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GT200900120A - Acidos bifenilcarboxilicos sustituidos y sus derivados - Google Patents

Acidos bifenilcarboxilicos sustituidos y sus derivados

Info

Publication number
GT200900120A
GT200900120A GT200900120A GT200900120A GT200900120A GT 200900120 A GT200900120 A GT 200900120A GT 200900120 A GT200900120 A GT 200900120A GT 200900120 A GT200900120 A GT 200900120A GT 200900120 A GT200900120 A GT 200900120A
Authority
GT
Guatemala
Prior art keywords
bifenyl
derivatives
substituted
carboxyl acids
carboxyl
Prior art date
Application number
GT200900120A
Other languages
English (en)
Inventor
Francis Wilson
Alison Reid
Valerie Reader
Richard John Harrison
Mihiro Sunose
Remedios Hernandez Perni
Jeremy Major
Cyrille Boussard
Kathryn Smelt
Jess Taylor
Adeline Leformal
Andrew Cansfield
Svenja Burckhardt
Chih Yung Ho
Yan Zhang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GT200900120A publication Critical patent/GT200900120A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

LA PRESENTE INVENCIÓN SE RELACIONA CON COMPUESTOS QUE TIENEN LA FORMULA GENERAL (I) CON X, Y, R1, R2, R3, R4, R9 Y R10 DEFINIDOS EN EL EXPEDIENTE. DICHOS COMPUESTOS TIENEN UTILIDAD EN EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER Y PARA LA MODULACION DE LA ACTIVIDAD (GAMA)-SECRETASA.
GT200900120A 2006-04-21 2009-05-11 Acidos bifenilcarboxilicos sustituidos y sus derivados GT200900120A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06112938A EP1849762B1 (en) 2006-04-21 2006-04-21 Substituted biphenyl carboxylic acids and derivatives thereof

Publications (1)

Publication Number Publication Date
GT200900120A true GT200900120A (es) 2009-11-16

Family

ID=36688012

Family Applications (1)

Application Number Title Priority Date Filing Date
GT200900120A GT200900120A (es) 2006-04-21 2009-05-11 Acidos bifenilcarboxilicos sustituidos y sus derivados

Country Status (35)

Country Link
US (1) US7557244B2 (es)
EP (2) EP1849762B1 (es)
JP (1) JP5479088B2 (es)
KR (1) KR101542255B1 (es)
CN (1) CN101687758B (es)
AP (1) AP2008004656A0 (es)
AR (1) AR060568A1 (es)
AU (1) AU2007240335B2 (es)
BR (1) BRPI0710656A2 (es)
CA (1) CA2650006C (es)
CR (2) CR10375A (es)
CY (1) CY1109399T1 (es)
DE (1) DE602006007810D1 (es)
DK (1) DK1849762T3 (es)
EA (1) EA016129B9 (es)
ES (2) ES2328616T3 (es)
GE (1) GEP20115269B (es)
GT (1) GT200900120A (es)
IL (2) IL194852A0 (es)
MA (1) MA30475B1 (es)
MX (1) MX2008013445A (es)
MY (1) MY148953A (es)
NO (1) NO20084517L (es)
NZ (1) NZ573000A (es)
PE (1) PE20080364A1 (es)
PL (1) PL1849762T3 (es)
PT (1) PT1849762E (es)
SI (1) SI1849762T1 (es)
SM (1) SMP200800061B (es)
TN (1) TNSN08413A1 (es)
TW (1) TWI399362B (es)
UA (1) UA95952C2 (es)
UY (1) UY30301A1 (es)
WO (1) WO2007124394A1 (es)
ZA (1) ZA200809856B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101896452B (zh) 2007-10-19 2013-07-31 詹森药业有限公司 连接有碳的γ-分泌酶调节剂
AU2008312362A1 (en) * 2007-10-19 2009-04-23 Janssen Pharmaceutica, N.V. Gsm intermediates
KR101569391B1 (ko) 2007-10-19 2015-11-16 얀센 파마슈티카 엔.브이. γ-세크레타아제의 피페리디닐 및 피페라지닐 조절제
AU2008312371B2 (en) * 2007-10-19 2013-06-20 Janssen Pharmaceutica, N.V. Amine linked modulators of gamma-secretase
US20110092554A1 (en) * 2007-11-19 2011-04-21 Richard Chesworth 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
CA2710477A1 (en) 2007-12-20 2009-07-09 Envivo Pharmaceuticals, Inc. Tetrasubstituted benzenes
EP2488031A4 (en) 2009-10-16 2014-07-23 Merck Sharp & Dohme DIARYL ETHER DERIVATIVES AS A NOTCH-PROOFING GAMMETRETASE INHIBITOR
US8785481B2 (en) 2010-09-29 2014-07-22 Merck Sharp & Dohme Corp. Ether benzotriazole derivatives
CA2828764A1 (en) * 2011-03-03 2012-09-07 Treventis Corporation Anti-amyloid compounds and methods
WO2015109109A1 (en) 2014-01-15 2015-07-23 Forum Pharmaceuticals Inc. Fused morpholinopyrimidines and methods of use thereof
US9802927B2 (en) 2015-06-10 2017-10-31 Denali Therapeutics, Inc. Oxadiazine compounds and methods of use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877399A (en) * 1994-01-27 1999-03-02 Johns Hopkins University Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
JP3802581B2 (ja) * 1995-03-01 2006-07-26 富山化学工業株式会社 新規なビフェニル誘導体またはその塩およびそれらを含有する抗炎症剤
AU5702201A (en) * 2000-04-13 2001-10-30 Mayo Foundation Abeta<sub>42</sub> lowering agents
DE10131899A1 (de) 2001-07-04 2003-02-27 Boehringer Ingelheim Pharma In vitro-Screening-Assay für gamma-Secretase
MXPA04012783A (es) * 2002-06-27 2005-02-24 Fujisawa Pharmaceutical Co Derivados de aminoalcohol.
GB0305918D0 (en) * 2003-03-14 2003-04-23 Glaxo Group Ltd Novel compounds
WO2005110963A1 (en) * 2004-05-19 2005-11-24 Cellzome Ag (biphenyl-3-yl)-carboxylic acids and derivatives thereof and their use in therapy
GB0416508D0 (en) * 2004-07-23 2004-08-25 Merck Sharp & Dohme Therapeutic agents
WO2006022237A1 (ja) * 2004-08-24 2006-03-02 Kissei Pharmaceutical Co., Ltd. 脂肪肝の予防または治療剤
US8148572B2 (en) * 2005-10-06 2012-04-03 Astrazeneca Ab Compounds

