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CY1109729T1 - Τερφαινυλ παραγωγα για θεραπεια της νοσου του alzheimer - Google Patents

Τερφαινυλ παραγωγα για θεραπεια της νοσου του alzheimer

Info

Publication number
CY1109729T1
CY1109729T1 CY20101100039T CY101100039T CY1109729T1 CY 1109729 T1 CY1109729 T1 CY 1109729T1 CY 20101100039 T CY20101100039 T CY 20101100039T CY 101100039 T CY101100039 T CY 101100039T CY 1109729 T1 CY1109729 T1 CY 1109729T1
Authority
CY
Cyprus
Prior art keywords
alzheimer
trefinyl
products
disease treatment
compounds
Prior art date
Application number
CY20101100039T
Other languages
English (en)
Inventor
Francis Wilson
Alison Reid
Valerie Reader
Richard John Harrison
Mihiro Sunose
Remedios Hernadez-Perni
Jeremy Major
Cyrille Boussard
Kathryn Smelt
Formal Adeline Le
Andrew Cansfield
Svenja Burckhardt
Jess Taylor
Original Assignee
Cellzome Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36293499&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1109729(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cellzome Limited filed Critical Cellzome Limited
Publication of CY1109729T1 publication Critical patent/CY1109729T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/38—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/33—Polycyclic acids
    • C07C63/331—Polycyclic acids with all carboxyl groups bound to non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/65—Halogen-containing esters of unsaturated acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Η παρούσα εφεύρεση αφορά ενώσεις που έχουν το γενικό τύπο (I) με τους ορισμούς των Χ, Υ, R1, R2, R3, R4, R9, R10 να δίνονται παρακάτω και διαλυτώματα, υδρίτες, εστέρες και φαρμακευτικώς αποδεκτά άλατα αυτών. Επιπλέον η εφεύρεση αφορά τη χρήση των εν λόγω ενώσεων για τη θεραπεία της νόσου του Alzheimer και χρήση τους για την ρύθμιση της δραστικότητας της γ-εκκριματάσης.
CY20101100039T 2006-04-21 2010-01-14 Τερφαινυλ παραγωγα για θεραπεια της νοσου του alzheimer CY1109729T1 (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06112934A EP1847524B1 (en) 2006-04-21 2006-04-21 Terphenyl derivatives for treatment of Alzheimer's disease

Publications (1)

Publication Number Publication Date
CY1109729T1 true CY1109729T1 (el) 2014-09-10

Family

ID=36293499

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100039T CY1109729T1 (el) 2006-04-21 2010-01-14 Τερφαινυλ παραγωγα για θεραπεια της νοσου του alzheimer

Country Status (35)

Country Link
US (1) US8106236B2 (el)
EP (2) EP1847524B1 (el)
JP (1) JP5422827B2 (el)
KR (1) KR101494906B1 (el)
CN (1) CN101484410B (el)
AR (1) AR060621A1 (el)
AT (1) ATE445586T1 (el)
AU (1) AU2007240382B2 (el)
BR (1) BRPI0710632A2 (el)
CA (1) CA2649845C (el)
CR (2) CR10376A (el)
CY (1) CY1109729T1 (el)
DE (1) DE602006009764D1 (el)
DK (1) DK1847524T3 (el)
EA (1) EA016908B1 (el)
ES (2) ES2333539T3 (el)
GE (1) GEP20115211B (el)
HK (1) HK1134923A1 (el)
IL (2) IL194853A0 (el)
MA (1) MA30420B1 (el)
MX (1) MX2008013447A (el)
MY (1) MY148988A (el)
NO (1) NO20084516L (el)
NZ (1) NZ572999A (el)
PE (1) PE20080267A1 (el)
PL (1) PL1847524T3 (el)
PT (1) PT1847524E (el)
SI (1) SI1847524T1 (el)
SM (1) SMP200800062B (el)
TN (1) TNSN08414A1 (el)
TW (1) TWI435720B (el)
UA (1) UA95766C2 (el)
UY (1) UY30300A1 (el)
WO (1) WO2007124351A1 (el)
ZA (1) ZA200809857B (el)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2333539T3 (es) 2006-04-21 2010-02-23 Cellzome Limited Derivados de terfenilo para el tratamiento de la enfermedad de alzheimer.
CN101896452B (zh) 2007-10-19 2013-07-31 詹森药业有限公司 连接有碳的γ-分泌酶调节剂
CA2703636A1 (en) 2007-10-19 2009-04-23 Janssen Pharmaceutica N.V. Amine linked modulators of .gamma.-secretase
CN101903334A (zh) * 2007-10-19 2010-12-01 詹森药业有限公司 Gsm中间体
CN101903347B (zh) 2007-10-19 2013-03-27 詹森药业有限公司 带哌啶基和哌嗪基的γ-分泌酶调节剂
US20110092554A1 (en) * 2007-11-19 2011-04-21 Richard Chesworth 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
WO2009075874A1 (en) * 2007-12-13 2009-06-18 Amgen Inc. Gamma secretase modulators
CA2710477A1 (en) 2007-12-20 2009-07-09 Envivo Pharmaceuticals, Inc. Tetrasubstituted benzenes
BRPI0908837A2 (pt) * 2008-03-11 2015-07-21 Neurosearch As Derivado de triarila, composição farmacêutica, uso de um derivado de triarila, e, método para tratar, prevenir ou para o alívio de uma doença, um distúrbio ou uma condição de um corpo de animal vivo
US7968725B2 (en) * 2008-07-22 2011-06-28 Janssen Pharmaceutica N.V. Pyridinyl modulators of γ-secretase
CA2828748C (en) * 2011-03-03 2019-06-25 Denovamed Inc. Antimicrobial / adjuvant compounds and methods
CN103012200B (zh) * 2011-09-20 2014-12-17 北京大学 具有β-分泌酶抑制功能的化合物及其制备方法与应用
WO2015109109A1 (en) 2014-01-15 2015-07-23 Forum Pharmaceuticals Inc. Fused morpholinopyrimidines and methods of use thereof
US9802927B2 (en) 2015-06-10 2017-10-31 Denali Therapeutics, Inc. Oxadiazine compounds and methods of use thereof
JPWO2022114105A1 (el) * 2020-11-27 2022-06-02

