CY1118883T1 - Μεθοδος παρασκευης βορτιοξετινης - Google Patents
Μεθοδος παρασκευης βορτιοξετινηςInfo
- Publication number
- CY1118883T1 CY1118883T1 CY20171100483T CY171100483T CY1118883T1 CY 1118883 T1 CY1118883 T1 CY 1118883T1 CY 20171100483 T CY20171100483 T CY 20171100483T CY 171100483 T CY171100483 T CY 171100483T CY 1118883 T1 CY1118883 T1 CY 1118883T1
- Authority
- CY
- Cyprus
- Prior art keywords
- preparation
- bortioxetine
- formula
- vortexetine
- dimethylthiophenol
- Prior art date
Links
- AMNLXDDJGGTIPL-UHFFFAOYSA-N 2,4-dimethylbenzenethiol Chemical class CC1=CC=C(S)C(C)=C1 AMNLXDDJGGTIPL-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N diethylenediamine Natural products C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 1
- 150000004885 piperazines Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cephalosporin Compounds (AREA)
- Compounds Of Unknown Constitution (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Παρέχεται μια μέθοδος για την παρασκευή βορτιοξετίνης στην οποία μια ένωση με τύπο I, τύπο I αντιδρά με προαιρετικά υποκατεστημένη πιπεραζίνη και 2, 4-διμεθυλο-θειοφαινόλη(ικό άλας) που ακολουθείται από αποσυμπλοκοποίηση.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361767883P | 2013-02-22 | 2013-02-22 | |
| DKPA201300104 | 2013-02-22 | ||
| PCT/EP2014/053313 WO2014128207A1 (en) | 2013-02-22 | 2014-02-20 | Vortioxetine manufacturing process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1118883T1 true CY1118883T1 (el) | 2018-01-10 |
Family
ID=59215387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20171100483T CY1118883T1 (el) | 2013-02-22 | 2017-05-03 | Μεθοδος παρασκευης βορτιοξετινης |
Country Status (38)
| Country | Link |
|---|---|
| US (1) | US9353073B2 (el) |
| EP (1) | EP2958903B1 (el) |
| JP (1) | JP6464098B2 (el) |
| KR (1) | KR102230628B1 (el) |
| CN (1) | CN104995181B (el) |
| AP (1) | AP2015008640A0 (el) |
| AU (1) | AU2014220735B2 (el) |
| BR (1) | BR112015019268B1 (el) |
| CA (1) | CA2901821A1 (el) |
| CL (1) | CL2015002309A1 (el) |
| CR (1) | CR20150423A (el) |
| CY (1) | CY1118883T1 (el) |
| DK (1) | DK2958903T3 (el) |
| DO (1) | DOP2015000187A (el) |
| EA (1) | EA027756B1 (el) |
| ES (1) | ES2625380T3 (el) |
| GE (1) | GEP201706749B (el) |
| HK (1) | HK1216098A1 (el) |
| HR (1) | HRP20170607T1 (el) |
| IL (1) | IL240501B (el) |
| LT (1) | LT2958903T (el) |
| MA (1) | MA38338B1 (el) |
| ME (1) | ME02671B (el) |
| MX (1) | MX362355B (el) |
| MY (1) | MY172337A (el) |
| PE (1) | PE20151589A1 (el) |
| PH (1) | PH12015501807B1 (el) |
| PL (1) | PL2958903T3 (el) |
| PT (1) | PT2958903T (el) |
| RS (1) | RS55932B1 (el) |
| RU (1) | RU2652265C2 (el) |
| SG (1) | SG11201506651SA (el) |
| SI (1) | SI2958903T1 (el) |
| SM (1) | SMT201700238T1 (el) |
| TN (1) | TN2015000335A1 (el) |
| UA (1) | UA116236C2 (el) |
| WO (1) | WO2014128207A1 (el) |
| ZA (1) | ZA201506050B (el) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS62051B1 (sr) | 2010-08-18 | 2021-07-30 | Biosplice Therapeutics Inc | Diketoni i hidroksiketoni kao aktivatori katenin signalnog puta |
