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CY1108621T1 - Ενωσεις συγχωνευμενου δακτυλιου αζαδεκαλινης ως ρυθμιστες υποδοχεα γλυκοκορτικοειδων - Google Patents

Ενωσεις συγχωνευμενου δακτυλιου αζαδεκαλινης ως ρυθμιστες υποδοχεα γλυκοκορτικοειδων

Info

Publication number
CY1108621T1
CY1108621T1 CY20081101413T CY081101413T CY1108621T1 CY 1108621 T1 CY1108621 T1 CY 1108621T1 CY 20081101413 T CY20081101413 T CY 20081101413T CY 081101413 T CY081101413 T CY 081101413T CY 1108621 T1 CY1108621 T1 CY 1108621T1
Authority
CY
Cyprus
Prior art keywords
corticides
azadekalini
glucic
compounded
regulators
Prior art date
Application number
CY20081101413T
Other languages
English (en)
Inventor
Robin D Clark
Nicholas C Ray
Paul M Blaney
Christopher A Hurley
Karen Williams
Original Assignee
Corcept Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corcept Therapeutics, Inc. filed Critical Corcept Therapeutics, Inc.
Publication of CY1108621T1 publication Critical patent/CY1108621T1/el

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/06—Antiarrhythmics
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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Abstract

Η παρούσα εφεύρεση παρέχει μιαν νεωτερική κατηγορία ενώσεων συγχωνευμένου δακτυλίου αζαδεκαλίνης καθώς και μεθόδους για την χρήση των ενώσεων ως ρυθμιστές υποδοχέα γλυκοκορτιδοειδών.
CY20081101413T 2004-03-09 2008-12-05 Ενωσεις συγχωνευμενου δακτυλιου αζαδεκαλινης ως ρυθμιστες υποδοχεα γλυκοκορτικοειδων CY1108621T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55183604P 2004-03-09 2004-03-09
EP05725295A EP1735308B1 (en) 2004-03-09 2005-03-09 Fused ring azadecalin glucocorticoid receptor modulators

Publications (1)

Publication Number Publication Date
CY1108621T1 true CY1108621T1 (el) 2014-04-09

Family

ID=34961932

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081101413T CY1108621T1 (el) 2004-03-09 2008-12-05 Ενωσεις συγχωνευμενου δακτυλιου αζαδεκαλινης ως ρυθμιστες υποδοχεα γλυκοκορτικοειδων

Country Status (18)

