DE117269C - - Google Patents
Info
- Publication number
- DE117269C DE117269C DENDAT117269D DE117269DA DE117269C DE 117269 C DE117269 C DE 117269C DE NDAT117269 D DENDAT117269 D DE NDAT117269D DE 117269D A DE117269D A DE 117269DA DE 117269 C DE117269 C DE 117269C
- Authority
- DE
- Germany
- Prior art keywords
- bismuth
- water
- solution
- solutions
- bismuth nitrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- RXPAJWPEYBDXOG-UHFFFAOYSA-N hydron;methyl 4-methoxypyridine-2-carboxylate;chloride Chemical compound Cl.COC(=O)C1=CC(OC)=CC=N1 RXPAJWPEYBDXOG-UHFFFAOYSA-N 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 6
- 102000004169 proteins and genes Human genes 0.000 claims description 5
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- 229910017604 nitric acid Inorganic materials 0.000 claims description 4
- 230000015271 coagulation Effects 0.000 claims description 3
- 238000005345 coagulation Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- 239000011780 sodium chloride Substances 0.000 claims description 2
- QGWDKKHSDXWPET-UHFFFAOYSA-E pentabismuth;oxygen(2-);nonahydroxide;tetranitrate Chemical class [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[O-2].[Bi+3].[Bi+3].[Bi+3].[Bi+3].[Bi+3].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O QGWDKKHSDXWPET-UHFFFAOYSA-E 0.000 claims 1
- 229910052797 bismuth Inorganic materials 0.000 description 9
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 235000018102 proteins Nutrition 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000007795 chemical reaction product Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 230000009967 tasteless effect Effects 0.000 description 3
- 102000009027 Albumins Human genes 0.000 description 2
- 108010088751 Albumins Proteins 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000009965 odorless effect Effects 0.000 description 2
- KJFMBFZCATUALV-UHFFFAOYSA-N phenolphthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2C(=O)O1 KJFMBFZCATUALV-UHFFFAOYSA-N 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- HWSISDHAHRVNMT-UHFFFAOYSA-N Bismuth subnitrate Chemical compound O[NH+]([O-])O[Bi](O[N+]([O-])=O)O[N+]([O-])=O HWSISDHAHRVNMT-UHFFFAOYSA-N 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 150000001621 bismuth Chemical class 0.000 description 1
- 229940073609 bismuth oxychloride Drugs 0.000 description 1
- 229960001482 bismuth subnitrate Drugs 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 229940079905 intestinal adsorbents bismuth preparations Drugs 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- BWOROQSFKKODDR-UHFFFAOYSA-N oxobismuth;hydrochloride Chemical compound Cl.[Bi]=O BWOROQSFKKODDR-UHFFFAOYSA-N 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/94—Bismuth compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Description
KAISERLICHESIMPERIAL
PATENTAMT.PATENT OFFICE.
Das Verfahren zur Darstellung von Wismutheiweifsverbindungen aus natürlichen, wasserlöslichen Eiweifskörpern, welche das Wismuth in einer festen — nicht ionisirbaren — Form enthalten, besteht darin, dafs wässerige Lösungen von Eiweifs mit Lösungen von Wismuthnitrat entweder in kochsalzhaltigem Wasser oder in Salpetersäure gefällt und nach erfolgter Coagulation einige Zeit erhitzt werden. Von der Art, in der die Lösungen des Wismuthsalzes zur Anwendung gelangen, hängt die Form ab, in der das Wismuth in den Producten enthalten ist. Kommt das Wismuthnitrat in einer Kochsalzlösung zur Anwendung, so enthält das Endproduct Wismuthoxychlorid organisch gebunden; wird es hingegen in salpetersaurer Lösung angewendet, so ist es in dem Endproducte in Form von Wismuthsubnitrat enthalten.The process for the preparation of bismuth protein compounds from natural, water-soluble protein bodies, which contain bismuth contained in a solid - non-ionizable - form consists in the fact that aqueous solutions precipitated from albumen with solutions of bismuth nitrate either in saline water or in nitric acid and afterwards Coagulation can be heated for some time. Of the manner in which the solutions of the bismuth salt come into use, depends on the form in which the bismuth is contained in the products. Comes the bismuth nitrate for use in a saline solution, the end product will contain bismuth oxychloride organically bound; if, on the other hand, it is used in a nitric acid solution, it is contained in the end product in the form of bismuth subnitrate.
In der chemischen Literatur finden sich wohl Angaben darüber, dafs Eiweifsstoffe durch Schwermetallsalze gefällt werden (s. z. B. Jahresbericht über die Fortschritte der Thierchemie, Bd. 17, S. 11), in dem Handbuch der organischen Chemie von Gmelin-Krauth, 4. Aufl., IV. Bd., III. Th., S. 2241 ist sogar eine solche in Bezug auf Wismuthnitrat enthalten. Aus diesen Literaturstellen war aber das Ergebnifs des vorliegenden Verfahrens nicht vorherzusehen, da der durch einfaches Fällen des Eiweifses mit Wismuthnitrat erhaltene Niederschlag das Metall nicht in fester, sondern nur in sehr loser Bindung enthält. Aus demselben kann durch Behandlung mit verdünnter Säure, z. B. Salzsäure, das Wismuth leicht ausgezogen werden, desgleichen wird er durch Schwefelalkalien sofort geschwärzt. Ebenso enthält ein im Handel befindliches Wismutheiweifspräparat —· s. Merck's Jahresbericht 1888, S. 11 und 12 — das Wismuth nur in loser Bindung. Beim Uebergiefsen mit Wasser geht es nach kurzer Berührung mit demselben in eine klebrige Masse über, wobei die Verbindung in ihre Bestandtheile zerlegt wird; das Eiweifs geht in Lösung und der Rückstand enthält den weitaus gröfsten Theil des Wismuths. In the chemical literature there are probably indications that albuminous substances pass through Heavy metal salts are precipitated (see e.g. annual report on the progress of animal chemistry, Vol. 17, p. 11), in the handbook of organic chemistry by Gmelin-Krauth, 4th ed., IV. Vol., III. Th., P. 2241 there is even one in relation to bismuth nitrate. the end However, the result of the present proceedings could not be foreseen from these references, there is the precipitate obtained by simply felling the albumen with bismuth nitrate does not contain the metal in a tight bond, but only in a very loose bond. From the same can by treatment with dilute acid, e.g. B. hydrochloric acid, the bismuth slightly pulled out in the same way it is immediately blackened by sulphurous alkalis. Also contains a commercially available bismuth protein preparation - see Merck's annual report 1888, P. 11 and 12 - the bismuth only in loosely Binding. When pouring over water it goes into after a short contact with it a sticky mass over which the compound is broken down into its constituent parts; the Albumen goes into solution, and the residue contains by far the greatest part of the bismuth.
Das Wismutheiweifspräparat des Handels besitzt einen widerlichen Geruch und faden Geschmack. Im Gegensatze zu diesen Verbindungen werden die neuen Wismutheiweifspräparate durch Wasser oder verdünnte Säuren nicht zerlegt. Durch Schwefelalkalien werden sie nur sehr allmählich hellbraun gefärbt und sind zudem geschmack- und geruchlos.The bismuth protein preparation on the market has a disgusting smell and tasteless taste. In contrast to these compounds are the new bismuth preparations not decomposed by water or diluted acids. With alkaline sulfur they become only very gradually colored light brown and are also tasteless and odorless.
Nach Analysen enthalten die nach Beispiel I dargestellten Präparate etwa 21,5 pCt. Bi. According to analyzes, the preparations presented according to Example I contain about 21.5 pCt. Bi.
I. 242 g krystallisirtes Wismuthnitrat werden in 1200 ecm Kochsalzlösung von 250B. heifs gelöst und nach dem Filtriren unter Rühren zu der Lösung von 500 g Albumin in 5 1 Wasser zulaufen gelassen. Es beginnt sofort Coagulation, welche durch gutes, fortgesetztes Rühren beschleunigt und zu Ende geführt wird. Hierauf setzt man zu dem Reactionsproduete das gleiche Volumen heilsen Wassers, kocht auf durch Einleitung von Dampf und filtrirt heifs. Der Rückstand wird so langeI. 242 g of crystallized bismuth nitrate are dissolved in 1,200 cc of saline solution of 25 0 B. remains hot and after filtration with stirring to the solution of 500 g of albumin in 5 1 of water were allowed to run. Coagulation begins immediately, which is accelerated and brought to an end by good, continued stirring. The same volume of healthy water is then added to the reaction product, boiled by the introduction of steam, and hot filtered. The residue will be so long
mit Wasser gewaschen, bis die Waschwässer neutral und wismuthfrei sind. Hierauf wird geprefst, getrocknet und pulverisirt.washed with water until the wash waters are neutral and free of bismuth. Then will pressed, dried and pulverized.
II. 242 g Wismuthnitrat werden in dem 2 bis 21I2 fachen Gewicht an Salpetersäure von 1,21 spec. Gewicht gelöst. Diese Lösung lä'fst man nun zu einer wie oben bereiteten Albuminlösung einlaufen und verfährt im Uebrigen, wie unter Beispiel I angegeben.II. 242 g of bismuth nitrate are 2 to 2 1 I 2 times the weight of nitric acid of 1.21 spec. Weight solved. This solution is now run into an albumin solution prepared as above and the rest of the procedure is as indicated in Example I.
III. 100 g Casein werden in 500 ecm Wasser suspendirt und mit Natronlauge unter gelindem Erwärmen neutralisirt (Phenolphtalein als Indicator). Zu dieser Lösung fügt man eine mit Hülfe von Kochsalz bewirkte Auflösung von 48 g krystallisirtem Wismuthnitrat in circa 250 Wasser unter heftigem Rühren, bis eine gleichmäfsig flockige, dichte Fällung entstanden ist. Man erhitzt hierauf zum Kochen und hält . einige Stunden hindurch in gelindem Sieden, filtrirt dann heifs, wäscht einige Male mit sehr verdünnter Salzsäure und dann reichlich mit destillirtem Wasser, preist ab, trocknet und pulvert. Das Präparat stellt ein rahmweifses, geruch- und geschmackloses Pulver dar.III. 100 g of casein are in 500 ecm of water suspended and neutralized with sodium hydroxide solution with gentle warming (phenolphthalein as an indicator). To this solution is added a dissolution of 48 g of crystallized bismuth nitrate in approx 250 water with vigorous stirring until a uniformly flaky, dense precipitate formed is. It is then heated to a boil and held. for a few hours in mild Boil, then filter hot, wash a few times with very dilute hydrochloric acid, and then wash abundantly with distilled water, praises, dries and powdered. The preparation represents a creamy white, odorless and tasteless powder.
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE117269C true DE117269C (en) |
Family
ID=386545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DENDAT117269D Active DE117269C (en) |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE117269C (en) |
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- DE DENDAT117269D patent/DE117269C/de active Active
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