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08325182A (ja) * 1995-05-31 1996-12-10 Fuji Yakuhin Kogyo Kk 置換テルフェニル誘導体とそれらを含有する抗血栓剤
FR2767525B1 (fr) * 1997-08-21 1999-11-12 Cird Galderma Derives biphenyliques substitues par un radical aromatique ou heteroaromatique et compositions pharmaceutiques et cosmetiques les contenant
JP2002544258A (ja) 1999-05-12 2002-12-24 ニューロサーチ、アクティーゼルスカブ イオンチャネル調節剤
AU2001257022B2 (en) 2000-04-13 2005-02-03 Mayo Foundation For Medical Education And Research Abeta 42 lowering agents
EP1278734A2 (en) 2000-04-24 2003-01-29 Merck Frosst Canada & Co. Method of treatment using phenyl and biaryl derivatives as prostaglandin e inhibitors and compounds useful therefore
JP4387104B2 (ja) * 2001-02-20 2009-12-16 アイシス イノベイシヨン リミテツド 金属含有デンドリマー
FR2838439B1 (fr) * 2002-04-11 2005-05-20 Sanofi Synthelabo Derives de terphenyle, leur preparation, les compositions pharmaceutqiues en contenant
WO2004052921A1 (en) * 2002-12-05 2004-06-24 Axys Pharmaceuticals, Inc. Cyanomethyl derivatives as cysteine protease inhibitors
GB0305918D0 (en) 2003-03-14 2003-04-23 Glaxo Group Ltd Novel compounds
CN100441185C (zh) * 2003-04-30 2008-12-10 麦克弗罗斯特加拿大有限公司 8-(3-联芳基)苯基喹啉磷酸二酯酶-4抑制剂
WO2005110963A1 (en) * 2004-05-19 2005-11-24 Cellzome Ag (biphenyl-3-yl)-carboxylic acids and derivatives thereof and their use in therapy
GB0416508D0 (en) 2004-07-23 2004-08-25 Merck Sharp & Dohme Therapeutic agents
AU2006281497B2 (en) * 2005-08-15 2012-06-07 F. Hoffmann-La Roche Ag Piperidine and piperazine derivatives as P2X3 antagonists
WO2007039736A1 (en) 2005-10-06 2007-04-12 Astrazeneca Ab Novel compounds
ES2333539T3 (es) 2006-04-21 2010-02-23 Cellzome Limited Derivados de terfenilo para el tratamiento de la enfermedad de alzheimer.

Also Published As

Publication number Publication date
SMAP200800062A (it) 2008-11-19
CA2649845A1 (en) 2007-11-01
DE602006009764D1 (de) 2009-11-26
CR10376A (es) 2009-02-26
EA016908B1 (ru) 2012-08-30
US20070254957A1 (en) 2007-11-01
TNSN08414A1 (en) 2010-04-14
NZ572999A (en) 2012-06-29
KR101494906B1 (ko) 2015-02-24
PL1847524T3 (pl) 2010-03-31
NO20084516L (no) 2009-01-13
DK1847524T3 (da) 2010-01-11
UA95766C2 (ru) 2011-08-25
TWI435720B (zh) 2014-05-01
UY30300A1 (es) 2007-08-31
SMP200800062B (it) 2009-07-14
GEP20115211B (en) 2011-04-26
EP1847524A1 (en) 2007-10-24
PE20080267A1 (es) 2008-05-16
ZA200809857B (en) 2009-08-26
AU2007240382B2 (en) 2013-05-02
EP1847524B1 (en) 2009-10-14
TW200810746A (en) 2008-03-01
CR10452A (es) 2009-02-23
EA200802173A1 (ru) 2009-06-30
AU2007240382A1 (en) 2007-11-01
MY148988A (en) 2013-06-28
WO2007124351A1 (en) 2007-11-01
MX2008013447A (es) 2009-03-10
IL194789A0 (en) 2009-08-03
SI1847524T1 (sl) 2010-01-29
CN101484410A (zh) 2009-07-15
BRPI0710632A2 (pt) 2011-08-23
JP5422827B2 (ja) 2014-02-19
JP2009538275A (ja) 2009-11-05
HK1134923A1 (en) 2010-05-20
US8106236B2 (en) 2012-01-31
CA2649845C (en) 2014-09-16
AR060621A1 (es) 2008-07-02
ES2392352T3 (es) 2012-12-10
PT1847524E (pt) 2009-12-18
MA30420B1 (fr) 2009-05-04
ES2333539T3 (es) 2010-02-23
IL194853A0 (en) 2009-08-03
CN101484410B (zh) 2013-08-21
ATE445586T1 (de) 2009-10-15
EP2016039B1 (en) 2012-08-01
KR20090024678A (ko) 2009-03-09
EP2016039A1 (en) 2009-01-21

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