DE60017888D1 - Dinatrium-salze, monohydrate und ethanol-solvate - Google Patents
Dinatrium-salze, monohydrate und ethanol-solvateInfo
- Publication number
- DE60017888D1 DE60017888D1 DE60017888T DE60017888T DE60017888D1 DE 60017888 D1 DE60017888 D1 DE 60017888D1 DE 60017888 T DE60017888 T DE 60017888T DE 60017888 T DE60017888 T DE 60017888T DE 60017888 D1 DE60017888 D1 DE 60017888D1
- Authority
- DE
- Germany
- Prior art keywords
- ethanol solvate
- delivery agents
- disodium salt
- ethanol
- monohydrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title abstract 8
- 239000012453 solvate Substances 0.000 title abstract 4
- 150000004682 monohydrates Chemical class 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 abstract 4
- 229940124447 delivery agent Drugs 0.000 abstract 3
- 125000003816 2-hydroxybenzoyl group Chemical group OC1=C(C(=O)*)C=CC=C1 0.000 abstract 2
- XRTHAPZDZPADIL-UHFFFAOYSA-N 8-[(5-chloro-2-hydroxybenzoyl)amino]octanoic acid Chemical compound OC(=O)CCCCCCCNC(=O)C1=CC(Cl)=CC=C1O XRTHAPZDZPADIL-UHFFFAOYSA-N 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- GYSCBCSGKXNZRH-UHFFFAOYSA-N 1-benzothiophene-2-carboxamide Chemical compound C1=CC=C2SC(C(=O)N)=CC2=C1 GYSCBCSGKXNZRH-UHFFFAOYSA-N 0.000 abstract 1
- GHVNFZFCNZKVNT-UHFFFAOYSA-N Decanoic acid Natural products CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical class [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- WWZKQHOCKIZLMA-UHFFFAOYSA-M octanoate Chemical compound CCCCCCCC([O-])=O WWZKQHOCKIZLMA-UHFFFAOYSA-M 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- XUHVCHNJCBBXMP-UHFFFAOYSA-M sodium;10-[(2-hydroxybenzoyl)amino]decanoate Chemical compound [Na+].OC1=CC=CC=C1C(=O)NCCCCCCCCCC([O-])=O XUHVCHNJCBBXMP-UHFFFAOYSA-M 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
- C07D265/26—Two oxygen atoms, e.g. isatoic anhydride
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12775499P | 1999-04-05 | 1999-04-05 | |
| US127754P | 1999-04-05 | ||
| US18614200P | 2000-03-01 | 2000-03-01 | |
| US18614300P | 2000-03-01 | 2000-03-01 | |
| US186143P | 2000-03-01 | ||
| US186142P | 2000-03-01 | ||
| US19128600P | 2000-03-21 | 2000-03-21 | |
| US191286P | 2000-03-21 | ||
| PCT/US2000/009390 WO2000059863A1 (en) | 1999-04-05 | 2000-04-05 | Disodium salts, monohydrates, and ethanol solvates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60017888D1 true DE60017888D1 (de) | 2005-03-10 |
| DE60017888T2 DE60017888T2 (de) | 2006-01-19 |
Family
ID=27494697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60017888T Expired - Lifetime DE60017888T2 (de) | 1999-04-05 | 2000-04-05 | Dinatrium-salze, monohydrate und ethanol-solvate |
Country Status (11)
| Country | Link |
|---|---|
| US (6) | US20020065255A1 (de) |
| EP (1) | EP1175390B1 (de) |
| JP (2) | JP4588221B2 (de) |
| AT (1) | ATE288415T1 (de) |
| AU (1) | AU4216700A (de) |
| CA (1) | CA2369591C (de) |
| DE (1) | DE60017888T2 (de) |
| ES (1) | ES2235854T3 (de) |
| IL (4) | IL145546A0 (de) |
| NZ (1) | NZ534409A (de) |
| WO (1) | WO2000059863A1 (de) |
Families Citing this family (113)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6610329B2 (en) | 1993-04-22 | 2003-08-26 | Emisphere Technologies Inc. | Compositions for the delivery of antigens |
| SI9720025A (sl) | 1996-03-29 | 1999-08-31 | Emishphere Technologies, Inc. | Spojine in sestavki za prenos aktivne snovi |
| US6358504B1 (en) | 1997-02-07 | 2002-03-19 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| DE69925276T2 (de) | 1998-07-27 | 2005-10-06 | Emisphere Technologies, Inc. | Stoffe und zusammensetzungen für die verabreichung aktiver substanzen |
| US6440929B1 (en) | 1998-07-27 | 2002-08-27 | Emisphere Technologies, Inc. | Pulmonary delivery of active agents |
| US6991798B1 (en) | 1998-08-07 | 2006-01-31 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| TR200100366T2 (tr) | 1998-08-07 | 2001-11-21 | Emisphere Technologies, Inc. | Aktif madde dağıtmaya mahsus bileşikler ve bileşimler. |
