CO5690579A2 - Derivados de diarilcicloalquilo, metodo para su produccion y su uso como medicamentos - Google Patents
Derivados de diarilcicloalquilo, metodo para su produccion y su uso como medicamentosInfo
- Publication number
- CO5690579A2 CO5690579A2 CO05085505A CO05085505A CO5690579A2 CO 5690579 A2 CO5690579 A2 CO 5690579A2 CO 05085505 A CO05085505 A CO 05085505A CO 05085505 A CO05085505 A CO 05085505A CO 5690579 A2 CO5690579 A2 CO 5690579A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- ring
- case
- phenyl
- alkanediyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
1.- Un compuesto de la fórmula Ien la que e anillo A es cicloalcanodiilo (C3-C8) o cicloalquenodiilo(C3-C8), donde en los anillos cicloalcanodiilo o cicloalquenodiilo uno o más átomos de carbono pueden estar reemplazados con átomos de oxígeno;e anillo B es a) fenilo; o b) un anillo heteroaromático de 5 a 12 miembros que puede contener de uno a cuatro heteroátomos seleccionados entre el grupo compuesto por N, O y S, y un anillo aromático de 8 a 14 miembros o cicloalquilo (C3-C8);R1 es a) en el caso del anillo B = a):SCF3, OCF2-CHF2, O-fenilo, O-alquil (C1-C6)-O-alquilo (C1-C3):b) en el caso del anillo B = b):H, F, CI, Br, OH, NO2, CF3, OCF3, OCF2-CF3, SCF3, OCF2-CHF2, O-fenilo, alquilo (C1-C6), O-alquilo (C1-C6), O-alquil (C1-C6)-O-alquilo (C1-C3);c) en el caso del anillo B = a) y R4 = fenilo:alquilo (C1-C6) o O-alquilo (C1-C6);R2 es H o CF3;R4 es a) en el caso del anillo B = a):fenilo;b) en el caso del anillo B = b):H, F, CI, Br, OH, NO2, CF3, OCF3, alquilo (C1-C6), O-alquilo (C1-C6);c) en el caso del anillo B = a) y R1 = a):alquilo (C1-C6);R5 es H, F, CI, Br, OH, NO2, CF3, OCF3, alquilo (C1-C6), O-alquilo (C1-C6);R3 es H o alquilo (C1-C6);X es alcanodiilo (C1-C6), donde en el grupo alcanodiilo, uno o más átomos de carbono pueden reemplazarse por átomos de oxígeno;Y es alcanodiilo (C1-C6), donde en el grupo alcanodiilo, uno o más átomos de carbono pueden reemplazarse por átomos de oxígeno;y sus sales fisiológicamente aceptables.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10308353A DE10308353A1 (de) | 2003-02-27 | 2003-02-27 | Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5690579A2 true CO5690579A2 (es) | 2006-10-31 |
Family
ID=32920627
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO05085505A CO5690579A2 (es) | 2003-02-27 | 2005-08-26 | Derivados de diarilcicloalquilo, metodo para su produccion y su uso como medicamentos |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US7160911B2 (es) |
| EP (1) | EP1599454B1 (es) |
| JP (1) | JP2006519197A (es) |
| KR (1) | KR20050106053A (es) |
| CN (1) | CN100439346C (es) |
| AR (1) | AR043430A1 (es) |
| AU (1) | AU2004216520B2 (es) |
| BR (1) | BRPI0407901A (es) |
| CA (1) | CA2516573A1 (es) |
| CO (1) | CO5690579A2 (es) |
| DE (1) | DE10308353A1 (es) |
| HR (1) | HRP20050740A2 (es) |
| IL (1) | IL170313A (es) |
| MA (1) | MA27741A1 (es) |
| MX (1) | MXPA05008993A (es) |
| NO (1) | NO20054382L (es) |
| PL (1) | PL377741A1 (es) |
| RU (1) | RU2005129999A (es) |
| TW (1) | TW200505880A (es) |
| WO (1) | WO2004075815A2 (es) |
| ZA (1) | ZA200505763B (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4436129B2 (ja) * | 2001-08-31 | 2010-03-24 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | ジアリールシクロアルキル誘導体、その製造法及びｐｐａｒ−活性剤としてのその使用 |
| US7399777B2 (en) * | 2001-08-31 | 2008-07-15 | Sanofi-Aventis Deutschland Gmbh | Diarylcycloalkyl derivatives, processes for their preparation and their use as pharmceuticals |
