CY1106497T1 - Νεες αρυλοξυ-αλκυλ-διαλκυλαμινες - Google Patents
Νεες αρυλοξυ-αλκυλ-διαλκυλαμινεςInfo
- Publication number
- CY1106497T1 CY1106497T1 CY20071100491T CY071100491T CY1106497T1 CY 1106497 T1 CY1106497 T1 CY 1106497T1 CY 20071100491 T CY20071100491 T CY 20071100491T CY 071100491 T CY071100491 T CY 071100491T CY 1106497 T1 CY1106497 T1 CY 1106497T1
- Authority
- CY
- Cyprus
- Prior art keywords
- alkyl
- group
- independently
- dialkylamines
- perfluorinated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Gynecology & Obstetrics (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Indole Compounds (AREA)
- Detergent Compositions (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει ενώσεις χρήσιμες στη σύνθεση βιολογικώς δραστικών ενώσεων, και μεθόδους για την παραγωγή τους, όπου οι ενώσεις έχουν τον τύπο (I) στον οποίο: τα R1 και R2, ανεξαρτήτως, επιλέγονται από Η, C1-C12 αλκύλιο ή C1-C6 υπερφθοριωμένο αλκύλιο, το Χ παριστάνει απομακρυνόμενη ομάδα, το Α είναι Ο ή S, το m είναι ακέραιος από 1 έως 3, κατά προτίμηση 2, τα R3, R4, R5 και R6 επιλέγονται ανεξαρτήτως από Η, αλογόνο, -ΝO2, αλκύλιο, αλκοξυ, C1-C6 υπερφθοριωμένο αλκύλιο, ΟΗ ή τους C1-C4 εστέρες ή αλκυλαιθέρες τους, -CN, -O-R1, -O-Ar, -S-R1, -S-Ar, -SO-R1, -SO-Ar, -SO2-R1, -SΟ2-Ar, -CO-R1, -CO-Ar, -CO2-R1, ή -CΟ2-Ar, και το Υ επιλέγεται από α) την ομάδα (i) όπου τα R7 και R8 επιλέγονται ανεξαρτήτως από την ομάδα Η, C1-C6 αλκυλίου ή φαινυλίου, ή β) ένα προαιρετικώς υποκατεστημένο 5-, 6- ή 7-μελή κορεσμένο, ακόρεστο ή μερικώς ακόρεστο ετεροκυκλικό ή δικυκλικό ετεροκυκλικό δακτύλιο που περιέχει μέχρι 2 ετεροάτομα επιλεγόμενα από την ομάδα που αποτελείται από -Ο-, -ΝΗ-, -N(C1-C4 αλκύλιο)-, -Ν= και-S(Ο)n-.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95081897A | 1997-10-15 | 1997-10-15 | |
| US09/161,653 US6005102A (en) | 1997-10-15 | 1998-09-28 | Aryloxy-alkyl-dialkylamines |
| PCT/US1998/021609 WO1999019293A1 (en) | 1997-10-15 | 1998-10-14 | Novel aryloxy-alkyl-dialkylamines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1106497T1 true CY1106497T1 (el) | 2012-01-25 |
Family
ID=26858006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20071100491T CY1106497T1 (el) | 1997-10-15 | 2007-04-05 | Νεες αρυλοξυ-αλκυλ-διαλκυλαμινες |
Country Status (27)
| Country | Link |
|---|---|
| EP (2) | EP1025077B1 (el) |
| JP (1) | JP2001519410A (el) |
| KR (1) | KR100669836B1 (el) |
| CN (1) | CN1231458C (el) |
| AR (1) | AR015183A1 (el) |
| AT (1) | ATE355264T1 (el) |
| AU (1) | AU757630C (el) |
| BR (1) | BR9813069A (el) |
| CA (1) | CA2306343C (el) |
| CY (1) | CY1106497T1 (el) |
| DE (1) | DE69837210T2 (el) |
| DK (1) | DK1025077T3 (el) |
| EA (1) | EA003937B1 (el) |
| EE (1) | EE200000225A (el) |
| ES (1) | ES2281937T3 (el) |
| HK (1) | HK1026889A1 (el) |
| HU (1) | HUP0004419A3 (el) |
| ID (1) | ID24417A (el) |
| IL (2) | IL135343A0 (el) |
| NO (1) | NO20001938L (el) |
| NZ (1) | NZ503793A (el) |
| PL (1) | PL198443B1 (el) |
| PT (1) | PT1025077E (el) |
| SI (1) | SI1025077T1 (el) |
| SK (1) | SK286460B6 (el) |
| TR (1) | TR200001012T2 (el) |
| WO (1) | WO1999019293A1 (el) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6479535B1 (en) | 1998-05-15 | 2002-11-12 | Wyeth | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations |
| CA2329530A1 (en) * | 1998-05-15 | 1999-11-25 | American Home Products Corporation | 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole in combination with estrogens |
| PL354179A1 (en) * | 1999-09-13 | 2003-12-29 | Wyethwyeth | Glucopyranosides conjugates of 2-(4-hydroxy-phenyl)-1-[4-(2-amin-1-yl-ethoxy)-benzyl]-1h-indol-5-ols |
| EP1656938A1 (en) | 2000-07-06 | 2006-05-17 | Wyeth | Combinations of SSRI and estrogenic agents |
