DE69829308D1 - Cellulase aus actinomycetes und herstellungsverfahren dafür - Google Patents
Cellulase aus actinomycetes und herstellungsverfahren dafürInfo
- Publication number
- DE69829308D1 DE69829308D1 DE69829308T DE69829308T DE69829308D1 DE 69829308 D1 DE69829308 D1 DE 69829308D1 DE 69829308 T DE69829308 T DE 69829308T DE 69829308 T DE69829308 T DE 69829308T DE 69829308 D1 DE69829308 D1 DE 69829308D1
- Authority
- DE
- Germany
- Prior art keywords
- cellulase
- actinomycetes
- manufacturing
- actinomycete
- producible
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
- C12N9/2437—Cellulases (3.2.1.4; 3.2.1.74; 3.2.1.91; 3.2.1.150)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/189—Enzymes
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/386—Preparations containing enzymes, e.g. protease or amylase
- C11D3/38645—Preparations containing enzymes, e.g. protease or amylase containing cellulase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01004—Cellulase (3.2.1.4), i.e. endo-1,4-beta-glucanase
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M16/00—Biochemical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. enzymatic
- D06M16/003—Biochemical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. enzymatic with enzymes or microorganisms
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06P—DYEING OR PRINTING TEXTILES; DYEING LEATHER, FURS OR SOLID MACROMOLECULAR SUBSTANCES IN ANY FORM
- D06P5/00—Other features in dyeing or printing textiles, or dyeing leather, furs, or solid macromolecular substances in any form
- D06P5/02—After-treatment
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06P—DYEING OR PRINTING TEXTILES; DYEING LEATHER, FURS OR SOLID MACROMOLECULAR SUBSTANCES IN ANY FORM
- D06P5/00—Other features in dyeing or printing textiles, or dyeing leather, furs, or solid macromolecular substances in any form
- D06P5/13—Fugitive dyeing or stripping dyes
- D06P5/137—Fugitive dyeing or stripping dyes with other compounds
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06P—DYEING OR PRINTING TEXTILES; DYEING LEATHER, FURS OR SOLID MACROMOLECULAR SUBSTANCES IN ANY FORM
- D06P5/00—Other features in dyeing or printing textiles, or dyeing leather, furs, or solid macromolecular substances in any form
- D06P5/15—Locally discharging the dyes
- D06P5/158—Locally discharging the dyes with other compounds
-
- D—TEXTILES; PAPER
- D21—PAPER-MAKING; PRODUCTION OF CELLULOSE
- D21C—PRODUCTION OF CELLULOSE BY REMOVING NON-CELLULOSE SUBSTANCES FROM CELLULOSE-CONTAINING MATERIALS; REGENERATION OF PULPING LIQUORS; APPARATUS THEREFOR
- D21C5/00—Other processes for obtaining cellulose, e.g. cooking cotton linters ; Processes characterised by the choice of cellulose-containing starting materials
- D21C5/005—Treatment of cellulose-containing material with microorganisms or enzymes
-
- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M2101/00—Chemical constitution of the fibres, threads, yarns, fabrics or fibrous goods made from such materials, to be treated
- D06M2101/02—Natural fibres, other than mineral fibres
- D06M2101/04—Vegetal fibres
- D06M2101/06—Vegetal fibres cellulosic
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Textile Engineering (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Animal Husbandry (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Plant Pathology (AREA)
