DE3851152D1 - Cyclosporin-augenmittel. - Google Patents

Cyclosporin-augenmittel.

Info

Publication number: DE3851152D1
Authority: DE; Germany
Prior art keywords: cyclosporine; enhance; corn oil; agents; composition
Prior art date: 1987-09-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE3851152T

Other languages

English (en)

Other versions

DE3851152T2 (de

Inventor

Renee Kaswan

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

University of Georgia Research Foundation Inc UGARF

Original Assignee

University of Georgia Research Foundation Inc UGARF

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-09-03

Filing date

1988-08-31

Publication date

1994-09-22

1987-09-03 Priority claimed from US07/092,466 external-priority patent/US4839342A/en

1988-08-31 Application filed by University of Georgia Research Foundation Inc UGARF filed Critical University of Georgia Research Foundation Inc UGARF

1994-09-22 Application granted granted Critical

1994-09-22 Publication of DE3851152D1 publication Critical patent/DE3851152D1/de

1995-01-26 Publication of DE3851152T2 publication Critical patent/DE3851152T2/de

2008-09-01 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 4
108010036949 Cyclosporine Proteins 0.000 title abstract 4
229960001265 ciclosporin Drugs 0.000 title abstract 4
229930182912 cyclosporin Natural products 0.000 title abstract 4
239000000203 mixture Substances 0.000 abstract 3
239000002285 corn oil Substances 0.000 abstract 2
235000005687 corn oil Nutrition 0.000 abstract 2
LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 abstract 2
GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 abstract 2
QCHFTSOMWOSFHM-WPRPVWTQSA-N (+)-Pilocarpine Chemical compound C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C QCHFTSOMWOSFHM-WPRPVWTQSA-N 0.000 abstract 1
PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 abstract 1
QCHFTSOMWOSFHM-UHFFFAOYSA-N SJ000285536 Natural products C1OC(=O)C(CC)C1CC1=CN=CN1C QCHFTSOMWOSFHM-UHFFFAOYSA-N 0.000 abstract 1
229960004308 acetylcysteine Drugs 0.000 abstract 1
229940087168 alpha tocopherol Drugs 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
239000002260 anti-inflammatory agent Substances 0.000 abstract 1
229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
229940088710 antibiotic agent Drugs 0.000 abstract 1
229940121375 antifungal agent Drugs 0.000 abstract 1
-1 antifungals Substances 0.000 abstract 1
239000003963 antioxidant agent Substances 0.000 abstract 1
235000006708 antioxidants Nutrition 0.000 abstract 1
239000003443 antiviral agent Substances 0.000 abstract 1
229940121357 antivirals Drugs 0.000 abstract 1
OJGDCBLYJGHCIH-UHFFFAOYSA-N bromhexine Chemical compound C1CCCCC1N(C)CC1=CC(Br)=CC(Br)=C1N OJGDCBLYJGHCIH-UHFFFAOYSA-N 0.000 abstract 1
229960003870 bromhexine Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003246 corticosteroid Substances 0.000 abstract 1
229960001334 corticosteroids Drugs 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000003172 expectorant agent Substances 0.000 abstract 1
230000035876 healing Effects 0.000 abstract 1
208000026278 immune system disease Diseases 0.000 abstract 1
239000000314 lubricant Substances 0.000 abstract 1
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 abstract 1
239000004292 methyl p-hydroxybenzoate Substances 0.000 abstract 1
229960002216 methylparaben Drugs 0.000 abstract 1
229940066491 mucolytics Drugs 0.000 abstract 1
229960001416 pilocarpine Drugs 0.000 abstract 1
239000003755 preservative agent Substances 0.000 abstract 1
239000004094 surface-active agent Substances 0.000 abstract 1
230000004489 tear production Effects 0.000 abstract 1
229960000984 tocofersolan Drugs 0.000 abstract 1
230000000699 topical effect Effects 0.000 abstract 1
239000005526 vasoconstrictor agent Substances 0.000 abstract 1
239000000080 wetting agent Substances 0.000 abstract 1
239000002076 α-tocopherol Substances 0.000 abstract 1
235000004835 α-tocopherol Nutrition 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Ophthalmology & Optometry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicinal Preparation (AREA)

DE3851152T 1987-09-03 1988-08-31 Cyclosporin-augenmittel. Expired - Lifetime DE3851152T2 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US07/092,466 US4839342A (en)	1987-09-03	1987-09-03	Method of increasing tear production by topical administration of cyclosporin
US11721887A	1987-11-04	1987-11-04
US18782388A	1988-04-29	1988-04-29
PCT/US1988/003039 WO1989001772A1 (en)	1987-09-03	1988-08-31	Ocular cyclosporin composition

Publications (2)

Publication Number	Publication Date
DE3851152D1 true DE3851152D1 (de)	1994-09-22
DE3851152T2 DE3851152T2 (de)	1995-01-26

Family

ID=27377210

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE3851152T Expired - Lifetime DE3851152T2 (de)	1987-09-03	1988-08-31	Cyclosporin-augenmittel.