| ATE288415T1 (de) * | 1999-04-05 | 2005-02-15 | Emisphere Tech Inc | Dinatrium-salze, monohydrate und ethanol-solvate |
| US7129274B1 (en) | 1999-11-05 | 2006-10-31 | Emisphere Technologies Inc. | Phenoxy carboxylic acid compounds and compositions for delivering active agents |
| US7279597B1 (en) | 1999-11-05 | 2007-10-09 | Emisphere Technologies, Inc. | Phenyl amine carboxylic acid compounds and compositions for delivering active agents |
| WO2001051454A1 (en) * | 2000-01-13 | 2001-07-19 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| EP1299348B1 (de) | 2000-06-29 | 2008-04-09 | Emisphere Technologies, Inc. | Verbindungen und gemische zur verabreichung eines aktiven agens |
| US7049283B2 (en) * | 2000-12-06 | 2006-05-23 | Novartis Ag | Pharmaceutical compositions for the oral delivery of pharmacologically active agents |
| CA2446929C (en) * | 2001-06-01 | 2013-04-09 | Novartis Ag | Orally administering parathyroid hormone and calcitonin |
| EP1420827B8 (de) * | 2001-08-17 | 2009-12-23 | Novartis AG | 5-cnac zur oralen verabreichung von parathormonfragmenten |
| JP5196701B2 (ja) * | 2001-11-29 | 2013-05-15 | エミスフィアー テクノロジーズ インコーポレイテッド | クロモリンナトリウムの経口投与用製剤 |
| JP4508646B2 (ja) | 2002-01-09 | 2010-07-21 | エミスフェアー・テクノロジーズ・インク | ４−［（４−クロロ−２−ヒドロキシベンゾイル）アミノ］ブタン酸ナトリウムの多形体 |
| AU2003208945B2 (en) | 2002-02-20 | 2008-05-01 | Emisphere Technologies, Inc | Method for administering GLP-1 molecules |
| US20050054557A1 (en) * | 2002-05-09 | 2005-03-10 | Goldberg Michael M. | Compositions for delivering parathyroid hormone and calcitonin |
| TW200403052A (en) * | 2002-07-17 | 2004-03-01 | Novartis Ag | Use of organic compounds |
| PE20040724A1 (es) * | 2002-08-01 | 2004-12-06 | Novartis Ag | Composicion para la administracion oral de calcitonina |
| ES2330638T3 (es) | 2003-07-11 | 2009-12-14 | Novartis Ag | Composiciones farmaceuticas dosificadas en forma oral que contienen un agente de suministro en forma micronizada. |
| US7749954B2 (en) * | 2003-07-23 | 2010-07-06 | Novartis Ag | Use of calcitonin in osteoarthritis |
| DE60325906D1 (de) | 2003-08-08 | 2009-03-05 | Amgen Fremont Inc | Antikörper gegen parath-hormon (pth) und ihre verwendungen |
| US7318925B2 (en) * | 2003-08-08 | 2008-01-15 | Amgen Fremont, Inc. | Methods of use for antibodies against parathyroid hormone |
| MXPA06001916A (es) | 2003-08-20 | 2006-05-17 | Lilly Co Eli | Compuestos, metodos y formulaciones para el suministro oral de un compuesto peptidico similar a glucagona (glp)-i o un peptido agonista del receptor de melanocortina 4 (mc4). |
| EP1658273B1 (de) | 2003-08-20 | 2007-01-03 | Eli Lilly And Company | Verbindungen, verfahren und formulierungen zur oralen verabreichung einer glucagon like peptide (glp)-1-verbindung oder eines am melanocortin-4-rezeptor (mc4) als agonist wirkenden peptids |
| US20060286129A1 (en) | 2003-12-19 | 2006-12-21 | Emisphere Technologies, Inc. | Oral GLP-1 formulations |
| WO2005115406A2 (en) | 2004-04-16 | 2005-12-08 | Emisphere Technologies, Inc. | 8-(2-hydroxyphenoxy)octyldiethanolamine and salts thereof for delivery of active agents |
| EA013518B1 (ru) * | 2004-05-06 | 2010-06-30 | Эмисфире Текнолоджис, Инк. | Кристаллические полиморфные формы n-[8-(2-гидроксибензоил)амино]каприлата натрия |
| KR20070008720A (ko) | 2004-05-06 | 2007-01-17 | 에미스페어 테크놀로지스, 인코포레이티드 | 습윤 헤파린의 고체 투여형 |
| KR101193228B1 (ko) * | 2004-05-06 | 2012-10-22 | 에미스페어 테크놀로지스, 인코포레이티드 | 모노소듐 ｎ-［8-(2-히드록시벤조일)아미노］카프릴레이트의 결정 다형 형태 |
| CN1953753B (zh) * | 2004-05-06 | 2011-02-09 | 爱密斯菲尔科技公司 | N-[8-(2-羟基苯甲酰基)氨基]辛酸一钠的晶体的多晶 |
| RU2403237C2 (ru) * | 2004-05-14 | 2010-11-10 | Эмисфире Текнолоджис, Инк. | Составы и смеси для доставки активных агентов |
| CA2566161C (en) | 2004-05-14 | 2013-10-01 | Emisphere Technologies, Inc. | Aryl ketone compounds and compositions for delivering active agents |
| NZ597499A (en) | 2004-05-14 | 2013-04-26 | Emisphere Tech Inc | Compounds and compositions for delivering active agents |
