[go: up one dir, main page]

DE60036930D1 - Humanes cytokin als ligand des zalpha rezeptors und dessen verwendungen - Google Patents

Humanes cytokin als ligand des zalpha rezeptors und dessen verwendungen

Info

Publication number
DE60036930D1
DE60036930D1 DE60036930T DE60036930T DE60036930D1 DE 60036930 D1 DE60036930 D1 DE 60036930D1 DE 60036930 T DE60036930 T DE 60036930T DE 60036930 T DE60036930 T DE 60036930T DE 60036930 D1 DE60036930 D1 DE 60036930D1
Authority
DE
Germany
Prior art keywords
humanese
cytokin
ligand
polypeptide
zalpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60036930T
Other languages
English (en)
Other versions
DE60036930T2 (de
Inventor
Julie E Novak
Scott R Presnell
Cindy A Sprecher
Donald C Foster
Richard D Holly
Jane A Gross
Janet V Johnston
Andrew J Nelson
Stacey R Dillon
Angela K Hammond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zymogenetics Inc
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27385745&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60036930(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Application granted granted Critical
Publication of DE60036930D1 publication Critical patent/DE60036930D1/de
Publication of DE60036930T2 publication Critical patent/DE60036930T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/55Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • External Artificial Organs (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60036930T 1999-03-09 2000-03-09 Humanes cytokin als ligand des zalpha rezeptors und dessen verwendungen Expired - Lifetime DE60036930T2 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US26490899A 1999-03-09 1999-03-09
US264908 1999-03-09
US26599299A 1999-03-11 1999-03-11
US265992 1999-03-11
US14201399P 1999-07-01 1999-07-01
US142013P 1999-07-01
PCT/US2000/006067 WO2000053761A2 (en) 1999-03-09 2000-03-09 Human cytokine as ligand of the zalpha receptor and uses thereof

Publications (2)

Publication Number Publication Date
DE60036930D1 true DE60036930D1 (de) 2007-12-13
DE60036930T2 DE60036930T2 (de) 2008-10-09

Family

ID=27385745

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60036930T Expired - Lifetime DE60036930T2 (de) 1999-03-09 2000-03-09 Humanes cytokin als ligand des zalpha rezeptors und dessen verwendungen

Country Status (23)