| US20040242566A1 (en) | 2003-03-25 | 2004-12-02 | Syrrx, Inc. | Dipeptidyl peptidase inhibitors |
| US7638638B2 (en) | 2003-05-14 | 2009-12-29 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| ZA200602051B (en) | 2003-08-13 | 2007-10-31 | Takeda Pharmaceutical | 4-pyrimidone derivatives and their use as peptidyl peptidase inhibitors |
| JPWO2006016637A1 (ja) | 2004-08-11 | 2008-05-01 | 杏林製薬株式会社 | 新規環状アミノ安息香酸誘導体 |
| DE102004040736B4 (de) | 2004-08-23 | 2007-01-11 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung von Diarylcycloalkylderivaten |
| DE102004060227B3 (de) * | 2004-12-15 | 2006-07-20 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung von Oxazolen durch Kondensation von aromatischen Aldehyden mit α-Ketoximen zu N-Oxiden und nachfolgende Reaktion mit aktivierten Säurederivaten |
| KR20070116644A (ko) * | 2005-03-23 | 2007-12-10 | 교린 세이야꾸 가부시키 가이샤 | 신규 환상 아미노페닐알칸산 유도체 |
| PE20070522A1 (es) | 2005-09-14 | 2007-07-11 | Takeda Pharmaceutical | 2-[6-(3-amino-piperidin-1-il)-3-metil-2,4-dioxo-3,4-dihidro-2h-pirimidin-1-ilmetil]-4-fluoro-benzonitrilo como inhibidor de dipeptidil peptidasa y composiciones farmaceuticas que lo contienen |
| CA2622642C (en) | 2005-09-16 | 2013-12-31 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| AU2006299091A1 (en) | 2005-09-29 | 2007-04-12 | Sanofi-Aventis | Phenyl- and pyridinyl- 1, 2 , 4 - oxadiazolone derivatives, processes for their preparation and their use as pharmaceuticals |
| WO2007112347A1 (en) | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
| TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
| US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
| US8153644B2 (en) * | 2007-05-22 | 2012-04-10 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| US8115011B2 (en) * | 2007-05-22 | 2012-02-14 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| US8211884B2 (en) * | 2008-08-06 | 2012-07-03 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| US8324385B2 (en) * | 2008-10-30 | 2012-12-04 | Madrigal Pharmaceuticals, Inc. | Diacylglycerol acyltransferase inhibitors |
| CN102245024A (zh) * | 2008-12-17 | 2011-11-16 | 维尔制药公司 | 二酰甘油酰基转移酶抑制剂 |
Family Cites Families (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2663336B1 (fr) | 1990-06-18 | 1992-09-04 | Adir | Nouveaux derives peptidiques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| AU658955B2 (en) * | 1992-01-28 | 1995-05-04 | Sumitomo Chemical Company, Limited | An oxazoline derivative, its production and its use |
| ZA941003B (en) | 1993-02-15 | 1995-08-14 | Wellcome Found | Hypolipidaemic compounds |
| IL108634A0 (en) | 1993-02-15 | 1994-05-30 | Wellcome Found | Hypolipidaemic heterocyclic compounds, their prepatation and pharmaceutical compositions containing them |
| JP3144624B2 (ja) | 1995-06-02 | 2001-03-12 | 杏林製薬株式会社 | Ｎ−ベンジルジオキソチアゾリジルベンズアミド誘導体及びその製造法 |
| CA2241567A1 (en) | 1996-01-17 | 1997-07-24 | Novo Nordisk A/S | Fused 1,2,4-thiadiazine and fused 1,4-thiazine derivatives, their preparation and use |
| CA2264243C (en) | 1996-08-30 | 2004-10-05 | Novo Nordisk A/S | Glp-1 derivatives |
| TW492957B (en) | 1996-11-07 | 2002-07-01 | Novartis Ag | N-substituted 2-cyanopyrrolidnes |
| CN1190434C (zh) | 1996-12-31 | 2005-02-23 | 雷迪实验室有限公司 | 新的杂环化合物、其制备方法和含有它们的药物组合物及其在治疗糖尿病和相关疾病中的应用 |
| AUPO713297A0 (en) * | 1997-06-02 | 1997-06-26 | Fujisawa Pharmaceutical Co., Ltd. | Oxazole compound |
| DE19726167B4 (de) | 1997-06-20 | 2008-01-24 | Sanofi-Aventis Deutschland Gmbh | Insulin, Verfahren zu seiner Herstellung und es enthaltende pharmazeutische Zubereitung |
