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CO5540302A2 - Heteroarilos multiciclicos con quinuclidinas para el tratamiento de enfermedades - Google Patents

Heteroarilos multiciclicos con quinuclidinas para el tratamiento de enfermedades

Info

Publication number
CO5540302A2
CO5540302A2 CO03108314A CO03108314A CO5540302A2 CO 5540302 A2 CO5540302 A2 CO 5540302A2 CO 03108314 A CO03108314 A CO 03108314A CO 03108314 A CO03108314 A CO 03108314A CO 5540302 A2 CO5540302 A2 CO 5540302A2
Authority
CO
Colombia
Prior art keywords
alkyl
substituted
halogenated
heterocycloalkyl
alkynyl
Prior art date
Application number
CO03108314A
Other languages
English (en)
Inventor
Donn G Wishka
Steven C Reitz
David W Piotrowski
Vincent E Groopi Jr
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of CO5540302A2 publication Critical patent/CO5540302A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

1.- Un compuesto de formula I: En donde W essiempre que el enlace entre el grupo -C(=X)- y el grupo W puede estar unido a cualquiera de los átomos de carbono disponibles dentro del grupo W como aparecen en R3, R6, y R15;X es O, o S;Cada R1 es H, alquilo, cicloalquilo, alquilo halogenado, fenilo sustituido, o naftilo sustituido;R2 es H, alquilo, alquilo halogenado, alquilo sustituido, cicloalquilo, o arilo;Z---Z´---Z´´ se selecciona entre N(R4)-C(R3)=C(R3), N=C (R3) -C (R15)2,C(R3) =C (R3) -N(R4) , C(R3)2-N(R4) -C(R3)2, C(R15)2-C(R3) =N, N(R4) -C(R3)2-C(R3)2,C(R3)2-C(R3)2-N(R4), O-C(R3)=C(R3), O-C(R3)2-C(R3)2, C(R3)2-O-C(R3)2, C(R3) =C(R3) -O, C(R3)2-C(R3)2-O, S-C(R3)=C(R3), S-C(R3)2-C(R3)2, C(R3)2-S-C(R3)2, C(R3)=C (R3)-S,o C(R3)2-C(R3)2-S;Cada R3 es independientemente un enlace con la molécula central, siempre que solamente un R3 y ningún R6 ni R15 sea también dicho enlace, H, F, Br, Cl, I, alquilo, alquilo sustituido, alquilo halogenado, alquenilo, alquenilo sustituido, alquenilo halogenado, alquinilo, alquinilo sustituido, alquinilo halogenado, heterocicloalquilo, heterocicloalquilo sustituido, heterocicloalquilo láctamico, -CN, -NO2, -OR1, -C(O)N(R10)2, -NR1COR16, -N(R10)2, -SR1, -S(O)2R1, -C(O)R16,-CO2R1, arilo, R7, o R9, siempre que cuando R2 es H,Cuando Q es N, siendo J, L y M iguales c CH, y cuando Z- - -Z´- - - Z´´ es NH-CR3=CR3, el R3 para Z´´ no puede estar unido a la molécula central si R3, para Z´ es H; J, L, M, y Q son N o C(R6) siempre que solamente uno de J, L, M, o Q, sea N y los demás sean C(R6) , y ...
CO03108314A 2001-06-12 2003-12-10 Heteroarilos multiciclicos con quinuclidinas para el tratamiento de enfermedades CO5540302A2 (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US29771201P 2001-06-12 2001-06-12
US29771001P 2001-06-12 2001-06-12
US29770801P 2001-06-12 2001-06-12
US29771101P 2001-06-12 2001-06-12
US29770901P 2001-06-12 2001-06-12
US32859601P 2001-10-11 2001-10-11
US37349502P 2002-04-18 2002-04-18

Publications (1)

Publication Number Publication Date
CO5540302A2 true CO5540302A2 (es) 2005-07-29

Family

ID=27569623

Family Applications (1)

Application Number Title Priority Date Filing Date
CO03108314A CO5540302A2 (es) 2001-06-12 2003-12-10 Heteroarilos multiciclicos con quinuclidinas para el tratamiento de enfermedades

Country Status (17)

Country Link
US (1) US7067515B2 (es)
EP (1) EP1406901A1 (es)
JP (1) JP2004537532A (es)
KR (1) KR20040018266A (es)
CN (1) CN1511154A (es)
AR (1) AR036040A1 (es)
BR (1) BR0210384A (es)
CA (1) CA2445467A1 (es)
CO (1) CO5540302A2 (es)
CZ (1) CZ20033377A3 (es)
EA (1) EA200301216A1 (es)
IL (1) IL159344A0 (es)
MX (1) MXPA03011484A (es)
NO (1) NO20035522D0 (es)
PE (1) PE20030431A1 (es)
PL (1) PL367311A1 (es)
WO (1) WO2002100857A1 (es)

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AR036040A1 (es) 2004-08-04
NO20035522D0 (no) 2003-12-11
MXPA03011484A (es) 2004-03-18
CZ20033377A3 (cs) 2004-11-10
CN1511154A (zh) 2004-07-07
WO2002100857A1 (en) 2002-12-19
JP2004537532A (ja) 2004-12-16
KR20040018266A (ko) 2004-03-02
PE20030431A1 (es) 2003-05-26
PL367311A1 (en) 2005-02-21
CA2445467A1 (en) 2002-12-19
IL159344A0 (en) 2004-06-01
EA200301216A1 (ru) 2004-06-24
EP1406901A1 (en) 2004-04-14

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