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DE3586021D1 - Penicillin-derivate als entzuendungshemmende und degenerierungskaempfende arzneimittel. - Google Patents

Penicillin-derivate als entzuendungshemmende und degenerierungskaempfende arzneimittel.

Info

Publication number
DE3586021D1
DE3586021D1 DE8585109208T DE3586021T DE3586021D1 DE 3586021 D1 DE3586021 D1 DE 3586021D1 DE 8585109208 T DE8585109208 T DE 8585109208T DE 3586021 T DE3586021 T DE 3586021T DE 3586021 D1 DE3586021 D1 DE 3586021D1
Authority
DE
Germany
Prior art keywords
inflammatory
penicillin derivatives
degenerating
agent
degenerating agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8585109208T
Other languages
English (en)
Inventor
Kevan R Thompson
Paul E Finke
James B Doherty
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE3586021D1 publication Critical patent/DE3586021D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8585109208T 1984-07-30 1985-07-24 Penicillin-derivate als entzuendungshemmende und degenerierungskaempfende arzneimittel. Expired - Fee Related DE3586021D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63570084A 1984-07-30 1984-07-30

Publications (1)

Publication Number Publication Date
DE3586021D1 true DE3586021D1 (de) 1992-06-17

Family

ID=24548767

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585109208T Expired - Fee Related DE3586021D1 (de) 1984-07-30 1985-07-24 Penicillin-derivate als entzuendungshemmende und degenerierungskaempfende arzneimittel.

Country Status (3)

Country Link
EP (1) EP0170192B1 (de)
JP (1) JPS6143115A (de)
DE (1) DE3586021D1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4847247A (en) * 1984-07-30 1989-07-11 Merck & Co., Inc. Penicillin derivatives as anti-inflammatory and antidegenerative agents
JPS62198687A (ja) * 1986-02-27 1987-09-02 Taiho Yakuhin Kogyo Kk ２β−置換チオメチルペニシリン誘導体
JPH0645624B2 (ja) * 1986-11-10 1994-06-15 大鵬薬品工業株式会社 ２β−Ｎ−置換テトラゾ−ルチオメチルペニシリン誘導体
GB2206579B (en) * 1987-07-10 1991-05-29 Erba Farmitalia 6a and 6b-(substituted methyl)-penicillanic acid derivatives
DE69805975T2 (de) 1997-12-29 2002-12-19 Research Corp. Technologies, Inc. 2-beta-substituierte-6-alkylidenpenizillansäure-derivate als beta-laktamase inhibitoren
US6407091B1 (en) 1999-04-15 2002-06-18 Research Corporation Technologies, Inc. β-lactamase inhibiting compounds
DE60214740T2 (de) 2001-07-24 2007-10-04 Southern Methodist University Foundation for Research, Dallas 3-substituierte 7-alkylidene-3-cephem-4-carbonsäuren als beta-lactamase inhibitoren
US7022691B2 (en) 2002-04-04 2006-04-04 John D. Buynak Inhibitors of serine and metallo-β-lactamases
CN104650119B (zh) * 2015-02-10 2017-04-05 中国科学院长春应用化学研究所 一种β‑内酰胺化合物的制备方法
WO2018030840A1 (ko) * 2016-08-12 2018-02-15 가톨릭대학교 산학협력단 연조직 경화용 조성물

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3546211A (en) * 1967-06-22 1970-12-08 Research Corp Polycyclic b-lactams
GB2076812A (en) * 1980-05-22 1981-12-09 Ciba Geigy Ag Penam-dioxide compounds, processes for their manufacture, and their use
CA1180005A (en) * 1980-10-24 1984-12-27 Solange Adam-Molina .beta.-LACTAMS
US4493839A (en) * 1982-05-24 1985-01-15 Merck & Co., Inc. 1-Carbapenem-3-carboxylic esters as anti-inflammatory agents
EP0124081A3 (de) * 1983-05-02 1986-11-26 Merck & Co. Inc. Substituierte Cephalosporinsulfone mit Antientzündungs- und Antidegenerativwirkung, sie enthaltende Zusammensetzungen und Verfahren zur Herstellung

Also Published As

Publication number Publication date
JPS6143115A (ja) 1986-03-01
EP0170192B1 (de) 1992-05-13
EP0170192A1 (de) 1986-02-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee