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CY1107405T1 - Σyνθεση φεντανyλης για ρινικh χορhγηση - Google Patents

Σyνθεση φεντανyλης για ρινικh χορhγηση

Info

Publication number
CY1107405T1
CY1107405T1 CY20081100405T CY081100405T CY1107405T1 CY 1107405 T1 CY1107405 T1 CY 1107405T1 CY 20081100405 T CY20081100405 T CY 20081100405T CY 081100405 T CY081100405 T CY 081100405T CY 1107405 T1 CY1107405 T1 CY 1107405T1
Authority
CY
Cyprus
Prior art keywords
fentanyl
administration
nutrition
nose
results
Prior art date
Application number
CY20081100405T
Other languages
English (en)
Inventor
Jesper Grarup
Hannen Wulff Nielsen
Original Assignee
Nycomed Danmark Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8159630&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1107405(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nycomed Danmark Aps filed Critical Nycomed Danmark Aps
Publication of CY1107405T1 publication Critical patent/CY1107405T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Otolaryngology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Η θεραπεία του οξέος πόνου με μία ικανοποιητική δοσολογία με ενδορινική χορήγηση φεντανύλης έχει σαν αποτέλεσμα χρόνο για εμφάνιση δράσης συγκρίσιμο προς ενδοφλέβια χορήγηση και μία σημαντικά ταχύτερη εμφάνιση δράσης από ότι η ρινική τιτλοδότηση της φεντανύλης. Η ρινική χορήγηση μιας επαρκούς ποσότητας φεντανύλης για να ληφθεί ανακούφιση πόνου έχει χαμηλότερες μέγιστες συγκεντρώσεις πλάσματος συγκρίσιμες προς ενδοφλέβια χορήγηση και έχει σαν αποτέλεσμα χαμηλά ποσοστά αντίθετων γεγονότων όπως αναπνευστικής καταστολής, ναυτίας και εμέτου. Αποκαλύπτονται επίσης συνθέσεις για χρήση στη μέθοδο.
CY20081100405T 2000-07-31 2008-04-14 Σyνθεση φεντανyλης για ρινικh χορhγηση CY1107405T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200001154 2000-07-31
EP01960190A EP1307194B2 (en) 2000-07-31 2001-07-31 Fentanyl composition for nasal administration

Publications (1)

Publication Number Publication Date
CY1107405T1 true CY1107405T1 (el) 2012-12-19

Family

ID=8159630

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20081100405T CY1107405T1 (el) 2000-07-31 2008-04-14 Σyνθεση φεντανyλης για ρινικh χορhγηση
CY20131100788T CY1114645T1 (el) 2000-07-31 2013-09-11 Συνθεση αλατος φεντανυλης για ρινικη χορηγηση

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY20131100788T CY1114645T1 (el) 2000-07-31 2013-09-11 Συνθεση αλατος φεντανυλης για ρινικη χορηγηση

Country Status (24)

Country Link
US (3) US8017627B2 (el)
EP (3) EP1642578B2 (el)
JP (2) JP4898073B2 (el)
KR (2) KR20080053423A (el)
CN (2) CN100346788C (el)
AT (1) ATE388705T1 (el)
AU (2) AU2001281746C1 (el)
CA (1) CA2417727C (el)
CY (2) CY1107405T1 (el)
DE (2) DE60133203T3 (el)
DK (2) DK1642578T3 (el)
EA (1) EA006384B1 (el)
EE (1) EE05420B1 (el)
ES (2) ES2302742T5 (el)
HK (1) HK1089106A1 (el)
IL (2) IL154041A0 (el)
IS (1) IS2803B (el)
NO (2) NO330565B1 (el)
NZ (1) NZ524396A (el)
PL (1) PL207845B1 (el)
PT (2) PT1642578E (el)
SI (2) SI1307194T2 (el)
UA (2) UA77398C2 (el)
WO (1) WO2002009707A1 (el)

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