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CO4940472A1 - Pirazolopirimidonas para la disfuncion sexual - Google Patents

Pirazolopirimidonas para la disfuncion sexual

Info

Publication number
CO4940472A1
CO4940472A1 CO98022516A CO98022516A CO4940472A1 CO 4940472 A1 CO4940472 A1 CO 4940472A1 CO 98022516 A CO98022516 A CO 98022516A CO 98022516 A CO98022516 A CO 98022516A CO 4940472 A1 CO4940472 A1 CO 4940472A1
Authority
CO
Colombia
Prior art keywords
alkyl
alkoxy
optionally substituted
atom
attached
Prior art date
Application number
CO98022516A
Other languages
English (en)
Inventor
Mark Edward Bunnage
John Paul Mathia
Street Stephen Derek Albert
Anthony Wood
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27268823&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO4940472(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9708406.5A external-priority patent/GB9708406D0/en
Priority claimed from GB9715380A external-priority patent/GB9715380D0/en
Priority claimed from GBGB9722954.6A external-priority patent/GB9722954D0/en
Application filed by Pfizer filed Critical Pfizer
Publication of CO4940472A1 publication Critical patent/CO4940472A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un compuesto de fórmula (IA) o (IB):o una sal farmacéutica o veterinariamente aceptable del mismo o un solvato farmacéutica o veterinariamente aceptable de cualquier entidad, en la que:R1 es alquilo C1 a C3 sustituido con cicloalquilo C3 a C6 , CONR5 R6 o un grupo heterocíclico unido a través de un átomo de N, seleccionado entre pirazolilo, imidazolilo, triazolilo, pirrolidinilo, piperidinilo, morfolinilo y 4-R9 -piperazinilo; (CH2 )n Het o (CH2 )n Ar; R2 es alquilo C1 a C6 ; R3 es alquilo C1 a C6 ; opcionalmente sustituido con alcoxi C1 -C4 ; R4 es SO2 NR7 R8 ; cada R5 y R6 se seleccionan independientemente entre H y alquilo C1 a C4 opcionalmente sustituido con alcoxi C1 a C4 o, junto con el átomo de nitrógeno al que están unidos, forman un grupo pirrolidinilo, piperidinilo, morfolinilo o 4-R9 -piperazinilo; R7 y R8 , junto con el átomo de nitrógeno al que están unidos, forman un grupo 4-R10 -piperazinilo; R9 es alquilo C1 a C4 ; R10 es H o alquilo C1 a C4 opcionalmente sustituido con OH, alcoxi C1 a C4 o CONH2 ; Het es un grupo heterocíclico de 6 miembros unidos a través de un átomo de C, que contiene uno o dos átomos de nitrógeno, opcionalmente en forma de su mono-N-óxido, o un grupo heterocíclico de 5 miembros unido a través de un átomo de C, que contiene de uno a cuatro heteroátomos seleccionados entre nitrógeno, oxígeno y azufre, donde cada uno de dichos grupos heterocíclicos está opcionalmente sustituido con uno o dos sustituyentes seleccionados entre alquilo C1 a C4 , opcionalmente sustituido con alcoxi C1 a C4 , alcoxi C1 a C4 , halo y NH2 ; Ar es fenilo opcionalmente sustituido con uno o dos sustituyentes seleccionados entre alquilo C1 a C4 , alcoxi C1 a C4 , halo, CN, CONH2 , NO2 , NH2 , NHSO2 (alquilo C1 a C4 ) y SO2 NH2 ; y n es O ó 1.
CO98022516A 1997-04-25 1998-04-23 Pirazolopirimidonas para la disfuncion sexual CO4940472A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9708406.5A GB9708406D0 (en) 1997-04-25 1997-04-25 Therapeutic agents
GB9715380A GB9715380D0 (en) 1997-07-22 1997-07-22 Therapeutic agents
GBGB9722954.6A GB9722954D0 (en) 1997-10-30 1997-10-30 Therapeutic agents

Publications (1)

Publication Number Publication Date
CO4940472A1 true CO4940472A1 (es) 2000-07-24

Family

ID=27268823

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98022516A CO4940472A1 (es) 1997-04-25 1998-04-23 Pirazolopirimidonas para la disfuncion sexual

Country Status (32)

Country Link
US (2) US6723719B1 (es)
EP (1) EP0977756A1 (es)
JP (2) JP3563078B2 (es)
KR (2) KR100390612B1 (es)
CN (2) CN1188415C (es)
AP (1) AP1002A (es)
AR (1) AR015595A1 (es)
AU (1) AU730670B2 (es)
BG (1) BG103828A (es)
BR (1) BR9810233A (es)
CA (1) CA2288910C (es)
CO (1) CO4940472A1 (es)
CZ (1) CZ299633B6 (es)
DZ (1) DZ2465A1 (es)
EA (2) EA002057B1 (es)
HK (1) HK1027808A1 (es)
HR (1) HRP980222B1 (es)
ID (1) ID22834A (es)
IL (5) IL132276A0 (es)
IS (1) IS5200A (es)
MA (1) MA24529A1 (es)
NO (1) NO314585B1 (es)
NZ (1) NZ338075A (es)
OA (1) OA11168A (es)
PA (1) PA8450401A1 (es)
PE (1) PE68699A1 (es)
PL (1) PL336586A1 (es)
RS (1) RS50118B (es)
SK (1) SK285991B6 (es)
TN (1) TNSN98053A1 (es)
TR (1) TR199902646T2 (es)
WO (1) WO1998049166A1 (es)

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