MA18433A1 - Procede pour la synthese de la chaine laterale hydroxyacetyle de steroides du type pregnagne, nouveaux 21-hydroxy-20-oxo-17 alpha-pregnagnes et produits pharmaceutiques en renfermant - Google Patents
Procede pour la synthese de la chaine laterale hydroxyacetyle de steroides du type pregnagne, nouveaux 21-hydroxy-20-oxo-17 alpha-pregnagnes et produits pharmaceutiques en renfermantInfo
- Publication number
- MA18433A1 MA18433A1 MA18627A MA18627A MA18433A1 MA 18433 A1 MA18433 A1 MA 18433A1 MA 18627 A MA18627 A MA 18627A MA 18627 A MA18627 A MA 18627A MA 18433 A1 MA18433 A1 MA 18433A1
- Authority
- MA
- Morocco
- Prior art keywords
- alpha
- side chain
- pregnagnes
- pregnagne
- oxo
- Prior art date
Links
- -1 HYDROXYACETYL SIDE CHAIN Chemical group 0.000 title abstract 3
- 150000003431 steroids Chemical class 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 229940127557 pharmaceutical product Drugs 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- OTKFCIVOVKCFHR-UHFFFAOYSA-N (Methylsulfinyl)(methylthio)methane Chemical compound CSCS(C)=O OTKFCIVOVKCFHR-UHFFFAOYSA-N 0.000 abstract 1
- GPWNWKWQOLEVEQ-UHFFFAOYSA-N 2,4-diaminopyrimidine-5-carbaldehyde Chemical compound NC1=NC=C(C=O)C(N)=N1 GPWNWKWQOLEVEQ-UHFFFAOYSA-N 0.000 abstract 1
- JWMFYGXQPXQEEM-NUNROCCHSA-N 5β-pregnane Chemical compound C([C@H]1CC2)CCC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](CC)[C@@]2(C)CC1 JWMFYGXQPXQEEM-NUNROCCHSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000000380 anti-gestagenic effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000008570 general process Effects 0.000 abstract 1
- 125000000350 glycoloyl group Chemical group O=C([*])C([H])([H])O[H] 0.000 abstract 1
- 229910052739 hydrogen Chemical group 0.000 abstract 1
- 239000001257 hydrogen Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 125000004184 methoxymethyl group Chemical group [H]C([H])([H])OC([H])([H])* 0.000 abstract 1
- 239000003270 steroid hormone Substances 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0014—Androstane derivatives substituted in position 17 alfa, not substituted in position 17 beta
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J33/005—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
- C07J33/007—Cyclic thioketals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0007—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa
- C07J5/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond not substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Steroid Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH577878 | 1978-05-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA18433A1 true MA18433A1 (fr) | 1979-12-31 |
Family
ID=4299178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA18627A MA18433A1 (fr) | 1978-05-26 | 1979-05-10 | Procede pour la synthese de la chaine laterale hydroxyacetyle de steroides du type pregnagne, nouveaux 21-hydroxy-20-oxo-17 alpha-pregnagnes et produits pharmaceutiques en renfermant |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4424159A (fr) |
| EP (1) | EP0005758B1 (fr) |
| JP (1) | JPS54154750A (fr) |
| AT (1) | ATE3430T1 (fr) |
| AU (1) | AU523501B2 (fr) |
| CA (1) | CA1140538A (fr) |
| DD (1) | DD143912A5 (fr) |
| DE (1) | DE2965422D1 (fr) |
| DK (1) | DK216479A (fr) |
| ES (1) | ES480899A1 (fr) |
| FI (1) | FI791629A (fr) |
| GR (1) | GR72921B (fr) |
| HU (1) | HU183086B (fr) |
| MA (1) | MA18433A1 (fr) |
| NO (1) | NO791729L (fr) |
| PL (1) | PL215880A1 (fr) |
| PT (1) | PT69667A (fr) |
| RO (1) | RO76167A (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU572589B2 (en) | 1983-12-14 | 1988-05-12 | Upjohn Company, The | 11(alpha)-difluoromethyl and (e)-and (z)-11-fluoromethylene steroids |
| US5003063A (en) * | 1987-08-14 | 1991-03-26 | The Upjohn Company | Conversion of steroidal 17-cyanohydrins to corticoids |
| DE3744054A1 (de) * | 1987-12-21 | 1989-06-29 | Schering Ag | Verwendung von antigestagenen zur herstellung von arzneimitteln |
| SI3392260T1 (sl) * | 2012-12-18 | 2023-01-31 | Washington University | Nevroaktivni 19-alkoksi-17-substituirani steroidi, uporabni pri postopkih zdravljenja |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH241645A (de) * | 1939-07-28 | 1946-03-31 | Ciba Geigy | Verfahren zur Darstellung von Carbonylverbindungen der Cyclopentanopoly-hydrophenanthren-Reihe. |
| FR2406613A1 (fr) * | 1977-10-21 | 1979-05-18 | Owens Corning Fiberglass Corp | Composition d'impregnation pour nappes cablees de pneumatiques |
| LU77457A1 (fr) * | 1977-05-31 | 1979-01-19 |
-
1979
- 1979-05-10 MA MA18627A patent/MA18433A1/fr unknown
- 1979-05-14 EP EP79101468A patent/EP0005758B1/fr not_active Expired
- 1979-05-14 DE DE7979101468T patent/DE2965422D1/de not_active Expired
- 1979-05-14 AT AT79101468T patent/ATE3430T1/de not_active IP Right Cessation
- 1979-05-23 FI FI791629A patent/FI791629A/fi not_active Application Discontinuation
- 1979-05-23 RO RO7997620A patent/RO76167A/fr unknown
- 1979-05-23 DD DD21310079A patent/DD143912A5/de unknown
- 1979-05-24 GR GR59166A patent/GR72921B/el unknown
- 1979-05-24 CA CA000328276A patent/CA1140538A/fr not_active Expired
- 1979-05-24 ES ES480899A patent/ES480899A1/es not_active Expired
- 1979-05-24 PT PT69667A patent/PT69667A/pt unknown
- 1979-05-25 NO NO791729A patent/NO791729L/no unknown
- 1979-05-25 AU AU47426/79A patent/AU523501B2/en not_active Ceased
- 1979-05-25 DK DK216479A patent/DK216479A/da not_active Application Discontinuation
- 1979-05-25 HU HU79CI1937A patent/HU183086B/hu unknown
- 1979-05-26 PL PL21588079A patent/PL215880A1/xx unknown
- 1979-05-26 JP JP6460879A patent/JPS54154750A/ja active Pending
-
1982
- 1982-02-03 US US06/345,309 patent/US4424159A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| FI791629A (fi) | 1979-11-27 |
| CA1140538A (fr) | 1983-02-01 |
| PT69667A (en) | 1979-06-01 |
| ATE3430T1 (de) | 1983-06-15 |
| JPS54154750A (en) | 1979-12-06 |
| GR72921B (fr) | 1984-01-11 |
| HU183086B (en) | 1984-04-28 |
| US4424159A (en) | 1984-01-03 |
| DD143912A5 (de) | 1980-09-17 |
| AU4742679A (en) | 1979-11-29 |
| RO76167A (fr) | 1981-11-04 |
| PL215880A1 (fr) | 1980-12-01 |
| AU523501B2 (en) | 1982-07-29 |
| DK216479A (da) | 1979-11-27 |
| EP0005758A1 (fr) | 1979-12-12 |
| EP0005758B1 (fr) | 1983-05-18 |
| ES480899A1 (es) | 1980-08-16 |
| DE2965422D1 (en) | 1983-07-07 |
| NO791729L (no) | 1979-11-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE2963097D1 (en) | Process for the preparation of beta-lactam derivatives, the novel derivatives so obtainable and pharmaceutical compositions containing them | |
| MA18433A1 (fr) | Procede pour la synthese de la chaine laterale hydroxyacetyle de steroides du type pregnagne, nouveaux 21-hydroxy-20-oxo-17 alpha-pregnagnes et produits pharmaceutiques en renfermant | |
| FR2325677A1 (fr) | Composition d'appret, produit composite utilisant cette composition et procede pour sa preparation | |
| FR2433541A1 (fr) | Nouveau procede de preparation de certains steroides | |
| PT71715A (fr) | Nouveaux derives d'amino-14 steroides et procede pour leurpreparation | |
| FR2444686A1 (fr) | Procede pour la synthese de steroides | |
| DE69504049T2 (de) | Neue progesteronverbindung und ihre verwendung | |
| DE59108246D1 (de) | UNGESÄTTIGTE 15-DEHYDRO-17alpha-CYANOMETHYL-17beta- HYDROXYSTEROIDE | |
| DE69312849T2 (de) | Mercapto-acetamid-derivate | |
| Andersson et al. | Piperidine derivatives. I. preparation of piperidine-2, 6-dicarboxylic acid and its n-methyl derivative | |
| ES418421A1 (es) | Un procedimiento para la preparacion de nuevos 17-aza este-roides sustituidos en la posicion 21. | |
| JPS59184200A (ja) | ステロイド化合物、その製造法及び薬剤 | |
| US3107241A (en) | 17alpha-(2-carboxyethyl) androsta-4, 6-diene-3beta, 17beta-diol gamma-lactone and esters thereof | |
| US2661357A (en) | Production of 16-keto-17-hydroxy steroids | |
| GB893145A (en) | Improvements in or relating to steroids and the manufacture thereof | |
| JPS5257142A (en) | Process for preparing dihalovinyl-cyclopropanecarboxylic acid derivati ves | |
| JPS5813551A (ja) | １３−アザトロンボキサン類似化合物、その製造方法及びその化合物を有効成分として含有するトロンボキサン起因疾患治療剤 | |
| JPS53144563A (en) | Preparation of steroid derivatives | |
| JPS53144562A (en) | Preparation of steroid derivatives | |
| JPS54103859A (en) | Preparation of 3,17-dihydroxypregn-5-ene-2-yne | |
| GB840430A (en) | Water-soluble steroids and pharmaceutical compositions containing them | |
| DE1543842B2 (de) | 3-Oxo-2-oxa-4,9,l 1-gonatriene, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel | |
| CH275272A (de) | Verfahren zur Darstellung des 4,5-3,11,20-Triketo-17(B),21-dioxypregnens. | |
| GB777689A (en) | Cyclopentanopolyhydrophenanthrene compounds and their preparation | |
| GB763946A (en) | Improved etiocholanic acid derivatives and methods for their production |