Country Status (12)

Country	Link
US (1)	US5411952A (de)
EP (1)	EP0391909B1 (de)
JP (1)	JPH0667850B2 (de)
KR (1)	KR920003601B1 (de)
AT (1)	ATE109970T1 (de)
DE (1)	DE3851152T2 (de)
DK (1)	DK54390A (de)
ES (1)	ES2012116A6 (de)
GR (1)	GR1000558B (de)
IE (1)	IE65582B1 (de)
PH (1)	PH24814A (de)
WO (1)	WO1989001772A1 (de)

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SE448386B (sv) *	1978-10-18	1987-02-16	Sandoz Ag	Nya cyklosporinderivat, forfarande for framstellning av dem samt farmaceutisk komposition innehallande dem
EP0098456B1 (de) *	1980-02-14	1989-05-24	Sandoz Ag	Peptide die einen (1S,2R,3R)- oder (1R,2S,3S)-1-Nitrilo-1-carbonyl-3-methyl-2-oxyheptan oder -hept-5-en-Rest enthalten brauchbar in totaler Synsthese von Cyclosporinen, und Verfahren zu ihrer Herstellung
US4396542A (en) *	1980-02-14	1983-08-02	Sandoz Ltd.	Method for the total synthesis of cyclosporins, novel cyclosporins and novel intermediates and methods for their production
DE3260468D1 (en) *	1981-01-09	1984-09-06	Sandoz Ag	Novel cyclosporins
WO1983001252A1 (en) *	1981-10-09	1983-04-14	Hakanson, Rolf	A drug based on a substance p antagonist
EP0145714A1 (de) *	1983-05-25	1985-06-26	Alcon Laboratories, Inc.	Ophthalmisches gel
US4708861A (en) *	1984-02-15	1987-11-24	The Liposome Company, Inc.	Liposome-gel compositions
CH667274A5 (de) *	1984-03-23	1988-09-30	Sandoz Ag	Cyclosporine, ihre herstellung und diese enthaltende pharmazeutische zusammensetzungen.
US4963367A (en) *	1984-04-27	1990-10-16	Medaphore, Inc.	Drug delivery compositions and methods
EP0170623B1 (de) *	1984-08-02	1990-11-28	Sandoz Ag	Pharmazeutische Anwendung von (NVA)2-Cyclosporine
GB8422253D0 (en) *	1984-09-04	1984-10-10	Sandoz Ltd	Organic compounds
EP0194972B1 (de) *	1985-03-11	1992-07-29	Sandoz Ag	Cyclosporine
US4649047A (en) *	1985-03-19	1987-03-10	University Of Georgia Research Foundation, Inc.	Ophthalmic treatment by topical administration of cyclosporin
JPS61249918A (ja) *	1985-04-26	1986-11-07	Yutaka Mizushima	点眼剤
US4745100A (en) *	1985-05-14	1988-05-17	Eye Research Institute Of Retina Foundation	Stimulation of tear secretion
US4861580A (en) *	1985-10-15	1989-08-29	The Liposome Company, Inc.	Composition using salt form of organic acid derivative of alpha-tocopheral
GB8528032D0 (en) *	1985-11-13	1985-12-18	Ici Plc	Ocular treatment
US4923699A (en) *	1988-06-03	1990-05-08	Kaufman Herbert E	Eye treatment suspension

1988
- 1988-08-31 AT AT88908033T patent/ATE109970T1/de not_active IP Right Cessation
- 1988-08-31 KR KR1019890700680A patent/KR920003601B1/ko not_active IP Right Cessation
- 1988-08-31 EP EP88908033A patent/EP0391909B1/de not_active Expired - Lifetime
- 1988-08-31 WO PCT/US1988/003039 patent/WO1989001772A1/en active IP Right Grant
- 1988-08-31 DE DE3851152T patent/DE3851152T2/de not_active Expired - Lifetime
- 1988-08-31 JP JP63507463A patent/JPH0667850B2/ja not_active Expired - Lifetime
- 1988-09-02 IE IE266388A patent/IE65582B1/en not_active IP Right Cessation
- 1988-09-02 ES ES8802718A patent/ES2012116A6/es not_active Expired - Lifetime
- 1988-09-02 PH PH37495A patent/PH24814A/en unknown
- 1988-09-05 GR GR880100578A patent/GR1000558B/el not_active IP Right Cessation
1990
- 1990-02-06 US US07/474,683 patent/US5411952A/en not_active Expired - Lifetime
- 1990-03-01 DK DK054390A patent/DK54390A/da not_active Application Discontinuation

Also Published As

Publication number	Publication date
PH24814A (en)	1990-10-30
JPH0667850B2 (ja)	1994-08-31
EP0391909A1 (de)	1990-10-17
JPH03503159A (ja)	1991-07-18
KR920003601B1 (ko)	1992-05-04
US5411952A (en)	1995-05-02
WO1989001772A1 (en)	1989-03-09
EP0391909B1 (de)	1994-08-17
GR880100578A (en)	1989-06-22
GR1000558B (el)	1992-08-26
ATE109970T1 (de)	1994-09-15
IE882663L (en)	1989-03-03
ES2012116A6 (es)	1990-03-01
KR890701084A (ko)	1989-12-19
DK54390A (da)	1990-05-03
DK54390D0 (da)	1990-03-01
DE3851152T2 (de)	1995-01-26
IE65582B1 (en)	1995-11-01

Publication	Publication Date	Title
DE3851152D1 (de)	1994-09-22	Cyclosporin-augenmittel.
AU690377B2 (en)	1998-04-23	Application of superoxide dismutase in liposomes
MX9702349A (es)	1997-06-28	Usos de derivado de 9-deoxi prostaglandina para tratar glaucoma.
ATE153855T1 (de)	1997-06-15	Zusammensetzungen zur behandlung von glaukoma die prostaglandine und clonidinderivate enthalten
ATE165237T1 (de)	1998-05-15	Starkschaumende orale zusammensetzung
EP1225168A3 (de)	2003-03-26	Prostaglandin-Derivate zur Behandlung von Glaukom und ocularer Hypertension
CA2059403A1 (en)	1992-07-16	Use of Carrageenans in Topical Ophthalmic Compositions
IE831611L (en)	1984-01-13	Topical anti-inflammatory compositions
IE811654L (en)	1982-02-01	Ophthalmic composition
DE3172298D1 (en)	1985-10-24	Pharmaceutical compositions
IT1170214B (it)	1987-06-03	Composizione farmaceutica per la cura delle arteriopatie periferiche
DK0631772T3 (da)	1999-12-06	Retinoidholdig sammensætning
DE69715228D1 (de)	2002-10-10	Einen carboanhydrase-hemmer und xanthangummi enthaltendes augenarzneimittel
DE3167210D1 (en)	1984-12-20	Pharmaceutical composition
KR880007068A (ko)	1988-08-26	13-시스 레티노산의 용도
KR950000138A (ko)	1995-01-03	안(眼)국소용 조성물
KR880001290A (ko)	1988-04-22	β-차단제 및 필로카르핀-함유 제제
KR950702422A (ko)	1995-07-29	(에스)-티몰롤 헤미하이드레이트를 함유하는 안약 국소 조성물(ophthalmic topical composition containing (s)-timolol hemihydrate)
KR880009656A (ko)	1988-10-04	국소 치근막 질환의 치료 또는 예방법
MY100229A (en)	1990-05-29	Topical anti-inflammatory compositions.
BE904737A (fr)	1986-11-07	Derives de l'acide octenoique.
IT1257884B (it)	1996-02-16	Formulazioni farmaceutiche per il trattamento di malattie periferiche vascolari a base di vincamina o di un suo sale farmaceuticamente accettabile.
IT1241928B (it)	1994-02-01	Composizione oftalmica per l'uso nel mantenimento della midriasi oculare
IT1273628B (it)	1997-07-08	Composizioni farmaceutiche per la cura della talassemia contenenti derivati dell'acido butirrico e in particolare isobutirramide

Legal Events

Date	Code	Title	Description
1995-09-14	8364	No opposition during term of opposition