DE60019280D1 - Verfahren zur fermentativen herstellung von l-aminosäuren unter verwendung eines amplifizierten gnd-gens - Google Patents

Verfahren zur fermentativen herstellung von l-aminosäuren unter verwendung eines amplifizierten gnd-gens

Info

Publication number: DE60019280D1
Authority: DE; Germany
Prior art keywords: amino acid; amino acids; amplified; bacteria; gnd gene
Prior art date: 2000-03-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60019280T

Other languages

English (en)

Other versions

DE60019280T2 (de

Inventor

K Dunicau

Ashling Mccormack

Cliona Stapelton

Kevin Burke

Bettina Moeckel

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Evonik Operations GmbH

National University of Ireland Galway NUI

Original Assignee

Degussa GmbH

National University of Ireland Galway NUI

National University of Ireland

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-03-20

Filing date

2000-07-05

Publication date

2005-05-12

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24116938&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60019280(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2000-07-05 Application filed by Degussa GmbH, National University of Ireland Galway NUI, National University of Ireland filed Critical Degussa GmbH

2005-05-12 Publication of DE60019280D1 publication Critical patent/DE60019280D1/de

2006-05-11 Application granted granted Critical

2006-05-11 Publication of DE60019280T2 publication Critical patent/DE60019280T2/de

2020-07-06 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

150000008575 L-amino acids Chemical class 0.000 title abstract 6
238000000034 method Methods 0.000 title abstract 3
101150014950 gnd gene Proteins 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
241000894006 Bacteria Species 0.000 abstract 2
AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 abstract 2
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 2
239000001963 growth medium Substances 0.000 abstract 2
108090000623 proteins and genes Proteins 0.000 abstract 2
108020001657 6-phosphogluconate dehydrogenase Proteins 0.000 abstract 1
102000004567 6-phosphogluconate dehydrogenase Human genes 0.000 abstract 1
241000186031 Corynebacteriaceae Species 0.000 abstract 1
AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 abstract 1
229930182844 L-isoleucine Natural products 0.000 abstract 1
108010042687 Pyruvate Oxidase Proteins 0.000 abstract 1
239000004473 Threonine Substances 0.000 abstract 1
230000003247 decreasing effect Effects 0.000 abstract 1
229960000310 isoleucine Drugs 0.000 abstract 1
WPLOVIFNBMNBPD-ATHMIXSHSA-N subtilin Chemical compound CC1SCC(NC2=O)C(=O)NC(CC(N)=O)C(=O)NC(C(=O)NC(CCCCN)C(=O)NC(C(C)CC)C(=O)NC(=C)C(=O)NC(CCCCN)C(O)=O)CSC(C)C2NC(=O)C(CC(C)C)NC(=O)C1NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C1NC(=O)C(=C/C)/NC(=O)C(CCC(N)=O)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C2NC(=O)CNC(=O)C3CCCN3C(=O)C(NC(=O)C3NC(=O)C(CC(C)C)NC(=O)C(=C)NC(=O)C(CCC(O)=O)NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(N)CC=4C5=CC=CC=C5NC=4)CSC3)C(C)SC2)C(C)C)C(C)SC1)CC1=CC=CC=C1 WPLOVIFNBMNBPD-ATHMIXSHSA-N 0.000 abstract 1
229960002898 threonine Drugs 0.000 abstract 1
229960004799 tryptophan Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

DE60019280T 2000-03-20 2000-07-05 Verfahren zur fermentativen herstellung von l-aminosäuren unter verwendung eines amplifizierten gnd-gens Expired - Lifetime DE60019280T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US53126500A	2000-03-20	2000-03-20
US531265		2000-03-20
PCT/EP2000/006299 WO2001071012A1 (en)	2000-03-20	2000-07-05	Process for the fermentative preparation of l-amino acids with amplification of the gnd gene

Publications (2)

Publication Number	Publication Date
DE60019280D1 true DE60019280D1 (de)	2005-05-12
DE60019280T2 DE60019280T2 (de)	2006-05-11

Family

ID=24116938

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60019280T Expired - Lifetime DE60019280T2 (de)	2000-03-20	2000-07-05	Verfahren zur fermentativen herstellung von l-aminosäuren unter verwendung eines amplifizierten gnd-gens

Country Status (14)

Country	Link
US (2)	US20030119154A1 (de)
EP (1)	EP1179076B9 (de)
KR (1)	KR100826815B1 (de)
CN (1)	CN1350586A (de)
AT (1)	ATE292687T1 (de)
AU (1)	AU6431600A (de)
BR (1)	BR0010817A (de)
CA (1)	CA2374265A1 (de)
DE (1)	DE60019280T2 (de)
ES (1)	ES2240135T3 (de)
MX (1)	MXPA01011643A (de)
PL (1)	PL358912A1 (de)
SK (1)	SK16542001A3 (de)
WO (1)	WO2001071012A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1330526B1 (de) *	2000-11-04	2010-04-21	Evonik Degussa GmbH	Verfahren zur fermentativen herstellung von l-aminosäuren unter verwendung von stämmen aus der familie der enterobacteriaceae
US20030017554A1 (en) *	2000-11-15	2003-01-23	Mechthild Rieping	Process for the fermentative preparation of L-amino acids using strains of the enterobacteriaceae family
DE10210527A1 (de)	2002-03-09	2003-09-18	Degussa	Allele des aceA-Gens aus coryneformen Bakterien
JP5572279B2 (ja) *	2004-05-20	2014-08-13	味の素株式会社	コハク酸生産菌及びコハク酸の製造方法
DE102005032426A1 (de) *	2004-12-18	2006-06-22	Degussa Ag	Allele des gnd-Gens aus coryneformen Bakterien
US8647642B2 (en)	2008-09-18	2014-02-11	Aviex Technologies, Llc	Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
KR101335853B1 (ko)	2011-12-01	2013-12-02	씨제이제일제당 (주)	Ｌ-아미노산 및 리보플라빈을 동시에 생산하는 미생물 및 이를 이용한 ｌ-아미노산 및 리보플라빈을 생산하는 방법
CN105602966B (zh) *	2016-01-08	2019-03-15	广西大学	一种编码6-磷酸葡萄糖酸脱氢酶的基因及其应用
US11180535B1 (en)	2016-12-07	2021-11-23	David Gordon Bermudes	Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en)	2016-12-07	2021-09-28	David Gordon Bermudes	Chimeric protein toxins for expression by therapeutic bacteria
CN114729339B (zh) *	2021-01-29	2023-01-03	Cj第一制糖株式会社	新真菌硫酮还原酶变体及使用其生产l-赖氨酸的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2165546B (en) *	1984-08-21	1989-05-17	Asahi Chemical Ind	A plasmid containing a gene for tetracycline resistance and dna fragments derived therefrom
GB2223754B (en) *	1988-09-12	1992-07-22	Degussa	Dna encoding phosphoenolpyruvate carboxylase
DE3943117A1 (de) *	1989-12-27	1991-07-04	Forschungszentrum Juelich Gmbh	Verfahren zur fermentativen herstellung von aminosaeure, insbesondere l-lysin, dafuer geeignete mikroorganismen und rekombinante dna
DE4027453A1 (de) *	1990-08-30	1992-03-05	Degussa	Neue plasmide aus corynebacterium glutamicum und davon abgeleitete plasmidvektoren
US5830716A (en) *	1993-10-28	1998-11-03	Ajinomoto Co., Inc.	Increased amounts of substances by modifying a microorganism to increase production of NADPH from NADH
JPH09224662A (ja) *	1996-02-23	1997-09-02	Mitsubishi Chem Corp	６−ホスホグルコン酸デヒドロゲナーゼおよびそれをコードするｄｎａ
DE60030400T2 (de) *	1999-07-09	2007-09-13	Degussa Gmbh	Für den opac-gen kodierende nukleotidsequenzen
AU6362200A (en) *	1999-07-23	2001-02-13	Archer-Daniels-Midland Company	Methods for producing L-amino acids by increasing cellular NADPH

2000
- 2000-07-05 DE DE60019280T patent/DE60019280T2/de not_active Expired - Lifetime
- 2000-07-05 BR BR0010817-0A patent/BR0010817A/pt not_active Application Discontinuation
- 2000-07-05 SK SK1654-2001A patent/SK16542001A3/sk unknown
- 2000-07-05 AT AT00951336T patent/ATE292687T1/de not_active IP Right Cessation
- 2000-07-05 AU AU64316/00A patent/AU6431600A/en not_active Abandoned
- 2000-07-05 WO PCT/EP2000/006299 patent/WO2001071012A1/en active IP Right Grant
- 2000-07-05 MX MXPA01011643A patent/MXPA01011643A/es unknown
- 2000-07-05 CA CA002374265A patent/CA2374265A1/en not_active Abandoned
- 2000-07-05 CN CN00807548A patent/CN1350586A/zh active Pending
- 2000-07-05 KR KR1020017014821A patent/KR100826815B1/ko not_active Expired - Fee Related
- 2000-07-05 PL PL00358912A patent/PL358912A1/xx not_active Application Discontinuation
- 2000-07-05 ES ES00951336T patent/ES2240135T3/es not_active Expired - Lifetime
- 2000-07-05 EP EP00951336A patent/EP1179076B9/de not_active Expired - Lifetime
2002
- 2002-02-20 US US10/078,167 patent/US20030119154A1/en not_active Abandoned
2003
- 2003-10-17 US US10/686,736 patent/US20040063181A1/en not_active Abandoned

Also Published As

Publication number	Publication date
WO2001071012A1 (en)	2001-09-27
ES2240135T3 (es)	2005-10-16
KR20010113832A (ko)	2001-12-28
BR0010817A (pt)	2002-03-05
US20030119154A1 (en)	2003-06-26
CA2374265A1 (en)	2001-09-27
KR100826815B1 (ko)	2008-05-02
SK16542001A3 (sk)	2002-07-02
ATE292687T1 (de)	2005-04-15
EP1179076B1 (de)	2005-04-06
MXPA01011643A (es)	2003-02-27
EP1179076A1 (de)	2002-02-13
EP1179076B9 (de)	2005-11-30
PL358912A1 (en)	2004-08-23
AU6431600A (en)	2001-10-03
US20040063181A1 (en)	2004-04-01
DE60019280T2 (de)	2006-05-11
CN1350586A (zh)	2002-05-22

Publication	Publication Date	Title
KR101294499B1 (ko)	2013-08-07	광학 활성 키랄 아민의 제조 방법
ATE433494T1 (de)	2009-06-15	Verfahren zur herstellung von l-aminosäuren mittels fermentation eines bakteriums mit erhöhter expression von genen der xylose- benutzung
DE602004014158D1 (de)	2008-07-10	Verfahren zur herstellung von l-lysin oder l-threonin unter verwendung von escherichia-bakterien mit abgeschwächter malatenzymaktivität
RU99121636A (ru)	2002-05-27	Способ получения l-аминокислот методом ферментации
DE602004022584D1 (de)	2009-09-24	Neue kaumagenbakterienvarianten sowie verfahren zur herstellung von bernsteinsäure unter verwendung davon
ATE263246T1 (de)	2004-04-15	Verfahren zur fermentativen herstellung von l- aminosäuren unter verwendung coryneformer bakterien
ATE234933T1 (de)	2003-04-15	Verfahren zur herstellung von d-aminosäuren durch direkte gärung
DE60019280D1 (de)	2005-05-12	Verfahren zur fermentativen herstellung von l-aminosäuren unter verwendung eines amplifizierten gnd-gens
DE69842029D1 (de)	2011-01-13	Verfahren unter Verwendung von Milchsäurebakterien
HUP0104450A2 (hu)	2002-04-29	A tal génhez való nukleotidszekvenciák
ATE351908T1 (de)	2007-02-15	Verfahren zur fermentativen herstellung von l- aminosäuren durch verstärkung des zwf-gens
ATE357532T1 (de)	2007-04-15	Verfahren zur herstellung von l-lysin unter verwendung coryneformer bakterien die ein attenuiertes malat enzym-gen enthalten
ATE488597T1 (de)	2010-12-15	Verfahren zur herstellung optisch aktiver aminosäuren unter verwendung eines ganzzellenkatalysators
ATE274575T1 (de)	2004-09-15	Prozess zur fermentativen herstellung von d- pantothensäure mit coryneformen bakterien
DE60207914D1 (de)	2006-01-19	Verfahren zur Herstellung von L-Glutaminsäure
ATE265541T1 (de)	2004-05-15	Verfahren zur fermentativen herstellung von nicht-proteinogenen l-aminosäuren
ATE556145T1 (de)	2012-05-15	Verfahren zur herstellung von l-threonin oder l- lysin unter verwendung rekombinanter enterobacteriaceae mit erhöhter enolaseaktivität
ATE374831T1 (de)	2007-10-15	Verfahren zur fermentativen herstellung von l- aminosäuren durch verstärkung des tkt-gens
DE502006006144D1 (de)	2010-04-01	Verfahren zur Herstellung von L-Aminosäuren unter Verwendung von Stämmen der Familie Enterobacteriaceae mit verstärkter Expression von ytfQ-ORF
ATE381612T1 (de)	2008-01-15	Verfahren zur fermentativen herstellung von l- aminosäuren mittels koryneformen bakterien
WO2000017379A3 (en)	2000-09-21	An l-lysine-producing microorganism and a method for producing l-lysine using said microorganism
ATE428794T1 (de)	2009-05-15	Verfahren zur herstellung von l-aminosäuren unter verwendung von stämmen der familie enterobacteriaceae
ATE399863T1 (de)	2008-07-15	Verfahren zur herstellung von l-threonin unter verwendung von stämmen der enterobacteriaceae familie
DE60335174D1 (de)	2011-01-13	Verfahren zur herstellung von l-aminosäuren unter verwendung von stämmen aus der familie der enterobacteriaceae
ATE399875T1 (de)	2008-07-15	Verfahren zur fermentativen herstellung von l- aminosäuren durch enterobakteriaceae-stämmen mit verstärkter exprimierung des rseb-gens

Legal Events

Date	Code	Title	Description
2006-04-27	8363	Opposition against the patent
2007-04-19	8327	Change in the person/name/address of the patent owner	Owner name: DEGUSSA GMBH, 40474 DUESSELDORF, DE Owner name: NATIONAL UNIVERSITY OF IRELAND, GALWAY, IE
2008-01-10	8327	Change in the person/name/address of the patent owner	Owner name: EVONIK DEGUSSA GMBH, 40474 DUESSELDORF, DE Owner name: NATIONAL UNIVERSITY OF IRELAND, GALWAY, IE
2008-12-24	8365	Fully valid after opposition proceedings