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BR112022022471A2 - Síntese de intermediários de vinilciclobutila - Google Patents

Síntese de intermediários de vinilciclobutila

Info

Publication number
BR112022022471A2
BR112022022471A2 BR112022022471A BR112022022471A BR112022022471A2 BR 112022022471 A2 BR112022022471 A2 BR 112022022471A2 BR 112022022471 A BR112022022471 A BR 112022022471A BR 112022022471 A BR112022022471 A BR 112022022471A BR 112022022471 A2 BR112022022471 A2 BR 112022022471A2
Authority
BR
Brazil
Prior art keywords
synthesis
intermediates
vinylcyclobutyl
compound
salt
Prior art date
Application number
BR112022022471A
Other languages
English (en)
Inventor
G Smith Austin
T Corbett Michael
Fred Langille Neil
D Baucom Kyle
K Dornan Peter
St-Pierre Gabrielle
C Roosen Philipp
Cui Sheng
Profeta Roberto
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of BR112022022471A2 publication Critical patent/BR112022022471A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/62—Use of additives, e.g. for stabilisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/23—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/14—Preparation of carboxylic acid esters from carboxylic acid halides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SÍNTESE DE INTERMEDIÁRIOS DE VINILCICLOBUTILA. São proporcionados aqui processos para sintetizar intermediários úteis na preparação de inibidores de Mcl-1. Em particular são proporcionados aqui processos para sintetizar o composto F, ou um seu sal, em que R1 e OPG2 são descritos aqui. O composto F pode ser útil na síntese do composto A1, ou um seu sal ou solvato, ou do composto A2 ou um seu sal ou solvato.
BR112022022471A 2020-05-06 2021-05-04 Síntese de intermediários de vinilciclobutila BR112022022471A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063020877P 2020-05-06 2020-05-06
PCT/US2021/030548 WO2021226009A1 (en) 2020-05-06 2021-05-04 Synthesis of vinyl cyclobutyl intermediates

Publications (1)

Publication Number Publication Date
BR112022022471A2 true BR112022022471A2 (pt) 2022-12-13

Family

ID=76197567

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022022471A BR112022022471A2 (pt) 2020-05-06 2021-05-04 Síntese de intermediários de vinilciclobutila

Country Status (18)

Country Link
US (1) US20230183164A1 (pt)
EP (1) EP4146634A1 (pt)
JP (2) JP7494318B2 (pt)
KR (1) KR20230006552A (pt)
CN (1) CN115485267A (pt)
AR (1) AR122000A1 (pt)
AU (1) AU2021268617B2 (pt)
BR (1) BR112022022471A2 (pt)
CA (1) CA3181213A1 (pt)
CL (1) CL2022003054A1 (pt)
CO (1) CO2022015976A2 (pt)
CR (1) CR20220622A (pt)
IL (1) IL297523A (pt)
MX (1) MX2022013870A (pt)
PE (1) PE20230465A1 (pt)
TW (1) TWI867217B (pt)
UY (1) UY39200A (pt)
WO (1) WO2021226009A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118908912A (zh) * 2020-05-06 2024-11-08 安进公司 乙烯基保护的醇中间体的合成
CA3202548A1 (en) * 2020-11-25 2022-06-02 Amgen Inc. Enantioselective alkenylation of aldehydes

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3474B1 (ar) * 2014-08-29 2020-07-05 Amgen Inc مشتقات تيتراهيدرونافثالين التي تثبط بروتين mcl-1
US11306107B2 (en) * 2016-02-25 2022-04-19 Amgen Inc. Compounds that inhibit MCL-1 protein
JP6453507B2 (ja) * 2017-03-30 2019-01-16 アムジエン・インコーポレーテツド Ｍｃｌ−１タンパク質を阻害する化合物
TWI778443B (zh) * 2019-11-12 2022-09-21 美商基利科學股份有限公司 Mcl1抑制劑
CN114787139B (zh) * 2019-11-26 2025-03-11 吉利德科学公司 用于制备mcl1抑制剂的方法和中间体

Also Published As

Publication number Publication date
UY39200A (es) 2021-11-30
JP7494318B2 (ja) 2024-06-03
CL2022003054A1 (es) 2023-06-30
US20230183164A1 (en) 2023-06-15
CA3181213A1 (en) 2021-11-11
KR20230006552A (ko) 2023-01-10
CR20220622A (es) 2023-01-24
PE20230465A1 (es) 2023-03-14
EP4146634A1 (en) 2023-03-15
TW202208342A (zh) 2022-03-01
CO2022015976A2 (es) 2022-12-09
IL297523A (en) 2022-12-01
AU2021268617B2 (en) 2024-06-13
JP2024095652A (ja) 2024-07-10
MX2022013870A (es) 2022-11-30
AR122000A1 (es) 2022-08-03
AU2021268617A1 (en) 2022-12-15
JP2023524259A (ja) 2023-06-09
TWI867217B (zh) 2024-12-21
WO2021226009A1 (en) 2021-11-11
CN115485267A (zh) 2022-12-16

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