- Enzymes And Modification Thereof (AREA)
- Detergent Compositions (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- General Preparation And Processing Of Foods (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
- Paper (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US974042 | 1992-11-10 | ||
US104308 | 1993-08-09 | ||
US97404297A | 1997-11-19 | 1997-11-19 | |
US97404197A | 1997-11-19 | 1997-11-19 | |
US974041 | 1997-11-19 | ||
US09/104,308 US6187577B1 (en) | 1997-11-19 | 1998-06-24 | Cellulase producing Actinomycetes cellulase produced therefrom and method of producing same |
PCT/US1998/024649 WO1999025846A2 (en) | 1997-11-19 | 1998-11-18 | Cellulase produced by actinomycetes and method for producing same |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69829308D1 true DE69829308D1 (de) | 2005-04-14 |
DE69829308T2 DE69829308T2 (de) | 2006-05-11 |
Family
ID=27379706
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69829308T Expired - Lifetime DE69829308T2 (de) | 1997-11-19 | 1998-11-18 | Cellulase aus actinomycetes und herstellungsverfahren dafür |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP1032686B1 (de) |
JP (1) | JP3661995B2 (de) |
KR (1) | KR20010032219A (de) |
AT (1) | ATE290599T1 (de) |
AU (1) | AU749780B2 (de) |
CA (1) | CA2309764A1 (de) |
DE (1) | DE69829308T2 (de) |
DK (1) | DK1032686T3 (de) |
NZ (1) | NZ504197A (de) |
WO (1) | WO1999025846A2 (de) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6562612B2 (en) * | 1997-11-19 | 2003-05-13 | Genencor International, Inc. | Cellulase producing actinomycetes, cellulase produced therefrom and method of producing same |
DK1088080T3 (da) * | 1998-06-24 | 2007-02-19 | Genencor Int | Rekombinant produktion af cellulase fra actinomyceter |
NZ586014A (en) | 2007-12-19 | 2012-07-27 | Novozymes As | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same |
JP5702714B2 (ja) | 2008-04-30 | 2015-04-15 | ダニスコ・ユーエス・インク | 新規キメラアルファアミラーゼ変異体 |
DE102008024084A1 (de) * | 2008-05-17 | 2009-11-19 | Clariant International Ltd. | Wasch- und Reinigungsmittel |
WO2009149283A1 (en) | 2008-06-06 | 2009-12-10 | Danisco Us Inc. | Saccharification enzyme composition |
MX2010013108A (es) | 2008-06-06 | 2010-12-21 | Danisco Inc | Produccion de glucosa a partir de almidon usando alfa-amilasas de bacillus subtilis. |
CN103773749A (zh) | 2008-06-06 | 2014-05-07 | 丹尼斯科美国公司 | 来自枯草芽孢杆菌的变体α-淀粉酶及其使用方法 |
BRPI0922773B1 (pt) | 2008-12-04 | 2018-10-09 | Novozymes As | célula microbiana hospedeira transgênica, métodos para produzir um polipeptídeo tendo atividade de intensificação celulolítica e para degradar ou converter um material celulósico, construção de ácido nucleico, vetor de expressão, e, composição detergente. |
EP2379733A2 (de) | 2008-12-19 | 2011-10-26 | Novozymes Inc. | Verfahren zur steigerung der hydrolyse von cellulosehaltigem material |
EP3141609A1 (de) | 2008-12-19 | 2017-03-15 | Novozymes, Inc. | Methode für eine gesteigerte hydrolyse von cellulosehaltigem material in gegenwart von cellobiose dehydrogenase |
WO2010080527A1 (en) | 2008-12-19 | 2010-07-15 | Novozymes, Inc. | Methods for determining cellulolytic enhancing activity of a polypeptide |
US8426158B2 (en) | 2008-12-19 | 2013-04-23 | Novozymes, Inc. | Methods for increasing enzymatic hydrolysis of cellulosic material in the presence of a peroxidase |
