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DE60013287D1 - Früherkennung der flaviviren unter verwendung des ns1-glycoproteins - Google Patents

Früherkennung der flaviviren unter verwendung des ns1-glycoproteins

Info

Publication number
DE60013287D1
DE60013287D1 DE60013287T DE60013287T DE60013287D1 DE 60013287 D1 DE60013287 D1 DE 60013287D1 DE 60013287 T DE60013287 T DE 60013287T DE 60013287 T DE60013287 T DE 60013287T DE 60013287 D1 DE60013287 D1 DE 60013287D1
Authority
DE
Germany
Prior art keywords
early detection
glycoprotein
flavivires
flavivirus
infection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60013287T
Other languages
English (en)
Other versions
DE60013287T2 (de
Inventor
Marie Flamand
Francoise Megret
Sophie Alcon
Antoine Talarmin
Philippe Despres
Vincent Deubel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Pasteur
Original Assignee
Institut Pasteur
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9907290A external-priority patent/FR2794864A1/fr
Application filed by Institut Pasteur filed Critical Institut Pasteur
Publication of DE60013287D1 publication Critical patent/DE60013287D1/de
Application granted granted Critical
Publication of DE60013287T2 publication Critical patent/DE60013287T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1081—Togaviridae, e.g. flavivirus, rubella virus, hog cholera virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/18—Togaviridae; Flaviviridae
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2469/00—Immunoassays for the detection of microorganisms
    • G01N2469/10—Detection of antigens from microorganism in sample from host
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
DE60013287T 1999-06-09 2000-06-09 Früherkennung der flaviviren unter verwendung des ns1-glycoproteins Expired - Lifetime DE60013287T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
FR9907290A FR2794864A1 (fr) 1999-06-09 1999-06-09 Methode de detection precoce des flavivirus et ses applications
FR9907290 1999-06-09
FR9907361 1999-06-10
FR9907361A FR2794865B1 (fr) 1999-06-09 1999-06-10 Methode de detection precoce des flavivirus et ses applications
PCT/FR2000/001620 WO2000075665A1 (fr) 1999-06-09 2000-06-09 Detection precoce des flavivirus en utilisant la clycoproteine ns1

Publications (2)

Publication Number Publication Date
DE60013287D1 true DE60013287D1 (de) 2004-09-30
DE60013287T2 DE60013287T2 (de) 2005-09-15

Family

ID=26234982

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60013287T Expired - Lifetime DE60013287T2 (de) 1999-06-09 2000-06-09 Früherkennung der flaviviren unter verwendung des ns1-glycoproteins

Country Status (15)

Country Link
US (5) US6870032B1 (de)
EP (1) EP1190257B1 (de)
JP (1) JP4625215B2 (de)
KR (1) KR20020042533A (de)
CN (1) CN1360678B (de)
AT (1) ATE274701T1 (de)
AU (1) AU776844B2 (de)
BR (1) BRPI0011369B8 (de)
DE (1) DE60013287T2 (de)
ES (1) ES2226894T3 (de)
FR (1) FR2794865B1 (de)
HK (1) HK1045729B (de)
MX (1) MXPA01012662A (de)
PT (1) PT1190257E (de)
WO (1) WO2000075665A1 (de)

