DE602004014739D1 - Chemoenzymatisches verfahren zur stereoselektiven herstellung von optisch-angereicherten phenylglycidate - Google Patents
Chemoenzymatisches verfahren zur stereoselektiven herstellung von optisch-angereicherten phenylglycidateInfo
- Publication number
- DE602004014739D1 DE602004014739D1 DE602004014739T DE602004014739T DE602004014739D1 DE 602004014739 D1 DE602004014739 D1 DE 602004014739D1 DE 602004014739 T DE602004014739 T DE 602004014739T DE 602004014739 T DE602004014739 T DE 602004014739T DE 602004014739 D1 DE602004014739 D1 DE 602004014739D1
- Authority
- DE
- Germany
- Prior art keywords
- optically
- stereoselective
- manufacture
- alkyl
- phenyl glycidate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 3
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 title 1
- OTGHWLKHGCENJV-UHFFFAOYSA-N glycidic acid Chemical compound OC(=O)C1CO1 OTGHWLKHGCENJV-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 230000000707 stereoselective effect Effects 0.000 title 1
- -1 alkyl phenylglycidates Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN275DE2003 | 2003-03-12 | ||
| PCT/IB2004/000670 WO2004081219A1 (en) | 2003-03-12 | 2004-03-10 | Stereoselective chemoenzymatic process for preparing optically enriched phenylglycidates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004014739D1 true DE602004014739D1 (de) | 2008-08-14 |
Family
ID=32982880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004014739T Expired - Lifetime DE602004014739D1 (de) | 2003-03-12 | 2004-03-10 | Chemoenzymatisches verfahren zur stereoselektiven herstellung von optisch-angereicherten phenylglycidate |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7060471B2 (de) |
| EP (1) | EP1601778B1 (de) |
| JP (1) | JP4510809B2 (de) |
| CN (1) | CN100400669C (de) |
| AT (1) | ATE399876T1 (de) |
| AU (1) | AU2004219845B2 (de) |
| DE (1) | DE602004014739D1 (de) |
| MX (1) | MXPA05009720A (de) |
| WO (1) | WO2004081219A1 (de) |
| ZA (1) | ZA200507524B (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102827156A (zh) * | 2012-09-11 | 2012-12-19 | 湖南欧亚生物有限公司 | 一种达沙替尼的新的工业合成方法 |
| CN104692987B (zh) * | 2015-01-22 | 2017-05-17 | 北京大学 | 卤代醇及其衍生物的廉价高效合成方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6020174A (en) * | 1992-07-27 | 2000-02-01 | The Board Of Governors For Higher Education | Chemoenzymatic synthesis of the taxol C-13 side chain N-benzolyl- (2R,3S)-Phenylisoserine |
| NL1005338C2 (nl) * | 1997-02-21 | 1998-08-24 | Dsm Nv | Werkwijze voor de bereiding van een optisch actief fenylglycidylzuurderivaat. |
| JP3252900B2 (ja) * | 1997-10-27 | 2002-02-04 | 田辺製薬株式会社 | （２ｒ，３ｓ）型３−（４−低級アルコキシフェニル）グリシッド酸エステルの製法 |
-
2004
- 2004-03-10 JP JP2006506317A patent/JP4510809B2/ja not_active Expired - Fee Related
- 2004-03-10 US US10/798,199 patent/US7060471B2/en not_active Expired - Lifetime
- 2004-03-10 AU AU2004219845A patent/AU2004219845B2/en not_active Ceased
- 2004-03-10 DE DE602004014739T patent/DE602004014739D1/de not_active Expired - Lifetime
- 2004-03-10 CN CNB2004800066361A patent/CN100400669C/zh not_active Expired - Fee Related
- 2004-03-10 EP EP04719014A patent/EP1601778B1/de not_active Expired - Lifetime
- 2004-03-10 WO PCT/IB2004/000670 patent/WO2004081219A1/en active IP Right Grant
- 2004-03-10 MX MXPA05009720A patent/MXPA05009720A/es active IP Right Grant
- 2004-03-10 AT AT04719014T patent/ATE399876T1/de not_active IP Right Cessation
-
2005
- 2005-09-19 ZA ZA200507524A patent/ZA200507524B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE399876T1 (de) | 2008-07-15 |
| US20040259943A1 (en) | 2004-12-23 |
| EP1601778A1 (de) | 2005-12-07 |
| CN100400669C (zh) | 2008-07-09 |
| AU2004219845B2 (en) | 2007-10-04 |
| US7060471B2 (en) | 2006-06-13 |
| JP4510809B2 (ja) | 2010-07-28 |
| WO2004081219A1 (en) | 2004-09-23 |
| CN1759185A (zh) | 2006-04-12 |
| JP2006519603A (ja) | 2006-08-31 |
| ZA200507524B (en) | 2006-06-28 |
| AU2004219845A1 (en) | 2004-09-23 |
| EP1601778B1 (de) | 2008-07-02 |
| MXPA05009720A (es) | 2005-12-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |