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DE60102137D1 - Beta-aminsäure-derivate zur verwendung als matrix-metalloproteasen- und tna-alpha-inhibitoren - Google Patents

Beta-aminsäure-derivate zur verwendung als matrix-metalloproteasen- und tna-alpha-inhibitoren

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Publication number
DE60102137D1
DE60102137D1 DE60102137T DE60102137T DE60102137D1 DE 60102137 D1 DE60102137 D1 DE 60102137D1 DE 60102137 T DE60102137 T DE 60102137T DE 60102137 T DE60102137 T DE 60102137T DE 60102137 D1 DE60102137 D1 DE 60102137D1
Authority
DE
Germany
Prior art keywords
beta
acid derivatives
matrix metalloproteases
alpha inhibitors
aminic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60102137T
Other languages
English (en)
Other versions
DE60102137T2 (de
Inventor
Jingwu Duan
W King
Carl Decicco
P Maduskuie
E Voss
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
Bristol Myers Squibb Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co
Application granted granted Critical
Publication of DE60102137D1 publication Critical patent/DE60102137D1/de
Publication of DE60102137T2 publication Critical patent/DE60102137T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56Nitrogen atoms
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DE60102137T 2000-03-17 2001-03-15 Beta-aminsäure-derivate zur verwendung als matrix-metalloproteasen- und tna-alpha-inhibitoren Expired - Lifetime DE60102137T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US19018300P 2000-03-17 2000-03-17
US23546700P 2000-09-26 2000-09-26
US25206200P 2000-11-20 2000-11-20
PCT/US2001/008336 WO2001070734A2 (en) 2000-03-17 2001-03-15 Beta-amino acid derivatives as inhibitors of matrix metalloproteases and tnf-alpha

Publications (2)

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DE60102137D1 true DE60102137D1 (de) 2004-04-01
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NZ521245A (en) 2004-04-30
HK1049334A1 (en) 2003-05-09
AU2001250850A1 (en) 2001-10-03
JP2003528097A (ja) 2003-09-24
DE60102137T2 (de) 2004-10-21
EP1263756B1 (de) 2004-02-25
IL151018A0 (en) 2003-02-12
CA2400168A1 (en) 2001-09-27
WO2001070734A3 (en) 2002-03-14
US20020013341A1 (en) 2002-01-31
AR035174A1 (es) 2004-05-05
US6495565B2 (en) 2002-12-17
CN1420881A (zh) 2003-05-28
HK1049334B (zh) 2004-07-16
EP1263756A2 (de) 2002-12-11
ATE260272T1 (de) 2004-03-15
ES2215893T3 (es) 2004-10-16
WO2001070734A2 (en) 2001-09-27
BR0109469A (pt) 2003-04-29

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