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FR2794865B1 (fr) * 1999-06-09 2003-04-18 Pasteur Institut Methode de detection precoce des flavivirus et ses applications
US20060204523A1 (en) * 2001-11-26 2006-09-14 Khromykh Alexander A Flavivirus vaccine delivery system
US7473424B2 (en) * 2003-01-31 2009-01-06 The Scripps Research Institute Anti-dengue virus antibodies and compositions
US7189403B2 (en) * 2003-06-30 2007-03-13 Institut Pasteur Attenuated flavivirus strains containing a mutated M-ectodomain and their applications
WO2005024427A2 (en) 2003-09-09 2005-03-17 Idexx Laboratories, Inc. Detection of west nile virus infection and vaccination
US7074555B2 (en) 2004-04-28 2006-07-11 Idexx Laboratories, Inc. Detection of West Nile Virus
FR2870126B1 (fr) * 2004-05-17 2009-07-17 Pasteur Institut Vecteur lentiviral recombinant d'expression d'une proteine de flaviviridae et ses applications comme vaccin
JP4813471B2 (ja) * 2004-06-18 2011-11-09 ノバルティス ヴァクシンズ アンド ダイアグノスティクス インコーポレイテッド ハンタウイルス感染の診断のための方法および試薬
FR2871888A1 (fr) * 2004-06-22 2005-12-23 Pasteur Institut Methode de diagnostic ou de depistage d'une infection clinique ou asymptomatique par un flavivirus du groupe encephalitique
US8222029B2 (en) 2005-05-16 2012-07-17 Institut Pasteur Lentiviral vector-based vaccine
US20070211241A1 (en) * 2006-02-24 2007-09-13 Noriyuki Aizawa Optical defect inspection apparatus
US7629117B2 (en) * 2006-06-20 2009-12-08 Mahidol University Determination of risk of developing dengue hemorrhagic fever/dengue shock syndrome, methods and compositions therefor
JP2010506166A (ja) * 2006-10-05 2010-02-25 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ デング熱の診断及び治療
CN101226196B (zh) * 2008-02-02 2012-05-09 南方医科大学 一种检测ⅱ型登革病毒ns1抗原的免疫诊断试剂盒
US20090275499A1 (en) * 2008-02-29 2009-11-05 Marie Flamand Nonstructural protein ns1 as a novel therapeutic target against flaviviruses
CN101551393B (zh) * 2009-04-02 2012-09-19 南方医科大学 一种检测ⅳ型登革病毒ns1抗原的免疫诊断试剂盒
US8920804B2 (en) 2011-12-22 2014-12-30 Inbios International, Inc. Methods and materials for the detection of dengue virus infection
US10046045B2 (en) 2013-12-20 2018-08-14 The Regents Of The University Of Michigan Vaccine compositions and uses thereof
FR3017714A1 (fr) * 2014-02-18 2015-08-21 Biomerieux Sa Procede et kit pour determiner la probabilite pour un patient d'evoluer vers une dengue severe
FR3017713B1 (fr) * 2014-02-18 2018-01-12 Biomerieux Procede et kit pour determiner la probabilite pour un patient d'evoluer vers une dengue severe
DE102014205098B4 (de) 2014-03-19 2016-02-04 Universität Leipzig Verfahren und Verwendungen von Mitteln zum Nachweis einer Denguevirus-Infektion
CN105445458A (zh) * 2015-11-13 2016-03-30 山东省滨州畜牧兽医研究院 鉴别鸭坦布苏病毒感染动物和灭活苗免疫动物的elisa检测试剂盒
EP3750916A3 (de) 2016-02-11 2021-03-24 Massachusetts Institute Of Technology Monoklonale antikörper gegen das denguevirus-ns1-protein
EP3420357B1 (de) 2016-02-22 2023-12-20 Euroimmun Medizinische Labordiagnostika AG Immunoassay zur diagnose von zika virusinfektion
BR112019021872A2 (pt) 2017-04-26 2020-06-02 F. Hoffmann-La Roche Ag Polipeptídeo, método de produção de um polipeptídeo, métodos para detectar anticorpos, usos de um polipeptídeo e kits de reagentes
WO2018208741A1 (en) * 2017-05-08 2018-11-15 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Methods and compositions for the detection of flavivirus infections
CN109053882B (zh) * 2018-08-28 2019-08-23 东莞市朋志生物科技有限公司 一种ns1蛋白的结合蛋白以及应用
KR102218517B1 (ko) * 2019-01-23 2021-02-19 충북대학교 산학협력단 단일클론항체 쌍을 이용한 지카 바이러스의 검출 방법
KR102218561B1 (ko) * 2019-01-28 2021-02-19 충북대학교 산학협력단 단일클론항체 쌍을 이용한 뎅기 바이러스의 검출 방법
AU2020356408A1 (en) 2019-09-25 2022-03-31 Centre National De La Recherche Scientifique - Cnrs - A novel complex formed between the flaviviral non-structural NS1 protein and plasma lipoproteins
CN113355344B (zh) * 2021-08-10 2021-11-02 北京溯本源和生物科技有限公司 一种流感病毒ns1蛋白的表达质粒、重组蛋白和特异性单克隆抗体及应用
CN113683690B (zh) * 2021-08-19 2023-05-23 中国科学院微生物研究所 针对黄热病毒ns1蛋白的抗体及其应用
CN113621058B (zh) * 2021-08-19 2023-05-23 中国科学院微生物研究所 黄热病毒抗体及其应用

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FR10904E (fr) 1909-11-09 David Rojat Filtre réalisant dans le meme appareil la stérilisation par les rayons ultra-violets et la filtration, applicable aux liquides
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DD297997A5 (de) * 1989-06-06 1992-01-30 @��@����@��������`������������@��������k�� Proteine, vakzine und nukleinsaeuren
GB9209243D0 (en) * 1992-04-29 1992-06-17 Univ Singapore Dengue virus
FR2794865B1 (fr) * 1999-06-09 2003-04-18 Pasteur Institut Methode de detection precoce des flavivirus et ses applications

Also Published As

Publication number Publication date
US6870032B1 (en) 2005-03-22
BRPI0011369B1 (pt) 2019-03-19
CN1360678A (zh) 2002-07-24
CN1360678B (zh) 2013-07-03
US20120009216A1 (en) 2012-01-12
FR2794865B1 (fr) 2003-04-18
US20090068213A1 (en) 2009-03-12
AU776844B2 (en) 2004-09-23
US20050186562A1 (en) 2005-08-25
JP4625215B2 (ja) 2011-02-02
EP1190257A1 (de) 2002-03-27
ATE274701T1 (de) 2004-09-15
EP1190257B1 (de) 2004-08-25
US7670766B2 (en) 2010-03-02
ES2226894T3 (es) 2005-04-01
US8709427B2 (en) 2014-04-29
AU6447400A (en) 2000-12-28
WO2000075665A1 (fr) 2000-12-14
FR2794865A1 (fr) 2000-12-15
PT1190257E (pt) 2004-12-31
KR20020042533A (ko) 2002-06-05
DE60013287T2 (de) 2005-09-15
BR0011369A (pt) 2003-08-12
JP2003501661A (ja) 2003-01-14
MXPA01012662A (es) 2004-03-19
US20090226478A1 (en) 2009-09-10
HK1045729B (zh) 2005-03-18
US7282341B2 (en) 2007-10-16
HK1045729A1 (en) 2002-12-06
BRPI0011369B8 (pt) 2021-05-25

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