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CY1108106T1 - Χειμερικα μορια l1 ανθρωπινου θηλωματοϊου (hpv) και χρησεις τους - Google Patents

Χειμερικα μορια l1 ανθρωπινου θηλωματοϊου (hpv) και χρησεις τους

Info

Publication number
CY1108106T1
CY1108106T1 CY20081100480T CY081100480T CY1108106T1 CY 1108106 T1 CY1108106 T1 CY 1108106T1 CY 20081100480 T CY20081100480 T CY 20081100480T CY 081100480 T CY081100480 T CY 081100480T CY 1108106 T1 CY1108106 T1 CY 1108106T1
Authority
CY
Cyprus
Prior art keywords
hpv
windows
human patients
disclosed
chimeric proteins
Prior art date
Application number
CY20081100480T
Other languages
English (en)
Inventor
Susan Wilson
Wendy White
Joann A Suzich
Brian Mullikin
Original Assignee
Medimmune, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune, Llc filed Critical Medimmune, Llc
Publication of CY1108106T1 publication Critical patent/CY1108106T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/084—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5256—Virus expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5258—Virus-like particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20023—Virus like particles [VLP]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Αποκαλύπτονται χειμερικές πρωτεΐνες L1 HPV και παρόμοια με ιούς σωματίδια που τις περιέχουν τα οποία είναι ικανά να δημιουργούν αποκρίσεις εξουδετερωτικού αντισώματος υψηλού τίτλου έναντι δύο τουλάχιστον τύπων HPV. Οι αποκαλυπτόμενες χειμερικές πρωτεΐνες L1 HPV και VLP είναι χρήσιμες ως θεραπευτικά και προφυλακτικά αντιδραστήρια, καθώς και ως αντιδραστήρια για τη διάγνωση της μόλυνσης από θηλωματοϊό.
CY20081100480T 2000-06-21 2008-05-06 Χειμερικα μορια l1 ανθρωπινου θηλωματοϊου (hpv) και χρησεις τους CY1108106T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21283900P 2000-06-21 2000-06-21
EP01942170A EP1292328B1 (en) 2000-06-21 2001-06-12 Chimeric human papillomavirus (hpv) l1 molecules and uses therefor

Publications (1)

Publication Number Publication Date
CY1108106T1 true CY1108106T1 (el) 2014-02-12

Family

ID=22792617

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20081100480T CY1108106T1 (el) 2000-06-21 2008-05-06 Χειμερικα μορια l1 ανθρωπινου θηλωματοϊου (hpv) και χρησεις τους

Country Status (11)

Country Link
US (2) US6908613B2 (el)
EP (1) EP1292328B1 (el)
AT (1) ATE386105T1 (el)
AU (2) AU7545801A (el)
CA (1) CA2411945C (el)
CY (1) CY1108106T1 (el)
DE (1) DE60132770T2 (el)
DK (1) DK1292328T3 (el)
ES (1) ES2301551T3 (el)
PT (1) PT1292328E (el)
WO (1) WO2001097840A1 (el)

Families Citing this family (31)