| CA2566741C (en) | 2004-05-19 | 2014-06-10 | Emisphere Technologies, Inc. | Acyclovir formulations |
| BRPI0510906A (pt) * | 2004-05-19 | 2007-11-06 | Emisphere Tech Inc | composição farmacêutica tópica, composição para administração tópica e seu uso |
| EP1791553B1 (de) * | 2004-07-12 | 2013-10-23 | Emisphere Technologies, Inc. | Zusammensetzungen zur abgabe von peptid yy und pyy agonisten |
| CA2573856A1 (en) | 2004-08-03 | 2006-02-16 | Emisphere Technologies, Inc. | Antidiabetic oral insulin-biguanide combination |
| GB0422644D0 (en) * | 2004-10-12 | 2004-11-10 | Novartis Ag | Organic compounds |
| GB0427603D0 (en) * | 2004-12-16 | 2005-01-19 | Novartis Ag | Organic compounds |
| GB0427600D0 (en) | 2004-12-16 | 2005-01-19 | Novartis Ag | Organic compounds |
| AU2005321803B2 (en) * | 2004-12-29 | 2012-02-09 | Emisphere Technologies, Inc. | Pharmaceutical formulations of gallium salts |
| US8110547B2 (en) | 2005-01-12 | 2012-02-07 | Emisphere Technologies, Inc. | Compositions for buccal delivery of parathyroid hormone |
| WO2007005995A2 (en) * | 2005-07-05 | 2007-01-11 | Emisphere Technologies, Inc. | Compositions for buccal delivery of human growth hormone |
| US20070049557A1 (en) | 2005-08-24 | 2007-03-01 | Hashim Ahmed | Solid pharmaceutical dosage forms comprising bisphosphonates and modified amino acid carriers |
| PE20070548A1 (es) * | 2005-09-19 | 2007-07-12 | Emisphere Tech Inc | Formas cristalinas de la sal de di-sodio del acido n-(5-clorosaliciloil)-8-aminocaprilico |
| GB0522566D0 (en) * | 2005-11-04 | 2005-12-14 | Novartis Ag | Organic compounds |
| JP2009515993A (ja) | 2005-11-17 | 2009-04-16 | ノバルティス アクチエンゲゼルシャフト | 医薬組成物 |
| US20070232537A1 (en) * | 2005-12-19 | 2007-10-04 | Nastech Pharmaceutical Company Inc. | Intranasal pyy formulations with improved transmucosal pharmacokinetics |
| US8927015B2 (en) | 2006-04-12 | 2015-01-06 | Emisphere Technologies, Inc. | Formulations for delivering insulin |
| US8771712B2 (en) | 2006-05-09 | 2014-07-08 | Emisphere Technologies, Inc. | Topical administration of acyclovir |
| US9364502B2 (en) | 2006-06-28 | 2016-06-14 | Emisphere Technologies, Inc. | Gallium nitrate formulations |
| WO2008021088A2 (en) | 2006-08-08 | 2008-02-21 | The Regents Of The University Of Californina | Salicylanilides enhance oral delivery of therapeutic peptides |
| USRE48164E1 (en) | 2006-08-31 | 2020-08-18 | Emisphere Technologies Inc. | Compounds and compositions for delivering active agents |
| PT2059260E (pt) * | 2006-08-31 | 2013-09-03 | Novartis Ag | Composições farmacêuticas compreendendo hgh para distribuição oral |
| US10875826B2 (en) * | 2006-09-07 | 2020-12-29 | Emisphere Technologies, Inc. | Process for the manufacture of SNAC (salcaprozate sodium) |
| CN101621991A (zh) * | 2007-03-02 | 2010-01-06 | 诺瓦提斯公司 | 降钙素的口服施用 |
| ES2579229T3 (es) | 2007-03-13 | 2016-08-08 | Jds Therapeutics, Llc | Procedimientos y composiciones para la liberación sostenida de cromo |
| WO2009002867A2 (en) | 2007-06-26 | 2008-12-31 | Nutrition 21, Inc. | Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement |
| PT2460515T (pt) | 2007-08-09 | 2017-04-27 | Novartis Ag | Composições orais de calcitonina e suas aplicações |
| PT2215047E (pt) | 2007-11-02 | 2014-01-20 | Emisphere Tech Inc | Processo para o tratamento da deficiência de vitamina b12 |
| EP2676956A1 (de) * | 2008-08-01 | 2013-12-25 | Purdue Pharma L.P. | Tetrahydropyridinyl- und Dihydropyrrolylverbindungen und ihre Verwendung |
| CN104922655A (zh) | 2009-02-06 | 2015-09-23 | 加利福尼亚大学董事会 | 钙结合剂诱导毛发生长和/或甲生长 |
| CN102369018B (zh) | 2009-03-12 | 2016-08-03 | 关键生物科学有限公司 | 糖尿病和代谢综合征的治疗 |
| WO2011017346A2 (en) | 2009-08-03 | 2011-02-10 | Emisphere Technologies, Inc. | Fast-acting naproxen composition with reduced gastrointestinal effects |
| AU2011220867B2 (en) * | 2010-02-24 | 2014-05-15 | Emisphere Technologies, Inc. | Oral B12 therapy |
| US9402864B2 (en) * | 2010-06-09 | 2016-08-02 | Emisphere Technologies, Inc. | Oral iron deficiency therapy |
| US10449177B2 (en) | 2010-08-19 | 2019-10-22 | Buck Institute For Research On Aging | Methods of treating mild cognitive impairment (MCI) and related disorders |
| WO2012027440A1 (en) | 2010-08-24 | 2012-03-01 | Abbott Laboratories | Hiv core protein specific antibodies and uses thereof |
| TW201309346A (zh) * | 2011-01-05 | 2013-03-01 | Hospira Inc | 噴霧乾燥萬古黴素 |
| EP4070801A1 (de) | 2011-03-01 | 2022-10-12 | Nutrition 21, LLC | Zusammensetzungen aus insulin und chrom zur behandlung und vorbeugung von diabetes, hypoglykämie und verwandten erkrankungen |
| RU2616511C2 (ru) | 2011-11-02 | 2017-04-17 | Кибайосайнс Аг | Пептидные аналоги для лечения заболеваний и расстройств |
| PL3095484T3 (pl) | 2011-11-02 | 2018-10-31 | Keybioscience Ag | Mimetyki kalcytoniny do leczenia chorób i zaburzeń |
| US9533022B2 (en) * | 2011-11-02 | 2017-01-03 | KeyBioscience A/S | Peptide analogs for treating diseases and disorders |
| AU2013302390A1 (en) | 2012-08-16 | 2015-02-26 | Ohio State Innovation Foundation | Stat3 inhibitors and their anticancer use |
| WO2014036528A2 (en) | 2012-08-31 | 2014-03-06 | Ixchel Pharma, Llc | Agents useful for treating obesity, diabetes and related disorders |
| DK2897620T3 (da) | 2012-09-21 | 2020-08-17 | Intensity Therapeutics Inc | Fremgangsmåde til behandling af cancer |
| EP4335505A3 (de) | 2012-11-30 | 2024-06-05 | The Regents of The University of California | Antikonvulsive aktivität von steroiden |
| CN104043104B (zh) | 2013-03-15 | 2018-07-10 | 浙江创新生物有限公司 | 含盐酸万古霉素的喷雾干粉及其工业化制备方法 |
| AU2014287044B2 (en) * | 2013-07-12 | 2020-02-06 | Genentech, Inc. | Elucidation of ion exchange chromatography input optimization |
| JP6639389B2 (ja) | 2013-11-14 | 2020-02-05 | キーバイオサイエンス・アクチエンゲゼルシャフト | 疾患および障害を処置するためのカルシトニン模倣体 |
| EP3006045B3 (de) | 2014-10-07 | 2021-03-17 | Cyprumed GmbH | Pharmazeutische Formulierungen zur oralen Verabreichung von Peptid- oder Proteinarzneimitteln |
| JP6930913B2 (ja) | 2014-10-14 | 2021-09-01 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアＴｈｅ Ｒｅｇｅｎｔｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃａｌｉｆｏｒｎｉａ | 炎症を阻害するためのｃｄｋ９及びｂｒｄ４阻害剤の使用法 |
| GB201500263D0 (en) | 2015-01-08 | 2015-02-25 | Keybioscience Ag | Calcitonin analogues for treating diseases and disorders |
| EP3256114A4 (de) | 2015-02-09 | 2018-11-21 | Entera Bio Ltd. | Behandlung von osteoporose |
| CA2997343A1 (en) | 2015-10-07 | 2017-04-13 | Cyprumed Gmbh | Pharmaceutical formulations for the oral delivery of peptide drugs |
| AU2017217466A1 (en) | 2016-02-11 | 2018-08-23 | Nutrition 21, Llc | Chromium containing compositions for improving health and fitness |
| AU2017252575B2 (en) | 2016-04-22 | 2021-11-18 | Spoke Sciences, Inc. | Fast-acting plant-based medicinal compounds and nutritional supplements |
| SG11201901070YA (en) | 2016-08-17 | 2019-03-28 | Entera Bio Ltd | Formulations for oral administration of active agents |
| WO2018065634A1 (en) | 2016-10-07 | 2018-04-12 | Cyprumed Gmbh | Pharmaceutical compositions for the nasal delivery of peptide or protein drugs |
| EA201892396A1 (ru) | 2016-12-02 | 2019-04-30 | Ресептор Лайф Сайенсиз, Инк. | Быстродействующие растительные лекарственные соединения и биологически активные добавки |
| WO2018129200A2 (en) | 2017-01-05 | 2018-07-12 | The Regents Of The University Of California | Pac1 receptor agonists (maxcaps) and uses thereof |
| GB201704429D0 (en) | 2017-03-21 | 2017-05-03 | Keybioscience Ag | Calcitonin mimetics for treating diseases and disorders |
| GB201707955D0 (en) | 2017-05-18 | 2017-07-05 | Keybioscience Ag | Dual amylin and calcitonin receptor agonists for treating diseases and disorders |
| KR20200066319A (ko) * | 2017-10-05 | 2020-06-09 | 리셉터 홀딩스, 인크. | 개선된 생체이용률을 갖는 약초 조성물 |
| CA3078549A1 (en) * | 2017-10-05 | 2019-04-11 | Receptor Holdings, Inc. | Rapid onset and extended action plant-based and synthetic cannabinoid formulations |
| US11826414B2 (en) | 2017-10-23 | 2023-11-28 | Cz Biohub Sf, Llc | Measurement of afucosylated IgG Fc glycans and related vaccination methods |
| EP3773475A1 (de) | 2018-04-06 | 2021-02-17 | Cyprumed GmbH | Pharmazeutische zusammensetzungen zur transmukosalen abgabe von therapeutischen peptiden und proteinen |
| GB201813678D0 (en) | 2018-08-22 | 2018-10-03 | Keybioscience Ag | Acylated calcitonin mimetics |
| GB201813677D0 (en) | 2018-08-22 | 2018-10-03 | Keybioscience Ag | Calcitonin mimetics for treating diseases and disorders |
| JP7566336B2 (ja) | 2018-11-19 | 2024-10-15 | スポーク・サイエンシズ・インコーポレイテッド | カンナビノイド由来組成物の吸収変動を低減するｎ－アシル化脂肪アミノ酸 |
| CN111057165A (zh) * | 2020-01-13 | 2020-04-24 | 苏州健飞肠衣有限公司 | 一种高纯度肝素钠的制备方法 |
| US20240041983A1 (en) | 2020-09-07 | 2024-02-08 | Cyprumed Gmbh | Improved pharmaceutical formulations of glp-1 receptor agonists |
| CR20230308A (es) | 2020-12-11 | 2023-09-08 | Civi Biopharma Inc | Entrega oral de conjugados antisentido que tienen por blanco a pcsk9 |
| US11667614B2 (en) | 2021-04-16 | 2023-06-06 | Navinta III Inc. | Process for the preparation of highly pure Salcaprozic Acid and pharmaceutically acceptable salts thereof |
| EP4323330A1 (de) | 2021-04-16 | 2024-02-21 | Navinta III Inc | Verfahren zur herstellung von hochreiner salcaprozinsäure und pharmazeutisch akzeptablen salzen daraus |
| CA3216091A1 (en) | 2021-04-22 | 2022-10-27 | Henrik Oerum | Oral delivery of oligonucleotides |
| PH12023553506A1 (en) | 2021-07-16 | 2024-04-29 | Novo Nordisk As | Sodium n-(8-(2- hydroxybenzoyl)amino)caprylate polymorphic form a |
| CN119156221A (zh) | 2022-03-03 | 2024-12-17 | 西普鲁梅有限公司 | 治疗性肽和蛋白质的改进的口服药物制剂 |
| WO2024141760A1 (en) | 2022-12-30 | 2024-07-04 | Algipharma As | Compositions and methods to increase the systemic bioavailability of a polypeptide therapeutic agent undergoing oral administration |
| WO2024211393A2 (en) | 2023-04-04 | 2024-10-10 | Tulex Pharmaceuticals Inc. | Desmopressin oral compositions |
Family Cites Families (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES369853A1 (es) * | 1969-07-24 | 1971-07-16 | Bama S A Lab | Procedimiento para la obtencion de derivados del acido ep- silon-amino-caproico. |
| US3795739A (en) * | 1972-02-14 | 1974-03-05 | Hoffmann La Roche | Treatment of parkinson disease |
| US3939253A (en) * | 1973-11-02 | 1976-02-17 | Interx Research Corporation | Novel, transient pro-drug forms of l-dopa useful in the treatment of parkinson's disease |
| US4061466A (en) * | 1974-10-16 | 1977-12-06 | Ingvar Gosta Holger Sjoholm | Biologically active composition and the use thereof |
| DE2500157C2 (de) * | 1975-01-03 | 1983-09-15 | Hoechst Ag, 6230 Frankfurt | N-Acyl-4-(2-aminoäthyl)-benzoesäuren, deren Salze und Ester, Verfahren zu deren Herstellung und deren Verwendung |
| US4035507A (en) * | 1975-04-17 | 1977-07-12 | Interx Research Corporation | Novel, transient pro-drug forms of L-DOPA to treat Parkinson's disease |
| DE2517229A1 (de) * | 1975-04-18 | 1976-10-28 | Boehringer Mannheim Gmbh | Phenylalkylcarbonsaeure-derivate und verfahren zu ihrer herstellung |
| DE2532420A1 (de) * | 1975-07-19 | 1977-02-03 | Boehringer Mannheim Gmbh | Phenylessigsaeure-derivate und verfahren zu ihrer herstellung |
| CA1077842A (en) * | 1975-10-09 | 1980-05-20 | Minnesota Mining And Manufacturing Company | Albumin medicament carrier system |
| FR2374910A1 (fr) * | 1976-10-23 | 1978-07-21 | Choay Sa | Preparation a base d'heparine, comprenant des liposomes, procede pour l'obtenir et medicaments contenant de telles preparations |
| NZ196349A (en) | 1980-03-07 | 1984-08-24 | Interx Research Corp | Enhancement of absorption rate of orally administered polar bioactive agents |
| US4442090A (en) * | 1980-11-09 | 1984-04-10 | Kyoto Yakuhin Kogyo Kabushiki Kaisha | Absorption-promoting compounds, compositions thereof with pharmaceuticals and/or bases for rectal administration and method of use |
| US4900730A (en) * | 1981-01-14 | 1990-02-13 | Toyo Jozo Co., Ltd. | Preparation which promotes the absorption of peptides |
| GB2092136B (en) * | 1981-01-17 | 1985-06-05 | Mitsui Toatsu Chemicals | Production of n-substituted amide compounds |
| JPS58140026A (ja) * | 1982-01-14 | 1983-08-19 | Toyo Jozo Co Ltd | 吸収性良好な製剤 |
| FR2509175B1 (fr) | 1981-03-06 | 1987-01-16 | Toyo Jozo Kk | Preparation therapeutique ayant d'excellentes proprietes d'absorption |
| US4499299A (en) * | 1981-12-30 | 1985-02-12 | Ici Americas Inc. | Pharmaceutically active phenylcarboxylic acid derivatives |
| US4654327A (en) * | 1982-04-21 | 1987-03-31 | Research Corp. | Quaternary ammonium complexes of heparin |
| US4393192A (en) * | 1982-12-21 | 1983-07-12 | The Standard Oil Company | Crystalline copolymers prepared from N,N'-terephthaloyldi-beta-alanine and a glycol |
| DE3331009A1 (de) * | 1983-08-27 | 1985-03-14 | Basf Ag, 6700 Ludwigshafen | Verfahren zur erhoehung der enteralen resorbierbarkeit von heparin bzw. heparinoiden sowie das so erhaeltliche heparin- bzw. heparinoidpraeparat |
| US4692433A (en) * | 1983-10-12 | 1987-09-08 | The Regents Of The University Of California | Method and composition for regulating serum calcium levels of mammals |
| US4898729A (en) * | 1983-12-09 | 1990-02-06 | Euroceltique, S.A. | Treatment of hypertension, compounds and compositions for antihypertension and diuresis |
| US4757066A (en) * | 1984-10-15 | 1988-07-12 | Sankyo Company Limited | Composition containing a penem or carbapenem antibiotic and the use of the same |
| CA1234561A (en) | 1985-06-26 | 1988-03-29 | Kenneth M. White | Profiled body roller-reamer stabilizer |
| IL77186A0 (en) | 1985-11-29 | 1986-04-29 | Touitou Elka | Pharmaceutical insulin composition |
| US4689182A (en) | 1985-12-20 | 1987-08-25 | Warner-Lambert Company | Benzoic acid and benzoic acid ester derivatives having anti-inflammatory and analgesic activity |
| LU86258A1 (fr) * | 1986-01-21 | 1987-09-03 | Rech Dermatologiques C I R D S | Composes benzamido aromatique,leur procede de preparation et leur utilisation en medecine humaine ou veterinaire et en cosmetique |
| USRE35862E (en) * | 1986-08-18 | 1998-07-28 | Emisphere Technologies, Inc. | Delivery systems for pharmacological agents encapsulated with proteinoids |
| GB8705477D0 (en) | 1987-03-09 | 1987-04-15 | Carlton Med Prod | Drug delivery systems |
| JPH0725725B2 (ja) * | 1987-07-23 | 1995-03-22 | 保土谷化学工業株式会社 | ベンズアミド誘導体 |
| FR2636238B1 (fr) * | 1988-09-14 | 1994-01-21 | Morelle Jean | Nouvelles compositions antisudorales |
| GB8823731D0 (en) | 1988-10-10 | 1988-11-16 | Smith Kline French Lab | Biologically active compounds |
| FR2639395B1 (fr) | 1988-11-18 | 1991-02-15 | Rockwell Cim | Dispositif d'accouplement entre une vitre et un mecanisme de leve-vitre a bras oscillants dans un vehicule automobile |
| JPH02239980A (ja) | 1989-03-15 | 1990-09-21 | Fuji Photo Film Co Ltd | 感熱記録材料 |
| GB9007052D0 (en) * | 1990-03-29 | 1990-05-30 | Skua Investments Ltd | Pharmaceutical formulations |
| US5541155A (en) * | 1994-04-22 | 1996-07-30 | Emisphere Technologies, Inc. | Acids and acid salts and their use in delivery systems |
| US6099856A (en) * | 1992-06-15 | 2000-08-08 | Emisphere Technologies, Inc. | Active agent transport systems |
| US5629020A (en) * | 1994-04-22 | 1997-05-13 | Emisphere Technologies, Inc. | Modified amino acids for drug delivery |
| US6221367B1 (en) * | 1992-06-15 | 2001-04-24 | Emisphere Technologies, Inc. | Active agent transport systems |
| US5714167A (en) * | 1992-06-15 | 1998-02-03 | Emisphere Technologies, Inc. | Active agent transport systems |
| US5447728A (en) * | 1992-06-15 | 1995-09-05 | Emisphere Technologies, Inc. | Desferrioxamine oral delivery system |
| US5451410A (en) * | 1993-04-22 | 1995-09-19 | Emisphere Technologies, Inc. | Modified amino acids for encapsulating active agents |
| AU653026B2 (en) | 1991-06-07 | 1994-09-15 | Teikoku Seiyaku Kabushiki Kaisha | Physiologically active polypeptide-containing pharmaceutical composition |
| US5352461A (en) * | 1992-03-11 | 1994-10-04 | Pharmaceutical Discovery Corporation | Self assembling diketopiperazine drug delivery system |
| US5811127A (en) * | 1992-06-15 | 1998-09-22 | Emisphere Technologies, Inc. | Desferrioxamine oral delivery system |
| US5792451A (en) * | 1994-03-02 | 1998-08-11 | Emisphere Technologies, Inc. | Oral drug delivery compositions and methods |
| HU211995B (en) | 1992-06-30 | 1996-01-29 | Gyogyszerkutato Intezet | Process to prepare novel benzoyl amino acid derivs. and pharmaceutical compns. contg.them |
| EP0696208B1 (de) * | 1993-04-22 | 2001-08-22 | Emisphere Technologies, Inc. | Orale darreichungsform |
| US5958457A (en) * | 1993-04-22 | 1999-09-28 | Emisphere Technologies, Inc. | Compositions for the delivery of antigens |
| US5709861A (en) * | 1993-04-22 | 1998-01-20 | Emisphere Technologies, Inc. | Compositions for the delivery of antigens |
| US5643957A (en) * | 1993-04-22 | 1997-07-01 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5965121A (en) * | 1995-03-31 | 1999-10-12 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US6001347A (en) * | 1995-03-31 | 1999-12-14 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5650386A (en) * | 1995-03-31 | 1997-07-22 | Emisphere Technologies, Inc. | Compositions for oral delivery of active agents |
| BR9604880A (pt) * | 1995-03-31 | 1998-05-19 | Emisphere Tech Inc | Composto composição forma de unidade de dosagem métodos para administração de um agente biologicamente ativo para preparar uma composição para administração de um agente ativo e para preparar um composto e composição farmacológica |
| US5989539A (en) * | 1995-03-31 | 1999-11-23 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5866536A (en) * | 1995-03-31 | 1999-02-02 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US6090958A (en) * | 1995-03-31 | 2000-07-18 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5750147A (en) * | 1995-06-07 | 1998-05-12 | Emisphere Technologies, Inc. | Method of solubilizing and encapsulating itraconazole |
| US6051258A (en) | 1995-06-07 | 2000-04-18 | Emisphere Technologies, Inc. | Proteinoid emulsions and methods for preparation and use thereof |
| SI9720025A (sl) * | 1996-03-29 | 1999-08-31 | Emishphere Technologies, Inc. | Spojine in sestavki za prenos aktivne snovi |
| GB2314189B (en) | 1996-06-14 | 2000-08-09 | Mars Inc | Coin handling apparatus |
| US5879681A (en) * | 1997-02-07 | 1999-03-09 | Emisphere Technolgies Inc. | Compounds and compositions for delivering active agents |
| US5776888A (en) * | 1997-02-07 | 1998-07-07 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5804688A (en) * | 1997-02-07 | 1998-09-08 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5876710A (en) * | 1997-02-07 | 1999-03-02 | Emisphere Technologies Inc. | Compounds and compositions for delivering active agents |
| US5773647A (en) * | 1997-02-07 | 1998-06-30 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US6313088B1 (en) * | 1997-02-07 | 2001-11-06 | Emisphere Technologies, Inc. | 8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents |
| ES2263428T3 (es) * | 1997-02-07 | 2006-12-16 | Emisphere Technologies, Inc. | Compuesto y composicion para agentes activos de administracion. |
| US6051561A (en) * | 1997-02-07 | 2000-04-18 | Emisphere Technologies Inc. | Compounds and compositions for delivering active agents |
| US5990166A (en) * | 1997-02-07 | 1999-11-23 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US6060513A (en) * | 1997-02-07 | 2000-05-09 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5939381A (en) * | 1997-02-07 | 1999-08-17 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5863944A (en) * | 1997-04-30 | 1999-01-26 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| AR017426A1 (es) * | 1997-12-08 | 2001-09-05 | Smithkline Beecham Corp | Sal de monoargininilo del acido (e)-3-[1-n-butil-5-[2-(2-carboxifenil)metoxi-4-clorofenil]-1h-pirazol-4-il]-2-[(5-metoxi-2,3-dihidrobenzofuran-6-il)metil]-prop-2-enoico, composicion farmaceutica que la contiene, su uso para la manufactura de un medicamento y procedimiento para su preparacion |
| DE69925276T2 (de) | 1998-07-27 | 2005-10-06 | Emisphere Technologies, Inc. | Stoffe und zusammensetzungen für die verabreichung aktiver substanzen |
| TR200100366T2 (tr) | 1998-08-07 | 2001-11-21 | Emisphere Technologies, Inc. | Aktif madde dağıtmaya mahsus bileşikler ve bileşimler. |
| US6066015A (en) | 1998-08-17 | 2000-05-23 | Brown; James D. | Method and system for anchoring a buoy via a screw-type anchor |
| WO2000048589A1 (en) | 1999-02-22 | 2000-08-24 | Emisphere Holdings, Inc. | Solid oral dosage form containing heparin or a heparinoid in combination with a carrier |
| ATE288415T1 (de) * | 1999-04-05 | 2005-02-15 | Emisphere Tech Inc | Dinatrium-salze, monohydrate und ethanol-solvate |
| US7049283B2 (en) | 2000-12-06 | 2006-05-23 | Novartis Ag | Pharmaceutical compositions for the oral delivery of pharmacologically active agents |
| BRPI0615081A2 (pt) | 2005-08-25 | 2011-05-03 | Univ Arizona State | método para modelar migração de célula de cáncer não-linfócita, método para triagem de efeito de um agente quìmico ou biólogo, método para inibir migração de célula de tumor não-linfócita |
| US20070048725A1 (en) | 2005-08-25 | 2007-03-01 | Arrington Ben O'mar | Machine perfusion of tissue grafts for transplantation |
| WO2011048589A2 (en) | 2009-10-23 | 2011-04-28 | Ben Gurion University Of The Negev Research And Development Authority | Ion exchangers and methods of use thereof |
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2000
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- 2000-04-05 ES ES00921909T patent/ES2235854T3/es not_active Expired - Lifetime
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- 2000-04-05 JP JP2000609376A patent/JP4588221B2/ja not_active Expired - Lifetime
- 2000-04-05 EP EP00921909A patent/EP1175390B1/de not_active Expired - Lifetime
- 2000-04-05 CA CA2369591A patent/CA2369591C/en not_active Expired - Lifetime
- 2000-04-05 NZ NZ534409A patent/NZ534409A/xx not_active IP Right Cessation
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- 2000-04-05 DE DE60017888T patent/DE60017888T2/de not_active Expired - Lifetime
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2001
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- 2001-09-24 US US09/962,794 patent/US20020065255A1/en not_active Abandoned
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2003
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Also Published As
| Publication number | Publication date |
|---|---|
| EP1175390A4 (de) | 2002-09-04 |
| US8207227B2 (en) | 2012-06-26 |
| US20110251125A1 (en) | 2011-10-13 |
| JP2002541132A (ja) | 2002-12-03 |
| IL180118A (en) | 2010-12-30 |
| IL145546A (en) | 2007-10-31 |
| IL166158A0 (en) | 2006-01-15 |
| EP1175390A1 (de) | 2002-01-30 |
| AU4216700A (en) | 2000-10-23 |
| WO2000059863A1 (en) | 2000-10-12 |
| IL180118A0 (en) | 2007-06-03 |
| US8003697B2 (en) | 2011-08-23 |
| CA2369591C (en) | 2011-06-14 |
| US8658695B2 (en) | 2014-02-25 |
| US20020065255A1 (en) | 2002-05-30 |
| US7384982B2 (en) | 2008-06-10 |
| US20080269134A1 (en) | 2008-10-30 |
| ATE288415T1 (de) | 2005-02-15 |
| IL145546A0 (en) | 2002-06-30 |
| HK1045680A1 (en) | 2002-12-06 |
| EP1175390B1 (de) | 2005-02-02 |
| US20120264834A1 (en) | 2012-10-18 |
| DE60017888T2 (de) | 2006-01-19 |
| NZ534409A (en) | 2006-03-31 |
| JP4588221B2 (ja) | 2010-11-24 |
| JP2005068161A (ja) | 2005-03-17 |
| IL166158A (en) | 2010-12-30 |
| JP4642435B2 (ja) | 2011-03-02 |
| CA2369591A1 (en) | 2000-10-12 |
| US20040106825A1 (en) | 2004-06-03 |
| US7659311B2 (en) | 2010-02-09 |
| US20100099621A1 (en) | 2010-04-22 |
| ES2235854T3 (es) | 2005-07-16 |
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