DE60035517D1 - Gl50 moleküle, sowie verwendungen derselben - Google Patents
Gl50 moleküle, sowie verwendungen derselbenInfo
- Publication number
- DE60035517D1 DE60035517D1 DE60035517T DE60035517T DE60035517D1 DE 60035517 D1 DE60035517 D1 DE 60035517D1 DE 60035517 T DE60035517 T DE 60035517T DE 60035517 T DE60035517 T DE 60035517T DE 60035517 D1 DE60035517 D1 DE 60035517D1
- Authority
- DE
- Germany
- Prior art keywords
- nucleic acid
- acid molecules
- polypeptides
- expression vectors
- molecules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 101001019455 Homo sapiens ICOS ligand Proteins 0.000 title abstract 6
- 102100034980 ICOS ligand Human genes 0.000 title abstract 5
- 102000039446 nucleic acids Human genes 0.000 abstract 4
- 108020004707 nucleic acids Proteins 0.000 abstract 4
- 150000007523 nucleic acids Chemical class 0.000 abstract 4
- 239000013604 expression vector Substances 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 230000000692 anti-sense effect Effects 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000003259 recombinant expression Methods 0.000 abstract 1
- 238000012216 screening Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70532—B7 molecules, e.g. CD80, CD86
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15504399P | 1999-09-21 | 1999-09-21 | |
| US155043P | 1999-09-21 | ||
| PCT/US2000/025892 WO2001021796A2 (en) | 1999-09-21 | 2000-09-21 | Gl50 molecules and uses therefor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60035517D1 true DE60035517D1 (de) | 2007-08-23 |
| DE60035517T2 DE60035517T2 (de) | 2008-03-20 |
Family
ID=22553907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60035517T Expired - Lifetime DE60035517T2 (de) | 1999-09-21 | 2000-09-21 | Gl50 moleküle, sowie verwendungen derselben |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US6521749B1 (de) |
| EP (1) | EP1218504B1 (de) |
| JP (1) | JP4737905B2 (de) |
| AT (1) | ATE366814T1 (de) |
| AU (1) | AU7599500A (de) |
| DE (1) | DE60035517T2 (de) |
| DK (1) | DK1218504T3 (de) |
| ES (1) | ES2290052T3 (de) |
| PT (1) | PT1218504E (de) |
| WO (1) | WO2001021796A2 (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7112655B1 (en) | 1997-02-27 | 2006-09-26 | Japan Tobacco, Inc. | JTT-1 protein and methods of inhibiting lymphocyte activation |
| JP3521382B2 (ja) | 1997-02-27 | 2004-04-19 | 日本たばこ産業株式会社 | 細胞間接着及びシグナル伝達を媒介する細胞表面分子 |
| IL144635A0 (en) * | 1999-02-03 | 2002-05-23 | Amgen Inc | Novel polypeptides involved in immune response |
| US7708993B2 (en) | 1999-02-03 | 2010-05-04 | Amgen Inc. | Polypeptides involved in immune response |
| US8624010B1 (en) | 1999-02-03 | 2014-01-07 | Steven K. Yoshinaga | Nucleic acids encoding B7RP1 |
| US7435796B1 (en) | 1999-02-03 | 2008-10-14 | Amgen Inc. | Antibodies which bind B7RP1 |
| JP4210454B2 (ja) | 2001-03-27 | 2009-01-21 | 日本たばこ産業株式会社 | 炎症性腸疾患治療剤 |
| JP3871503B2 (ja) | 1999-08-30 | 2007-01-24 | 日本たばこ産業株式会社 | 免疫性疾患治療剤 |
| JP3597140B2 (ja) | 2000-05-18 | 2004-12-02 | 日本たばこ産業株式会社 | 副刺激伝達分子ａｉｌｉｍに対するヒトモノクローナル抗体及びその医薬用途 |