| US6376486B1 (en) | 2000-07-06 | 2002-04-23 | American Home Products Corporation | Methods of inhibiting sphincter incontinence |
| WO2002003988A2 (en) | 2000-07-06 | 2002-01-17 | Wyeth | Use of substituted indole compounds for treating neuropeptide y-related conditions |
| US6369051B1 (en) | 2000-07-06 | 2002-04-09 | American Home Products Corporation | Combinations of SSRI and estrogenic agents |
| AR029539A1 (es) | 2000-07-06 | 2003-07-02 | Wyeth Corp | Combinaciones de estatinas y agentes estrogenicos |
| US6455568B2 (en) | 2000-07-06 | 2002-09-24 | Wyeth | Combination therapy for inhibiting sphincter incontinence |
| CN1452497A (zh) | 2000-07-06 | 2003-10-29 | 惠氏公司 | Ssri和雌激素制剂的联合药物形式 |
| AU2001271782A1 (en) | 2000-07-06 | 2002-01-21 | Wyeth | Use of substituted insole compounds for treating excessive intraocular pressure |
| AR029538A1 (es) | 2000-07-06 | 2003-07-02 | Wyeth Corp | Composiciones farmaceuticas de agentes estrogenicos |
| EP1379493A2 (en) * | 2001-03-23 | 2004-01-14 | Eli Lilly and Company | Non-imidazole aryl alkylamines compounds as histamine h3 receptor antagonists, preparation and therapeutic uses |
| US7056931B2 (en) | 2001-05-22 | 2006-06-06 | Eli Lilly And Company | 2-substituted 1,2,3,4-tetrahydroquinolines and derivatives thereof, compositions and methods |
| ES2236536T3 (es) | 2001-05-22 | 2005-07-16 | Eli Lilly And Company | Derivados tetrahidroquinolino para la inhibicion de enfermedades asociadas con la privacion de estrogenos o con una respuesta fisiologica aberrante a estrogenos endogenos. |
| US7314937B2 (en) | 2002-03-21 | 2008-01-01 | Eli Lilly And Company | Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses |
| TW200418825A (en) | 2002-12-16 | 2004-10-01 | Hoffmann La Roche | Novel (R)-and (S) enantiomers of thiophene hydroxamic acid derivatives |
| BRPI0509191A (pt) * | 2004-04-07 | 2007-09-25 | Wyeth Corp | polimorfo cristalino, composição, métodos de preparar forma a polimórfica de acetato de bazedoxifeno, de tratar um mamìfero possuindo uma doença ou sìndrome associada com deficiência de estrogênio ou excesso de estrogênio, e com proliferação ou desenvolvimento anormal de tecidos endometriais, cáncer de mama em um mamìfero, e uma mulher pós-menopausal para um ou vários distúrbios vasomotores, de abaixar colesterol em um mamìfero, e de inibir perda óssea em um mamìfero, e, forma a polimorfa cristalina de acetato de bazedoxifeno |
| EP1732889A1 (en) | 2004-04-07 | 2006-12-20 | Wyeth | Crystalline polymorph of bazedoxifene acetate |
| BRPI0509385A (pt) | 2004-04-08 | 2007-09-18 | Wyeth Corp | composto, composição, métodos de preparar o sal, ea dispensão sólida, de tratar um mamìfero tendo uma doença ou sìndrome associadas com a deficiência de estrogênio ou excesso de estrogênio, uma doença ou distúrbio associados com a proliferação ou desenvolvimento anormal dos tecidos endometriais, de tratar cáncer de mama em um mamìfero, e uma mulher pós-menopáusica quanto a um ou mais distúrbios vasomotores, de reduzir colesterol, e de inibir perda óssea em um mamìfero, dispersão sólida, e, uso de um composto |
| US20060030591A1 (en) * | 2004-08-05 | 2006-02-09 | Wyeth | Crystalline polymorph of pipindoxifene hydrochloride monohydrate |
| RU2007124069A (ru) * | 2005-01-13 | 2009-02-20 | Вайет (Us) | Способы приготовления аминоэтоксибензиловых спиртов |
| US20100087661A1 (en) * | 2007-02-12 | 2010-04-08 | Josef Jirman | Method for the preparation of 5-benzyloxy-2-(4-benzyloxphenyl)-3-methyl-1h-indole |
| WO2009102771A1 (en) * | 2008-02-11 | 2009-08-20 | Wyeth | Methods of converting polymorphic form b of bazedoxifene acetate to polymorphic form a of bazedoxifene acetate |