WO2010088387A1 (en) | 2009-01-28 | 2010-08-05 | Novozymes, Inc. | Polypeptides having beta-glucosidase activity and polynucleotides encoding same |
US8629324B2 (en) | 2009-01-30 | 2014-01-14 | Novozymes, Inc. | Polypeptides having expansin activity and polynucleotides encoding same |
CN102365360A (zh) | 2009-03-24 | 2012-02-29 | 诺维信公司 | 具有乙酰木聚糖酯酶活性的多肽和编码该多肽的多核苷酸 |
MX2011012585A (es) | 2009-05-29 | 2011-12-14 | Novozymes Inc | Metodos para incrementar la degradacion o conversion de material celulosico. |
CN104480088A (zh) | 2009-06-02 | 2015-04-01 | 诺维信股份有限公司 | 具有纤维二糖水解酶活性的多肽和编码该多肽的多核苷酸 |
WO2011005867A1 (en) | 2009-07-07 | 2011-01-13 | Novozymes, Inc. | Polypeptides having cellulolytic enhancing activity activity and polynucleotides encoding same |
CN106085988A (zh) | 2009-09-17 | 2016-11-09 | 诺维信股份有限公司 | 具有纤维素分解增强活性的多肽及编码其的多核苷酸 |
EP2478095A1 (de) | 2009-09-18 | 2012-07-25 | Novozymes Inc. | Polypeptide mit beta-glucosidase-aktivität und dafür kodierende polynukleotide |
MX2012003473A (es) | 2009-09-29 | 2012-05-22 | Novozymes Inc | Polipeptidos que tienen actividad celulitica mejorada y polinucleotidos que codifican para los mismos. |
EP2483403B1 (de) | 2009-09-29 | 2017-11-15 | Novozymes Inc. | POLYPEPTIDE MIT XYLANASE-AKTIVITÄT UND DIESE KODIERENDE & xA; POLYNUKLEOTIDE |
BR112012007390A2 (pt) | 2009-09-30 | 2015-09-15 | Novozymes As | polipeptídeo isolado tendo atividade intensificadora celulolítica, polinucleotídeo isolado, métodos para produzir o polipeptídeo, para produzir um mutante de uma célula precursora, para inibir a expressão de um polipeptídeo, para produzir uma proteína, para degragar ou converter um material celulósico, para produzir um produto de fermentação, e para fermentar um material celulósico, planta transgênica, parte de planta ou célula de planta transformada com um polinucleotídeo, molécula inibidora de filamento duplo, e, composição detergente |
US8586827B2 (en) | 2009-09-30 | 2013-11-19 | Novozymes, Inc. | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same |
WO2011049945A2 (en) | 2009-10-23 | 2011-04-28 | Danisco Us Inc. | Methods for reducing blue saccharide |
BR112012006873A2 (pt) | 2009-10-23 | 2015-09-08 | Novozymes Inc | variante isolada, polinucleotideo isolado, metodo para produzir uma variante, planta transgenica, parte de planta ou celula d eplanta, e, metodos para degradar ou converter um materialcelulósico, para produzir um produto de fermentação, e, para fermentar um material celulósico. |
BR112012006847A2 (pt) | 2009-10-29 | 2015-09-08 | Novozymes As | polipeptídeo polinucleotídeo, célula hospedeira recombinante, métodos para produzir o polipeptídeo para produzir um mutante de uma célula parental, para inibir a expressão de um polipeptídeo, para produzir uma proteína, para degradar ou converter um material celulósico, para produzir um produto de fermentação, para produzir um produto de fermentação e pra fermentar um material celulósico, planta transgênica, parte da planta ou célula da planta, molécula de rna inibitória de filamento duplo, e, composição. |
WO2011057086A1 (en) | 2009-11-06 | 2011-05-12 | Novozymes, Inc. | Polypeptides having cellobiohydrolase activity and polynucleotides encoding same |
US9534211B2 (en) | 2009-11-06 | 2017-01-03 | Novozymes A/S | Polypeptides having xylanase activity and polynucleotides encoding same |
NZ600764A (en) | 2010-01-22 | 2013-11-29 | Dupont Nutrition Biosci Aps | Methods for producing amino-substituted glycolipid compounds |
DK2553093T3 (en) | 2010-03-31 | 2017-09-18 | Novozymes Inc | Cellobiohydrolase variants and polynucleotides encoding them |
WO2012003379A1 (en) | 2010-06-30 | 2012-01-05 | Novozymes A/S | Polypeptides having beta-glucosidase activity and polynucleotides encoding same |
EP2603595A1 (de) | 2010-08-12 | 2013-06-19 | Novozymes, Inc. | Zusammensetzungen mit einem polypeptid mit zellulolyseverstärkender wirkung und einer dioxyverbindung sowie ihre verwendung |
WO2012078656A1 (en) | 2010-12-06 | 2012-06-14 | Novozymes North America, Inc. | Methods of hydrolyzing oligomers in hemicellulosic liquor |
WO2012103322A1 (en) | 2011-01-26 | 2012-08-02 | Novozymes A/S | Polypeptides having endoglucanase activity and polynucleotides encoding same |
US9068176B2 (en) | 2011-01-26 | 2015-06-30 | Novozymes A/S | Polypeptides having endoglucanase activity and polynucleotides encoding same |
US9434972B2 (en) | 2011-01-31 | 2016-09-06 | Novozymes North America, Inc. | Processes for enzymatic refining of pretreated cellulosic material for saccharification |
WO2012130120A1 (en) | 2011-03-25 | 2012-10-04 | Novozymes A/S | Method for degrading or converting cellulosic material |
US20140031272A1 (en) | 2011-04-08 | 2014-01-30 | Danisco Us Inc. | Compositions |
CN103930555A (zh) | 2011-09-13 | 2014-07-16 | 诺维信北美公司 | 水解和发酵纤维素材料的方法 |
WO2013160248A2 (en) | 2012-04-23 | 2013-10-31 | Novozymes A/S | Polypeptides having alpha-glucuronidase activity and polynucleotides encoding same |
CN104245930A (zh) | 2012-04-23 | 2014-12-24 | 诺维信公司 | 具有葡萄糖醛酸酯酶活性的多肽以及编码其的多核苷酸 |
WO2022106072A1 (en) * | 2020-11-18 | 2022-05-27 | Aplicacion Y Suministros Textiles, S.A.U. | Textile stone washing process |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6313081B1 (en) * | 1995-04-28 | 2001-11-06 | Henkel Kommanditgesellschaft Auf Aktien (Kgaa) | Detergents comprising cellulases |
MX9708139A (es) * | 1995-04-28 | 1997-12-31 | Genencor Int | Detergentes que comprenden celulasa. |
AU1437997A (en) * | 1996-01-26 | 1997-08-20 | Novo Nordisk A/S | Production of sanitary paper |
-
1998
- 1998-11-18 JP JP2000521211A patent/JP3661995B2/ja not_active Expired - Fee Related
- 1998-11-18 KR KR1020007005415A patent/KR20010032219A/ko not_active Application Discontinuation
- 1998-11-18 DK DK98958079T patent/DK1032686T3/da active
- 1998-11-18 AT AT98958079T patent/ATE290599T1/de not_active IP Right Cessation
- 1998-11-18 AU AU14190/99A patent/AU749780B2/en not_active Ceased
- 1998-11-18 CA CA002309764A patent/CA2309764A1/en not_active Abandoned
- 1998-11-18 NZ NZ504197A patent/NZ504197A/en not_active IP Right Cessation
- 1998-11-18 DE DE69829308T patent/DE69829308T2/de not_active Expired - Lifetime
- 1998-11-18 WO PCT/US1998/024649 patent/WO1999025846A2/en active IP Right Grant
- 1998-11-18 EP EP98958079A patent/EP1032686B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU1419099A (en) | 1999-06-07 |
CA2309764A1 (en) | 1999-05-27 |
DK1032686T3 (da) | 2005-06-27 |
KR20010032219A (ko) | 2001-04-16 |
DE69829308T2 (de) | 2006-05-11 |
JP3661995B2 (ja) | 2005-06-22 |
WO1999025846A2 (en) | 1999-05-27 |
EP1032686B1 (de) | 2005-03-09 |
ATE290599T1 (de) | 2005-03-15 |
JP2001523463A (ja) | 2001-11-27 |
NZ504197A (en) | 2002-03-01 |
EP1032686A2 (de) | 2000-09-06 |
AU749780B2 (en) | 2002-07-04 |
WO1999025846A3 (en) | 1999-09-16 |
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