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CY1120637T1 - Πολυπεπτιδικα αντισωματα που ανταγωνιζονται cd40 - Google Patents

Πολυπεπτιδικα αντισωματα που ανταγωνιζονται cd40

Info

Publication number
CY1120637T1
CY1120637T1 CY181100398T CY181100398T CY1120637T1 CY 1120637 T1 CY1120637 T1 CY 1120637T1 CY 181100398 T CY181100398 T CY 181100398T CY 181100398 T CY181100398 T CY 181100398T CY 1120637 T1 CY1120637 T1 CY 1120637T1
Authority
CY
Cyprus
Prior art keywords
polypeptide antibodies
antibodies
polypeptide
competitive polypeptide
competitive
Prior art date
Application number
CY181100398T
Other languages
English (en)
Inventor
Anish Suri
Steven Sheriff
Suzanne Suchard
Aaron Yamniuk
Stanley Krystek
James Tamura
James Bryson
Steven Grant
Philip Drew
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46000407&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1120637(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CY1120637T1 publication Critical patent/CY1120637T1/el

Links

Classifications

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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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  • Cardiology (AREA)

Abstract

Παρέχονται πολυπεπτιδικά αντισώματα που ειδικώς συνδέουν νέο επίτοπο ανθρώπινου CD40. Τα πολυπεπτιδικά αντισώματα δεν παρουσιάζουν δραστικότητα αγωνιστή CD40. Τα πολυπεπτιδικά αντισώματα είναι χρήσιμα στη θεραπεία ασθενειών που ενέχουν ενεργοποίηση CD40, όπως αυτοάνοσων ασθενειών. Τα πολυπεπτιδικά αντισώματα μπορεί να είναι πεδίου αντισα'ίματα (dAbs) που περιλαμβάνει απλό VL ή VH πεδίο. Η ημίσεια ζωή των πολυπεπτιδικών αντισωμάτων μπορεί να αυξηθεί τροποποιώντας τα πολυπεπτιδικά αντισώματα ώστε να είναι διπλά ειδικά αντιδραστήρια που μπορούν επίσης να συνδέουν ανθρώπινη αλβουμίνη ορού (HSA).
CY181100398T 2011-04-21 2018-04-16 Πολυπεπτιδικα αντισωματα που ανταγωνιζονται cd40 CY1120637T1 (el)

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