[go: up one dir, main page]

DD140146A5 - Verfahren zur herstellung von pregnanverbindungen mit 19staendiger sauerstoffunktion - Google Patents

Verfahren zur herstellung von pregnanverbindungen mit 19staendiger sauerstoffunktion Download PDF

Info

Publication number
DD140146A5
DD140146A5 DD78205642A DD20564278A DD140146A5 DD 140146 A5 DD140146 A5 DD 140146A5 DD 78205642 A DD78205642 A DD 78205642A DD 20564278 A DD20564278 A DD 20564278A DD 140146 A5 DD140146 A5 DD 140146A5
Authority
DD
German Democratic Republic
Prior art keywords
group
compounds
formula
item
acid
Prior art date
Application number
DD78205642A
Other languages
German (de)
English (en)
Inventor
Michel Biollaz
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DD140146A5 publication Critical patent/DD140146A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/005—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
    • C07J33/007—Cyclic thioketals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
    • C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DD78205642A 1977-05-31 1978-05-29 Verfahren zur herstellung von pregnanverbindungen mit 19staendiger sauerstoffunktion DD140146A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU77457A LU77457A1 (fi) 1977-05-31 1977-05-31

Publications (1)

Publication Number Publication Date
DD140146A5 true DD140146A5 (de) 1980-02-13

Family

ID=19728591

Family Applications (1)

Application Number Title Priority Date Filing Date
DD78205642A DD140146A5 (de) 1977-05-31 1978-05-29 Verfahren zur herstellung von pregnanverbindungen mit 19staendiger sauerstoffunktion

Country Status (27)

Country Link
US (1) US4309423A (fi)
JP (1) JPS53149964A (fi)
AT (1) AT365609B (fi)
AU (1) AU520330B2 (fi)
BE (1) BE867634A (fi)
CA (1) CA1114367A (fi)
DD (1) DD140146A5 (fi)
DE (1) DE2823239A1 (fi)
DK (1) DK240078A (fi)
ES (5) ES470282A1 (fi)
FI (1) FI781628A (fi)
FR (3) FR2405712A1 (fi)
GB (1) GB1603675A (fi)
GR (1) GR71594B (fi)
HU (1) HU181861B (fi)
IL (1) IL54805A (fi)
IT (1) IT7849581A0 (fi)
LU (1) LU77457A1 (fi)
NL (1) NL7805632A (fi)
NO (1) NO781884L (fi)
NZ (1) NZ187431A (fi)
PH (1) PH14606A (fi)
PL (1) PL207237A1 (fi)
PT (1) PT68095A (fi)
SE (1) SE7806244L (fi)
SU (1) SU786906A3 (fi)
ZA (1) ZA783125B (fi)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA18433A1 (fr) * 1978-05-26 1979-12-31 Ciba Geigy Ag Procede pour la synthese de la chaine laterale hydroxyacetyle de steroides du type pregnagne, nouveaux 21-hydroxy-20-oxo-17 alpha-pregnagnes et produits pharmaceutiques en renfermant
US4261985A (en) * 1978-11-22 1981-04-14 Ciba-Geigy Corporation Novel diuretics
US5002940A (en) * 1984-11-06 1991-03-26 Ciba-Geigy Corporation Solid drug formulations and stable suspensions
US4659704A (en) * 1985-05-21 1987-04-21 Ramot University Authority For Applied Research & Industrial Development Ltd. 19-hydroxyaldosterone and its preparation
FR2656309B1 (fr) * 1989-12-22 1992-05-07 Roussel Uclaf Nouveaux produits sterouides comportant en position 10, un radical ethyle substitue, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant.
FR2676740B1 (fr) * 1991-05-23 1993-11-05 Roussel Uclaf Nouveaux derives sterouides du pregna-4,9(11),17(20)-trie-3-one, leur preparation, leur application a la preparation de composes sterouides de type pregna-4,9(11),16-triene-3,20-dione et nouveaux intermediaires.
DE4433374A1 (de) * 1994-09-20 1996-03-21 Hoechst Ag 17-Desoxi-corticosteroid-21-/O/-Carbonsäure- ester, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
AU2002218179B2 (en) * 2000-09-18 2006-11-16 Merck Serono Sa Method for the preparation of 21-hydroxy-6,19-oxidoprogesterone (21oh-6op)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1146651B (de) * 1956-07-28 1963-04-04 Giuseppe Giusi Vorschub-Schaltgetriebe fuer Maschinen zum Ausschneiden von runden Scheiben aus Kunststoffplatten, insbesondere Knopfrondellen
US3039926A (en) * 1958-10-10 1962-06-19 Pfizer & Co C 19-hydroxy pregnenes
CH425774A (de) * 1961-07-14 1966-12-15 Ciba Geigy Verfahren zur Herstellung von 19-Nor-steroiden
GB1041534A (en) * 1963-04-24 1966-09-07 Merck & Co Inc 20-spiroxane compounds
US3493564A (en) * 1968-02-29 1970-02-03 American Home Prod 2,19-epoxy-delta**4,6-steroids and intermediates for their synthesis
BR6915132D0 (pt) * 1969-04-02 1973-02-08 Ciba Geigy Processo para a obtencao de delta 4 6-ou delta 5(10) 6-3-oxo-19-nor-esteroides
US3849404A (en) * 1973-03-09 1974-11-19 Searle & Co Purification of 6,7-dihydro-17-hydroxy-3-oxo-3'h-cyclopropa(6,7)-17alpha-pregna-4,6-diene-21-carboxylic acid gamma-lactones
CA1049498A (en) * 1973-11-29 1979-02-27 Gunther Kruger Steroid compounds and processes therefor
JPS53116361A (en) * 1977-03-17 1978-10-11 Mitsubishi Chem Ind Ltd Preparation of 7 acylthioo44enee33oxosteroid

Also Published As

Publication number Publication date
GR71594B (fi) 1983-06-17
FI781628A (fi) 1978-12-01
AU520330B2 (en) 1982-01-28
AU3665078A (en) 1979-12-06
DE2823239A1 (de) 1978-12-14
FR2405958A1 (fr) 1979-05-11
IT7849581A0 (it) 1978-05-29
ATA393178A (de) 1981-06-15
JPS53149964A (en) 1978-12-27
NO781884L (no) 1978-12-01
PH14606A (en) 1981-10-02
ES470282A1 (es) 1979-09-16
GB1603675A (en) 1981-11-25
FR2408623A1 (fr) 1979-06-08
LU77457A1 (fi) 1979-01-19
SE7806244L (sv) 1978-12-01
FR2405958B1 (fi) 1982-01-15
ZA783125B (en) 1979-06-27
ES478127A1 (es) 1979-05-16
ES478125A1 (es) 1979-05-16
PT68095A (de) 1978-06-01
FR2408623B1 (fi) 1982-03-05
AT365609B (de) 1982-02-10
IL54805A (en) 1982-11-30
SU786906A3 (ru) 1980-12-07
IL54805A0 (en) 1978-07-31
HU181861B (en) 1983-11-28
US4309423A (en) 1982-01-05
FR2405712A1 (fr) 1979-05-11
PL207237A1 (pl) 1979-06-04
DK240078A (da) 1978-12-01
NZ187431A (en) 1980-05-27
NL7805632A (nl) 1978-12-04
FR2405712B1 (fi) 1982-09-10
ES478126A1 (es) 1979-05-16
CA1114367A (en) 1981-12-15
ES478128A1 (es) 1979-05-16
BE867634A (fr) 1978-11-30

Similar Documents

Publication Publication Date Title
EP0122232B1 (de) 20-Spiroxane und Analoge mit geöffnetem Ring E, Verfahren zu ihrer Herstellung, sowie pharmazeutische Präparate davon
EP0135476A2 (de) Steroid Carbonsäureester
CH641352A5 (de) 15-(hydroxy-, acyloxy- oder oxo-)steroide enthaltende mittel zur hemmung der biosynthese der mevalonsaeure.
DD140146A5 (de) Verfahren zur herstellung von pregnanverbindungen mit 19staendiger sauerstoffunktion
CH561739A5 (en) 4-Hydroxy-2-butenoic acid lactone steroid derivs - cardiotonic, anti-inflammatory, hypocholesterolaemic, mineralocorticoid agents
EP1226155B1 (de) 18-nor-steroide als selektiv wirksame estrogene
DE1593616A1 (de) Verfahren zur Herstellung von Steroidverbindungen
DD266801A5 (de) Verfahren zur herstellung einer oestrogen wirksamen verbindung
EP0005758B1 (de) Verfahren zum Aufbau der Hydroxyacetyl-Seitenkette von Steroiden des Pregnan-Typs, neue 21-Hydroxy-20-oxo-17alpha-pregnan-Verbindungen und pharmazeutische Präparate enthaltend dieselben
DE2744255A1 (de) Verfahren zur herstellung neuer steroidverbindungen mit 19-staendiger sauerstoffunktion
DE2309328A1 (de) 3-keto-7(alpha,beta)-nied.-alkyldelta hoch 5-steroide und verfahren zu ihrer herstellung
SATO et al. The Chemistry of the Spiroaminoketal Side Chain of Solasodine and Tomatidine. III. 1 The Reaction of O, N-Diacetylsolasodine in Acidic Media
DE1668124A1 (de) Steroidverbindungen
US3366651A (en) 6-chloro-6-dehydro-17alpha-(lower alkyl) progesterones
DE1543245B2 (de) 16-Methylen-19-norprogesteronderivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
US3290214A (en) Diuretic compositions containing 3'-oxo-4'-hydroxy-4'-cyclopenteno-(1', 2'-16, 17)-androstene compounds
US3414590A (en) 9beta, 10alpha-delta6, 16-bisdehydro progesterones and intermediates in the preparation thereof
CH620456A5 (en) Process for the preparation of D-homosteroids
DE1643054A1 (de) Neue 7-Methylsteroide
DE19548450A1 (de) 17alpha-Cyanomethylestra-4,9-dien-3-on-17beta-yl- derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE2028026A1 (de) Neue Steroide der Pregnanreihe
DD238801A5 (de) Verfahren zur herstellung neuer epoxysteroide
DE1618493A1 (de) Verfahren zur Herstellung von halogenierten Steroiden
DE1593620A1 (de) Verfahren zur Herstellung von Steroidverbindungen
DE1173466B (de) Verfahren zur Herstellung von Fluorsteroiden der Pregnan- oder Androstanreihe