| US20030031675A1 (en) | 2000-06-06 | 2003-02-13 | Mikesell Glen E. | B7-related nucleic acids and polypeptides useful for immunomodulation |
| US20030166531A1 (en) * | 2001-02-16 | 2003-09-04 | Genetics Institute, Inc. | Methods for modulating an immune response by modulating the interaction between CTLA4 and PP2A |
| JP4212278B2 (ja) | 2001-03-01 | 2009-01-21 | 日本たばこ産業株式会社 | 移植片拒絶反応抑制剤 |
| US7235631B2 (en) * | 2002-02-07 | 2007-06-26 | Mayo Foundation For Medical Education And Research | ICOS mutants |
| US20040102398A1 (en) * | 2002-11-23 | 2004-05-27 | Isis Pharmaceuticals Inc. | Modulation of B7H expression |
| AT500650B1 (de) | 2003-04-17 | 2009-11-15 | Altropus Gmbh | Immunogener rekombinanter antikörper |
| CA2614972C (en) * | 2005-07-18 | 2014-08-19 | Amgen Inc. | Human anti-b7rp1 neutralizing antibodies |
| EP2313432B1 (de) | 2008-06-30 | 2017-09-13 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Verwendung von cd31-peptiden bei der behandlung von thrombotischen erkrankungen und autoimmunerkrankungen |
| CA2769822C (en) * | 2009-08-13 | 2019-02-19 | The Johns Hopkins University | Methods of modulating immune function |
| CA2775761C (en) * | 2009-09-30 | 2018-08-28 | Memorial Sloan-Kettering Cancer Center | Combination immunotherapy for the treatment of cancer |
| WO2011097477A1 (en) * | 2010-02-04 | 2011-08-11 | The Trustees Of The University Of Pennsylvania | Icos critically regulates the expansion and function of inflammatory human th17 cells |
| CN102675470B (zh) * | 2012-04-01 | 2015-06-17 | 江苏省弗泰生物科技有限公司 | SCF-Fc融合蛋白 |
| PH12022550138A1 (en) | 2013-03-13 | 2023-03-06 | Amgen Inc | Proteins specific for baff and b7rp1 and uses thereof |
| US9458246B2 (en) | 2013-03-13 | 2016-10-04 | Amgen Inc. | Proteins specific for BAFF and B7RP1 |
| CN104232667A (zh) * | 2014-09-16 | 2014-12-24 | 宁夏医科大学 | FcRn介导的抗细粒棘球蚴靶向黏膜疫苗载体的构建方法 |
| PH12021552158A1 (en) | 2015-03-23 | 2022-05-02 | Jounce Therapeutics Inc | Antibodies to icos |
| KR20240046641A (ko) | 2015-04-17 | 2024-04-09 | 알파인 이뮨 사이언시즈, 인코포레이티드 | 조율가능한 친화성을 갖는 면역조절 단백질 |
| JP2018534927A (ja) | 2015-10-22 | 2018-11-29 | ジョンス セラピューティクス， インコーポレイテッド | Ｉｃｏｓ発現を決定する遺伝子シグネチャー |
| WO2017146538A1 (ko) * | 2016-02-26 | 2017-08-31 | 에스씨엠생명과학 주식회사 | 조절 t 세포 매개성 질환의 예방 또는 치료용 약학적 조성물 |
| KR102536850B1 (ko) | 2016-04-15 | 2023-05-26 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Icos 리간드 변이체 면역조절 단백질 및 그의 용도 |
| KR102758545B1 (ko) | 2017-10-10 | 2025-01-23 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Ctla-4 변이체 면역조절 단백질 및 이의 용도 |
| CN111712515A (zh) | 2017-10-18 | 2020-09-25 | 高山免疫科学股份有限公司 | 变体icos配体免疫调节蛋白及相关组合物和方法 |
| US12297253B2 (en) | 2018-01-03 | 2025-05-13 | Alpine Immune Sciences, Inc. | Multi-domain immunomodulatory proteins and methods of use thereof |
| CA3093856A1 (en) * | 2018-03-12 | 2019-09-19 | Board Of Regents, The University Of Texas System | Immuno-exosomes and methods of use thereof |
| WO2020070288A1 (en) | 2018-10-05 | 2020-04-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and systems for controlling the agonistic properties of antibody variable domains by light |
