DE508334C - Process for the production of sustainable solutions of arsenobenzenes - Google Patents
Process for the production of sustainable solutions of arsenobenzenesInfo
- Publication number
- DE508334C DE508334C DEI33493D DEI0033493D DE508334C DE 508334 C DE508334 C DE 508334C DE I33493 D DEI33493 D DE I33493D DE I0033493 D DEI0033493 D DE I0033493D DE 508334 C DE508334 C DE 508334C
- Authority
- DE
- Germany
- Prior art keywords
- arsenobenzenes
- pyrazolone
- production
- phenyl
- solutions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
Verfahren zur Herstellung haltbarer Lösungen von Arsenobenzolen Es wurde gefunden, däß die Haltbarkeit von Arsenobenzolen in wäßriger Lösung dadurch außerordentlich erhöht wird, daß man ihnen Pyrazolonderivate, die nicht saure Eigenschaften haben wie das i-Phenyl-2, 3-dimethyl-5-pyrazolon, i-Phenyl-2, 3, d.-trimethyl-5-pyrazolon, i-Phenyl-2, 3-dimethvl-.I-dimet'hylamino-5-pyrazolon usw. zusetzt. In vitr o ist die Stabilität derartiger Lösungen schon zu erkennen, wenn man sie mit Blut zusammenmischt. Während die nicht stabilen Lösungen ausflocken, bleiben die stabilen klar.Process for the preparation of durable solutions of arsenobenzenes Es it was found that the shelf life of arsenobenzenes in aqueous solution thereby It is greatly increased that they are given pyrazolone derivatives which do not have acidic properties have like i-phenyl-2, 3-dimethyl-5-pyrazolone, i-phenyl-2, 3, d.-trimethyl-5-pyrazolone, i-Phenyl-2, 3-dimethvl-.I-dimet'hylamino-5-pyrazolone, etc. added. In vitr o is to recognize the stability of such solutions just by mixing them with blood. While the unstable solutions flocculate, the stable ones remain clear.
Man stellt die stabilen Lösungen her, indem man die Pvrazolonverbindungen und Arsenobenzole bereits in festem Zustande vermischt und dann das Gemisch auflöst. Man kann aber auch den bereits fertigen Lösungen verschiedenster Konzentration der nicht sauren Pyrazolonderivate die Arsenobenzole hinzusetzen oder umgekehrt verfahren.The stable solutions are prepared by adding the pvrazolone compounds and arsenobenzenes already mixed in a solid state and then the mixture dissolves. But you can also use the ready-made solutions of various concentrations of the Add the arsenobenzenes to non-acidic pyrazolone derivatives, or vice versa.
Am vorteilhaftesten läßt sich das Verfahren bei solchen Arsenobenzolen anwenden, «-elche Keto- oder Aldehvdgruppen im Molekül enthalten, auch wenn die Keto- oder Aldehydgruppen ihr Sauerstoffatom gegen stickstoffhaltige Reste ausgetauscht haben, wie es bei der Umsetzung mit Sernicarbazid der Fall ist.The process works most advantageously with such arsenobenzenes apply, «- which contain keto or aldehyde groups in the molecule, even if the Keto or aldehyde groups have exchanged their oxygen atom for nitrogen-containing radicals as is the case with the implementation with sernicarbazide.
Beispiele i. In i0 ccm einer iprozentigen Lösung von i Plienyl-2, 3-dimethyl-5-pyrazolon löst man o,2 g Dinatriumphenolat des Semicarbazons des 3-Oxv-d.-arsenobenzaldehvds (i) auf. Die Lösung kann sofort verwendet werden. 2. 0.21- Dinatriumphenolat des Sernicarbazons des 3-Oxy-.I-arsenobenzaldehyds (i) werden mit o, i g i-Phenyl-2, 3-dimethyl-5-pyrazolon gemischt und bei Bedarf in 8 ccm Wasser gelöst. Das Verhältnis zwischen dem i-Phenyl-2, 3-dimethyl-5-pyrazolon und der Arsenoverbindung kann auch geändert werden.Examples i. In 10 cc of an i% solution of i Plienyl-2, 3-dimethyl-5-pyrazolone is dissolved in 0.2 g of disodium phenolate of the semicarbazone of 3-Oxv-d.-arsenobenzaldehyde (i) on. The solution can be used immediately. 2.21- disodium phenolate des Sernicarbazones of 3-oxy-.I-arsenobenzaldehyde (i) are combined with o, i g i-phenyl-2, 3-dimethyl-5-pyrazolone mixed and, if necessary, dissolved in 8 cc of water. The relationship between the i-phenyl-2, 3-dimethyl-5-pyrazolone and the arseno compound can also be changed.