Country Link
US (4) US7928237B2 (el)
EP (1) EP1735308B1 (el)
JP (1) JP4931794B2 (el)
KR (1) KR101185281B1 (el)
CN (1) CN101027301B (el)
AT (1) ATE407934T1 (el)
AU (1) AU2005222421B2 (el)
CA (1) CA2558899C (el)
CY (1) CY1108621T1 (el)
DE (1) DE602005009687D1 (el)
DK (1) DK1735308T3 (el)
ES (1) ES2313317T3 (el)
HK (1) HK1104813A1 (el)
IL (1) IL177982A (el)
NZ (1) NZ550362A (el)
PT (1) PT1735308E (el)
WO (1) WO2005087769A1 (el)
ZA (1) ZA200608306B (el)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602005009687D1 (de) * 2004-03-09 2008-10-23 Corcept Therapeutics Inc Azadecalinverbindungen mit kondensiertem ring als glucocorticoidrezeptormodulatoren
TWI410422B (zh) 2007-01-15 2013-10-01 Mitsubishi Tanabe Pharma Corp 縮合四氫喹啉衍生物及其醫藥用途
EP2211845B1 (en) 2007-10-17 2017-02-22 Laboratoire HRA Pharma Glucocorticoid receptor antagonists such as mifepristone for treating cushing's syndrome
EP3607942A1 (en) 2008-11-07 2020-02-12 University of Sheffield Medicament and method of diagnosis
JP5637568B2 (ja) * 2009-05-12 2014-12-10 コーセプト セラピューティクス， インコーポレイテッド 固体形態および調製のためのプロセス
WO2011053574A1 (en) * 2009-10-30 2011-05-05 Merck Sharp & Dohme Corp. 2- [1-PHENYL-5-HYDROXY-4a-SUBSTITUTED-HEXAHYDROCYCLOPENTA [F] INDAZOL-5-YL] ETHYL PHENYL DERIVATIVES AS GLUCOCORTICOID RECEPTOR LIGANDS
ES2579311T3 (es) * 2010-01-15 2016-08-09 Rigel Pharmaceuticals, Inc. Ensayo de exploración empleando DEX y GDF8
CN103080108A (zh) * 2010-08-27 2013-05-01 科赛普特治疗公司 吡啶基-胺稠合的氮杂萘烷调节剂
AU2012204232A1 (en) * 2011-01-07 2013-06-27 Corcept Therapeutics, Inc. Combination steroid and glucocorticoid receptor antagonist therapy
US9006568B2 (en) 2012-02-15 2015-04-14 Phillips 66 Company Synthesis of photovoltaic conjugated polymers
WO2013130420A1 (en) * 2012-02-27 2013-09-06 Corcept Therapeutics, Inc. Phenyl heterocycloalkyl glucocorticoid receptor modulators
PL3338781T3 (pl) 2012-05-25 2020-03-31 Corcept Therapeutics Incorporated Modulatory receptorów glukokortykoidowych typu azadekaliny skondensowanej z heteroaryloketonem
US12226412B2 (en) 2012-05-25 2025-02-18 Corcept Therapeutics, Inc. Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
US8859774B2 (en) 2012-05-25 2014-10-14 Corcept Therapeutics, Inc. Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
WO2014088795A1 (en) 2012-12-03 2014-06-12 Phillips 66 Company Benzo [1,2-b:4,5-b'] dithiophene-thienothiophene based conjugated polymers
FI3848027T3 (fi) * 2013-11-25 2023-05-04 Corcept Therapeutics Inc Oktahydrofuusioituja atsadekaliiniglukokortikoidireseptorin modulaattoreita
WO2015077537A1 (en) * 2013-11-25 2015-05-28 Corcept Therapeutics, Inc. Heteroaryl-ether fused azadecalin glucocorticoid receptor modulators
CN107530435A (zh) * 2015-03-02 2018-01-02 科赛普特治疗学股份有限公司 使用糖皮质激素受体拮抗剂和生长抑素治疗acth分泌型肿瘤
CN107530339B (zh) 2015-03-30 2021-03-16 科赛普特治疗学股份有限公司 糖皮质激素受体拮抗剂联合糖皮质激素用于治疗肾上腺功能不全
KR20180052120A (ko) 2015-08-13 2018-05-17 코어셉트 쎄라퓨틱스, 잉크. Acth-의존성 쿠싱 증후군을 감별 진단하는 방법
US9905769B2 (en) 2015-10-01 2018-02-27 Phillips 66 Company Process of manufacturing an electron transport material
US10099963B2 (en) 2015-10-01 2018-10-16 Phillips 66 Company Formation of films for organic photovoltaics
US10312448B2 (en) 2015-10-01 2019-06-04 Phillips 66 Company Process of manufacturing an electron transport material
US9911919B2 (en) 2015-10-01 2018-03-06 Phillips 66 Company Process of manufacturing an electron transport material
US10418555B2 (en) 2015-10-01 2019-09-17 Phillips 66 Company Formation of films for organic photovoltaics
JP6765443B2 (ja) 2016-01-19 2020-10-07 コーセプト セラピューティクス， インコーポレイテッド 異所性クッシング症候群の鑑別診断
PH12018501848B1 (en) 2016-03-01 2024-02-23 Corcept Therapeutics Inc The use of glucocorticoid receptor modulators to potentiate checkpoint inhibitors
US9943505B2 (en) 2016-09-09 2018-04-17 Corcept Therapeutics, Inc. Glucocorticoid receptor modulators to treat pancreatic cancer
CA3053806A1 (en) 2017-03-09 2018-09-13 Corcept Therapeutics, Inc. Use of glucocorticoid receptor modulators in the treatment of catecholamine-secreting tumors
EP3600282A4 (en) 2017-03-31 2020-08-19 Corcept Therapeutics, Inc. GLUCOCORTICOID RECEPTOR MODULATORS FOR THE TREATMENT OF COLD CANCER
AU2018289307B2 (en) 2017-06-20 2024-02-01 Corcept Therapeutics, Inc. Methods of treating neuroepithelial tumors using selective glucocorticoid receptor modulators
IL263184A (en) 2018-11-21 2020-05-31 Yarden Yosef Method of treating cancer and compositions for same
US11234971B2 (en) 2018-12-19 2022-02-01 Corcept Therapeutics Incorporated Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
WO2020132023A1 (en) 2018-12-19 2020-06-25 Corcept Therapeutics Incorporated Pharmaceutical formulations containing relacorilant, a heteroaryl-ketone fused azadecalin compound
US11389432B2 (en) 2018-12-19 2022-07-19 Corcept Therapeutics Incorporated Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
CN113490496A (zh) 2019-02-22 2021-10-08 科赛普特治疗学股份有限公司 一种杂芳基-酮稠合氮杂萘烷糖皮质激素受体调节剂瑞拉可兰的治疗用途
AU2020367769B2 (en) 2019-10-16 2023-10-12 Corcept Therapeutics Incorporated Method of normalizing the neutrophil to lymphocyte ratio in cancer patients with a selective glucocorticoid receptor antagonist
KR20220113767A (ko) 2019-12-11 2022-08-16 코어셉트 쎄라퓨틱스 인코포레이티드 미리코릴란트로 항정신병약-유도 체중 증가를 치료하는 방법
WO2021127376A1 (en) 2019-12-21 2021-06-24 Corcept Therapeutics Incorporated Treatment of, and differential diagnosis between, acth-dependent cushing's syndrome and acth-independent cushing's syndrome
KR20220140567A (ko) * 2020-02-10 2022-10-18 코어셉트 쎄라퓨틱스 인코포레이티드 선택적 글루코코르티코이드 수용체 조절제를 사용하여 항-종양 반응을 자극하는 방법
CN116113627A (zh) 2020-06-22 2023-05-12 科赛普特治疗公司 季吲哚糖皮质激素受体拮抗剂
WO2022134033A1 (en) 2020-12-25 2022-06-30 Corcept Therapeutics Incorporated Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
CN116829556A (zh) * 2021-02-03 2023-09-29 江苏恒瑞医药股份有限公司 稠合的氮杂三环类衍生物、其制备方法及其在医药上的应用
EP4452968A1 (en) 2021-12-21 2024-10-30 Corcept Therapeutics Incorporated Bicyclic indazole glucocorticoid receptor antagonists
AU2022417485A1 (en) 2021-12-21 2024-07-04 Corcept Therapeutics Incorporated Piperazine indazole glucocorticoid receptor antagonists
US20230416250A1 (en) * 2022-06-28 2023-12-28 Corcept Therapeutics Incorporated Methods of preparing heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
US20240317742A1 (en) * 2023-02-24 2024-09-26 Corcept Therapeutics Incorporated Methods of preparing intermediates of heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8828669D0 (en) * 1988-12-08 1989-01-11 Lilly Industries Ltd Organic compounds
JP4498602B2 (ja) * 1998-03-10 2010-07-07 リサーチ・トライアングル・インスティチュート 新規なオピエート化合物、その調製法及び使用法
GB9911053D0 (en) * 1999-05-12 1999-07-14 Pharmacia & Upjohn Spa 4,5,6,7-tetrahydroindazole derivatives process for their preparation and their use as antitumour agents
WO2003061651A1 (en) * 2002-01-22 2003-07-31 The Regents Of The University Of California Non-steroidal ligands for the glucocorticoid receptor, compositions and uses thereof
DE602005009687D1 (de) * 2004-03-09 2008-10-23 Corcept Therapeutics Inc Azadecalinverbindungen mit kondensiertem ring als glucocorticoidrezeptormodulatoren
JP5637568B2 (ja) * 2009-05-12 2014-12-10 コーセプト セラピューティクス， インコーポレイテッド 固体形態および調製のためのプロセス

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US20070281928A1 (en) 2007-12-06
ES2313317T3 (es) 2009-03-01
EP1735308A1 (en) 2006-12-27
DK1735308T3 (da) 2009-01-19
ZA200608306B (en) 2009-02-25
JP2007528417A (ja) 2007-10-11
ATE407934T1 (de) 2008-09-15
CN101027301B (zh) 2011-06-29
KR101185281B1 (ko) 2012-09-21
CA2558899A1 (en) 2005-09-22
KR20070029684A (ko) 2007-03-14
CA2558899C (en) 2013-02-05
EP1735308B1 (en) 2008-09-10
US20120225856A1 (en) 2012-09-06
JP4931794B2 (ja) 2012-05-16
HK1104813A1 (en) 2008-01-25
US7928237B2 (en) 2011-04-19
AU2005222421A1 (en) 2005-09-22
US8557839B2 (en) 2013-10-15
US20140179671A1 (en) 2014-06-26
CN101027301A (zh) 2007-08-29
US20110166110A1 (en) 2011-07-07
AU2005222421B2 (en) 2010-09-23
DE602005009687D1 (de) 2008-10-23
PT1735308E (pt) 2008-12-02
IL177982A (en) 2012-09-24
NZ550362A (en) 2010-06-25
IL177982A0 (en) 2006-12-31

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