| CA3154999A1 (en) | 2019-10-28 | 2021-05-06 | Catherine Eugenie Chaillan Huntington | Dry powder formulations of thymic stromal lymphopoietin (tslp)-binding antibodies and methods of use thereof |
| WO2023198851A1 (en) | 2022-04-14 | 2023-10-19 | Institut National de la Santé et de la Recherche Médicale | Methods for controlling the tumor cell killing by light |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4837306A (en) * | 1985-02-25 | 1989-06-06 | The Ontario Cancer Institute | Method for selecting hybridomas producing antibodies specific to the P-glycoprotein cell suface antigen and a cDNA clone encoding the C-terminal portion of the antigen |
| US6641809B1 (en) * | 1990-03-26 | 2003-11-04 | Bristol-Myers Squibb Company | Method of regulating cellular processes mediated by B7 and CD28 |
| US6130316A (en) * | 1993-07-26 | 2000-10-10 | Dana Farber Cancer Institute | Fusion proteins of novel CTLA4/CD28 ligands and uses therefore |
| JP3521382B2 (ja) | 1997-02-27 | 2004-04-19 | 日本たばこ産業株式会社 | 細胞間接着及びシグナル伝達を媒介する細胞表面分子 |
| AU752433B2 (en) | 1997-09-23 | 2002-09-19 | Bundesrepublik Deutschland letzvertreten durch Den Direktor des Robert-Koch-Instituts | Costimulating T-cell polypeptide, monoclonal antibodies, their preparation and use |
| IL144635A0 (en) * | 1999-02-03 | 2002-05-23 | Amgen Inc | Novel polypeptides involved in immune response |
-
2000
- 2000-09-21 AT AT00965251T patent/ATE366814T1/de not_active IP Right Cessation
- 2000-09-21 DK DK00965251T patent/DK1218504T3/da active
- 2000-09-21 DE DE60035517T patent/DE60035517T2/de not_active Expired - Lifetime
- 2000-09-21 EP EP00965251A patent/EP1218504B1/de not_active Expired - Lifetime
- 2000-09-21 JP JP2001525354A patent/JP4737905B2/ja not_active Expired - Fee Related
- 2000-09-21 WO PCT/US2000/025892 patent/WO2001021796A2/en active IP Right Grant
- 2000-09-21 PT PT00965251T patent/PT1218504E/pt unknown
- 2000-09-21 AU AU75995/00A patent/AU7599500A/en not_active Abandoned
- 2000-09-21 US US09/667,135 patent/US6521749B1/en not_active Expired - Fee Related
- 2000-09-21 ES ES00965251T patent/ES2290052T3/es not_active Expired - Lifetime
-
2002
- 2002-12-12 US US10/318,855 patent/US7521532B2/en not_active Expired - Fee Related
-
2005
- 2005-12-19 US US11/311,754 patent/US7601813B2/en not_active Expired - Fee Related
-
2009
- 2009-08-18 US US12/542,901 patent/US7976840B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001021796A9 (en) | 2002-12-05 |
| US20040054158A1 (en) | 2004-03-18 |
| US7976840B2 (en) | 2011-07-12 |
| US20100055091A1 (en) | 2010-03-04 |
| EP1218504B1 (de) | 2007-07-11 |
| WO2001021796A2 (en) | 2001-03-29 |
| EP1218504A2 (de) | 2002-07-03 |
| WO2001021796A3 (en) | 2001-08-09 |
| US7601813B2 (en) | 2009-10-13 |
| AU7599500A (en) | 2001-04-24 |
| DE60035517T2 (de) | 2008-03-20 |
| JP2003510047A (ja) | 2003-03-18 |
| US20060099635A1 (en) | 2006-05-11 |
| PT1218504E (pt) | 2007-10-22 |
| ES2290052T3 (es) | 2008-02-16 |
| US6521749B1 (en) | 2003-02-18 |
| ATE366814T1 (de) | 2007-08-15 |
| JP4737905B2 (ja) | 2011-08-03 |
| US7521532B2 (en) | 2009-04-21 |
| DK1218504T3 (da) | 2007-11-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |