CO4970814A1 - Formulaciones de tiagabine de liberacion prolongada con efec tos secundarios reducidos - Google Patents
Formulaciones de tiagabine de liberacion prolongada con efec tos secundarios reducidosInfo
- Publication number
- CO4970814A1 CO4970814A1 CO99003109A CO99003109A CO4970814A1 CO 4970814 A1 CO4970814 A1 CO 4970814A1 CO 99003109 A CO99003109 A CO 99003109A CO 99003109 A CO99003109 A CO 99003109A CO 4970814 A1 CO4970814 A1 CO 4970814A1
- Authority
- CO
- Colombia
- Prior art keywords
- weight
- group
- tiagabine
- release formulation
- prolonged release
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Una formulación de liberación prolongada que comprende tiagabinecombinado en una matriz con un polímero hidrofílico seleccionado del grupo conformado por un polietilenóxido de alto peso molecular e hidroxipropilmetilcelulosa. Una formulación de liberación prolongada que comprende tiagabine encapsulado dentro de una formulación con un material hidrofóbico seleccionado del grupo conformado por ceras, behenato de glicerilo, triglicéridos y mezclas de éstos. Una formulación de liberación prolongada que comprende desde 0,5 hasta 30% en peso de tiagabine combinado en una matriz que contiene: a. desde 15 hasta 80% en peso de polietilenóxido de alto peso molecular; b. desde 5 hasta 80% en peso de un material de relleno seleccionado del grupo conformado por celulosa microcristalina, almidón y azúcares; c. desde 0,1 hasta 4% en peso de dióxido de silicio; d. desde 0,1 hasta 1,5% en peso de un preservativo seleccionado del grupo conformado por tocoferol, BHA y BHT; e. desde 0,1 hasta 6% en peso de un primer lubricante seleccionado del grupo conformado por una cera, ácido esteárico, un estearato y un aceite vegetal hidrogenado; y f. desde 0,05% hasta 1% en peso de un segundo lubricante seleccionado del grupo conformado por estearato de magnesio, estearato de calcio y talco.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7213098P | 1998-01-22 | 1998-01-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO4970814A1 true CO4970814A1 (es) | 2000-11-07 |
Family
ID=22105780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO99003109A CO4970814A1 (es) | 1998-01-22 | 1999-01-21 | Formulaciones de tiagabine de liberacion prolongada con efec tos secundarios reducidos |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20070053980A1 (es) |
| EP (1) | EP1049470B1 (es) |
| JP (1) | JP2002501022A (es) |
| KR (1) | KR20010034313A (es) |
| CN (1) | CN1145484C (es) |
| AR (1) | AR018041A1 (es) |
| AT (1) | ATE350035T1 (es) |
| AU (1) | AU2239599A (es) |
| BG (1) | BG104692A (es) |
| CA (1) | CA2318448A1 (es) |
| CO (1) | CO4970814A1 (es) |
| DE (1) | DE69934670D1 (es) |
| HU (1) | HUP0101739A3 (es) |
| IL (1) | IL137324A0 (es) |
| NO (1) | NO20003677L (es) |
| NZ (1) | NZ505725A (es) |
| PL (1) | PL194595B1 (es) |
| SA (1) | SA99200204B1 (es) |
| SK (1) | SK11072000A3 (es) |
| TR (2) | TR200505223T2 (es) |
| TW (1) | TW585787B (es) |
| WO (1) | WO1999037302A1 (es) |
| ZA (1) | ZA99407B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6872734B2 (en) | 2000-10-20 | 2005-03-29 | Abbott Laboratories | Use of tiagabine for treatment of diabetic neuropathy and migraine |
| KR100510270B1 (ko) * | 2002-11-29 | 2005-08-26 | 센츄론(주) | 펠렛타이저를 이용한 서방성 제제의 제조방법 |
| CN102908327B (zh) * | 2011-08-05 | 2015-03-11 | 江苏恒瑞医药股份有限公司 | 伊伐布雷定或其可药用盐的缓释制剂 |
| KR102051132B1 (ko) * | 2017-03-17 | 2019-12-02 | 주식회사 종근당 | 미라베그론 또는 이의 염을 포함하는 방출조절용 약제학적 조성물 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5009897A (en) * | 1988-06-24 | 1991-04-23 | Abbott Laboratories | Pharmaceutical granules and tablets made therefrom |
| US5126145A (en) * | 1989-04-13 | 1992-06-30 | Upsher Smith Laboratories Inc | Controlled release tablet containing water soluble medicament |