Country Link
EP (3) EP1881070B1 (de)
JP (1) JP4405686B2 (de)
KR (1) KR100743640B1 (de)
CN (5) CN102406937A (de)
AT (1) ATE377076T1 (de)
AU (2) AU777842B2 (de)
BR (1) BR0008772B1 (de)
CA (1) CA2366921C (de)
CZ (1) CZ302921B6 (de)
DE (1) DE60036930T2 (de)
DK (1) DK1165791T3 (de)
ES (1) ES2295019T3 (de)
HU (1) HU229148B1 (de)
IL (5) IL145288A0 (de)
MX (1) MXPA01009074A (de)
NO (2) NO331551B1 (de)
NZ (1) NZ514708A (de)
PL (1) PL207350B1 (de)
PT (1) PT1165791E (de)
RU (1) RU2346951C2 (de)
UA (1) UA84387C2 (de)
WO (1) WO2000053761A2 (de)
ZA (1) ZA017370B (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6057128A (en) 1998-03-17 2000-05-02 Genetics Institute, Inc. MU-1, member of the cytokine receptor family
US7198789B2 (en) 1998-03-17 2007-04-03 Genetics Institute, Llc Methods and compositions for modulating interleukin-21 receptor activity
US7189400B2 (en) 1998-03-17 2007-03-13 Genetics Institute, Llc Methods of treatment with antagonists of MU-1
CN102406937A (zh) * 1999-03-09 2012-04-11 津莫吉尼蒂克斯公司 新的细胞因子zalpha11配体
CA2460916A1 (en) * 2001-10-04 2003-04-10 Laura Carter Methods and compositions for modulating interleukin-21 receptor activity
AU2002336676A1 (en) 2001-11-05 2003-05-19 Zymogenetics, Inc Il-21 antagonists
DK1531850T3 (da) * 2002-06-07 2012-06-04 Zymogenetics Inc Anvendelse af 1L-21 og monoklonalt antistof til behandling af solide cancere
EP1553982A4 (de) 2002-07-15 2008-03-26 Wyeth Corp VERFAHREN UND ZUSAMMENSETZUNGEN ZUR MODULIERUNG DER ENTWICKLUNG UND FUNKTION VON T-HELFER-ZELLEN (T sb H /sb )
EP1782823A3 (de) * 2002-10-11 2007-05-16 Novo Nordisk A/S IL-21 Peptiden und Nukleinsäuren
PL376118A1 (en) * 2002-10-11 2005-12-12 Novo Nordisk A/S Treatment of allergic conditions by use of il 21
AU2003302250B2 (en) * 2002-12-13 2009-08-27 Zymogenetics, Inc. IL-21 production in prokaryotic hosts
KR20050119120A (ko) * 2003-03-14 2005-12-20 와이어쓰 인간 ⅰl-21 수용체에 대한 항체 및 그것의 용도
WO2004112703A2 (en) * 2003-06-19 2004-12-29 Centocor, Inc. Interleukin-21 analogs
EP1925626A1 (de) * 2003-07-21 2008-05-28 Transgene S.A. Neue multifunktionelle Cytokine
DE602004031341D1 (de) 2003-07-21 2011-03-24 Transgene Sa Multifunktionelle cytokine
EP1670501A2 (de) * 2003-09-25 2006-06-21 ZymoGenetics, Inc. Verfahren zur behandlung von autoimmunkrankheiten mit il-21
US20060228331A1 (en) 2003-10-10 2006-10-12 Novo Nordisk A/S IL-21 Derivatives and variants
CN102516386A (zh) * 2003-10-10 2012-06-27 诺沃挪第克公司 Il-21衍生物
ES2428358T3 (es) 2003-10-17 2013-11-07 Novo Nordisk A/S Terapia de combinación
CA2551879A1 (en) * 2004-01-15 2005-07-28 Novo Nordisk A/S Use of interleukin-21 for the treatment of autoimune diseases and allograft rejection
ES2397241T3 (es) 2004-01-21 2013-03-05 Novo Nordisk Health Care Ag Conjugación de péptidos mediante transglutaminasa
GT200600148A (es) 2005-04-14 2006-11-22 Metodos para el tratamiento y la prevencion de fibrosis
US8034326B2 (en) 2005-04-18 2011-10-11 Novo Nordisk A/S IL-21 variants
EP2567973B1 (de) 2005-11-28 2014-05-14 Zymogenetics, Inc. IL-21-Antagonisten
US8475784B2 (en) 2006-10-26 2013-07-02 Novo Nordisk A/S IL-21 variants
EP2109620B1 (de) 2006-12-21 2012-08-22 Novo Nordisk A/S Interleukin-21-varianten mit geänderter bindung an den il-21-rezeptor
CN102027011B (zh) 2007-12-07 2014-09-03 津莫吉尼蒂克斯公司 抗人il-21单克隆抗体
EP2296689A1 (de) 2008-05-23 2011-03-23 Wyeth LLC Behandlungsverfahren unter verwendung von bindungsproteinen des interleukin-21-rezeptors
AR071885A1 (es) 2008-05-23 2010-07-21 Wyeth Corp Proteinas de union al receptor de interleuquina 21
EP2344180A2 (de) 2008-09-23 2011-07-20 Wyeth LLC Verfahren zur vorhersage der produktion von aktivierenden signalen durch vernetzende bindungsproteine
CN102021196B (zh) * 2009-11-20 2013-06-26 上海杰隆生物工程股份有限公司 毕赤酵母生产重组人白细胞介素21的方法
BR112014032677A2 (pt) 2012-06-27 2019-01-15 Univ Rutgers ensaios rápido para ativação de célula t por medições de rna usando citometria de fluxo
WO2015110930A1 (en) 2014-01-24 2015-07-30 Pfizer Inc. Modified interleukin 21 receptor proteins
EP2982693A1 (de) * 2014-08-07 2016-02-10 Affimed Therapeutics AG CD3 Bindungsdomäne
US12012441B2 (en) 2020-10-26 2024-06-18 Neptune Biosciences Llc Engineered human IL-21 cytokines and methods for using the same
CN112662694A (zh) * 2020-12-25 2021-04-16 康九生物科技(长春)有限公司 一种麦芽糖结合蛋白、麦芽糖结合蛋白表达载体、重组工程菌及其应用