| AU2010237209A1 (en) * | 2009-04-13 | 2011-09-01 | Sandoz Ag | Processes for the synthesis of bazedoxifene acetate and intermediates thereof |
| US8569483B2 (en) | 2011-06-21 | 2013-10-29 | Divi's Laboratories, Ltd. | Process for the preparation of bazedoxifene acetate and intermediates thereof |
| CN104151265B (zh) * | 2013-05-13 | 2016-10-05 | 上海医药工业研究院 | 醋酸巴多昔芬中间体的制备方法 |
| JP2016518449A (ja) | 2013-05-15 | 2016-06-23 | インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ | インドール製剤を調製するためのプロセスおよび中間体 |
| IT201800006562A1 (it) * | 2018-06-21 | 2019-12-21 | Procedimento e intermedi utili per la preparazione di indoli | |
| IT201900001923A1 (it) | 2019-02-11 | 2020-08-11 | Erregierre Spa | Sali di bazedoxifene utili per la preparazione di bazedoxifene acetato |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH448121A (de) | 1963-03-13 | 1967-12-15 | Hoffmann La Roche | Verfahren zur Herstellung substituierter Hydrazinverbindungen |
| WO1991007107A1 (en) * | 1989-11-13 | 1991-05-30 | Pfizer Inc. | Oxazolidinedione hypoglycemic agents |
| GB9326332D0 (en) | 1993-12-23 | 1994-02-23 | Karo Bio | Indole derivatives |
| JP2000515133A (ja) * | 1996-07-01 | 2000-11-14 | イーライ・リリー・アンド・カンパニー | 血糖降下性および脂質低下性の化合物 |
| YU40999A (sh) * | 1997-02-27 | 2002-06-19 | American Cyanamid Company | N-hidroksi-2-(alkil,aril ili heteroaril sulfanil,sulfinil ili sulfonil)-3-supstituisani alkil,aril ili heteroarilamidi, kao inhibitori za matrične metaloproteinaze |
| JP2001523254A (ja) * | 1997-04-30 | 2001-11-20 | イーライ・リリー・アンド・カンパニー | 抗血栓剤 |
-
1998
- 1998-10-14 DK DK98953459T patent/DK1025077T3/da active
- 1998-10-14 JP JP2000515866A patent/JP2001519410A/ja active Pending
- 1998-10-14 EA EA200000416A patent/EA003937B1/ru not_active IP Right Cessation
- 1998-10-14 EP EP98953459A patent/EP1025077B1/en not_active Expired - Lifetime
- 1998-10-14 PL PL339908A patent/PL198443B1/pl not_active IP Right Cessation
- 1998-10-14 ES ES98953459T patent/ES2281937T3/es not_active Expired - Lifetime
- 1998-10-14 PT PT98953459T patent/PT1025077E/pt unknown
- 1998-10-14 CN CNB988121492A patent/CN1231458C/zh not_active Expired - Fee Related
- 1998-10-14 BR BR9813069-2A patent/BR9813069A/pt not_active Application Discontinuation
- 1998-10-14 AU AU10831/99A patent/AU757630C/en not_active Ceased
- 1998-10-14 EP EP07003195A patent/EP1777214A3/en not_active Withdrawn
- 1998-10-14 CA CA2306343A patent/CA2306343C/en not_active Expired - Fee Related
- 1998-10-14 DE DE69837210T patent/DE69837210T2/de not_active Expired - Lifetime
- 1998-10-14 SK SK537-2000A patent/SK286460B6/sk not_active IP Right Cessation
- 1998-10-14 EE EEP200000225A patent/EE200000225A/xx unknown
- 1998-10-14 ID IDW20000680A patent/ID24417A/id unknown
- 1998-10-14 WO PCT/US1998/021609 patent/WO1999019293A1/en active IP Right Grant
- 1998-10-14 NZ NZ503793A patent/NZ503793A/xx unknown
- 1998-10-14 AT AT98953459T patent/ATE355264T1/de not_active IP Right Cessation
- 1998-10-14 TR TR2000/01012T patent/TR200001012T2/xx unknown
- 1998-10-14 SI SI9830877T patent/SI1025077T1/sl unknown
- 1998-10-14 KR KR1020007004031A patent/KR100669836B1/ko not_active IP Right Cessation
- 1998-10-14 IL IL13534398A patent/IL135343A0/xx active IP Right Grant
- 1998-10-14 AR ARP980105112A patent/AR015183A1/es unknown
- 1998-10-14 HU HU0004419A patent/HUP0004419A3/hu unknown
-
2000
- 2000-03-29 IL IL135343A patent/IL135343A/en not_active IP Right Cessation
- 2000-04-13 NO NO20001938A patent/NO20001938L/no not_active Application Discontinuation
- 2000-09-26 HK HK00106079A patent/HK1026889A1/xx not_active IP Right Cessation
-
2007
- 2007-04-05 CY CY20071100491T patent/CY1106497T1/el unknown
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