| US9533976B2 (en) | 2013-02-22 | 2017-01-03 | Samumed, Llc | γ-diketones as WNT/β-catenin signaling pathway activators |
| KR102165385B1 (ko) | 2014-08-20 | 2020-10-15 | 사뮤메드, 엘엘씨 | 피부 노화 및 주름의 치료 및 예방을 위한 감마-디케톤 |
| WO2016125191A2 (en) | 2015-02-04 | 2016-08-11 | Mylan Laboratories Limited | Processes for the preparation of vortioxetine hydrobromide |
| EP3274330A1 (en) | 2015-03-26 | 2018-01-31 | Cipla Limited | Method for making serotonin reuptake inhibitors |
| CN106279065A (zh) * | 2015-05-12 | 2017-01-04 | 北京深蓝海生物医药科技有限公司 | 一种氢溴酸沃替西汀的精制转晶方法 |
| JO3456B1 (ar) | 2015-05-13 | 2020-07-05 | H Lundbeck As | فيروتيوكسيتين بيروجلوتامات |
| EP3414216B1 (en) * | 2016-02-08 | 2020-10-21 | AAA Chemistry ApS | Arylation of aliphatic amines |
| BR112018003930A2 (pt) | 2016-07-01 | 2018-09-25 | H Lundbeck As | regimes de dosagem de vortioxetina para início rápido de efeito antidepressivo |
| US10519121B2 (en) | 2016-12-30 | 2019-12-31 | Apicore Us Llc | Process and novel polymorphic form of vortioxetine and its pharmaceutically acceptable salts |
| CN109912538B (zh) * | 2019-01-22 | 2021-03-12 | 安徽赛乐普制药有限公司 | 一种抗抑郁药沃替西汀的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA81749C2 (uk) * | 2001-10-04 | 2008-02-11 | Х. Луннбек А/С | Фенілпіперазинові похідні як інгібітори зворотного захоплення серотоніну |
| CA2467118A1 (en) * | 2001-12-20 | 2003-07-03 | H. Lundbeck A/S | Aryloxyphenyl and arylsulfanylphenyl derivatives |
| RS52205B2 (sr) * | 2006-06-16 | 2021-05-31 | H Lundbeck A/S | 1-[2-(2,4-dimetilfenilsulfanil)-fenil]piperazin kao jedinjenje sa kombinovanom aktivnošću ponovnog uzimanja serotonina, 5-ht3 i 5-ht1a, za tretman kognitivnih oštećenja |
| TW201033181A (en) * | 2009-02-17 | 2010-09-16 | Lundbeck & Co As H | Purification of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine |
-
2014
- 2014-02-20 ME MEP-2017-91A patent/ME02671B/me unknown
- 2014-02-20 MY MYPI2015002072A patent/MY172337A/en unknown
- 2014-02-20 MA MA38338A patent/MA38338B1/fr unknown
- 2014-02-20 CA CA2901821A patent/CA2901821A1/en not_active Abandoned
- 2014-02-20 WO PCT/EP2014/053313 patent/WO2014128207A1/en active Application Filing
- 2014-02-20 SM SM20170238T patent/SMT201700238T1/it unknown
- 2014-02-20 CN CN201480009227.0A patent/CN104995181B/zh active Active
- 2014-02-20 RS RS20170399A patent/RS55932B1/sr unknown
- 2014-02-20 ES ES14705524.8T patent/ES2625380T3/es active Active
- 2014-02-20 MX MX2015010656A patent/MX362355B/es active IP Right Grant
- 2014-02-20 PE PE2015001720A patent/PE20151589A1/es active IP Right Grant
- 2014-02-20 RU RU2015134407A patent/RU2652265C2/ru active
- 2014-02-20 EP EP14705524.8A patent/EP2958903B1/en active Active
- 2014-02-20 JP JP2015558446A patent/JP6464098B2/ja active Active
- 2014-02-20 LT LTEP14705524.8T patent/LT2958903T/lt unknown
- 2014-02-20 EA EA201591349A patent/EA027756B1/ru not_active IP Right Cessation
- 2014-02-20 UA UAA201509642A patent/UA116236C2/uk unknown
- 2014-02-20 PL PL14705524T patent/PL2958903T3/pl unknown
- 2014-02-20 PT PT147055248T patent/PT2958903T/pt unknown