3. 0,2g Dinatriumphenolat des Semicarbazons des 3-Oxv-d.-arsenobenzaldehvds (i) «-erden mit o,i g i-Phenyl-2, 3-dimethvl-.I-dimethylamino-5-pyrazolon gemischt und bei Bedarf in 8 ccm Wasser gelöst. Das Verhältnis zwischen dem i-Phenvl-2, 3-dimethvl-4-dimethylamino-5-pyrazolon und der Arsenoverbindung kann auch geändert werden.3. 0.2g disodium phenolate of the semicarbazone des 3-Oxv-d.-arsenobenzaldehvds (i) «earths mixed with o, i g i-phenyl-2, 3-dimethyl-.I-dimethylamino-5-pyrazolone and if necessary dissolved in 8 cc of water. The ratio between the i-Phenvl-2, 3-dimethvl-4-dimethylamino-5-pyrazolone and the arsenic compound can also be changed.
.I. 0,2 g Dinatriumphenolat des d.-Arseno-2-oxybenzaldehyds werden mit o,i g i-Phenyl-2, 3-dimethyl-5-pyrazolon gemischt und bei Bedarf in 8 ccm Wasser gelöst..I. 0.2 g of disodium phenolate of d.-arseno-2-oxybenzaldehyde mixed with o, i g i-phenyl-2,3-dimethyl-5-pyrazolone and, if necessary, in 8 cc of water solved.
5. 0,2- Dinatriump'henolat des Semicarbazons von . Arseno-3-oxvacetophenon mischt man mit o, i g i-Phenyl-2, 3-dimethyl-5-pyrazolon und löst die Mischung bei Bedarf in 8 ccm Wasser.5. 0,2- disodium phenolate of semicarbazone of. Arseno-3-oxvacetophenone is mixed with o, ig i-phenyl-2,3-dimethyl-5-pyrazolone and, if necessary, the mixture is dissolved in 8 cc of water.
C. 0,2 g d. Arseno-3-oxvacetoplienon werden mit o, i g i-Phenyl-2, 3-dimethylpyrazolon gemischt und bei Bedarf in 8 ccm Wasser gelöst.C. 0.2 g d. Arseno-3-oxvacetoplienon are combined with o, i g i-phenyl-2, 3-dimethylpyrazolone mixed and, if necessary, dissolved in 8 cc of water.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEI33493D DE508334C (en) | 1928-02-10 | 1928-02-10 | Process for the production of sustainable solutions of arsenobenzenes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEI33493D DE508334C (en) | 1928-02-10 | 1928-02-10 | Process for the production of sustainable solutions of arsenobenzenes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE508334C true DE508334C (en) | 1930-09-27 |
Family
ID=7188434
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEI33493D Expired DE508334C (en) | 1928-02-10 | 1928-02-10 | Process for the production of sustainable solutions of arsenobenzenes |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE508334C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE937373C (en) * | 1952-11-08 | 1956-01-05 | Hoechst Ag | Process for the production of aqueous pharmaceutical solutions |
| DE940060C (en) * | 1952-08-01 | 1956-03-08 | Hoechst Ag | Process for the production of aqueous solutions of drugs that are poorly soluble in water |
-
1928
- 1928-02-10 DE DEI33493D patent/DE508334C/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE940060C (en) * | 1952-08-01 | 1956-03-08 | Hoechst Ag | Process for the production of aqueous solutions of drugs that are poorly soluble in water |
| DE937373C (en) * | 1952-11-08 | 1956-01-05 | Hoechst Ag | Process for the production of aqueous pharmaceutical solutions |
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