[go: up one dir, main page]

CR20220622A - Síntesis de intermedios de vinil ciclobutilo - Google Patents

Síntesis de intermedios de vinil ciclobutilo

Info

Publication number
CR20220622A
CR20220622A CR20220622A CR20220622A CR20220622A CR 20220622 A CR20220622 A CR 20220622A CR 20220622 A CR20220622 A CR 20220622A CR 20220622 A CR20220622 A CR 20220622A CR 20220622 A CR20220622 A CR 20220622A
Authority
CR
Costa Rica
Prior art keywords
cyclobutyl
intermediates
vinyl
synthesis
compound
Prior art date
Application number
CR20220622A
Other languages
English (en)
Inventor
Kyle D Baucom
Gabrielle St-Pierre
Peter K Dornan
Philipp C Roosen
Austin G Smith
Michael T Corbett
Roberto Profeta
Neil Fred Langille
Sheng Cui
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of CR20220622A publication Critical patent/CR20220622A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/14—Preparation of carboxylic acid esters from carboxylic acid halides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/62—Use of additives, e.g. for stabilisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/23—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

En la presente se proporcionan procesos para sintetizar intermedios útiles en la preparación de inhibidores de Mcl-1. En particular, en la presente se proporcionan procesos para sintetizar el compuesto F, o una sal del mismo, en donde R<sup>1</sup> y OGP<sup>2</sup> se describen en la presente. El compuesto F puede ser útil para sintetizar el compuesto A1, o una sal o solvato del mismo, y el compuesto A2, o una sal o solvato del mismo. (F),<br /> (A1) y (A2). <br />
CR20220622A 2020-05-06 2021-05-04 Síntesis de intermedios de vinil ciclobutilo CR20220622A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063020877P 2020-05-06 2020-05-06
PCT/US2021/030548 WO2021226009A1 (en) 2020-05-06 2021-05-04 Synthesis of vinyl cyclobutyl intermediates

Publications (1)

Publication Number Publication Date
CR20220622A true CR20220622A (es) 2023-01-24

Family

ID=76197567

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20220622A CR20220622A (es) 2020-05-06 2021-05-04 Síntesis de intermedios de vinil ciclobutilo

Country Status (18)

Country Link
US (1) US20230183164A1 (es)
EP (1) EP4146634A1 (es)
JP (2) JP7494318B2 (es)
KR (1) KR20230006552A (es)
CN (1) CN115485267A (es)
AR (1) AR122000A1 (es)
AU (1) AU2021268617B2 (es)
BR (1) BR112022022471A2 (es)
CA (1) CA3181213A1 (es)
CL (1) CL2022003054A1 (es)
CO (1) CO2022015976A2 (es)
CR (1) CR20220622A (es)
IL (1) IL297523A (es)
MX (1) MX2022013870A (es)
PE (1) PE20230465A1 (es)
TW (1) TWI867217B (es)
UY (1) UY39200A (es)
WO (1) WO2021226009A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2021268569B2 (en) * 2020-05-06 2024-06-13 Amgen Inc. Synthesis of vinylic protected alcohol intermediates
AU2021385537A1 (en) * 2020-11-25 2023-06-22 Amgen Inc. Enantioselective alkenylation of aldehydes

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3474B1 (ar) * 2014-08-29 2020-07-05 Amgen Inc مشتقات تيتراهيدرونافثالين التي تثبط بروتين mcl-1
WO2017147410A1 (en) * 2016-02-25 2017-08-31 Amgen Inc. Compounds that inhibit mcl-1 protein
JP6453507B2 (ja) 2017-03-30 2019-01-16 アムジエン・インコーポレーテツド Ｍｃｌ−１タンパク質を阻害する化合物
TWI778443B (zh) * 2019-11-12 2022-09-21 美商基利科學股份有限公司 Mcl1抑制劑
PT4065567T (pt) 2019-11-26 2024-11-08 Gilead Sciences Inc Processos e intermediários para a preparação de inibidores de mcl1

Also Published As

Publication number Publication date
CA3181213A1 (en) 2021-11-11
JP2024095652A (ja) 2024-07-10
IL297523A (en) 2022-12-01
MX2022013870A (es) 2022-11-30
TW202208342A (zh) 2022-03-01
EP4146634A1 (en) 2023-03-15
TWI867217B (zh) 2024-12-21
BR112022022471A2 (pt) 2022-12-13
UY39200A (es) 2021-11-30
KR20230006552A (ko) 2023-01-10
JP2023524259A (ja) 2023-06-09
US20230183164A1 (en) 2023-06-15
CN115485267A (zh) 2022-12-16
AU2021268617B2 (en) 2024-06-13
AU2021268617A1 (en) 2022-12-15
WO2021226009A1 (en) 2021-11-11
CL2022003054A1 (es) 2023-06-30
AR122000A1 (es) 2022-08-03
CO2022015976A2 (es) 2022-12-09
JP7494318B2 (ja) 2024-06-03
PE20230465A1 (es) 2023-03-14

Similar Documents

Publication Publication Date Title
CR20220622A (es) Síntesis de intermedios de vinil ciclobutilo
PH12019502883A1 (en) Synthesis of omecamtiv mecarbil
MX2010003599A (es) Intermediarios y metodos para la sintesis de analogos de halicondrina b.
MX2023012178A (es) Compuesto de peptído corto de prolina modificado con anillo y uso del mismo.
MX2020007565A (es) Nuevos oxadiazoles.
MX2022013871A (es) Sintesis de productos intermedios de alcohol protegido vinilico.
MX2019002442A (es) Marcador de resistencia al moho pulverulento para calabazas de invierno, calabazas de invierno resistentes al moho pulverulento, metodo para producir calabazas de invierno resistentes al moho pulverulento mediante su uso y metodo para impartir resistencia al moho pulverulento a las calabazas de invierno.
CR20220621A (es) Síntesis de intermedios para inhibidores de mcl-1 macrocíclicos mediante un cierre de anillo
MX2024003004A (es) Procesos e intermedios para la síntesis de adagrasib.
TW200722434A (en) Stereoselective synthesis of β-nucleosides
MY195435A (en) Anticancer Compounds
MX2021007505A (es) Síntesis de 3-metil-1,2,4-tiadiazol-5-carbohidrazida o de su forma deuterada con metil-d3.
MX2021012240A (es) Sulfonildiazoles y n-(fluorosulfonil)azoles y metodos para elaborarlos.
MX2020010348A (es) Proceso para la fermentacion de ascomycota.
MX2023006144A (es) Alquenilacion enantioselectiva de aldehidos.
PH12022550266A1 (en) A method for preparing ivosidenib and an intermediate thereof
AU2017239848B2 (en) Novel compound and synthesis method therefor
EP4171366A4 (en) SYNTHESIS OF PATIENT-SPECIFIC LANGUAGE MODELS
PH12021553075A1 (en) Novel spirobicyclic intermediates
MX2009013336A (es) Sintesis de 3-aminopirazoles sustituidos.
EP3999847A4 (en) SEQUENCING OF BIOPOLYMERS BY MOTION-CONTROLLED ELECTRON TUNNELING
MX2019014989A (es) Proceso para la preparacion de (s,s)-secoisolariciresinol diglucosido y (r,r)-secoisolariciresinol diglucosido.
MX2022008398A (es) Metodos para la preparacion de 3-bromo-1-(3-cloropiridin-2-il)-1h- pirazol-5-carboxilato de etilo.
TW200708507A (en) A process for the preparation of tetrazolyltetrahydrocyclopentapyrazoles
MX2022002102A (es) Proceso para preparar un intermediario inhibidor de e-selectina.