| JP2001510195A (ja) | 1997-07-16 | 2001-07-31 | ノボ ノルディスク アクティーゼルスカブ | 縮合化１，２，４−チアジアジン誘導体、その調製及び使用 |
| CO4970713A1 (es) | 1997-09-19 | 2000-11-07 | Sanofi Synthelabo | Derivados de carboxamidotiazoles, su preparacion, composiciones farmaceuticas que los contienen |
| DE69941777D1 (de) * | 1998-03-10 | 2010-01-21 | Ono Pharmaceutical Co | Carbonsäurederivate und medikamente die diese als aktiven wirkstoff enthalten |
| DE19823831A1 (de) | 1998-05-28 | 1999-12-02 | Probiodrug Ges Fuer Arzneim | Neue pharmazeutische Verwendung von Isoleucyl Thiazolidid und seinen Salzen |
| SE9801992D0 (sv) | 1998-06-04 | 1998-06-04 | Astra Ab | New 3-aryl-2-hydroxypropionic acid derivative I |
| MA26634A1 (fr) | 1998-06-04 | 2004-12-20 | Astra Ab | Nouveaux derives de l'acide 3-aryl propionique et analogues |
| US6221897B1 (en) | 1998-06-10 | 2001-04-24 | Aventis Pharma Deutschland Gmbh | Benzothiepine 1,1-dioxide derivatives, a process for their preparation, pharmaceuticals comprising these compounds, and their use |
| DE19828113A1 (de) | 1998-06-24 | 2000-01-05 | Probiodrug Ges Fuer Arzneim | Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV |
| DE19828114A1 (de) | 1998-06-24 | 2000-01-27 | Probiodrug Ges Fuer Arzneim | Produgs instabiler Inhibitoren der Dipeptidyl Peptidase IV |
| BR9911752A (pt) * | 1998-07-01 | 2001-04-03 | Takeda Chemical Industries Ltd | Agente de regulagem da função do receptor relacionado com a retinóide, derivados de oxazol, de imidazol e de tiazol, composto, processo para regular uma função de receptor relacionado com a retinóide, e, uso de um derivado |
| DE19845405C2 (de) | 1998-10-02 | 2000-07-13 | Aventis Pharma Gmbh | Arylsubstituierte Propanolaminderivate und deren Verwendung |
| US6589969B1 (en) * | 1998-10-16 | 2003-07-08 | Ono Pharmaceutical Co., Ltd. | Carboxylic acid derivatives and drugs containing the same as the active ingredient |
| GB9900416D0 (en) | 1999-01-08 | 1999-02-24 | Alizyme Therapeutics Ltd | Inhibitors |
| DE19916108C1 (de) | 1999-04-09 | 2001-01-11 | Aventis Pharma Gmbh | Mit Zuckerresten substituierte 1,4-Benzothiazepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und deren Verwendung |
| JP2002542245A (ja) | 1999-04-16 | 2002-12-10 | ノボ ノルディスク アクティーゼルスカブ | 置換イミダゾール、それらの製造および使用 |
| MXPA01010880A (es) | 1999-04-28 | 2002-05-06 | Aventis Pharma Gmbh | Derivados de acido diarilico como ligandos de receptor ppar. |
| EE200100558A (et) * | 1999-04-28 | 2002-12-16 | Aventis Pharma Deutschland Gmbh | Triarüülhappe derivaat, seda sisaldav farmatseutiline kompositsioon ja ühendi raviotstarbeline kasutamine |
| WO2000066585A1 (en) | 1999-04-30 | 2000-11-09 | Neurogen Corporation | 9H-PYRIMIDO[4,5-b]INDOLE DERIVATIVES: CRF1 SPECIFIC LIGANDS |
| GB9911863D0 (en) | 1999-05-21 | 1999-07-21 | Knoll Ag | Therapeutic agents |
| CA2376919C (en) | 1999-06-18 | 2008-11-04 | Merck & Co., Inc. | Arylthiazolidinedione and aryloxazolidinedione derivatives |
| WO2001004146A2 (en) | 1999-07-09 | 2001-01-18 | Cohesion Technologies, Inc. | Ecarin polypeptides, polynucleotides encoding ecarin, and methods for use thereof |
| PT1204654E (pt) | 1999-07-29 | 2003-11-28 | Lilly Co Eli | Benzofurilpiperazinas agonistas do receptor 5-ht2c da serotonina |
| CA2383781A1 (en) | 1999-09-01 | 2001-03-08 | Aventis Pharma Deutschland Gmbh | Sulfonyl carboxamide derivatives, method for their production and their use as medicaments |
| AU7115300A (en) * | 1999-09-08 | 2001-04-10 | Glaxo Group Limited | Oxazole ppar antagonists |
| TWI302149B (en) | 1999-09-22 | 2008-10-21 | Bristol Myers Squibb Co | Substituted acid derivatives useful as antiodiabetic and antiobesity agents and method |
| US6414002B1 (en) * | 1999-09-22 | 2002-07-02 | Bristol-Myers Squibb Company | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method |
| PL357118A1 (en) | 1999-12-03 | 2004-07-12 | Astrazeneca Ab | Crystalline form of (s)-2 ethoxy-3-[4-(2-{4-methanesulfonyloxyphenyl} ethoxy) phenyl] propanoic acid |
| SE9904413D0 (sv) | 1999-12-03 | 1999-12-03 | Astra Ab | Comminuted form |
| EP2266665B1 (en) | 2000-03-31 | 2016-05-11 | Royalty Pharma Collection Trust | Method for the improvement of islet signaling in diabetes mellitus and for its prevention |
| KR20030007548A (ko) | 2000-04-25 | 2003-01-23 | 교린 세이야꾸 가부시키 가이샤 | 티아졸리딘디온 유도체의 신규한 안정한 결정 및 이의제조방법 |
| PT1277736E (pt) | 2000-04-28 | 2007-10-12 | Asahi Kasei Pharma Corp | Novos compostos bicíclicos |
| BR0110638A (pt) | 2000-05-11 | 2003-03-25 | Bristol Myers Squibb Co | Análogos de tetraidroisoquinolina úteis como secretagogos de hormÈnio do crescimento |
| WO2001091752A1 (en) | 2000-05-30 | 2001-12-06 | Merck & Co., Inc. | Melanocortin receptor agonists |
| SK17252002A3 (sk) | 2000-06-09 | 2003-05-02 | Aventis Pharma Deutschland Gmbh | Deriváty acylfenylmočoviny, spôsoby ich výroby a použitie ako liečivo |
| EP1182251A1 (en) * | 2000-08-11 | 2002-02-27 | Yissum Research Development Company of the Hebrew University of Jerusalem | Methods for identifying compounds that inhibit ubiquitin-mediated proteolysis of IkB |
| TWI243162B (en) | 2000-11-10 | 2005-11-11 | Taisho Pharmaceutical Co Ltd | Cyanopyrrolidine derivatives |
| CA2431983C (en) | 2000-12-21 | 2010-06-08 | Aventis Pharma Deutschland Gmbh | Novel 1,2-diphenylazetidinones, processes for their preparation, medicaments comprising these compounds and their use for treating impaired lipid metabolism |
| EP1726586A1 (en) * | 2000-12-25 | 2006-11-29 | Ono Pharmaceutical Co., Ltd. | Dihydronaphthalene derivative compounds and agent comprising the derivative as active ingredient |
| PE20021091A1 (es) | 2001-05-25 | 2003-02-04 | Aventis Pharma Gmbh | Derivados de fenilurea sustituidos con carbonamida y procedimiento para su preparacion |
| DE10154689A1 (de) | 2001-11-09 | 2003-05-22 | Probiodrug Ag | Substituierte Aminoketonverbindungen |
| US6623261B2 (en) | 2001-07-21 | 2003-09-23 | Thomas C. Edwards | Single-degree-of-freedom controlled-clearance univane™ fluid-handling machine |
| DE10142734A1 (de) * | 2001-08-31 | 2003-03-27 | Aventis Pharma Gmbh | Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| JP4436129B2 (ja) * | 2001-08-31 | 2010-03-24 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | ジアリールシクロアルキル誘導体、その製造法及びｐｐａｒ−活性剤としてのその使用 |
| IL164249A0 (en) | 2002-04-11 | 2005-12-18 | Aventis Pharma Gmbh | Acyl-3-carboxphenylurea derivatives, processes forpreparing them and their use |
| DE10215908B4 (de) | 2002-04-11 | 2005-08-18 | Aventis Pharma Deutschland Gmbh | Acyl-3-carboxyphenyl-harnstoffderivate und deren Verwendung als Arzneimittel |
| DE10225635C1 (de) | 2002-06-07 | 2003-12-24 | Aventis Pharma Gmbh | N-Benzoylureido-Zimtsäurederivate, Verfahren zu deren Herstellung und deren Verwendung |
| DE10231370B4 (de) | 2002-07-11 | 2006-04-06 | Sanofi-Aventis Deutschland Gmbh | Thiophenglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel |
| DE10258008B4 (de) | 2002-12-12 | 2006-02-02 | Sanofi-Aventis Deutschland Gmbh | Heterocyclische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel |
| DE10258007B4 (de) | 2002-12-12 | 2006-02-09 | Sanofi-Aventis Deutschland Gmbh | Aromatische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel |
| US7094795B2 (en) * | 2003-02-27 | 2006-08-22 | Sanofi-Aventis Deutschland Gmbh | Process for preparing the enantiomeric forms of cis-configured 1,3-cyclohexanediol derivatives |
| DE10308355A1 (de) * | 2003-02-27 | 2004-12-23 | Aventis Pharma Deutschland Gmbh | Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel |
| DE10308351A1 (de) * | 2003-02-27 | 2004-11-25 | Aventis Pharma Deutschland Gmbh | 1,3-substituierte Cycloalkylderivate mit sauren, meist heterocyclischen Gruppen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US7148246B2 (en) * | 2003-02-27 | 2006-12-12 | Sanofi-Aventis Deutschland Gmbh | Cycloalkyl derivatives having bioisosteric carboxylic acid groups, processes for their preparation and their use as pharmaceuticals |
-
2003
- 2003-02-27 DE DE10308353A patent/DE10308353A1/de not_active Withdrawn
-
2004
- 2004-02-19 MX MXPA05008993A patent/MXPA05008993A/es active IP Right Grant
- 2004-02-19 KR KR1020057016020A patent/KR20050106053A/ko not_active Application Discontinuation
- 2004-02-19 WO PCT/EP2004/001584 patent/WO2004075815A2/de active Application Filing
- 2004-02-19 AU AU2004216520A patent/AU2004216520B2/en not_active Ceased
- 2004-02-19 BR BRPI0407901-9A patent/BRPI0407901A/pt not_active IP Right Cessation
- 2004-02-19 RU RU2005129999/04A patent/RU2005129999A/ru not_active Application Discontinuation
- 2004-02-19 CN CNB2004800054472A patent/CN100439346C/zh not_active Expired - Fee Related
- 2004-02-19 CA CA002516573A patent/CA2516573A1/en not_active Abandoned
- 2004-02-19 PL PL377741A patent/PL377741A1/pl not_active Application Discontinuation
- 2004-02-19 EP EP04712502A patent/EP1599454B1/de not_active Expired - Lifetime
- 2004-02-19 JP JP2006501890A patent/JP2006519197A/ja active Pending
- 2004-02-25 TW TW093104700A patent/TW200505880A/zh unknown
- 2004-02-27 US US10/789,019 patent/US7160911B2/en not_active Expired - Lifetime
- 2004-02-27 AR ARP040100633A patent/AR043430A1/es not_active Application Discontinuation
-
2005
- 2005-07-19 ZA ZA200505763A patent/ZA200505763B/en unknown
- 2005-08-16 IL IL170313A patent/IL170313A/en not_active IP Right Cessation
- 2005-08-26 MA MA28464A patent/MA27741A1/fr unknown
- 2005-08-26 CO CO05085505A patent/CO5690579A2/es not_active Application Discontinuation
- 2005-08-26 HR HR20050740A patent/HRP20050740A2/xx not_active Application Discontinuation
- 2005-09-21 NO NO20054382A patent/NO20054382L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL170313A (en) | 2010-11-30 |
| DE10308353A1 (de) | 2004-12-02 |
| HRP20050740A2 (en) | 2006-08-31 |
| NO20054382L (no) | 2005-09-21 |
| AU2004216520B2 (en) | 2010-01-07 |
| AR043430A1 (es) | 2005-07-27 |
| MXPA05008993A (es) | 2005-10-18 |
| CN100439346C (zh) | 2008-12-03 |
| RU2005129999A (ru) | 2006-03-27 |
| AU2004216520A1 (en) | 2004-09-10 |
| BRPI0407901A (pt) | 2006-02-14 |
| CA2516573A1 (en) | 2004-09-10 |
| KR20050106053A (ko) | 2005-11-08 |
| ZA200505763B (en) | 2006-05-31 |
| TW200505880A (en) | 2005-02-16 |
| EP1599454A2 (de) | 2005-11-30 |
| WO2004075815A2 (de) | 2004-09-10 |
| US7160911B2 (en) | 2007-01-09 |
| MA27741A1 (fr) | 2006-02-01 |
| US20040204462A1 (en) | 2004-10-14 |
| EP1599454B1 (de) | 2012-12-26 |
| PL377741A1 (pl) | 2006-02-20 |
| JP2006519197A (ja) | 2006-08-24 |
| WO2004075815A3 (de) | 2004-12-29 |
| CN1753880A (zh) | 2006-03-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Application withdrawn |