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CO6761389A2 - Inhibidores de nampt y rock - Google Patents

Inhibidores de nampt y rock

Info

Publication number
CO6761389A2
CO6761389A2 CO13143136A CO13143136A CO6761389A2 CO 6761389 A2 CO6761389 A2 CO 6761389A2 CO 13143136 A CO13143136 A CO 13143136A CO 13143136 A CO13143136 A CO 13143136A CO 6761389 A2 CO6761389 A2 CO 6761389A2
Authority
CO
Colombia
Prior art keywords
nampt
rock inhibitors
compounds
rock
inhibit
Prior art date
Application number
CO13143136A
Other languages
English (en)
Inventor
Kevin R Woller
Omar J Shah
Michael MICHAELIDES
Michael L Curtin
Bryan K Sorensen
Howard R Heyman
Richard F Clark
Chris Tse
Anil Vasudevan
Helmut Mack
Todd M Hansen
Ramzi Sweis
Marina A Pliushchev
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45034200&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6761389(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of CO6761389A2 publication Critical patent/CO6761389A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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Abstract

Compuestos que inhiben la actividad de la NAMPT, composiciones que contienen los compuestos y métodos para tratar enfermedades en las cuales se expresa la NAMPT. Compuestos que inhiben la actividad de la ROCK, composiciones que contienen los compuestos y métodos para tratar enfermedades en las cuales se expresa la ROCK.
CO13143136A 2010-11-15 2013-06-14 Inhibidores de nampt y rock CO6761389A2 (es)

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US41372210P 2010-11-15 2010-11-15
US201161474015P 2011-04-11 2011-04-11
US201161525405P 2011-08-19 2011-08-19

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CO6761389A2 true CO6761389A2 (es) 2013-09-30

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US (2) US9302989B2 (es)
EP (1) EP2640698A1 (es)
JP (2) JP6117104B2 (es)
KR (1) KR20140009251A (es)
CN (1) CN103313968A (es)
AR (1) AR083855A1 (es)
AU (2) AU2011329233A1 (es)
BR (1) BR112013012078A2 (es)
CA (1) CA2816594A1 (es)
CL (1) CL2013001340A1 (es)
CO (1) CO6761389A2 (es)
CR (1) CR20130267A (es)
DO (1) DOP2013000106A (es)
EC (1) ECSP13012993A (es)
GT (1) GT201300124A (es)
IL (1) IL225862A0 (es)
MX (1) MX2013005454A (es)
PE (1) PE20140913A1 (es)
PH (1) PH12013500975A1 (es)
RU (1) RU2013126657A (es)
SG (3) SG10202010119TA (es)
TW (1) TW201238950A (es)
UY (1) UY33726A (es)
WO (1) WO2012067965A1 (es)

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