ES2271615T3 - N-aril-2-oxazolidinona-5-carboxamidas y sus derivados y su uso como antibacterianos. - Google Patents
N-aril-2-oxazolidinona-5-carboxamidas y sus derivados y su uso como antibacterianos. Download PDFInfo
- Publication number
- ES2271615T3 ES2271615T3 ES03743112T ES03743112T ES2271615T3 ES 2271615 T3 ES2271615 T3 ES 2271615T3 ES 03743112 T ES03743112 T ES 03743112T ES 03743112 T ES03743112 T ES 03743112T ES 2271615 T3 ES2271615 T3 ES 2271615T3
- Authority
- ES
- Spain
- Prior art keywords
- substituted
- alkyl
- het
- nr3r3
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229940088710 antibiotic agent Drugs 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 2
- -1 -OH Chemical group 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000005017 substituted alkenyl group Chemical group 0.000 abstract 1
- 125000005415 substituted alkoxy group Chemical group 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
- ZBZJXHCVGLJWFG-UHFFFAOYSA-N trichloromethyl(.) Chemical compound Cl[C](Cl)Cl ZBZJXHCVGLJWFG-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/12—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un compuesto de fórmula I: (Ver fórmula) o una de sus sales farmacéuticamente aceptable, en la que: A es una estructura i, ii o iii (Ver fórmula) C es arilo o heteroarilo, donde cada uno de los grupos arilo y heteroarilo está opcionalmente sustituido con 1-3 de R2; B se selecciona entre cicloalquilo, cicloalquilo sustituido, cicloalquenilo, cicloalquenilo sustituido, arilo, arilo sustituido, het y het sustituido, o B y un R2, si están presentes, junto con los átomos de carbono de fenilo a los que B y el R2 están unidos, forman un het, siendo el het opcionalmente un het sustituido, con la condición de que cuando C es fenilo opcionalmente sustituido con R2, B no sea (Ver fórmula), donde Q se selecciona independientemente entre H, alquilo C1-C6, -O-alquilo C1-C6, fenilo, bencilo, -OH, CF3, CCl3, -NR3R3, -alquileno C1-C6-NR3R3, alquileno C1-C6-(CH2fenil)-NR3R3, alquileno C1-C6-(CH2bencil)-NR3R3, y (Ver fórmula) R1 se selecciona entre H, -OH, alquilo, cicloalquilo, alcoxi, alquenilo, amino, alquilo sustituido, alcoxi sustituido y alquenilo sustituido; Cada R2 se selecciona independientemente entre H, alquilo, amino, NO2, -CN, halo y alquilo sustituido; y Cada R3 se selecciona independientemente entre H o alquilo C1-C6.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35949502P | 2002-02-25 | 2002-02-25 | |
| US359495P | 2002-02-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2271615T3 true ES2271615T3 (es) | 2007-04-16 |
Family
ID=27766097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES03743112T Expired - Lifetime ES2271615T3 (es) | 2002-02-25 | 2003-02-24 | N-aril-2-oxazolidinona-5-carboxamidas y sus derivados y su uso como antibacterianos. |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US6919329B2 (es) |
| EP (1) | EP1478629B1 (es) |
| JP (1) | JP2005524660A (es) |
| KR (1) | KR100613532B1 (es) |
| CN (1) | CN1639135A (es) |
| AP (1) | AP1902A (es) |
| AR (1) | AR038536A1 (es) |
| AT (1) | ATE342258T1 (es) |
| AU (1) | AU2003210807A1 (es) |
| BR (1) | BR0307924A (es) |
| CA (1) | CA2476038A1 (es) |
| CO (1) | CO5611128A2 (es) |