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DK1126876T3 (da) 1998-10-16 2007-07-02 Glaxosmithkline Biolog Sa Adjuvanssystemer og vacciner
US6908613B2 (en) * 2000-06-21 2005-06-21 Medimmune, Inc. Chimeric human papillomavirus (HPV) L1 molecules and uses therefor
DE10137102A1 (de) 2001-07-30 2003-02-27 Deutsches Krebsforsch Polyvalente Vakzine gegen durch Papillomaviren verursachte Erkrankungen, Verfahren zu deren Herstellung und deren Verwendung
GB0206360D0 (en) * 2002-03-18 2002-05-01 Glaxosmithkline Biolog Sa Viral antigens
GB0206359D0 (en) * 2002-03-18 2002-05-01 Glaxosmithkline Biolog Sa Viral antigens
WO2004056389A1 (en) * 2002-12-20 2004-07-08 Glaxosmithkline Biologicals Sa Hpv-16 and -18 l1 vlp vaccine
US7858098B2 (en) * 2002-12-20 2010-12-28 Glaxosmithkline Biologicals, S.A. Vaccine
WO2004062584A2 (en) * 2003-01-10 2004-07-29 Regents Of The University Of Colorado Therapeutic and prophylactic vaccine for the treatment and prevention of papillomavirus infection
US20060029612A1 (en) * 2004-04-15 2006-02-09 Large Scale Biology Corporation Prevention and treatment of recurrent respiratory papillomatosis
BRPI0512042B8 (pt) * 2004-06-16 2021-05-25 Glaxosmithkline Biologicals Sa composição imunogênica, vacina, uso de uma composição ou vacina, método para produzir uma composição imunogênica, e, uso de vlps ou capsômeros de hpv 16 e 18 com vlps ou capsômeros de pelo menos um outro hpv do tipo causador de câncer
US7758866B2 (en) * 2004-06-16 2010-07-20 Glaxosmithkline Biologicals, S.A. Vaccine against HPV16 and HPV18 and at least another HPV type selected from HPV 31, 45 or 52
DE602005022458D1 (de) * 2004-09-10 2010-09-02 Asahi Glass Co Ltd Impfstoff gegen humanes papillomavirus zur oralen verabreichung
JP4182074B2 (ja) * 2005-03-03 2008-11-19 ファナック株式会社 ハンド及びハンドリングロボット
US20060240456A1 (en) * 2005-03-22 2006-10-26 Liaohai Chen Nanosized biological container and manufacture thereof
CA2606092A1 (en) * 2005-04-26 2006-11-02 Glaxosmithkline Biologicals S.A. Vaccine
MX2007013475A (es) * 2005-04-26 2008-04-02 Glaxosmithkline Biolog Sa Vacuna.
WO2007038145A2 (en) * 2005-09-08 2007-04-05 Large Scale Biology Corporation Modified tobacco mosaic virus particles as scaffolds for display of protein antigens for vaccine applications
US8450056B2 (en) * 2008-05-02 2013-05-28 University Of Rochester Arrayed imaging reflectometry (AIR) sensor chip comprising virus-like particles suitable for the detection of antiviral immune responses
US20120064115A1 (en) 2009-05-01 2012-03-15 Corinne John Recombinant virus-like particles encoded by multi-gene vector
WO2021013076A1 (zh) * 2019-07-19 2021-01-28 神州细胞工程有限公司 嵌合的人乳头瘤病毒45型l1蛋白
WO2021013069A1 (zh) * 2019-07-19 2021-01-28 神州细胞工程有限公司 嵌合的人乳头瘤病毒11型l1蛋白
CN114174320B (zh) * 2019-07-19 2024-05-24 神州细胞工程有限公司 嵌合的人乳头瘤病毒18型l1蛋白
EP4001297A4 (en) * 2019-07-19 2023-09-27 Sinocelltech Ltd CHIMERIC PAPILLOMAVIRUS L1 PROTEIN
CA3147849A1 (en) * 2019-07-19 2021-01-28 Sinocelltech Ltd. Polyvalent immunogenicity composition for human papillomavirus
CN114127295B (zh) * 2019-07-19 2024-05-14 神州细胞工程有限公司 嵌合的人乳头瘤病毒16型l1蛋白
CN114127127B (zh) * 2019-07-19 2024-04-09 神州细胞工程有限公司 嵌合的人乳头瘤病毒35型l1蛋白
CN114127100B (zh) * 2019-07-19 2024-04-02 神州细胞工程有限公司 嵌合的人乳头瘤病毒39型l1蛋白
CN110646612A (zh) * 2019-09-30 2020-01-03 源道隆（苏州）医学科技有限公司 一种用于检测血清hpv抗体的试剂及试剂盒
TWI858159B (zh) * 2020-10-13 2024-10-11 大陸商神州細胞工程有限公司 人乳頭瘤病毒多價免疫原性組合物
KR20230129506A (ko) * 2021-01-14 2023-09-08 사이노셀테크 엘티디. 인간 유두종 바이러스 유사 입자 백신의 안정한 제제
CN117737311B (zh) * 2024-02-20 2024-04-19 湖南派智生物科技有限公司 检测犬乳头瘤病毒的通用引物对、试剂、试剂盒及应用

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US5618536A (en) 1992-09-03 1997-04-08 The United States Of America As Represented By The Department Of Health And Human Services Chimeric papillomavirus-like particles
ES2264563T3 (es) * 1994-10-07 2007-01-01 Loyola University Of Chicago Particulas semejantes al virus del papiloma, proteinas de fusion y procedimiento para su preparacion.
DE69635954T2 (de) * 1995-07-19 2006-11-30 Merck & Co., Inc. Synthetische hpv-11 ähnliche partikel
AUPO390396A0 (en) * 1996-11-29 1996-12-19 Csl Limited Novel promiscuous T helper cell epitopes
FR2767217B1 (fr) * 1997-08-06 1999-11-12 Conception Organisation Logist Systeme de lecture et d'authentification d'un code magnetique
US6228368B1 (en) * 1997-10-06 2001-05-08 Loyola University Of Chicago Papilloma virus capsomere formulations and method of use
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US6908613B2 (en) * 2000-06-21 2005-06-21 Medimmune, Inc. Chimeric human papillomavirus (HPV) L1 molecules and uses therefor

Also Published As

Publication number Publication date
DE60132770D1 (de) 2008-03-27
US20060127979A1 (en) 2006-06-15
DE60132770T2 (de) 2009-05-07
AU2001275458B2 (en) 2004-08-19
DK1292328T3 (da) 2008-06-16
CA2411945C (en) 2015-05-26
US7390487B2 (en) 2008-06-24
WO2001097840A1 (en) 2001-12-27
ATE386105T1 (de) 2008-03-15
US6908613B2 (en) 2005-06-21
EP1292328A1 (en) 2003-03-19
AU7545801A (en) 2002-01-02
PT1292328E (pt) 2008-05-19
ES2301551T3 (es) 2008-07-01
CA2411945A1 (en) 2001-12-27
US20040224305A1 (en) 2004-11-11
EP1292328B1 (en) 2008-02-13
EP1292328A4 (en) 2005-01-26

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