RU2004126145A - N-{[(2s)-4-(3,4-дифторбензил)морфолин-2ил]-метил}-2-{3- [(метилсульфонил)амино]фени л}ацетамид в качестве антагониста ccr-3 для лечения восполительных состояний - Google Patents
N-{[(2s)-4-(3,4-дифторбензил)морфолин-2ил]-метил}-2-{3- [(метилсульфонил)амино]фени л}ацетамид в качестве антагониста ccr-3 для лечения восполительных состояний Download PDFInfo
- Publication number
- RU2004126145A RU2004126145A RU2004126145/04A RU2004126145A RU2004126145A RU 2004126145 A RU2004126145 A RU 2004126145A RU 2004126145/04 A RU2004126145/04 A RU 2004126145/04A RU 2004126145 A RU2004126145 A RU 2004126145A RU 2004126145 A RU2004126145 A RU 2004126145A
- Authority
- RU
- Russia
- Prior art keywords
- treatment
- compound
- formula
- difluorbenzene
- phenies
- Prior art date
Links
- GOYDNIKZWGIXJT-UHFFFAOYSA-N 1,2-difluorobenzene Chemical compound FC1=CC=CC=C1F GOYDNIKZWGIXJT-UHFFFAOYSA-N 0.000 title 1
- 102100024167 C-C chemokine receptor type 3 Human genes 0.000 title 1
- 101710149862 C-C chemokine receptor type 3 Proteins 0.000 title 1
- -1 METHYLSULPHONYL Chemical class 0.000 title 1
- DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 3
- 125000003277 amino group Chemical group 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 230000004968 inflammatory condition Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Claims (9)
1. Соединение формулы (I)
и его соли и сольваты.
2. Способ получения соединения формулы (I) или его соли или сольвата, включающий сочетание соединения формулы (II) или его соли с соединением формулы (III)
3. Соединение по п.1 для использованиия в качестве терапевтического агента.
4. Способ лечения человека или животного, страдающего воспалительным состоянием или восприимчивого к нему, включающий введение эффективного количества соединения по п.1.
5. Фармацевтическая композиция, содержащая соединение по п.1 и физиологически приемлемый носитель для него.
6. Соединение формулы (II)
7. Соединение формулы (IIBR)
где А представляет собой защищенную аминогруппу.
8. Соединение формулы (IIB)
где А представляет собой защищенную аминогруппу.
9. Соединение формулы (V)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0207449.0A GB0207449D0 (en) | 2002-03-28 | 2002-03-28 | Novel compounds |
| GB0207449.0 | 2002-03-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2004126145A true RU2004126145A (ru) | 2005-06-27 |
Family
ID=9933998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2004126145/04A RU2004126145A (ru) | 2002-03-28 | 2003-03-27 | N-{[(2s)-4-(3,4-дифторбензил)морфолин-2ил]-метил}-2-{3- [(метилсульфонил)амино]фени л}ацетамид в качестве антагониста ccr-3 для лечения восполительных состояний |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US20060058299A1 (ru) |
| EP (1) | EP1487453B1 (ru) |
| JP (1) | JP4490110B2 (ru) |
| KR (1) | KR20040095347A (ru) |
| CN (1) | CN1642553A (ru) |
| AR (1) | AR039177A1 (ru) |
| AT (1) | ATE454892T1 (ru) |
| AU (1) | AU2003216905A1 (ru) |
| BR (1) | BR0308719A (ru) |
| CA (1) | CA2479910A1 (ru) |
| DE (1) | DE60330952D1 (ru) |
| ES (1) | ES2339436T3 (ru) |
| GB (1) | GB0207449D0 (ru) |
| IL (1) | IL163648A0 (ru) |
| IS (1) | IS7415A (ru) |
| MX (1) | MXPA04009458A (ru) |
| NO (1) | NO20044098L (ru) |
| PL (1) | PL372930A1 (ru) |
| RU (1) | RU2004126145A (ru) |
| TW (1) | TW200400823A (ru) |
| WO (1) | WO2003082291A1 (ru) |
| ZA (1) | ZA200406990B (ru) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2514824C2 (ru) * | 2008-07-31 | 2014-05-10 | Санофи-Авентис | Пирролидинилалкиламидные производные, их получение и терапевтическое применение в качестве лигандов рецептора ccr3 |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003275257A1 (en) | 2002-09-26 | 2004-04-19 | Bristol-Myers Squibb Company | N-substituted heterocyclic amines as modulators of chemokine receptor activity |
| JP2009501792A (ja) * | 2005-07-21 | 2009-01-22 | アストラゼネカ・アクチエボラーグ | ケモカイン受容体のモジュレーターとしてのｎ−ベンジル−モルホリン誘導体 |
| EP1931620A1 (en) * | 2005-09-22 | 2008-06-18 | Sanofi-Aventis | Amino-alkyl-amide derivatives as ccr3 receptor liquids |