| US5273758A (en) * | 1991-03-18 | 1993-12-28 | Sandoz Ltd. | Directly compressible polyethylene oxide vehicle for preparing therapeutic dosage forms |
| WO1995005808A1 (en) * | 1993-08-24 | 1995-03-02 | Abbott Laboratories | Oil-based tableting method |
| US5430021A (en) * | 1994-03-18 | 1995-07-04 | Pharmavene, Inc. | Hydrophobic drug delivery systems |
| ZA953078B (en) * | 1994-04-28 | 1996-01-05 | Alza Corp | Effective therapy for epilepsies |
| DK0830132T3 (da) * | 1995-05-05 | 2002-04-29 | Novo Nordisk As | Farmaceutisk formulering indeholdende tiagabinhydrochlorid samt fremgangsmåden til dets fremstilling |
| US5783212A (en) * | 1996-02-02 | 1998-07-21 | Temple University--of the Commonwealth System of Higher Education | Controlled release drug delivery system |
| ATE212550T1 (de) * | 1997-08-01 | 2002-02-15 | Elan Corp Plc | Tiagabinhaltige arzneizubereitungen mit gesteuerter wirkstoffverabreichung |
| US5843477A (en) * | 1997-09-30 | 1998-12-01 | Bayer Corporation | Lubricants for use in tabletting |
-
1999
- 1999-01-20 ZA ZA9900407A patent/ZA99407B/xx unknown
- 1999-01-21 CO CO99003109A patent/CO4970814A1/es unknown
- 1999-01-22 WO PCT/US1999/001242 patent/WO1999037302A1/en not_active Application Discontinuation
- 1999-01-22 AR ARP990100254A patent/AR018041A1/es unknown
- 1999-01-22 DE DE69934670T patent/DE69934670D1/de not_active Expired - Lifetime
- 1999-01-22 PL PL99342767A patent/PL194595B1/pl unknown
- 1999-01-22 KR KR1020007008031A patent/KR20010034313A/ko not_active IP Right Cessation
- 1999-01-22 AU AU22395/99A patent/AU2239599A/en not_active Abandoned
- 1999-01-22 TR TR2005/05223T patent/TR200505223T2/xx unknown
- 1999-01-22 CN CNB998040886A patent/CN1145484C/zh not_active Expired - Fee Related
- 1999-01-22 CA CA002318448A patent/CA2318448A1/en not_active Abandoned
- 1999-01-22 AT AT99902409T patent/ATE350035T1/de not_active IP Right Cessation
- 1999-01-22 JP JP2000528284A patent/JP2002501022A/ja not_active Withdrawn
- 1999-01-22 SK SK1107-2000A patent/SK11072000A3/sk unknown
- 1999-01-22 TR TR2000/02102T patent/TR200002102T2/xx unknown
- 1999-01-22 EP EP99902409A patent/EP1049470B1/en not_active Expired - Lifetime
- 1999-01-22 IL IL13732499A patent/IL137324A0/xx unknown
- 1999-01-22 NZ NZ505725A patent/NZ505725A/xx unknown
- 1999-01-22 HU HU0101739A patent/HUP0101739A3/hu unknown
- 1999-03-16 TW TW088100990A patent/TW585787B/zh not_active IP Right Cessation
- 1999-06-01 SA SA99200204A patent/SA99200204B1/ar unknown
-
2000
- 2000-07-18 NO NO20003677A patent/NO20003677L/no not_active Application Discontinuation
- 2000-08-15 BG BG104692A patent/BG104692A/xx unknown
-
2006
- 2006-11-03 US US11/592,694 patent/US20070053980A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| NO20003677L (no) | 2000-09-20 |
| PL342767A1 (en) | 2001-07-02 |
| CN1145484C (zh) | 2004-04-14 |
| NZ505725A (en) | 2003-01-31 |
| SA99200204B1 (ar) | 2006-10-11 |
| CA2318448A1 (en) | 1999-07-29 |
| TW585787B (en) | 2004-05-01 |
| KR20010034313A (ko) | 2001-04-25 |
| EP1049470B1 (en) | 2007-01-03 |
| HUP0101739A3 (en) | 2002-10-28 |
| ZA99407B (en) | 1999-07-20 |
| ATE350035T1 (de) | 2007-01-15 |
| TR200505223T2 (tr) | 2006-04-21 |
| US20070053980A1 (en) | 2007-03-08 |
| HUP0101739A2 (hu) | 2002-03-28 |
| AR018041A1 (es) | 2001-10-31 |
| TR200002102T2 (tr) | 2000-12-21 |
| JP2002501022A (ja) | 2002-01-15 |
| IL137324A0 (en) | 2001-07-24 |
| BG104692A (en) | 2001-05-31 |
| CN1293571A (zh) | 2001-05-02 |
| NO20003677D0 (no) | 2000-07-18 |
| SK11072000A3 (sk) | 2001-01-18 |
| AU2239599A (en) | 1999-08-09 |
| WO1999037302A1 (en) | 1999-07-29 |
| DE69934670D1 (de) | 2007-02-15 |
| EP1049470A1 (en) | 2000-11-08 |
| PL194595B1 (pl) | 2007-06-29 |
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