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DE410365C - Process for the preparation of a colloidally soluble heavy metal salt of 2-phenylquinoline-4-carboxylic acid - Google Patents

Process for the preparation of a colloidally soluble heavy metal salt of 2-phenylquinoline-4-carboxylic acid

Info

Publication number
DE410365C
DE410365C DER52709D DER0052709D DE410365C DE 410365 C DE410365 C DE 410365C DE R52709 D DER52709 D DE R52709D DE R0052709 D DER0052709 D DE R0052709D DE 410365 C DE410365 C DE 410365C
Authority
DE
Germany
Prior art keywords
phenylquinoline
carboxylic acid
heavy metal
metal salt
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DER52709D
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CARL PAAL DR
Original Assignee
CARL PAAL DR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CARL PAAL DR filed Critical CARL PAAL DR
Priority to DER52709D priority Critical patent/DE410365C/en
Application granted granted Critical
Publication of DE410365C publication Critical patent/DE410365C/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/50—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4
    • C07D215/52—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 4 with aryl radicals attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Colloid Chemistry (AREA)

Description

Verfahren zur Darstellung eines kolloidal löslichen Schwermetallsalzes der 2-Phenylchinolin-4-carbonsäure. Das Silbersalz der 2-Phenylchinolin-4-carbonsäure ist in Wasser nahezu unlöslich, wodurch seine therapeutische Verwendung erheblich beeinträchtigt wird. Es ist nun gelungen, dieses Salz in eine besonders wirksame Form überzuführen. Erzeugt man nämlich das Salz in Gegenwart von Eiweißstoffen oder ihren Abbauprodukten oder behandelt man es mit Lösungen dieser Stoffe, so erhält man in beiden Fällen kolloidale Lösungen, aus denen man, gegebenenfalls nach vorheriger Dialyse, das Salz durch Eindampfen oder Fällen mittels organischer Lösungsmittel, beispielsweise Alkohol oder Aceton, gewinnen kann. Mit Vorteil lassen sich bei der Herstellung des neuen Produktes Nucleinsäure, Casein, Protalbin- und Lysalbinsäure verwenden. Das Silbersalz der 2-Phenylchinolin-4-carbonsäure zeichnet sich durch besonders helle Farbe aus. Seine Lösungen weisen den großen Vorzug der Haltbarkeit, und Kochbeständigkeit auf, es tritt beim Kochen nicht einmal eine Farbveränderung auf. Diese Beständigkeit eines Silbersalzes in Gegenwart organischer Stoffe ist ganz besonders auffallend und wertvoll. Das neue Produkt übt eine spezifische Wirkung auf das Trachom aus. Außerdem zeichnet es sich durch besondere Schmerzlosigkeit bei der Injektion aus.Process for the preparation of a colloidally soluble heavy metal salt of 2-phenylquinoline-4-carboxylic acid. The silver salt of 2-phenylquinoline-4-carboxylic acid is almost insoluble in water, which makes its therapeutic use considerable is affected. It has now been possible to turn this salt into a particularly effective one Transfer form. If you produce the salt in the presence of proteins or their breakdown products or if it is treated with solutions of these substances, this is how it is obtained one in both cases colloidal solutions, from which one, if necessary after previous Dialysis, the salt by evaporation or precipitation with organic solvents, for example alcohol or acetone, can win. With the Production of the new product nucleic acid, casein, protalbinic and lysalbic acid use. The silver salt of 2-phenylquinoline-4-carboxylic acid is characterized by particularly light color. His solutions have the great advantage of durability, and boil resistance, there is not even a change in color when boiled on. This resistance of a silver salt in the presence of organic substances is particularly striking and valuable. The new product has a specific effect on the trachoma. It is also characterized by particular painlessness when injecting.

B e i s p i e 1 : Eine Lösung von protalbinsaurem Natrium wird so lange mit Silbernitratlösung versetzt, bis die zunächst entstandene Fällung beim Umrühren wieder verschwindet. Man läßt hierauf eine der verbrauchten Silbermenge äquivalente Menge von 2-phenylchinolin-4-carbonsaurem Natrium in wäßriger Lösung hinzufließen, wobei man die Flüssigkeit in steter Bewegung erhält. Die entstandene Lösung unterwirft man nun der Dialyse und dampft sie schließlich unter Benutzung eines Vakuums zum Trocknen ein. Der erhaltene Rückstand ist fast farblos und in Wasser leicht löslich. Der Silbergehalt beträgt etwa ro Prozent. Mit Wasser erhält man kochbeständige, kolloidale Lösungen.Example 1: A solution of sodium protalbinate will do so mixed with silver nitrate solution for a long time until the precipitate initially formed in the Stirring disappears again. One then leaves one of the silver consumed equivalent amount of 2-phenylquinoline-4-carboxylic acid sodium in aqueous solution to flow in, whereby the liquid is kept in constant motion. The resulting The solution is now subjected to dialysis and finally steamed using it a vacuum to dry. The residue obtained is almost colorless and in Easily soluble in water. The silver content is around ro percent. Preserves with water one boil-resistant, colloidal solutions.

Claims (1)

PATENTANSPRUCH: Verfahren zur Herstellung eines kolloidal löslichen Schwermetallsalzes der 2-Phenylchinolin-4-carbonsäure, dadurch gekennzeichnet, daß man entweder das Silbersalz der Säure bei Gegenwart von Eiweißstoffen oder deren Abbauprodukten erzeugt oder das frisch gefällte Salz mit Lösungen dieser Stoffe behandelt.PATENT CLAIM: Process for the production of a colloidally soluble one Heavy metal salt of 2-phenylquinoline-4-carboxylic acid, characterized in that either the silver salt of the acid in the presence of proteins or their Decomposition products or the freshly precipitated salt with solutions of these substances treated.
DER52709D 1921-03-30 1921-03-30 Process for the preparation of a colloidally soluble heavy metal salt of 2-phenylquinoline-4-carboxylic acid Expired DE410365C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DER52709D DE410365C (en) 1921-03-30 1921-03-30 Process for the preparation of a colloidally soluble heavy metal salt of 2-phenylquinoline-4-carboxylic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DER52709D DE410365C (en) 1921-03-30 1921-03-30 Process for the preparation of a colloidally soluble heavy metal salt of 2-phenylquinoline-4-carboxylic acid

Publications (1)

Publication Number Publication Date
DE410365C true DE410365C (en) 1925-03-03

Family

ID=7409256

Family Applications (1)

Application Number Title Priority Date Filing Date
DER52709D Expired DE410365C (en) 1921-03-30 1921-03-30 Process for the preparation of a colloidally soluble heavy metal salt of 2-phenylquinoline-4-carboxylic acid

Country Status (1)

Country Link
DE (1) DE410365C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2776290A (en) * 1957-01-01 Hydroxy cevchoninates and carboxylic

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2776290A (en) * 1957-01-01 Hydroxy cevchoninates and carboxylic

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