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK368882A (da) 1981-08-25 1983-02-26 Alan John Kingsman Expessions vektorer
US4579821A (en) 1981-11-23 1986-04-01 University Patents, Inc. Control of DNA sequence transcription
US4656134A (en) 1982-01-11 1987-04-07 Board Of Trustees Of Leland Stanford Jr. University Gene amplification in eukaryotic cells
US4486533A (en) 1982-09-02 1984-12-04 St. Louis University Filamentous fungi functional replicating extrachromosomal element
US4599311A (en) 1982-08-13 1986-07-08 Kawasaki Glenn H Glycolytic promotersfor regulated protein expression: protease inhibitor
US4977092A (en) 1985-06-26 1990-12-11 Amgen Expression of exogenous polypeptides and polypeptide products including hepatitis B surface antigen in yeast cells
US4601978A (en) 1982-11-24 1986-07-22 The Regents Of The University Of California Mammalian metallothionein promoter system
US4713339A (en) 1983-01-19 1987-12-15 Genentech, Inc. Polycistronic expression vector construction
US4661454A (en) 1983-02-28 1987-04-28 Collaborative Research, Inc. GAL1 yeast promoter linked to non galactokinase gene
US5139936A (en) 1983-02-28 1992-08-18 Collaborative Research, Inc. Use of the GAL1 yeast promoter
US4650764A (en) 1983-04-12 1987-03-17 Wisconsin Alumni Research Foundation Helper cell
US4870008A (en) 1983-08-12 1989-09-26 Chiron Corporation Secretory expression in eukaryotes
US4931373A (en) 1984-05-25 1990-06-05 Zymogenetics, Inc. Stable DNA constructs for expression of α-1 antitrypsin
US4766073A (en) 1985-02-25 1988-08-23 Zymogenetics Inc. Expression of biologically active PDGF analogs in eucaryotic cells
EP0184576B1 (de) 1984-12-06 1990-06-27 Fina Research S.A. Promotoren für die Expression von fremden Genen in Hefe, Plasmide, die diese Promotoren enthalten, sowie deren Verwendung zur Herstellung von Polypeptiden
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
GR860984B (en) 1985-04-17 1986-08-18 Zymogenetics Inc Expression of factor vii and ix activities in mammalian cells
US4882279A (en) 1985-10-25 1989-11-21 Phillips Petroleum Company Site selective genomic modification of yeast of the genus pichia
US4935349A (en) 1986-01-17 1990-06-19 Zymogenetics, Inc. Expression of higher eucaryotic genes in aspergillus
GB8611832D0 (en) 1986-05-15 1986-06-25 Holland I B Polypeptide
US4980289A (en) 1987-04-27 1990-12-25 Wisconsin Alumni Research Foundation Promoter deficient retroviral vector
US5063154A (en) 1987-06-24 1991-11-05 Whitehead Institute For Biomedical Research Pheromone - inducible yeast promoter
ES2092468T3 (es) 1988-01-22 1996-12-01 Zymogenetics Inc Metodos para producir analogos de receptores secretados.
US5567584A (en) 1988-01-22 1996-10-22 Zymogenetics, Inc. Methods of using biologically active dimerized polypeptide fusions to detect PDGF