| CY (1) | CY1105797T1 (es) |
| DE (1) | DE60308998T2 (es) |
| DK (1) | DK1478629T3 (es) |
| EA (1) | EA007490B1 (es) |
| EC (1) | ECSP045245A (es) |
| ES (1) | ES2271615T3 (es) |
| GE (1) | GEP20074198B (es) |
| HR (1) | HRP20040717A2 (es) |
| IS (1) | IS7376A (es) |
| MA (1) | MA27180A1 (es) |
| MX (1) | MXPA04008205A (es) |
| MY (1) | MY135233A (es) |
| NO (1) | NO20044062L (es) |
| NZ (1) | NZ534521A (es) |
| OA (1) | OA12779A (es) |
| PL (1) | PL372461A1 (es) |
| PT (1) | PT1478629E (es) |
| SI (1) | SI1478629T1 (es) |
| TN (1) | TNSN04163A1 (es) |
| TW (1) | TW200305568A (es) |
| UA (1) | UA80112C2 (es) |
| WO (1) | WO2003072553A1 (es) |
| YU (1) | YU72804A (es) |
| ZA (1) | ZA200406362B (es) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7141588B2 (en) * | 2002-02-25 | 2006-11-28 | Pfizer, Inc. | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
| BR0315206A (pt) * | 2002-10-10 | 2005-08-16 | Pharmacia & Upjohn Co Llc | Compostos antimicrobianos de 1-aril-diidropiridona |
| EP1615916A1 (en) * | 2003-04-09 | 2006-01-18 | Pharmacia & Upjohn Company LLC | Antimicrobial 3.1.0 bicyclohexylphenyl-oxazolidinone derivatives and analogues |
| US8324398B2 (en) | 2003-06-03 | 2012-12-04 | Rib-X Pharmaceuticals, Inc. | Process for the synthesis of biaryl oxazolidinones |
| CA2528089C (en) | 2003-06-03 | 2015-11-24 | Rib-X Pharmaceuticals, Inc. | Biaryl heterocyclic compounds and methods of making and using the same |
| EP1656357A1 (en) * | 2003-07-02 | 2006-05-17 | Merck & Co., Inc. | Oxazolidinone antibiotics and derivatives thereof |
| KR20060113625A (ko) | 2003-07-02 | 2006-11-02 | 머크 앤드 캄파니 인코포레이티드 | 시클로프로필기 치환된 옥사졸리디논 항생제 및 그의유도체 |
| TW200526626A (en) | 2003-09-13 | 2005-08-16 | Astrazeneca Ab | Chemical compounds |
| US7304050B2 (en) * | 2003-09-16 | 2007-12-04 | Pfizer Inc. | Antibacterial agents |
| EP1713785A1 (en) | 2003-12-17 | 2006-10-25 | Rib-X Pharmaceuticals, Inc. | Halogenated biaryl heterocyclic compounds and methods of making and using the same |
| KR100854211B1 (ko) | 2003-12-18 | 2008-08-26 | 동아제약주식회사 | 신규한 옥사졸리디논 유도체, 그의 제조방법 및 이를유효성분으로 하는 항생제용 약학 조성물 |
| WO2005082900A2 (en) * | 2004-01-28 | 2005-09-09 | Pharmacia & Upjohn Company Llc | Oxazolidinone amidoximes as antibacterial agents |
| CA2575702A1 (en) * | 2004-08-06 | 2006-02-16 | Pharmacia & Upjohn Company Llc | Oxindole oxazolidinones as antibacterial agents |
| EP1819699A2 (en) * | 2004-11-29 | 2007-08-22 | Pharmacia & Upjohn Company LLC | Diazepine oxazolidinones as antibacterial agents |
| EE05394B1 (et) * | 2004-12-24 | 2011-04-15 | Janssen Pharmaceutica N.V. | Kinoliinihendid kasutamiseks latentse tuberkuloosi ravis |
| KR20070113233A (ko) | 2005-02-18 | 2007-11-28 | 아스트라제네카 아베 | 항균성 피페리딘 유도체 |
| AU2006231919A1 (en) | 2005-04-06 | 2006-10-12 | Pharmacia & Upjohn Company Llc | 7-fluoro-1,3-dihydro-indol-2-one oxazolidinones as antibacterial agents |
| EP1874782A1 (en) | 2005-04-15 | 2008-01-09 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| JP5534497B2 (ja) | 2005-06-08 | 2014-07-02 | メリンタ セラピューティクス，インコーポレイテッド | トリアゾール類の合成方法 |
| CA2610978A1 (en) | 2005-06-29 | 2007-01-04 | Pharmacia & Upjohn Company Llc | Homomorpholine oxazolidinones as antibacterial agents |