- 2014-02-20 AU AU2014220735A patent/AU2014220735B2/en active Active
- 2014-02-20 KR KR1020157021985A patent/KR102230628B1/ko active Active
- 2014-02-20 US US14/767,350 patent/US9353073B2/en active Active
- 2014-02-20 GE GEAP201413919A patent/GEP201706749B/en unknown
- 2014-02-20 AP AP2015008640A patent/AP2015008640A0/xx unknown
- 2014-02-20 SG SG11201506651SA patent/SG11201506651SA/en unknown
- 2014-02-20 DK DK14705524.8T patent/DK2958903T3/en active
- 2014-02-20 BR BR112015019268-8A patent/BR112015019268B1/pt active IP Right Grant
- 2014-02-20 SI SI201430214T patent/SI2958903T1/sl unknown
-
2015
- 2015-08-06 TN TN2015000335A patent/TN2015000335A1/en unknown
- 2015-08-10 DO DO2015000187A patent/DOP2015000187A/es unknown
- 2015-08-11 IL IL240501A patent/IL240501B/en active IP Right Grant
- 2015-08-17 PH PH12015501807A patent/PH12015501807B1/en unknown
- 2015-08-18 CL CL2015002309A patent/CL2015002309A1/es unknown
- 2015-08-18 CR CR20150423A patent/CR20150423A/es unknown
- 2015-08-20 ZA ZA2015/06050A patent/ZA201506050B/en unknown
-
2016
- 2016-04-08 HK HK16104011.9A patent/HK1216098A1/zh unknown
-
2017
- 2017-04-18 HR HRP20170607TT patent/HRP20170607T1/hr unknown
- 2017-05-03 CY CY20171100483T patent/CY1118883T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1118883T1 (el) | Μεθοδος παρασκευης βορτιοξετινης | |
| CY1120635T1 (el) | Βενζαμιδια αμινοετεροαρυλιου ως αναστολεις κινασης | |
| UA113643C2 (xx) | N-цикліламіди як нематоциди | |
| EA201600091A1 (ru) | 4-членные кольцевые карбоксамиды, применяемые в качестве нематоцидов | |
| CY1118950T1 (el) | Νεα παραγωγα πυραζολιου | |
| CR20140468A (es) | Inhibidores de diacilglicerol aciltransferasa 2 | |
| BR112016029333A2 (pt) | síntese de compostos de carbamoilpiridona policíclico | |
| EA201690473A1 (ru) | Комбинированный состав двух противовирусных соединений | |
| MX378288B (es) | Inhibidores de pirimidina del fgfr4. | |
| UY34591A (es) | Compuestos de imidazopirrolidinona | |
| EA201591634A1 (ru) | Дигидропиридопиримидиновые соединения | |
| EA201591805A1 (ru) | Оксабицикло [2.2.2] кислоты - модуляторы gpr120 | |
| CR20140306A (es) | Fluormetil -5,6-dihidro-4h-[1,3] oxazinas | |
| CY1118593T1 (el) | Πρωτοτυπα παραγωγα πυραζινης | |
| PH12015502665A1 (en) | Improvements in or relating to organic compounds | |
| MX2017016030A (es) | Derivado de dihidropirrolopirazol sustituido. | |
| EA201691412A1 (ru) | Гидроксиформамидные производные и их применение | |
| UA111333C2 (uk) | Спосіб одержання l-аргінінової солі периндроприлу | |
| MX2015016332A (es) | Inhibidores de alk biciclicos fusionados. | |
| MX2015013365A (es) | Derivados de urea y su uso como inhibidores de proteina de union de acidos grasos (puag). | |
| CR20160083A (es) | Compuestos con actividad pesticida | |
| CY1121116T1 (el) | Νεα μεθοδος για την συνθεση αγομελατινης | |
| MX2015013374A (es) | Derivados de urea y su uso como inhibidores de proteina de uniuon a acidos grasos (puag). | |
| AR101951A1 (es) | Síntesis de ent-progesterona e intermediarios de la misma | |
| MX2016000487A (es) | Piridina-2-carboxamidas como nematicidas. |