US4956288A (en) 1988-04-22 1990-09-11 Biogen, Inc. Method for producing cells containing stably integrated foreign DNA at a high copy number, the cells produced by this method, and the use of these cells to produce the polypeptides coded for by the foreign DNA
US5037743A (en) 1988-08-05 1991-08-06 Zymogenetics, Inc. BAR1 secretion signal
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5162228A (en) 1988-12-28 1992-11-10 Takeda Chemical Industries, Ltd. Gylceraldehyde-3-phosphate dehydrogenase gene and promoter
US5124263A (en) 1989-01-12 1992-06-23 Wisconsin Alumni Research Foundation Recombination resistant retroviral helper cell and products produced thereby
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
US5162222A (en) 1989-07-07 1992-11-10 Guarino Linda A Use of baculovirus early promoters for expression of foreign genes in stably transformed insect cells or recombinant baculoviruses
IL99552A0 (en) 1990-09-28 1992-08-18 Ixsys Inc Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof
US5298418A (en) 1991-09-16 1994-03-29 Boyce Thompson Institute For Plant Research, Inc. Cell line isolated from larval midgut tissue of Trichoplusia ni
US5641670A (en) 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
JPH08502646A (ja) 1992-09-14 1996-03-26 ファイザー・インコーポレイテッド 不死化細胞およびその使用
CA2168202A1 (en) 1993-07-30 1995-03-16 Joseph Dougherty Efficient gene transfer into primary lymphocytes
RU2220979C2 (ru) * 1993-08-12 2004-01-10 Иммьюнекс Корпорейшн ПОЛИПЕПТИД ЛИГАНДА flt3 (ВАРИАНТЫ), ПОЛИНУКЛЕОТИД(ВАРИАНТЫ), ЭКСПРЕССИРУЮЩИЙ ВЕКТОР(ВАРИАНТЫ), ЛИНИЯ КЛЕТОК СНО (ВАРИАНТЫ), СПОСОБ ПРОДУЦИРОВАНИЯ ПОЛИПЕПТИДА ЛИГАНДА flt3 (ВАРИАНТЫ), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ (ВАРИАНТЫ)
US6117679A (en) 1994-02-17 2000-09-12 Maxygen, Inc. Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
US5795966A (en) * 1995-02-22 1998-08-18 Immunex Corp Antagonists of interleukin-15
JP2000500014A (ja) 1995-11-09 2000-01-11 ザイモジェネティクス,インコーポレイティド ピヒア・メタノリカ中で異種ポリペプチドを生産するための組成物と方法
JP2002515746A (ja) 1996-07-17 2002-05-28 ザイモジェネティクス,インコーポレイティド ピヒア・メタノリカの形質転換
WO1998002536A2 (en) 1996-07-17 1998-01-22 Zymogenetics, Inc. Preparation of pichia methanolica auxotrophic mutants
AU5702298A (en) 1996-12-03 1998-06-29 Abgenix, Inc. Transgenic mammals having human Ig loci including plural VH and VK regions nd antibodies produced therefrom
IL122818A0 (en) * 1997-07-10 1998-08-16 Yeda Res & Dev Chimeric interleukin-6 soluble receptor/ligand protein analogs thereof and uses thereof
US6057128A (en) * 1998-03-17 2000-05-02 Genetics Institute, Inc. MU-1, member of the cytokine receptor family
CN102406937A (zh) * 1999-03-09 2012-04-11 津莫吉尼蒂克斯公司 新的细胞因子zalpha11配体
US9418201B1 (en) 2015-11-19 2016-08-16 International Business Machines Corporation Integration of functional analysis and common path pessimism removal in static timing analysis