| EP1902048A1 (en) * | 2005-07-06 | 2008-03-26 | Pharmacia & Upjohn Company LLC | Oxazolidinone carboxamides containing azetidine and cyclobutane as antibacterial agents |
| WO2007004032A1 (en) * | 2005-07-06 | 2007-01-11 | Pharmacia & Upjohn Company Llc | Oxazolidiones containing cyclobutane as antibacterial agents |
| CA2633563A1 (en) * | 2005-12-23 | 2007-06-28 | Astrazeneca Ab | Antibacterial pyrrolopyridines, pyrrolopyrimidines, and pyrroloazepines |
| WO2007088478A1 (en) * | 2006-02-01 | 2007-08-09 | Pfizer Products Inc. | Indazole oxazolidinones as antibacterial agents |
| CA2647605A1 (en) | 2006-03-31 | 2007-10-11 | Research Foundation Itsuu Laboratory | Novel compound having heterocyclic ring |
| EP2062878A4 (en) * | 2006-08-30 | 2010-09-08 | Shionogi & Co | HYDRAZINE AMIDE DERIVATIVE |
| JP5207382B2 (ja) * | 2006-08-30 | 2013-06-12 | 塩野義製薬株式会社 | ウレア誘導体 |
| JP5455906B2 (ja) * | 2007-08-06 | 2014-03-26 | ミクウルク ファーマシューティカルズ，インコーポレイテッド | 細菌感染症治療のための抗微生物性オルト−フルオロフェニルオキサゾリジノン |
| US8530646B2 (en) | 2007-10-02 | 2013-09-10 | Research Foundation Itsuu Laboratory | Oxazolidinone derivative having 7-membered hetero ring |
| PE20110368A1 (es) * | 2008-08-18 | 2011-06-13 | Univ Yale | Moduladores de mif |
| US9643922B2 (en) | 2008-08-18 | 2017-05-09 | Yale University | MIF modulators |
| US9540322B2 (en) | 2008-08-18 | 2017-01-10 | Yale University | MIF modulators |
| RU2522582C2 (ru) * | 2008-11-20 | 2014-07-20 | Панацеа Биотек Лтд. | Новые противомикробные средства |
| MY156354A (en) | 2009-02-03 | 2016-02-15 | Merck Sharp & Dohme | Crystalline form of r)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate |
| BR112012000657A2 (pt) | 2009-06-26 | 2016-11-16 | Panacea Biotec Ltd | novos azabicilohexanos |
| CN104086528A (zh) | 2010-07-15 | 2014-10-08 | 拜耳知识产权有限责任公司 | 作为杀虫剂的新杂环化合物 |
| UA112897C2 (uk) | 2012-05-09 | 2016-11-10 | Байєр Фарма Акцієнгезелльшафт | Біциклічно заміщені урацили та їх застосування для лікування і/або профілактики захворювань |
| ES2900838T3 (es) | 2014-02-21 | 2022-03-18 | Shanghai Micurx Pharmaceutical Co Ltd | Profármacos de O-carbonil fosforamidato solubles en agua para administración terapéutica |
| JP7205529B2 (ja) * | 2018-02-26 | 2023-01-17 | 住友化学株式会社 | オキサゾリジノン化合物の製造方法 |
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| US5043443A (en) | 1988-07-29 | 1991-08-27 | Du Pont Merck Pharmaceutical Company | Aminomethyloxooxazolidinyl arylbenzene derivatives |
| US5182403A (en) | 1988-09-15 | 1993-01-26 | The Upjohn Company | Substituted 3(5'indazolyl) oxazolidin-2-ones |
| US5164510A (en) | 1988-09-15 | 1992-11-17 | The Upjohn Company | 5'Indolinyl-5β-amidomethyloxazolidin-2-ones |
| US5225565A (en) | 1988-09-15 | 1993-07-06 | The Upjohn Company | Antibacterial 3-(fused-ring substituted)phenyl-5β-amidomethyloxazolidin-2-ones |
| EP0417044A3 (en) | 1989-09-07 | 1991-06-12 | Ciba-Geigy Ag | Oxazolidinones and thiones as plantgrowth regulators |
| US5231188A (en) | 1989-11-17 | 1993-07-27 | The Upjohn Company | Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents |
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| DE4425612A1 (de) | 1994-07-20 | 1996-04-04 | Bayer Ag | 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone |
| DE4425609A1 (de) | 1994-07-20 | 1996-01-25 | Bayer Ag | Benzofuranyl- und Benzothienyloxazolidinone |
| DE19514313A1 (de) | 1994-08-03 | 1996-02-08 | Bayer Ag | Benzoxazolyl- und Benzothiazolyloxazolidinone |
| DE4429461A1 (de) * | 1994-08-19 | 1996-02-22 | Merck Patent Gmbh | Adhäsionsrezeptor-Antagonisten |
| PL183512B1 (pl) | 1994-10-26 | 2002-06-28 | Upjohn Co | Przeciwbakteryjne fenylooksazolidynony |
| RU2128660C1 (ru) | 1994-11-15 | 1999-04-10 | Фармация Энд Апджон Компани | Бициклические оксазин- или тиазин-оксазолидиноны или их фармацевтически приемлемые соли и способы лечения микробных инфекций |
| CA2208603A1 (en) | 1995-02-03 | 1996-08-08 | The Upjohn Company | Hetero-aromatic ring substituted phenyloxazolidinone antimicrobials |
| HRP960159A2 (en) | 1995-04-21 | 1997-08-31 | Bayer Ag | Benzocyclopentane oxazolidinones containing heteroatoms |
| ATE204874T1 (de) | 1995-05-11 | 2001-09-15 | Upjohn Co | Spirocyclische und bicyclische diazinyl- und carbazinyloxazolidinone |
| CA2228647A1 (en) | 1995-09-01 | 1997-03-13 | Pharmacia & Upjohn Company | Phenyloxazolidinones having a c-c bond to 4-8 membered heterocyclic rings |
| DE19601264A1 (de) | 1996-01-16 | 1997-07-17 | Bayer Ag | Pyrido-annellierte Thienyl- und Furanyl-Oxazolidinone |
| DE19601265A1 (de) | 1996-01-16 | 1997-07-17 | Bayer Ag | 2-Oxo- und 2-Thio-1,2-dihydrochinolinyl-oxazolidinone |
| DE19601627A1 (de) | 1996-01-18 | 1997-07-24 | Bayer Ag | Heteroatomhaltige Cyclopentanopyridyl-Oxazolidinone |
| GB9601666D0 (en) | 1996-01-27 | 1996-03-27 | Zeneca Ltd | Chemical compounds |
| DE19604223A1 (de) | 1996-02-06 | 1997-08-07 | Bayer Ag | Neue substituierte Oxazolidinone |
| GB9702213D0 (en) | 1996-02-24 | 1997-03-26 | Zeneca Ltd | Chemical compounds |
| GB9609919D0 (en) | 1996-05-11 | 1996-07-17 | Zeneca Ltd | Chemical compounds |
| US5990136A (en) | 1996-08-21 | 1999-11-23 | Pharmacia & Upjohn Company | Isoxazoline derivatives useful as antimicrobials |
| KR20010013192A (ko) | 1997-05-30 | 2001-02-26 | 로렌스 티. 마이젠헬더 | 티오카보닐 작용기를 갖는 옥사졸리디논 항균제 |
| DE19730847A1 (de) | 1997-07-18 | 1999-01-28 | Bayer Ag | Tricyclisch substituierte Oxazolidinone |
| GB9717804D0 (en) | 1997-08-22 | 1997-10-29 | Zeneca Ltd | Chemical compounds |
| US6083967A (en) | 1997-12-05 | 2000-07-04 | Pharmacia & Upjohn Company | S-oxide and S,S-dioxide tetrahydrothiopyran phenyloxazolidinones |
| DE19802235A1 (de) | 1998-01-22 | 1999-07-29 | Bayer Ag | Mit tricyclischen Indolen substituierte Oxazolidinone |
| DE19802239A1 (de) | 1998-01-22 | 1999-07-29 | Bayer Ag | Neue mit Bicyclen substituierte Oxazolidinone |
| JP2002501059A (ja) | 1998-01-23 | 2002-01-15 | ファルマシア・アンド・アップジョン・カンパニー | オキサゾリジノンの組合せライブラリー、組成物および調製方法 |
| DE19805117A1 (de) | 1998-02-09 | 1999-08-12 | Bayer Ag | Neue Oxazolidinone mit azolhaltigen Tricyclen |
| TR200003595T2 (tr) | 1998-06-05 | 2001-07-23 | Astrazeneca Ab | Kimyasal bileşikler |
| GB9821938D0 (en) | 1998-10-09 | 1998-12-02 | Zeneca Ltd | Chemical compounds |
| DE60019630T2 (de) | 1999-02-01 | 2006-03-16 | Pharmacia & Upjohn Co. Llc, Kalamazoo | 2-Fluoro-(oxido-Thiopyran-4-yl)Benzol Derivate |
| PT1181288E (pt) | 1999-05-27 | 2003-12-31 | Upjohn Co | Oxazolidinonas biciclicas como agentes antibacterianos |
| GB9928499D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical processes and intermediates |
| EA005567B1 (ru) | 1999-12-21 | 2005-04-28 | Фармация Энд Апджон Компани | Оксазолидиноны, обладающие сульфоксиминовой функциональностью |
| GB0009803D0 (en) | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| GB0100110D0 (en) | 2001-01-04 | 2001-02-14 | Univ Leeds | Modulation of calcium channel activity |
| GB0113297D0 (en) | 2001-06-01 | 2001-07-25 | Astrazeneca Ab | Chemical Process |
| EP1451164A2 (en) | 2001-07-12 | 2004-09-01 | PHARMACIA & UPJOHN COMPANY | Amide derivatives having improved solubility |
-
2003
- 2003-02-20 AR ARP030100552A patent/AR038536A1/es unknown
- 2003-02-21 MY MYPI20030608A patent/MY135233A/en unknown
- 2003-02-24 DE DE60308998T patent/DE60308998T2/de not_active Expired - Lifetime
- 2003-02-24 MX MXPA04008205A patent/MXPA04008205A/es active IP Right Grant
- 2003-02-24 JP JP2003571259A patent/JP2005524660A/ja active Pending
- 2003-02-24 PL PL03372461A patent/PL372461A1/xx unknown
- 2003-02-24 OA OA1200400221A patent/OA12779A/en unknown
- 2003-02-24 PT PT03743112T patent/PT1478629E/pt unknown
- 2003-02-24 EA EA200400893A patent/EA007490B1/ru not_active IP Right Cessation
- 2003-02-24 SI SI200330518T patent/SI1478629T1/sl unknown
- 2003-02-24 DK DK03743112T patent/DK1478629T3/da active
- 2003-02-24 AT AT03743112T patent/ATE342258T1/de not_active IP Right Cessation
- 2003-02-24 NZ NZ534521A patent/NZ534521A/en unknown
- 2003-02-24 CN CNA038044986A patent/CN1639135A/zh active Pending
- 2003-02-24 KR KR1020047013297A patent/KR100613532B1/ko not_active IP Right Cessation
- 2003-02-24 GE GEAP8378A patent/GEP20074198B/en unknown
- 2003-02-24 UA UA20040807036A patent/UA80112C2/uk unknown
- 2003-02-24 BR BR0307924-4A patent/BR0307924A/pt not_active IP Right Cessation
- 2003-02-24 AP APAP/P/2004/003110A patent/AP1902A/en active
- 2003-02-24 WO PCT/US2003/003125 patent/WO2003072553A1/en active IP Right Grant
- 2003-02-24 YU YU72804A patent/YU72804A/sh unknown
- 2003-02-24 US US10/373,286 patent/US6919329B2/en not_active Expired - Fee Related
- 2003-02-24 ES ES03743112T patent/ES2271615T3/es not_active Expired - Lifetime
- 2003-02-24 CA CA002476038A patent/CA2476038A1/en not_active Abandoned
- 2003-02-24 AU AU2003210807A patent/AU2003210807A1/en not_active Abandoned
- 2003-02-24 EP EP03743112A patent/EP1478629B1/en not_active Expired - Lifetime
- 2003-02-25 TW TW092103898A patent/TW200305568A/zh unknown
-
2004
- 2004-07-29 IS IS7376A patent/IS7376A/is unknown
- 2004-08-06 HR HR20040717A patent/HRP20040717A2/hr not_active Application Discontinuation
- 2004-08-11 ZA ZA200406362A patent/ZA200406362B/xx unknown
- 2004-08-13 CO CO04079406A patent/CO5611128A2/es not_active Application Discontinuation
- 2004-08-24 MA MA27837A patent/MA27180A1/fr unknown
- 2004-08-24 TN TNP2004000163A patent/TNSN04163A1/fr unknown
- 2004-08-25 EC EC2004005245A patent/ECSP045245A/es unknown
- 2004-09-24 NO NO20044062A patent/NO20044062L/no not_active Application Discontinuation
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2006
- 2006-11-17 CY CY20061101682T patent/CY1105797T1/el unknown
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