| HUP0500886A2 (en) * | 2005-09-23 | 2007-05-29 | Sanofi Aventis | Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use |
| HUP0500877A2 (en) * | 2005-09-22 | 2007-05-29 | Sanofi Aventis | Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use and intermediates |
| EP2785338A1 (en) * | 2011-12-01 | 2014-10-08 | Glaxo Group Limited | Methods of treatment and prevention of eye diseases |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS562929A (en) * | 1979-06-21 | 1981-01-13 | Sumitomo Chem Co Ltd | Preparation of optically active cyclopentenolone |
| CZ284687B6 (cs) * | 1986-04-30 | 1999-02-17 | Dainippon Pharmaceutical Co., Ltd. | Substituovaný benzamidový derivát, způsob jeho výroby a farmaceutický prostředek na jeho bázi |
| JPH01117882A (ja) * | 1987-10-30 | 1989-05-10 | Dainippon Pharmaceut Co Ltd | 複素環式カルボン酸アミド誘導体 |
| JPH03291274A (ja) * | 1990-04-09 | 1991-12-20 | Yoshitomi Pharmaceut Ind Ltd | アミノアルキルモルホリン誘導体の製造法 |
| JPH04270272A (ja) * | 1991-02-25 | 1992-09-25 | Yoshitomi Pharmaceut Ind Ltd | アミノアルキルモルホリン誘導体の製造法 |
| TW223629B (ru) * | 1992-03-06 | 1994-05-11 | Hoffmann La Roche | |
| US5219856A (en) * | 1992-04-06 | 1993-06-15 | E. I. Du Pont De Nemours And Company | Angiotensin-II receptor blocking, heterocycle substituted imidazoles |
| US6031097A (en) * | 1997-10-27 | 2000-02-29 | Neurogen Corporation | 1-(N-(arylalkylaminoalkyl) aminoisoquinolines; a new class of dopamine receptor subtype specific ligands |
| WO2000035877A1 (en) * | 1998-12-18 | 2000-06-22 | Du Pont Pharmaceuticals Company | Heterocyclic piperidines as modulators of chemokine receptor activity |
| AU7577200A (en) * | 1999-09-14 | 2001-04-17 | Aventis Pharmaceuticals Inc. | Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as D4 antagonists |
| MXPA03002814A (es) * | 2000-09-29 | 2003-10-14 | Glaxo Group Ltd | Derivados de morfolin-acetamida para el tratamiento de enfermedades inflamatorias. |
| US7157457B2 (en) * | 2000-09-29 | 2007-01-02 | Glaxo Group Limited | Compounds useful in the treatment of inflammatory diseases |
-
2002
- 2002-03-28 GB GBGB0207449.0A patent/GB0207449D0/en not_active Ceased
-
2003
- 2003-03-26 TW TW092106782A patent/TW200400823A/zh unknown
- 2003-03-27 JP JP2003579828A patent/JP4490110B2/ja not_active Expired - Lifetime
- 2003-03-27 PL PL03372930A patent/PL372930A1/xx not_active Application Discontinuation
- 2003-03-27 EP EP03712117A patent/EP1487453B1/en not_active Expired - Lifetime
- 2003-03-27 AR ARP030101090A patent/AR039177A1/es unknown
- 2003-03-27 AU AU2003216905A patent/AU2003216905A1/en not_active Abandoned
- 2003-03-27 IL IL16364803A patent/IL163648A0/xx unknown
- 2003-03-27 RU RU2004126145/04A patent/RU2004126145A/ru not_active Application Discontinuation
- 2003-03-27 WO PCT/EP2003/003339 patent/WO2003082291A1/en active Application Filing
- 2003-03-27 AT AT03712117T patent/ATE454892T1/de not_active IP Right Cessation
- 2003-03-27 DE DE60330952T patent/DE60330952D1/de not_active Expired - Lifetime
- 2003-03-27 CN CNA038068656A patent/CN1642553A/zh active Pending
- 2003-03-27 KR KR10-2004-7015447A patent/KR20040095347A/ko not_active Withdrawn
- 2003-03-27 MX MXPA04009458A patent/MXPA04009458A/es unknown
- 2003-03-27 BR BR0308719-0A patent/BR0308719A/pt not_active Application Discontinuation
- 2003-03-27 ES ES03712117T patent/ES2339436T3/es not_active Expired - Lifetime
- 2003-03-27 US US10/509,417 patent/US20060058299A1/en not_active Abandoned
- 2003-03-27 CA CA002479910A patent/CA2479910A1/en not_active Abandoned
-
2004
- 2004-08-19 IS IS7415A patent/IS7415A/is unknown
- 2004-09-01 ZA ZA200406990A patent/ZA200406990B/en unknown
- 2004-09-27 NO NO20044098A patent/NO20044098L/no not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2514824C2 (ru) * | 2008-07-31 | 2014-05-10 | Санофи-Авентис | Пирролидинилалкиламидные производные, их получение и терапевтическое применение в качестве лигандов рецептора ccr3 |
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200406990B (en) | 2005-11-08 |
| US20060058299A1 (en) | 2006-03-16 |
| IS7415A (is) | 2004-08-19 |
| JP2005525390A (ja) | 2005-08-25 |
| ATE454892T1 (de) | 2010-01-15 |
| TW200400823A (en) | 2004-01-16 |
| MXPA04009458A (es) | 2005-07-27 |
| IL163648A0 (en) | 2005-12-18 |
| EP1487453A1 (en) | 2004-12-22 |
| CA2479910A1 (en) | 2003-10-09 |
| BR0308719A (pt) | 2005-01-04 |
| CN1642553A (zh) | 2005-07-20 |
| EP1487453B1 (en) | 2010-01-13 |
| GB0207449D0 (en) | 2002-05-08 |
| JP4490110B2 (ja) | 2010-06-23 |
| NO20044098L (no) | 2004-10-04 |
| AU2003216905A1 (en) | 2003-10-13 |
| AR039177A1 (es) | 2005-02-09 |
| DE60330952D1 (de) | 2010-03-04 |
| ES2339436T3 (es) | 2010-05-20 |
| PL372930A1 (en) | 2005-08-08 |
| WO2003082291A1 (en) | 2003-10-09 |
| KR20040095347A (ko) | 2004-11-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| LU90956I2 (fr) | Metvix principe actif méthylaminolevulinique sous forme d'un selde préférence l'hyhrochlorure méthylaminolevulinique | |
| EP1862458A3 (en) | Therapeutic agents useful for treating pain | |
| ATE399782T1 (de) | Zur behandlung von schmerzen geeignete phenylcarbonsäureamidverbindungen | |
| RU2002109240A (ru) | Применение ретигабина для невропатических болей | |
| WO2005056524A3 (en) | Therapeutic agents useful for treating pain | |
| ATE375341T1 (de) | Thiadiazolylpiperazinderivate geeignet für die behandlung bzw. prävention von schmerzen | |
| EP2179987A3 (en) | Use of heterocyclic carbaldehyde derivatives against sickle cell anemia | |
| RU2010144637A (ru) | Замещенные гамма-лактамы в качестве терапевтических агентов | |
| ATE412646T1 (de) | Zur behandlung von schmerzen geeignete therapeutische mittel | |
| BR0316458A (pt) | Composto, composição farmacêutica, método de tratamento ou prevenção de doenças, método para intensificar a cognição em um paciente saudável, e, uso de um composto | |
| RU95112456A (ru) | Производные n-(3-пиперидинилкарбонил)-бета-аланина в качестве антагонистов фактора активации тромбоцитов (фат), способ получения, фармацевтическая композиция и способ лечения | |
| RU2004126145A (ru) | N-{[(2s)-4-(3,4-дифторбензил)морфолин-2ил]-метил}-2-{3- [(метилсульфонил)амино]фени л}ацетамид в качестве антагониста ccr-3 для лечения восполительных состояний | |
| ATE361918T1 (de) | 4-(4-methoxybenzyl)-n'-(5-nitro-1,3-thiazol-2- yl)harnstoff und dessen verwendung bei der behandlung von mit glycogensynthasekinase-3 (gsk3) assoziierten leiden | |
| BG106293A (en) | Method of inhibiting amyloid protein aggregation and imaging amyloid deposits | |
| DE60035429D1 (de) | Verwendung von sulfodehydroabietinsäure zur behandlung entzündlicher darmerkrankungen | |
| ATE361749T1 (de) | Benzthiazol-3 oxide zur behandlung von proliferativen störungen | |
| RU2005105691A (ru) | Пероральное введение кальцитонина | |
| JP2005525390A5 (ru) | ||
| DE602004022783D1 (de) | Heterozyklische harnstoff-derivate für die behandlung von schmerzen. | |
| RU2009127858A (ru) | Фармацевтическая композиция, включающая алискирен и авосентан | |
| RU2365594C2 (ru) | Применение циклических пептидов анабенопептинового типа для лечения состояния, при котором полезно ингибирование карбоксипептидазы u, новые анабенопептиновые производные и их промежуточные соединения | |
| EA200500687A1 (ru) | Применение дистронциевой соли 2-[n,n-ди(карбоксиметил)амино]-3-циано-4-карбоксиметилтиофен-5-карбоновой кислоты при получении лекарственных средств, предназначенных для лечения гастродуоденальной боли | |
| EA200300900A1 (ru) | Замещенные амины (варианты), способ их получения и их применение в качестве ингибиторов транспорта глицина (варианты), композиция (варианты), промежуточный иодид и способ его получения, способ лечения пациента (варианты) | |
| WO2005035500A3 (en) | Therapeutic agents useful for treating pain | |
| RU93009897A (ru) | 1-[ ω -(N,N-ЗАМЕЩЕННЫЕ АМИНО)АЛКИЛ]-2-(2′-АЦИЛЭТЕНИЛ)ПИРРОЛЫ И ИХ СОЛИ, ОБЛАДАЮЩИЕ АНТИАРИТМИЧЕСКОЙ И ПРОТИВОИШЕМИЧЕСКОЙ АКТИВНОСТЬЮ |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20060607 |