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UY29927A1 - Derivados sustituidos de la 5-fenil-2-tioxo-imidazolin-4-ona y de la 5-fenil-2-amino-imidazolidin-4-ona y sus sales, composiciones y aplicaciones - Google Patents

Derivados sustituidos de la 5-fenil-2-tioxo-imidazolin-4-ona y de la 5-fenil-2-amino-imidazolidin-4-ona y sus sales, composiciones y aplicaciones

Info

Publication number
UY29927A1
UY29927A1 UY29927A UY29927A UY29927A1 UY 29927 A1 UY29927 A1 UY 29927A1 UY 29927 A UY29927 A UY 29927A UY 29927 A UY29927 A UY 29927A UY 29927 A1 UY29927 A1 UY 29927A1
Authority
UY
Uruguay
Prior art keywords
fenil
ona
compositions
salts
tioxo
Prior art date
Application number
UY29927A
Other languages
English (en)
Inventor
Lindstrom Johan
Sahil Patel
Christopher Murray
Karin Kolmodin
Katharina Hogdin
Sven Hellberg
Miles Congreve
Gianni Chessari
Jeremy Burrows
Kihlstrom Jacob
Johan Hedstrom
Stefan Berg
Original Assignee
Astex Therapeutics Ltd
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38049092&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY29927(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astex Therapeutics Ltd, Astrazeneca Ab filed Critical Astex Therapeutics Ltd
Publication of UY29927A1 publication Critical patent/UY29927A1/es

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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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Abstract

Esta invención se refiere a compuestos novedosos que poseen la siguiente fórmula estructural I: y a sus sales farmacéuticamente aceptables, composiciones y métodos de uso. Dichos compuestos novedosos propocionan un tratamiento o profilaxis del deterioro cognoscito, la enfermedad de Alzheimer, la neurodegeneración y la demencia.
UY29927A 2005-11-21 2006-11-20 Derivados sustituidos de la 5-fenil-2-tioxo-imidazolin-4-ona y de la 5-fenil-2-amino-imidazolidin-4-ona y sus sales, composiciones y aplicaciones UY29927A1 (es)

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CA2630680A1 (en) 2007-05-24
TW200734311A (en) 2007-09-16
WO2007058602A2 (en) 2007-05-24
NO20082673L (no) 2008-07-23
AR057984A1 (es) 2008-01-09
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US20080293718A1 (en) 2008-11-27
US20090233930A9 (en) 2009-09-17
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