Also Published As

Publication number Publication date
TW200815320A (en) 2008-04-01
ES2328616T3 (es) 2009-11-16
WO2007124394A1 (en) 2007-11-01
UA95952C2 (ru) 2011-09-26
MA30475B1 (fr) 2009-06-01
CY1109399T1 (el) 2014-07-02
CN101687758A (zh) 2010-03-31
JP5479088B2 (ja) 2014-04-23
DK1849762T3 (da) 2009-10-12
SI1849762T1 (sl) 2009-12-31
EA016129B9 (ru) 2012-06-29
EP1849762A1 (en) 2007-10-31
AR060568A1 (es) 2008-06-25
AU2007240335B2 (en) 2013-05-02
NZ573000A (en) 2011-11-25
PE20080364A1 (es) 2008-05-16
MX2008013445A (es) 2009-03-10
SMAP200800061A (it) 2008-11-19
CR10451A (es) 2009-03-31
AP2008004656A0 (en) 2008-10-31
KR101542255B1 (ko) 2015-08-06
CA2650006A1 (en) 2007-11-01
KR20090024679A (ko) 2009-03-09
EP2021314B1 (en) 2013-01-23
PT1849762E (pt) 2009-09-16
US20070293567A1 (en) 2007-12-20
GEP20115269B (en) 2011-08-25
AU2007240335A1 (en) 2007-11-01
IL194790A0 (en) 2009-08-03
MY148953A (en) 2013-06-14
EA200802172A1 (ru) 2009-06-30
UY30301A1 (es) 2007-08-31
CR10375A (es) 2009-02-26
EA016129B1 (ru) 2012-02-28
BRPI0710656A2 (pt) 2011-08-16
EP2021314A1 (en) 2009-02-11
EP1849762B1 (en) 2009-07-15
TWI399362B (zh) 2013-06-21
NO20084517L (no) 2009-01-13
US7557244B2 (en) 2009-07-07
IL194790A (en) 2012-12-31
CN101687758B (zh) 2014-05-14
TNSN08413A1 (en) 2010-04-14
IL194852A0 (en) 2009-08-03
CA2650006C (en) 2016-08-23
DE602006007810D1 (de) 2009-08-27
PL1849762T3 (pl) 2009-12-31
ES2400530T3 (es) 2013-04-10
SMP200800061B (it) 2009-07-14
JP2009544573A (ja) 2009-12-17
ZA200809856B (en) 2009-06-24

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