-5-methyl-hexanové kyseliny (pregabalinu)
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JP2010043063A (ja) *	2008-05-09	2010-02-25	Agency For Science Technology & Research	川崎病の診断及び治療
US8546112B2 (en)	2008-05-21	2013-10-01	Sandoz Ag	Process for the stereoselective enzymatic hydrolysis of 5-methyl-3-nitromethyl-hexanoic acid ester
US20090312560A1 (en) *	2008-06-10	2009-12-17	Lambertus Thijs	Processes for making pregabalin and intermediates therefor
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IT1394292B1 (it)	2009-05-07	2012-06-06	Dipharma Francis Srl	Procedimento per la sintesi di pregabalina
WO2011141923A2 (en)	2010-05-14	2011-11-17	Lupin Limited	Improved synthesis of optically pure (s) - 3-cyano-5-methyl-hexanoic acid alkyl ester, an intermediate of (s)- pregabalin
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CN102952057B (zh) *	2012-11-07	2015-09-09	浙江普洛家园药业有限公司	一种4-异丁基吡咯烷-2-酮的制备方法
JP6225490B2 (ja) *	2013-05-31	2017-11-08	大日本印刷株式会社	医薬品包装体
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CN104557576B (zh) *	2014-12-19	2019-07-19	浙江华海药业股份有限公司	一种高纯度普瑞巴林的制备方法
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CN108358799B (zh) *	2018-04-24	2020-11-10	贵州师范大学	一种普瑞巴林的制备方法
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WO2007143113A2 (en) *	2006-05-31	2007-12-13	Teva Pharmaceutical Industries Ltd.	The use of enzymatic resolution for the preparation of intermediates of pregabalin

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Publication number	Publication date
EA200800908A1 (ru)	2008-12-30
CR8765A (es)	2008-01-02
TW200902481A (en)	2009-01-16
TW200846307A (en)	2008-12-01
AR049446A1 (es)	2006-08-02
BRPI0512347A (pt)	2008-03-04
MA28674B1 (fr)	2007-06-01
JP2009022272A (ja)	2009-02-05
EA200800909A1 (ru)	2008-08-29
HK1161307A1 (en)	2012-08-24
CN1972904B (zh)	2011-02-02
KR20080015152A (ko)	2008-02-18
US20090042262A1 (en)	2009-02-12
ATE455093T1 (de)	2010-01-15
JP2008504252A (ja)	2008-02-14
MXPA06014228A (es)	2007-02-14
DK1831154T3 (da)	2010-04-12
TW200846474A (en)	2008-12-01
WO2006000904A2 (en)	2006-01-05
ES2336014T3 (es)	2010-04-07
PT1831154E (pt)	2010-02-19
AU2005256945A1 (en)	2006-01-05
US7838686B2 (en)	2010-11-23
NO20065329L (no)	2006-12-19
CN102102114A (zh)	2011-06-22
CN1972904A (zh)	2007-05-30
EA015418B1 (ru)	2011-08-30
TWI402248B (zh)	2013-07-21
JP2008088191A (ja)	2008-04-17
US20110065168A1 (en)	2011-03-17
CN102102114B (zh)	2013-08-14
TWI405747B (zh)	2013-08-21
HK1104024A1 (en)	2008-01-04
EA011765B1 (ru)	2009-06-30
JP4800346B2 (ja)	2011-10-26
NO338097B1 (no)	2016-08-01
EP1831154A2 (de)	2007-09-12
EA200602099A1 (ru)	2007-04-27
CR20110483A (es)	2011-10-24
KR100847927B1 (ko)	2008-07-22
TWI357405B (en)	2012-02-01
EP1831154B1 (de)	2010-01-13
AP2006003846A0 (en)	2006-12-31
WO2006000904A3 (en)	2006-04-27
BRPI0512347B1 (pt)	2018-03-20
JP4782101B2 (ja)	2011-09-28
HRP20100054T1 (hr)	2010-05-31
US20050283023A1 (en)	2005-12-22
TWI377191B (en)	2012-11-21
JP4174551B2 (ja)	2008-11-05
KR100847928B1 (ko)	2008-07-22
JP2008133289A (ja)	2008-06-12
CA2571040A1 (en)	2006-01-05
TW200604139A (en)	2006-02-01
CA2571040C (en)	2009-09-15
GEP20104895B (en)	2010-02-25
JP4777332B2 (ja)	2011-09-21
US20120015412A1 (en)	2012-01-19
TWI396743B (zh)	2013-05-21
BRPI0512347B8 (pt)	2021-05-25
KR100847929B1 (ko)	2008-07-22
JP2008110985A (ja)	2008-05-15
KR20080015524A (ko)	2008-02-19
IL179614A0 (en)	2007-05-15
TWI399361B (zh)	2013-06-21
UA83575C2 (uk)	2008-07-25
AP2466A (en)	2012-09-17
NZ552220A (en)	2010-08-27
US8044227B2 (en)	2011-10-25
PL1831154T3 (pl)	2010-05-31
ME01067B (me)	2012-10-20
TW200900375A (en)	2009-01-01
SI1831154T1 (sl)	2010-03-31
KR20080015153A (ko)	2008-02-18
US8134023B2 (en)	2012-03-13
RS51210B (sr)	2010-12-31
CY1110337T1 (el)	2015-01-14
TW200846306A (en)	2008-12-01
AU2005256945B2 (en)	2008-11-13
JP4966183B2 (ja)	2012-07-04

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