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CO5640047A2 - Acidos fenoxiaceticos sustituidos como compuestos farmaceuticos utiles para el trtamiento de desordenes respiratorios, las composiciones farmaceuticas que los contienen y los procesos para su preparacion - Google Patents

Acidos fenoxiaceticos sustituidos como compuestos farmaceuticos utiles para el trtamiento de desordenes respiratorios, las composiciones farmaceuticas que los contienen y los procesos para su preparacion

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Publication number
CO5640047A2
CO5640047A2 CO05100592A CO05100592A CO5640047A2 CO 5640047 A2 CO5640047 A2 CO 5640047A2 CO 05100592 A CO05100592 A CO 05100592A CO 05100592 A CO05100592 A CO 05100592A CO 5640047 A2 CO5640047 A2 CO 5640047A2
Authority
CO
Colombia
Prior art keywords
halogen
alkyl
optionally substituted
substituents independently
independently selected
Prior art date
Application number
CO05100592A
Other languages
English (en)
Inventor
Roger Bonnert
Stephen Brough
Andrew Daves
Timothy Luker
Thomas Mcinally
Ian David Millichip
Garry Pairaudeau
Anil Patel
Rukhsana Rasul
Stephen Thom
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CO5640047A2 publication Critical patent/CO5640047A2/es

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    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
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Abstract

1.- Un compuesto de formula (I) o una sal farmacéuticamente aceptable de este: en la cual:X es halógeno, ciano, nitro, S(O)nR6 o alquiloC1-4, que está sustituido por uno o más átomos de halógeno;Y es seleccionado de hidrógeno, halógeno, CN, nitro, SO2R3, OR4, SR4, SOR3, SO2NR4R5, CONR4R5, NR4R5, NR6SO2R3, NR6CO2R6, NR6COR3, alqueniloC2-C6, alquiniloC2-C6, cicloalquiloC3-C7 o alquiloC1-6, estando los cuatro últimos grupos opcionalmente sustituidos por uno o más sustituyentes seleccionados independientemente de halógeno, OR6 y NR6R7, S(O)nR6, en donde n es 0, 1 o 2;Z es arilo o un anillo A, en donde A es un anillo aromático heterocíclico de seis miembros que contiene uno o más átomos de nitrógeno, o puede ser un biciclo fusionado 6,6 o 6,5 que contiene uno o más átomos de O, N, S, estando todos los anillos arilo o A opcionalmente sustituidos por uno o más sustituyentes seleccionados independientemente de hidrógeno, halógeno, CN, OH, SH, nitro, COR9, CO2R6, SO2R9, OR9, SR9, SOR9, SO2NR10R11, CONR10R11, NR10R11, NHSO2R9, NR9SO2R9, NR6CO2R6, NHCOR9, NR9COR9, NR6CONR4R5, NR6SO2NR4R5, arilo, heteroarilo, alqueniloC2-C6, alquiniloC2-C6, cicloalquiloC3-C7 o alquiloC1-6, estando los cuatro últimos grupos opcionalmente sustituidos por uno o más sustituyentes seleccionados independientemente de halógeno, cicloalquiloC3-C7, OR6, NR6R7, S(O)nR6 (en donde n es 0, 1 o 2), CONR6R7, NR6COR7, SO2NR6R7 y NR6SO2R7.R1 y R2 representan independientemente un átomo de hidrógeno, halógeno, alqueniloC2-C6, alquiniloC2-C6, cicloalquiloC3-C7 o un grupo alquiloC1-6, estando los cuatro últimos grupos opcionalmente sustituidos por uno o más sustituyentes seleccionados independientemente de halógeno, cicloalquiloC3-C7, NR6R7, OR6, S(O)nR6 (en donde n es 0, 1 o 2);o R1 y R2 juntos pueden formar un anillo de 3-8 miembros que contiene opcionalmente uno o más átomos seleccionados de O, S, NR6 y a su vez opcionalmente sustituidos por uno o más alquilo C1-C3 o halógeno; ...
CO05100592A 2003-04-07 2005-10-04 Acidos fenoxiaceticos sustituidos como compuestos farmaceuticos utiles para el trtamiento de desordenes respiratorios, las composiciones farmaceuticas que los contienen y los procesos para su preparacion CO5640047A2 (es)

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