Also Published As

Publication number Publication date
CN102406937A (zh) 2012-04-11
EP2295577A3 (de) 2012-08-08
IL145288A (en) 2010-11-30
IL207424A (en) 2013-04-30
WO2000053761A2 (en) 2000-09-14
EP1881070A3 (de) 2008-03-05
EP1881070B1 (de) 2012-10-03
DE60036930T2 (de) 2008-10-09
JP2002537839A (ja) 2002-11-12
CN1927883B (zh) 2011-09-21
CA2366921C (en) 2013-12-17
HUP0200418A2 (hu) 2002-05-29
MXPA01009074A (es) 2002-03-27
AU777842B2 (en) 2004-11-04
CN100500846C (zh) 2009-06-17
CN1827639A (zh) 2006-09-06
EP1165791B1 (de) 2007-10-31
IL145288A0 (en) 2002-06-30
ZA017370B (en) 2002-06-26
DK1165791T3 (da) 2008-02-11
AU2005200240A1 (en) 2005-02-17
HUP0200418A3 (en) 2003-12-29
NZ514708A (en) 2005-01-28
RU2004126135A (ru) 2006-02-10
BR0008772B1 (pt) 2011-11-01
CN101575377A (zh) 2009-11-11
CA2366921A1 (en) 2000-09-14
AU3731200A (en) 2000-09-28
ES2295019T3 (es) 2008-04-16
JP4405686B2 (ja) 2010-01-27
EP1165791A2 (de) 2002-01-02
CZ302921B6 (cs) 2012-01-18
NO331551B1 (no) 2012-01-23
PL351160A1 (en) 2003-03-24
KR100743640B1 (ko) 2007-07-27
CN1927883A (zh) 2007-03-14
NO20111085L (no) 2001-11-09
RU2346951C2 (ru) 2009-02-20
HU229148B1 (en) 2013-09-30
UA84387C2 (ru) 2008-10-27
EP1881070A2 (de) 2008-01-23
PL207350B1 (pl) 2010-12-31
IL195713A (en) 2010-11-30
EP2295577A2 (de) 2011-03-16
IL207403A (en) 2012-03-29
CN1378595A (zh) 2002-11-06
NO20014364D0 (no) 2001-09-07
WO2000053761A3 (en) 2000-12-21
CN101575377B (zh) 2012-12-26
KR20010103794A (ko) 2001-11-23
NO20014364L (no) 2001-11-09
PT1165791E (pt) 2008-01-16
BR0008772A (pt) 2002-05-07
ATE377076T1 (de) 2007-11-15
CZ20013184A3 (cs) 2002-04-17

Similar Documents

Publication Publication Date Title
DE60036930D1 (de) Humanes cytokin als ligand des zalpha rezeptors und dessen verwendungen
DE69829308D1 (de) Cellulase aus actinomycetes und herstellungsverfahren dafür
DE69834741D1 (de) Cellulase aus actinomycetes und herstellungsverfahren dafür
NO20043419L (no) Nytt cytokin, zcytor17-ligand
BG101384A (en) New pesticide proteins and strains
DK1015587T3 (da) DcR3 polypeptid, en TNFR-homolog
NZ514025A (en) Compositions and methods for the modification of gene transcription
WO2003020932A1 (fr) Nouvelles proteines de secretion et adn associe
ATE245435T1 (de) Totalsynthese des amino hip analogen von didemnin a
IL141869A0 (en) Mammalian transforming growth factor beta-9 (ztgfss9)
EP0967283A4 (de) Gene, die für proteine mit transglykolysierungsaktivität kodieren.
EP0794253A3 (de) Aminopeptidase GX und damit Hydrolysierungsverfahren von Proteine
IL142709A0 (en) Novel amino acid sequences, dna encoding the amino acid sequences, antibodies directed against such sequences and the different uses thereof
DE69734596D1 (de) "smoothened" proteine aus wirbeltieren
KR950700988A (ko) 미생물, 이들의 제조방법 및 이들의 사용(Micro-organisms, preparation method therefor and uses thereof)
YU59100A (sh) Postupak za dobijanje pirazolo (4,3-d) pirimidin-7-ona-3-piridilsulfonil jedinjenja i njihova intermedijera
DK1001929T3 (da) Fremgangsmåde til fremstilling af 3-cyano-2,4-dihalogen-5-flour-benzoesyrer
DE60023402D1 (de) Herstellung von 3-amino-2-chlor-4-methylpyridin aus aceton und ethylcyanoacetat
EP1092773A3 (de) Polypeptid und dessen Verwendungen
EP1295943A4 (de) Polypeptide mit aktivität der stimulierung von neutrophilen
WO2000070015A3 (fr) Cultures de cellules d'insecte se multipliant a 37°c, leur p rocede d'obtention, et leurs utilisations
DE69632205T2 (de) Herstellung von bacillus thuringiensis integrants
UA29770A (uk) Спосіб пригнічення репродукції вірусу імунодефіциту людини

Legal Events

Date Code Title Description
8363 Opposition against the patent