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CY1106111T1 - Ανασυνδυασμενος σταθepος κυτταρικος κλωνος, η παρασκευη και χρησιμοποιηση του - Google Patents

Ανασυνδυασμενος σταθepος κυτταρικος κλωνος, η παρασκευη και χρησιμοποιηση του

Info

Publication number
CY1106111T1
CY1106111T1 CY20061100911T CY061100911T CY1106111T1 CY 1106111 T1 CY1106111 T1 CY 1106111T1 CY 20061100911 T CY20061100911 T CY 20061100911T CY 061100911 T CY061100911 T CY 061100911T CY 1106111 T1 CY1106111 T1 CY 1106111T1
Authority
CY
Cyprus
Prior art keywords
cell clone
protein
preparation
stable
recombinant
Prior art date
Application number
CY20061100911T
Other languages
English (en)
Inventor
Manfred Reiter
Wolfgang Mundt
Friedrich Dorner
Original Assignee
Baxter Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=3683861&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1106111(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Baxter Aktiengesellschaft filed Critical Baxter Aktiengesellschaft
Publication of CY1106111T1 publication Critical patent/CY1106111T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/005—Protein-free medium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/70—Undefined extracts
    • C12N2500/76—Undefined extracts from plants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Περιγράφονται ένας σταθερός ανασυνδυασμένος κυτταρικός κλώνος, ο οποίος είναι σταθερός για τουλάχιστον 40 γενιές σε ελεύθερο ορού και πρωτεϊνών μέσο, μία βιομάζα που προήλθε από τον πολλαπλασιασμό του σταθερού κυτταρικού κλώνου σε συνθήκες καλλιέργειας ελεύθερες ορού και πρωτεϊνών και μία μέθοδος παρασκευής ανασυνδυασμένων πρωτεϊνών μέσω της βιομάζας. Επιπλέον, η εφεύρεση αφορά μία μέθοδο παραγωγής σταθερών ανασυνδυασμένων κυτταρικών κλώνων. Η εφεύρεση αφορά περαιτέρω την παρασκευή μιας ανασυνδυασμένης πρωτεΐνης σε ένα συνθετικό ελάχιστο μέσο ελεύθερο ορού και πρωτεϊνών.
CY20061100911T 1999-08-05 2006-07-03 Ανασυνδυασμενος σταθepος κυτταρικος κλωνος, η παρασκευη και χρησιμοποιηση του CY1106111T1 (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/AT1999/000197 WO2001011021A1 (de) 1999-08-05 1999-08-05 Rekombinanter stabiler zellklon, seine herstellung und verwendung

Publications (1)

Publication Number Publication Date
CY1106111T1 true CY1106111T1 (el) 2011-06-08

Family

ID=3683861

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061100911T CY1106111T1 (el) 1999-08-05 2006-07-03 Ανασυνδυασμενος σταθepος κυτταρικος κλωνος, η παρασκευη και χρησιμοποιηση του

Country Status (11)

Country Link
EP (1) EP1200561B1 (el)
JP (1) JP2003506077A (el)
AT (1) ATE330003T1 (el)
AU (1) AU780810B2 (el)
CA (1) CA2381173A1 (el)
CY (1) CY1106111T1 (el)
DE (1) DE59913565D1 (el)
DK (1) DK1200561T3 (el)
ES (1) ES2267280T3 (el)
PT (1) PT1200561E (el)
WO (1) WO2001011021A1 (el)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000517188A (ja) 1996-08-30 2000-12-26 ライフ テクノロジーズ，インコーポレイテッド 無血清哺乳動物細胞培養培地およびその使用
US6475725B1 (en) 1997-06-20 2002-11-05 Baxter Aktiengesellschaft Recombinant cell clones having increased stability and methods of making and using the same
AT409379B (de) 1999-06-02 2002-07-25 Baxter Ag Medium zur protein- und serumfreien kultivierung von zellen
EP1325147A2 (en) * 2000-10-02 2003-07-09 Novo Nordisk A/S Industrial-scale serum-free production of recombinant factor vii in mammalian cells
BR0212780A (pt) 2001-10-02 2004-10-13 Novo Nordisk Healthcare Ag Métodos para produzir polipeptìdeos em células eucarióticas, para cultivar células eucarióticas e para colher polipeptìdeos produzidos por células eucarióticas
CN1596302A (zh) * 2001-11-28 2005-03-16 桑多斯有限公司 细胞培养方法
CA2468971A1 (en) * 2001-12-04 2003-06-12 Mitsubishi Pharma Corporation Method of activating protein
NZ538094A (en) 2002-07-09 2007-01-26 Baxter Int Serum free and animal protein free culture medium for cultivation of cells
US8669109B2 (en) 2003-08-19 2014-03-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Methods of producing proteins in Chinese hamster ovary (CHO) cells
DE10338531A1 (de) * 2003-08-19 2005-04-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Reklonierung von Produktionszellen
DK1699821T3 (da) * 2003-12-31 2012-07-16 Merck Patent Gmbh Fc-ERYTHROPOIETIN-FUSIONSPROTEIN MED FORBEDREDE FARMAKOKINETIKKER
AU2011221414B2 (en) * 2004-10-29 2012-09-20 Takeda Pharmaceutical Company Limited Animal Protein-Free Media for Cultivation of Cells
US20060094104A1 (en) 2004-10-29 2006-05-04 Leopold Grillberger Animal protein-free media for cultivation of cells
JP5523674B2 (ja) * 2005-02-11 2014-06-18 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 植物タンパク質加水分解産物を含有する血清フリーの細胞培養液におけるポリペプチドの生産
PT2522717E (pt) 2006-01-04 2014-05-15 Baxter Healthcare Sa Meios de cultura celulares livres de oligopeptídeos
CA2742107A1 (en) * 2008-11-12 2010-05-20 Baxter International Inc. Method of producing serum-free insulin-free factor vii
WO2024024671A1 (ja) * 2022-07-27 2024-02-01 不二製油グループ本社株式会社 動物細胞増殖促進剤

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9022545D0 (en) * 1990-10-17 1990-11-28 Wellcome Found Culture medium
DE4313620A1 (de) * 1993-04-26 1994-10-27 Biotechnolog Forschung Gmbh Hamsterzellinien und Verfahren zur Glykoproteingewinnung
EP0666312A1 (en) * 1994-02-08 1995-08-09 Wolfgang A. Renner Process for the improvement of mammalian cell growth
EP2290053A1 (en) * 1994-11-10 2011-03-02 Baxter Healthcare S.A. Method for producing Influenza virus in protein-free cell culture medium
WO1996018734A1 (en) * 1994-12-16 1996-06-20 Novartis Ag Production of recombinant secretory component
AUPN442295A0 (en) * 1995-07-26 1995-08-17 Commonwealth Scientific And Industrial Research Organisation Regulated autocrine growth of mammalian cells
US5851800A (en) * 1996-05-14 1998-12-22 Pharmacia & Upjohn Ab Process for producing a protein

Also Published As

Publication number Publication date
AU780810B2 (en) 2005-04-21
ES2267280T3 (es) 2007-03-01
ATE330003T1 (de) 2006-07-15
DE59913565D1 (de) 2006-07-27
JP2003506077A (ja) 2003-02-18
EP1200561A1 (de) 2002-05-02
CA2381173A1 (en) 2001-02-15
PT1200561E (pt) 2006-09-29
AU5363699A (en) 2001-03-05
DK1200561T3 (da) 2006-10-16
WO2001011021A1 (de) 2001-02-15
EP1200561B1 (de) 2006-06-14

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