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CO5261562A1 - Compuestos fosfatos de aminoalquil glucosaminida y su uso como coadyudante e inmunoefectores - Google Patents

Compuestos fosfatos de aminoalquil glucosaminida y su uso como coadyudante e inmunoefectores

Info

Publication number
CO5261562A1
CO5261562A1 CO00085801A CO00085801A CO5261562A1 CO 5261562 A1 CO5261562 A1 CO 5261562A1 CO 00085801 A CO00085801 A CO 00085801A CO 00085801 A CO00085801 A CO 00085801A CO 5261562 A1 CO5261562 A1 CO 5261562A1
Authority
CO
Colombia
Prior art keywords
compounds
immunofectors
glucosaminida
aminoalquil
assistant
Prior art date
Application number
CO00085801A
Other languages
English (en)
Inventor
David A Johnson
C Gregory Sowell
Original Assignee
Corixa Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Corixa Corp filed Critical Corixa Corp
Publication of CO5261562A1 publication Critical patent/CO5261562A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C07H13/06—Fatty acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se describen y reivindican los compuestos de fosfato de aminoalquil glucosaminida (AGP) que son coadyuvantes e inmunoefectores. En los compuestos, un grupo aminoalquilo (aglicon) tiene una unión glicosídica a 2-dioxi-2-amino glucosa. Los compuestos se fosforilan en los carbonos 4 y 6 sobre anillo de glucosaminida y además comprenden tres residuos 3-alcanoiloxialcanoilo. Los compuestos de esta invención son moléculas inmunoefectoras que aumentan la producción de anticuerpos en animales inmunizados, estimulando la producción de citoquinas y activando a los macrófagos. De acuerdo con esta invención, se revelan los métodos para usar esos compuestos como coadyuvantes e inmunoefectores. <EMI FILE="00085801_1" ID="1" IMF=JPEG >
CO00085801A 1999-11-12 2000-11-10 Compuestos fosfatos de aminoalquil glucosaminida y su uso como coadyudante e inmunoefectores CO5261562A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/439,839 US6303347B1 (en) 1997-05-08 1999-11-12 Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors

Publications (1)

Publication Number Publication Date
CO5261562A1 true CO5261562A1 (es) 2003-03-31

Family

ID=23746342

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00085801A CO5261562A1 (es) 1999-11-12 2000-11-10 Compuestos fosfatos de aminoalquil glucosaminida y su uso como coadyudante e inmunoefectores

Country Status (12)

Country Link
US (1) US6303347B1 (es)
EP (1) EP1230250A2 (es)
JP (1) JP2003514783A (es)
CN (1) CN1409720A (es)
AR (1) AR026443A1 (es)
BR (1) BR0015501A (es)
CA (1) CA2391299A1 (es)
CO (1) CO5261562A1 (es)
MX (1) MXPA02004774A (es)
NO (1) NO20022207L (es)
NZ (1) NZ518860A (es)
WO (1) WO2001034617A2 (es)

Families Citing this family (196)

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